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PubMed code 28923383

Compile data set for download or QSAR
Found 2 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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PC sid
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Similars

Article
PubMed
n/an/a 205n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
In vitro Thromboxane A2 (TXA2) receptor antagonism was tested by its ability to inhibit the contraction of rat aorta induced by the stable thromboxan...


Eur J Med Chem 140: 155-171 (2017)


Article DOI: 10.1016/j.ejmech.2017.08.067
BindingDB Entry DOI: 10.7270/Q21G0PSB
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50278148
PNG
(CHEMBL4169916)
Show SMILES COc1cccc(Nc2cc(ncn2)N2CCN(CC2)C(=O)Nc2ccc(cc2)C(F)(F)F)c1
Show InChI InChI=1S/C23H23F3N6O2/c1-34-19-4-2-3-18(13-19)29-20-14-21(28-15-27-20)31-9-11-32(12-10-31)22(33)30-17-7-5-16(6-8-17)23(24,25)26/h2-8,13-15H,9-12H2,1H3,(H,30,33)(H,27,28,29)
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7.80E+3n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
In vitro Thromboxane A2 (TXA2) receptor antagonism was tested by its ability to inhibit the contraction of rat aorta induced by the stable thromboxan...


Eur J Med Chem 140: 155-171 (2017)


Article DOI: 10.1016/j.ejmech.2017.08.067
BindingDB Entry DOI: 10.7270/Q21G0PSB
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%