Found 16 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM2579
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| Purchase
CHEMBL
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 72 | n/a | n/a | n/a | n/a | n/a | n/a |
Jiangxi Science & Technology Normal University
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) incubated for 10 mins using FAM-labeled peptide and ATP by mobility shift assay |
Bioorg Med Chem 25: 5754-5763 (2017)
Article DOI: 10.1016/j.bmc.2017.09.003
BindingDB Entry DOI: 10.7270/Q2057JGW |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM16673
(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| DrugBank
Article
PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Jiangxi Science & Technology Normal University
Curated by ChEMBL
| Assay Description
Inhibition of CRAF (unknown origin) incubated for 10 mins using FAM-labeled peptide and ATP by mobility shift assay |
Bioorg Med Chem 25: 5754-5763 (2017)
Article DOI: 10.1016/j.bmc.2017.09.003
BindingDB Entry DOI: 10.7270/Q2057JGW |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM16673
(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| DrugBank
PDB
Article
PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Jiangxi Science & Technology Normal University
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) incubated for 10 mins using FAM-labeled peptide and ATP by mobility shift assay |
Bioorg Med Chem 25: 5754-5763 (2017)
Article DOI: 10.1016/j.bmc.2017.09.003
BindingDB Entry DOI: 10.7270/Q2057JGW |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM16673
(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| DrugBank
PDB
Article
PubMed
| n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
Jiangxi Science & Technology Normal University
Curated by ChEMBL
| Assay Description
Inhibition of BRAF (unknown origin) incubated for 10 mins using FAM-labeled peptide and ATP by mobility shift assay |
Bioorg Med Chem 25: 5754-5763 (2017)
Article DOI: 10.1016/j.bmc.2017.09.003
BindingDB Entry DOI: 10.7270/Q2057JGW |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50451031
(CHEMBL4217207)Show SMILES CNC(=O)c1cc(Oc2ccc(cc2)C2=NNC(C2)c2cccc(Br)c2)ccn1 |t:15| Show InChI InChI=1S/C22H19BrN4O2/c1-24-22(28)21-12-18(9-10-25-21)29-17-7-5-14(6-8-17)19-13-20(27-26-19)15-3-2-4-16(23)11-15/h2-12,20,27H,13H2,1H3,(H,24,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 540 | n/a | n/a | n/a | n/a | n/a | n/a |
Jiangxi Science & Technology Normal University
Curated by ChEMBL
| Assay Description
Inhibition of c-MET (unknown origin) incubated for 10 mins using FAM-labeled peptide and ATP by mobility shift assay |
Bioorg Med Chem 25: 5754-5763 (2017)
Article DOI: 10.1016/j.bmc.2017.09.003
BindingDB Entry DOI: 10.7270/Q2057JGW |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50451031
(CHEMBL4217207)Show SMILES CNC(=O)c1cc(Oc2ccc(cc2)C2=NNC(C2)c2cccc(Br)c2)ccn1 |t:15| Show InChI InChI=1S/C22H19BrN4O2/c1-24-22(28)21-12-18(9-10-25-21)29-17-7-5-14(6-8-17)19-13-20(27-26-19)15-3-2-4-16(23)11-15/h2-12,20,27H,13H2,1H3,(H,24,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 560 | n/a | n/a | n/a | n/a | n/a | n/a |
Jiangxi Science & Technology Normal University
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) incubated for 10 mins using FAM-labeled peptide and ATP by mobility shift assay |
Bioorg Med Chem 25: 5754-5763 (2017)
Article DOI: 10.1016/j.bmc.2017.09.003
BindingDB Entry DOI: 10.7270/Q2057JGW |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50451032
(CHEMBL4205052)Show SMILES CNC(=O)c1cc(Oc2ccc(cc2)C2=NNC(C2)c2ccccc2)ccn1 |t:15| Show InChI InChI=1S/C22H20N4O2/c1-23-22(27)21-13-18(11-12-24-21)28-17-9-7-16(8-10-17)20-14-19(25-26-20)15-5-3-2-4-6-15/h2-13,19,25H,14H2,1H3,(H,23,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Jiangxi Science & Technology Normal University
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) incubated for 10 mins using FAM-labeled peptide and ATP by mobility shift assay |
Bioorg Med Chem 25: 5754-5763 (2017)
Article DOI: 10.1016/j.bmc.2017.09.003
BindingDB Entry DOI: 10.7270/Q2057JGW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50451031
(CHEMBL4217207)Show SMILES CNC(=O)c1cc(Oc2ccc(cc2)C2=NNC(C2)c2cccc(Br)c2)ccn1 |t:15| Show InChI InChI=1S/C22H19BrN4O2/c1-24-22(28)21-12-18(9-10-25-21)29-17-7-5-14(6-8-17)19-13-20(27-26-19)15-3-2-4-16(23)11-15/h2-12,20,27H,13H2,1H3,(H,24,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Jiangxi Science & Technology Normal University
Curated by ChEMBL
| Assay Description
Inhibition of BRAF (unknown origin) incubated for 10 mins using FAM-labeled peptide and ATP by mobility shift assay |
Bioorg Med Chem 25: 5754-5763 (2017)
Article DOI: 10.1016/j.bmc.2017.09.003
BindingDB Entry DOI: 10.7270/Q2057JGW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50451032
(CHEMBL4205052)Show SMILES CNC(=O)c1cc(Oc2ccc(cc2)C2=NNC(C2)c2ccccc2)ccn1 |t:15| Show InChI InChI=1S/C22H20N4O2/c1-23-22(27)21-13-18(11-12-24-21)28-17-9-7-16(8-10-17)20-14-19(25-26-20)15-5-3-2-4-6-15/h2-13,19,25H,14H2,1H3,(H,23,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Jiangxi Science & Technology Normal University
Curated by ChEMBL
| Assay Description
Inhibition of BRAF (unknown origin) incubated for 10 mins using FAM-labeled peptide and ATP by mobility shift assay |
Bioorg Med Chem 25: 5754-5763 (2017)
Article DOI: 10.1016/j.bmc.2017.09.003
BindingDB Entry DOI: 10.7270/Q2057JGW |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50451031
(CHEMBL4217207)Show SMILES CNC(=O)c1cc(Oc2ccc(cc2)C2=NNC(C2)c2cccc(Br)c2)ccn1 |t:15| Show InChI InChI=1S/C22H19BrN4O2/c1-24-22(28)21-12-18(9-10-25-21)29-17-7-5-14(6-8-17)19-13-20(27-26-19)15-3-2-4-16(23)11-15/h2-12,20,27H,13H2,1H3,(H,24,28) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Jiangxi Science & Technology Normal University
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 (unknown origin) incubated for 10 mins using FAM-labeled peptide and ATP by mobility shift assay |
Bioorg Med Chem 25: 5754-5763 (2017)
Article DOI: 10.1016/j.bmc.2017.09.003
BindingDB Entry DOI: 10.7270/Q2057JGW |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50451031
(CHEMBL4217207)Show SMILES CNC(=O)c1cc(Oc2ccc(cc2)C2=NNC(C2)c2cccc(Br)c2)ccn1 |t:15| Show InChI InChI=1S/C22H19BrN4O2/c1-24-22(28)21-12-18(9-10-25-21)29-17-7-5-14(6-8-17)19-13-20(27-26-19)15-3-2-4-16(23)11-15/h2-12,20,27H,13H2,1H3,(H,24,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Jiangxi Science & Technology Normal University
Curated by ChEMBL
| Assay Description
Inhibition of CRAF (unknown origin) incubated for 10 mins using FAM-labeled peptide and ATP by mobility shift assay |
Bioorg Med Chem 25: 5754-5763 (2017)
Article DOI: 10.1016/j.bmc.2017.09.003
BindingDB Entry DOI: 10.7270/Q2057JGW |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50451031
(CHEMBL4217207)Show SMILES CNC(=O)c1cc(Oc2ccc(cc2)C2=NNC(C2)c2cccc(Br)c2)ccn1 |t:15| Show InChI InChI=1S/C22H19BrN4O2/c1-24-22(28)21-12-18(9-10-25-21)29-17-7-5-14(6-8-17)19-13-20(27-26-19)15-3-2-4-16(23)11-15/h2-12,20,27H,13H2,1H3,(H,24,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Jiangxi Science & Technology Normal University
Curated by ChEMBL
| Assay Description
Inhibition of EGFR (unknown origin) incubated for 10 mins using FAM-labeled peptide and ATP by mobility shift assay |
Bioorg Med Chem 25: 5754-5763 (2017)
Article DOI: 10.1016/j.bmc.2017.09.003
BindingDB Entry DOI: 10.7270/Q2057JGW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50451034
(CHEMBL4208998)Show SMILES CNC(=O)c1cc(Oc2ccc(cc2)C2=NNC(C2)c2ccc(OC)cc2)ccn1 |t:15| Show InChI InChI=1S/C23H22N4O3/c1-24-23(28)22-13-19(11-12-25-22)30-18-9-5-16(6-10-18)21-14-20(26-27-21)15-3-7-17(29-2)8-4-15/h3-13,20,26H,14H2,1-2H3,(H,24,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Jiangxi Science & Technology Normal University
Curated by ChEMBL
| Assay Description
Inhibition of BRAF (unknown origin) incubated for 10 mins using FAM-labeled peptide and ATP by mobility shift assay |
Bioorg Med Chem 25: 5754-5763 (2017)
Article DOI: 10.1016/j.bmc.2017.09.003
BindingDB Entry DOI: 10.7270/Q2057JGW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50451033
(CHEMBL4202658)Show SMILES CNC(=O)c1cc(Oc2ccc(cc2)C2CC(=NN2)c2ccc(cc2)[N+]([O-])=O)ccn1 |c:17| Show InChI InChI=1S/C22H19N5O4/c1-23-22(28)21-12-18(10-11-24-21)31-17-8-4-15(5-9-17)20-13-19(25-26-20)14-2-6-16(7-3-14)27(29)30/h2-12,20,26H,13H2,1H3,(H,23,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Jiangxi Science & Technology Normal University
Curated by ChEMBL
| Assay Description
Inhibition of BRAF (unknown origin) incubated for 10 mins using FAM-labeled peptide and ATP by mobility shift assay |
Bioorg Med Chem 25: 5754-5763 (2017)
Article DOI: 10.1016/j.bmc.2017.09.003
BindingDB Entry DOI: 10.7270/Q2057JGW |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50451033
(CHEMBL4202658)Show SMILES CNC(=O)c1cc(Oc2ccc(cc2)C2CC(=NN2)c2ccc(cc2)[N+]([O-])=O)ccn1 |c:17| Show InChI InChI=1S/C22H19N5O4/c1-23-22(28)21-12-18(10-11-24-21)31-17-8-4-15(5-9-17)20-13-19(25-26-20)14-2-6-16(7-3-14)27(29)30/h2-12,20,26H,13H2,1H3,(H,23,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Jiangxi Science & Technology Normal University
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) incubated for 10 mins using FAM-labeled peptide and ATP by mobility shift assay |
Bioorg Med Chem 25: 5754-5763 (2017)
Article DOI: 10.1016/j.bmc.2017.09.003
BindingDB Entry DOI: 10.7270/Q2057JGW |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50451034
(CHEMBL4208998)Show SMILES CNC(=O)c1cc(Oc2ccc(cc2)C2=NNC(C2)c2ccc(OC)cc2)ccn1 |t:15| Show InChI InChI=1S/C23H22N4O3/c1-24-23(28)22-13-19(11-12-25-22)30-18-9-5-16(6-10-18)21-14-20(26-27-21)15-3-7-17(29-2)8-4-15/h3-13,20,26H,14H2,1-2H3,(H,24,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Jiangxi Science & Technology Normal University
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) incubated for 10 mins using FAM-labeled peptide and ATP by mobility shift assay |
Bioorg Med Chem 25: 5754-5763 (2017)
Article DOI: 10.1016/j.bmc.2017.09.003
BindingDB Entry DOI: 10.7270/Q2057JGW |
More data for this
Ligand-Target Pair | |
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