Affinity Data by PubMed id=28557445

PubMed code 28557445

Found 11 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50239781 (CHEMBL4066936) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Drug Discovery, Bayer AG , Aprather Weg 18a, 42113 Wuppertal, Germany. Curated by ChEMBL					Assay Description Inhibition of human liver microsomes CYP3A4 using midazolam as substrate				J Med Chem 60: 5146-5161 (2017) Article DOI: 10.1021/acs.jmedchem.7b00449 BindingDB Entry DOI: 10.7270/Q2CZ399K
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50239781 (CHEMBL4066936) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Drug Discovery, Bayer AG , Aprather Weg 18a, 42113 Wuppertal, Germany. Curated by ChEMBL					Assay Description Inhibition of human liver microsomes CYP3A4 using midazolam as substrate preincubated with compound followed by substrate addition				J Med Chem 60: 5146-5161 (2017) Article DOI: 10.1021/acs.jmedchem.7b00449 BindingDB Entry DOI: 10.7270/Q2CZ399K
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50239781 (CHEMBL4066936) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Drug Discovery, Bayer AG , Aprather Weg 18a, 42113 Wuppertal, Germany. Curated by ChEMBL					Assay Description Inhibition of human liver microsomes CYP3A4 using testosterone as substrate preincubated with compound followed by substrate addition				J Med Chem 60: 5146-5161 (2017) Article DOI: 10.1021/acs.jmedchem.7b00449 BindingDB Entry DOI: 10.7270/Q2CZ399K
					More data for this Ligand-Target Pair
Cytochrome P450 2C19 (Homo sapiens (Human))	BDBM50239781 (CHEMBL4066936) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Drug Discovery, Bayer AG , Aprather Weg 18a, 42113 Wuppertal, Germany. Curated by ChEMBL					Assay Description Inhibition of human liver microsomes CYP2C19 using S-mephenytoin as substrate				J Med Chem 60: 5146-5161 (2017) Article DOI: 10.1021/acs.jmedchem.7b00449 BindingDB Entry DOI: 10.7270/Q2CZ399K
					More data for this Ligand-Target Pair
Cytochrome P450 2C9 (Homo sapiens (Human))	BDBM50239781 (CHEMBL4066936) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Drug Discovery, Bayer AG , Aprather Weg 18a, 42113 Wuppertal, Germany. Curated by ChEMBL					Assay Description Inhibition of human liver microsomes CYP2C9 using diclofenac as substrate				J Med Chem 60: 5146-5161 (2017) Article DOI: 10.1021/acs.jmedchem.7b00449 BindingDB Entry DOI: 10.7270/Q2CZ399K
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50239781 (CHEMBL4066936) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Drug Discovery, Bayer AG , Aprather Weg 18a, 42113 Wuppertal, Germany. Curated by ChEMBL					Assay Description Inhibition of human liver microsomes CYP3A4 using testosterone as substrate				J Med Chem 60: 5146-5161 (2017) Article DOI: 10.1021/acs.jmedchem.7b00449 BindingDB Entry DOI: 10.7270/Q2CZ399K
					More data for this Ligand-Target Pair
Cytochrome P450 1A2 (Homo sapiens (Human))	BDBM50239781 (CHEMBL4066936) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Drug Discovery, Bayer AG , Aprather Weg 18a, 42113 Wuppertal, Germany. Curated by ChEMBL					Assay Description Inhibition of human liver microsomes CYP1A2 using phenacetin as substrate				J Med Chem 60: 5146-5161 (2017) Article DOI: 10.1021/acs.jmedchem.7b00449 BindingDB Entry DOI: 10.7270/Q2CZ399K
					More data for this Ligand-Target Pair
Cytochrome P450 2B6 (Homo sapiens (Human))	BDBM50239781 (CHEMBL4066936) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Drug Discovery, Bayer AG , Aprather Weg 18a, 42113 Wuppertal, Germany. Curated by ChEMBL					Assay Description Inhibition of human liver microsomes CYP2B6 using bupropion as substrate				J Med Chem 60: 5146-5161 (2017) Article DOI: 10.1021/acs.jmedchem.7b00449 BindingDB Entry DOI: 10.7270/Q2CZ399K
					More data for this Ligand-Target Pair
Cytochrome P450 2C8 (Homo sapiens (Human))	BDBM50239781 (CHEMBL4066936) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Drug Discovery, Bayer AG , Aprather Weg 18a, 42113 Wuppertal, Germany. Curated by ChEMBL					Assay Description Inhibition of human liver microsomes CYP2C8 using amodiaquine as substrate				J Med Chem 60: 5146-5161 (2017) Article DOI: 10.1021/acs.jmedchem.7b00449 BindingDB Entry DOI: 10.7270/Q2CZ399K
					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Homo sapiens (Human))	BDBM50239781 (CHEMBL4066936) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Drug Discovery, Bayer AG , Aprather Weg 18a, 42113 Wuppertal, Germany. Curated by ChEMBL					Assay Description Inhibition of human liver microsomes CYP2D6 using dextromethorphan as substrate				J Med Chem 60: 5146-5161 (2017) Article DOI: 10.1021/acs.jmedchem.7b00449 BindingDB Entry DOI: 10.7270/Q2CZ399K
					More data for this Ligand-Target Pair
Cytochrome P450 2A6 (Homo sapiens (Human))	BDBM50239781 (CHEMBL4066936) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Drug Discovery, Bayer AG , Aprather Weg 18a, 42113 Wuppertal, Germany. Curated by ChEMBL					Assay Description Inhibition of human liver microsomes CYP2A6 using coumarin as substrate				J Med Chem 60: 5146-5161 (2017) Article DOI: 10.1021/acs.jmedchem.7b00449 BindingDB Entry DOI: 10.7270/Q2CZ399K
					More data for this Ligand-Target Pair

* indicates data uncertainty>20%