Affinity Data by PubMed id=28800229

PubMed code 28800229

Found 2 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50335099 (4-chlorobenzo[d]thiazol-2-amine \| CHEMBL1413383 \| ...) Show SMILES Nc1nc2c(Cl)cccc2s1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents	PDB Article PubMed	2.10E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
IOTA Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of N-terminal 6xHis-tagged PDE10A (unknown origin) expressed in BL21 (DE3) RIL cells using 3',5'-cGMP as substrate by microcalorimetric as...				J Med Chem 61: 1415-1424 (2018) Article DOI: 10.1021/acs.jmedchem.7b00404 BindingDB Entry DOI: 10.7270/Q2GX4DZ9
IOTA Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM14779 (Pyrazole carboxylic ester 2 \| ethyl 3,5-dimethyl-1...) Show SMILES CCOC(=O)c1c(C)n[nH]c1C Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	8.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
IOTA Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of human PDE4D catalytic domain using [3H]-cAMP as substrate after 30 mins by scintillation counting method				J Med Chem 61: 1415-1424 (2018) Article DOI: 10.1021/acs.jmedchem.7b00404 BindingDB Entry DOI: 10.7270/Q2GX4DZ9
IOTA Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

* indicates data uncertainty>20%