Affinity Data by PubMed id=28885019

PubMed code 28885019

Found 6 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM50241437 (CHEMBL4082927) Show SMILES CCN1CCN(CC1)c1ccccc1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.15E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Antagonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response admini...				J Med Chem 60: 7928-7934 (2017) Article DOI: 10.1021/acs.jmedchem.7b00875 BindingDB Entry DOI: 10.7270/Q20C4XX6
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Homo sapiens (Human))	BDBM50241432 (CHEMBL4061049) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Antagonist activity at human alpha4beta2 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response a...				J Med Chem 60: 7928-7934 (2017) Article DOI: 10.1021/acs.jmedchem.7b00875 BindingDB Entry DOI: 10.7270/Q20C4XX6
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM50241434 (CHEMBL3747954) Show SMILES CC[N+]1(CC)CCN(CC1)c1ccccc1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Antagonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response admini...				J Med Chem 60: 7928-7934 (2017) Article DOI: 10.1021/acs.jmedchem.7b00875 BindingDB Entry DOI: 10.7270/Q20C4XX6
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM50241432 (CHEMBL4061049) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Antagonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response admini...				J Med Chem 60: 7928-7934 (2017) Article DOI: 10.1021/acs.jmedchem.7b00875 BindingDB Entry DOI: 10.7270/Q20C4XX6
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM50241434 (CHEMBL3747954) Show SMILES CC[N+]1(CC)CCN(CC1)c1ccccc1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.21E+5	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Partial agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as induction of maximum current response administered for...				J Med Chem 60: 7928-7934 (2017) Article DOI: 10.1021/acs.jmedchem.7b00875 BindingDB Entry DOI: 10.7270/Q20C4XX6
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM50241432 (CHEMBL4061049) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Partial agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as induction of maximum current response administered for...				J Med Chem 60: 7928-7934 (2017) Article DOI: 10.1021/acs.jmedchem.7b00875 BindingDB Entry DOI: 10.7270/Q20C4XX6
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%