Affinity Data by PubMed id=29144746

PubMed code 29144746

Found 8 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Melatonin receptor type 1A (Homo sapiens (Human))	BDBM9019 (CHEMBL45 \| Melatonin \| N-[2-(5-methoxy-1H-indol-3-...) Show SMILES COc1ccc2[nH]cc(CCNC(C)=O)c2c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	0.304	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis				J Nat Prod 80: 3324-3329 (2017) Article DOI: 10.1021/acs.jnatprod.7b00853 BindingDB Entry DOI: 10.7270/Q2NK3HJW
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair
Melatonin receptor type 1A (Homo sapiens (Human))	BDBM50284268 (CHEMBL4175759) Show SMILES O=c1ccc2ccc(O\C=C\c3ccccc3)cc2o1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	370	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis				J Nat Prod 80: 3324-3329 (2017) Article DOI: 10.1021/acs.jnatprod.7b00853 BindingDB Entry DOI: 10.7270/Q2NK3HJW
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair
Melatonin receptor type 1A (Homo sapiens (Human))	BDBM50378564 (CHEMBL145781) Show SMILES O=c1ccc2ccc(OCc3ccccc3)cc2o1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	445	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis				J Nat Prod 80: 3324-3329 (2017) Article DOI: 10.1021/acs.jnatprod.7b00853 BindingDB Entry DOI: 10.7270/Q2NK3HJW
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair
Melatonin receptor type 1A (Homo sapiens (Human))	BDBM50284267 (Boropinal) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	786	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis				J Nat Prod 80: 3324-3329 (2017) Article DOI: 10.1021/acs.jnatprod.7b00853 BindingDB Entry DOI: 10.7270/Q2NK3HJW
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair
Melatonin receptor type 1A (Homo sapiens (Human))	BDBM50284266 (7-(2-PENTYNYLOXY)COUMARIN) Show SMILES CCC#CCOc1ccc2ccc(=O)oc2c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	888	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis				J Nat Prod 80: 3324-3329 (2017) Article DOI: 10.1021/acs.jnatprod.7b00853 BindingDB Entry DOI: 10.7270/Q2NK3HJW
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair
Melatonin receptor type 1A (Homo sapiens (Human))	BDBM50361373 (AURAPTENE) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis				J Nat Prod 80: 3324-3329 (2017) Article DOI: 10.1021/acs.jnatprod.7b00853 BindingDB Entry DOI: 10.7270/Q2NK3HJW
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair
Melatonin receptor type 1A (Homo sapiens (Human))	BDBM50361372 (CHEMBL156692) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	5.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis				J Nat Prod 80: 3324-3329 (2017) Article DOI: 10.1021/acs.jnatprod.7b00853 BindingDB Entry DOI: 10.7270/Q2NK3HJW
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair
Melatonin receptor type 1A (Homo sapiens (Human))	BDBM50354139 (CHEMBL221960) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	5.90E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis				J Nat Prod 80: 3324-3329 (2017) Article DOI: 10.1021/acs.jnatprod.7b00853 BindingDB Entry DOI: 10.7270/Q2NK3HJW
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%