Found 11 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50252231
(CHEMBL4072515)Show SMILES Cc1nn(c(Oc2ccc(cc2)-c2nc3cc(ccc3[nH]2)C(=O)NCc2ccccc2)c1[N+]([O-])=O)-c1ccccc1 Show InChI InChI=1S/C31H24N6O4/c1-20-28(37(39)40)31(36(35-20)24-10-6-3-7-11-24)41-25-15-12-22(13-16-25)29-33-26-17-14-23(18-27(26)34-29)30(38)32-19-21-8-4-2-5-9-21/h2-18H,19H2,1H3,(H,32,38)(H,33,34) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.5 | n/a | n/a | n/a | n/a | n/a | n/a |
National Research Centre
Curated by ChEMBL
| Assay Description
Inhibition of Chk2 (unknown origin) by ELISA based spectrophotometric analysis |
Eur J Med Chem 134: 392-405 (2017)
Article DOI: 10.1016/j.ejmech.2017.03.090
BindingDB Entry DOI: 10.7270/Q27P91T8 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50252253
(CHEMBL4093249)Show SMILES Cc1nn(c(Oc2ccc(cc2)-c2nc3cc(ccc3[nH]2)C(=O)NC2CCCCC2)c1[N+]([O-])=O)-c1ccccc1 Show InChI InChI=1S/C30H28N6O4/c1-19-27(36(38)39)30(35(34-19)23-10-6-3-7-11-23)40-24-15-12-20(13-16-24)28-32-25-17-14-21(18-26(25)33-28)29(37)31-22-8-4-2-5-9-22/h3,6-7,10-18,22H,2,4-5,8-9H2,1H3,(H,31,37)(H,32,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.90 | n/a | n/a | n/a | n/a | n/a | n/a |
National Research Centre
Curated by ChEMBL
| Assay Description
Inhibition of Chk2 (unknown origin) by ELISA based spectrophotometric analysis |
Eur J Med Chem 134: 392-405 (2017)
Article DOI: 10.1016/j.ejmech.2017.03.090
BindingDB Entry DOI: 10.7270/Q27P91T8 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50252229
(CHEMBL4063921)Show SMILES CNC(=O)c1ccc2[nH]c(nc2c1)-c1ccc(Oc2c(c(C)nn2-c2ccccc2)[N+]([O-])=O)cc1 Show InChI InChI=1S/C25H20N6O4/c1-15-22(31(33)34)25(30(29-15)18-6-4-3-5-7-18)35-19-11-8-16(9-12-19)23-27-20-13-10-17(24(32)26-2)14-21(20)28-23/h3-14H,1-2H3,(H,26,32)(H,27,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
National Research Centre
Curated by ChEMBL
| Assay Description
Inhibition of Chk2 (unknown origin) by ELISA based spectrophotometric analysis |
Eur J Med Chem 134: 392-405 (2017)
Article DOI: 10.1016/j.ejmech.2017.03.090
BindingDB Entry DOI: 10.7270/Q27P91T8 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50252230
(CHEMBL4085496)Show SMILES CC(C)NC(=O)c1ccc2[nH]c(nc2c1)-c1ccc(Oc2c(c(C)nn2-c2ccccc2)[N+]([O-])=O)cc1 Show InChI InChI=1S/C27H24N6O4/c1-16(2)28-26(34)19-11-14-22-23(15-19)30-25(29-22)18-9-12-21(13-10-18)37-27-24(33(35)36)17(3)31-32(27)20-7-5-4-6-8-20/h4-16H,1-3H3,(H,28,34)(H,29,30) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
National Research Centre
Curated by ChEMBL
| Assay Description
Inhibition of Chk2 (unknown origin) by ELISA based spectrophotometric analysis |
Eur J Med Chem 134: 392-405 (2017)
Article DOI: 10.1016/j.ejmech.2017.03.090
BindingDB Entry DOI: 10.7270/Q27P91T8 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50252228
(CHEMBL4090789)Show SMILES Cc1nn(c(Oc2ccc(cc2)-c2nc3cc(ccc3[nH]2)C(N)=O)c1[N+]([O-])=O)-c1ccccc1 Show InChI InChI=1S/C24H18N6O4/c1-14-21(30(32)33)24(29(28-14)17-5-3-2-4-6-17)34-18-10-7-15(8-11-18)23-26-19-12-9-16(22(25)31)13-20(19)27-23/h2-13H,1H3,(H2,25,31)(H,26,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
National Research Centre
Curated by ChEMBL
| Assay Description
Inhibition of Chk2 (unknown origin) by ELISA based spectrophotometric analysis |
Eur J Med Chem 134: 392-405 (2017)
Article DOI: 10.1016/j.ejmech.2017.03.090
BindingDB Entry DOI: 10.7270/Q27P91T8 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50163251
(2-(4-(4-hydroxyphenylthio)phenyl)-1H-benzo[d]imida...)Show SMILES NC(=O)c1ccc2nc([nH]c2c1)-c1ccc(Sc2ccc(O)cc2)cc1 Show InChI InChI=1S/C20H15N3O2S/c21-19(25)13-3-10-17-18(11-13)23-20(22-17)12-1-6-15(7-2-12)26-16-8-4-14(24)5-9-16/h1-11,24H,(H2,21,25)(H,22,23) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
National Research Centre
Curated by ChEMBL
| Assay Description
Inhibition of Chk2 (unknown origin) by ELISA based spectrophotometric analysis |
Eur J Med Chem 134: 392-405 (2017)
Article DOI: 10.1016/j.ejmech.2017.03.090
BindingDB Entry DOI: 10.7270/Q27P91T8 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50252232
(CHEMBL4103039)Show SMILES Cc1nn(c(Oc2ccc(cc2)-c2nc3cc(ccc3[nH]2)[N+]([O-])=O)c1[N+]([O-])=O)-c1ccc(cc1)C#N Show InChI InChI=1S/C24H15N7O5/c1-14-22(31(34)35)24(29(28-14)17-6-2-15(13-25)3-7-17)36-19-9-4-16(5-10-19)23-26-20-11-8-18(30(32)33)12-21(20)27-23/h2-12H,1H3,(H,26,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
National Research Centre
Curated by ChEMBL
| Assay Description
Inhibition of Chk2 (unknown origin) by ELISA based spectrophotometric analysis |
Eur J Med Chem 134: 392-405 (2017)
Article DOI: 10.1016/j.ejmech.2017.03.090
BindingDB Entry DOI: 10.7270/Q27P91T8 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50252227
(CHEMBL4100980)Show SMILES Cc1nn(c(Oc2ccc(cc2)-c2nc3cc(ccc3[nH]2)C(O)=O)c1[N+]([O-])=O)-c1ccc(cc1)C#N Show InChI InChI=1S/C25H16N6O5/c1-14-22(31(34)35)24(30(29-14)18-7-2-15(13-26)3-8-18)36-19-9-4-16(5-10-19)23-27-20-11-6-17(25(32)33)12-21(20)28-23/h2-12H,1H3,(H,27,28)(H,32,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
National Research Centre
Curated by ChEMBL
| Assay Description
Inhibition of Chk2 (unknown origin) by ELISA based spectrophotometric analysis |
Eur J Med Chem 134: 392-405 (2017)
Article DOI: 10.1016/j.ejmech.2017.03.090
BindingDB Entry DOI: 10.7270/Q27P91T8 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50252252
(CHEMBL4062848)Show SMILES Cc1nn(c(Oc2ccc(cc2)-c2nc3cc(ccc3[nH]2)C(N)=O)c1[N+]([O-])=O)-c1ccc(cc1)C#N Show InChI InChI=1S/C25H17N7O4/c1-14-22(32(34)35)25(31(30-14)18-7-2-15(13-26)3-8-18)36-19-9-4-16(5-10-19)24-28-20-11-6-17(23(27)33)12-21(20)29-24/h2-12H,1H3,(H2,27,33)(H,28,29) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
National Research Centre
Curated by ChEMBL
| Assay Description
Inhibition of Chk2 (unknown origin) by ELISA based spectrophotometric analysis |
Eur J Med Chem 134: 392-405 (2017)
Article DOI: 10.1016/j.ejmech.2017.03.090
BindingDB Entry DOI: 10.7270/Q27P91T8 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50252234
(CHEMBL4083002)Show SMILES Cc1nn(c(Oc2ccc(cc2)-c2nc3cc(ccc3[nH]2)C(O)=O)c1[N+]([O-])=O)-c1ccccc1 Show InChI InChI=1S/C24H17N5O5/c1-14-21(29(32)33)23(28(27-14)17-5-3-2-4-6-17)34-18-10-7-15(8-11-18)22-25-19-12-9-16(24(30)31)13-20(19)26-22/h2-13H,1H3,(H,25,26)(H,30,31) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
National Research Centre
Curated by ChEMBL
| Assay Description
Inhibition of Chk2 (unknown origin) by ELISA based spectrophotometric analysis |
Eur J Med Chem 134: 392-405 (2017)
Article DOI: 10.1016/j.ejmech.2017.03.090
BindingDB Entry DOI: 10.7270/Q27P91T8 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50252233
(CHEMBL4076911)Show SMILES Cc1nn(c(Oc2ccc(cc2)-c2nc3cc(ccc3[nH]2)[N+]([O-])=O)c1[N+]([O-])=O)-c1ccccc1 Show InChI InChI=1S/C23H16N6O5/c1-14-21(29(32)33)23(27(26-14)16-5-3-2-4-6-16)34-18-10-7-15(8-11-18)22-24-19-12-9-17(28(30)31)13-20(19)25-22/h2-13H,1H3,(H,24,25) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
National Research Centre
Curated by ChEMBL
| Assay Description
Inhibition of Chk2 (unknown origin) by ELISA based spectrophotometric analysis |
Eur J Med Chem 134: 392-405 (2017)
Article DOI: 10.1016/j.ejmech.2017.03.090
BindingDB Entry DOI: 10.7270/Q27P91T8 |
More data for this
Ligand-Target Pair | |
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