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PubMed code 29205034

Compile data set for download or QSAR
Found 39 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glutamate receptor ionotropic, NMDA 1/2A


(Rattus norvegicus (Rat)-RAT)		BDBM81977
PNG
(CAS_79055-68-8 | CB3371309 | D-AP5 | D-APV)
Show SMILES N[C@H](CCCP(O)(O)=O)C(O)=O |r|
Show InChI InChI=1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)/t4-/m1/s1
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 390n/an/an/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat GluN1a/GluN2A expressed in Xenopus laevis oocytes assessed as inhibition of glycine/glutamate-mediated current...

J Med Chem 60: 9885-9904 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01624
BindingDB Entry DOI: 10.7270/Q21R6SXD
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM81977
PNG
(CAS_79055-68-8 | CB3371309 | D-AP5 | D-APV)
Show SMILES N[C@H](CCCP(O)(O)=O)C(O)=O |r|
Show InChI InChI=1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)/t4-/m1/s1
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 2.80E+3n/an/an/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat GluN1a/GluN2B expressed in Xenopus laevis oocytes assessed as inhibition of glycine/glutamate-mediated current...

J Med Chem 60: 9885-9904 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01624
BindingDB Entry DOI: 10.7270/Q21R6SXD
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glutamate receptor ionotropic, NMDA 1/2A


(Rattus norvegicus (Rat)-RAT)		BDBM50246910
PNG
(CHEMBL4084540)
Show SMILES Cl.OC(=O)[C@H]1NCC[C@@H]1c1ccc(Cl)c(c1)C(O)=O |r|
Show InChI InChI=1S/C12H12ClNO4.ClH/c13-9-2-1-6(5-8(9)11(15)16)7-3-4-14-10(7)12(17)18;/h1-2,5,7,10,14H,3-4H2,(H,15,16)(H,17,18);1H/t7-,10+;/m1./s1
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 4.70E+3n/an/an/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat GluN1a/GluN2A expressed in Xenopus laevis oocytes assessed as inhibition of glycine/glutamate-mediated current...

J Med Chem 60: 9885-9904 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01624
BindingDB Entry DOI: 10.7270/Q21R6SXD
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM81977
PNG
(CAS_79055-68-8 | CB3371309 | D-AP5 | D-APV)
Show SMILES N[C@H](CCCP(O)(O)=O)C(O)=O |r|
Show InChI InChI=1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)/t4-/m1/s1
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 5.90E+3n/an/an/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat GluN1a/GluN2C expressed in Xenopus laevis oocytes assessed as inhibition of glycine/glutamate-mediated current...

J Med Chem 60: 9885-9904 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01624
BindingDB Entry DOI: 10.7270/Q21R6SXD
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50246910
PNG
(CHEMBL4084540)
Show SMILES Cl.OC(=O)[C@H]1NCC[C@@H]1c1ccc(Cl)c(c1)C(O)=O |r|
Show InChI InChI=1S/C12H12ClNO4.ClH/c13-9-2-1-6(5-8(9)11(15)16)7-3-4-14-10(7)12(17)18;/h1-2,5,7,10,14H,3-4H2,(H,15,16)(H,17,18);1H/t7-,10+;/m1./s1
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 1.00E+4n/an/an/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat GluN1a/GluN2B expressed in Xenopus laevis oocytes assessed as inhibition of glycine/glutamate-mediated current...

J Med Chem 60: 9885-9904 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01624
BindingDB Entry DOI: 10.7270/Q21R6SXD
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 3


(Rattus norvegicus)		BDBM50246919
PNG
(CHEMBL4099104)
Show SMILES Cl.OC(=O)[C@H]1NCC[C@@H]1c1ccc(F)c(c1)C(O)=O |r|
Show InChI InChI=1S/C12H12FNO4.ClH/c13-9-2-1-6(5-8(9)11(15)16)7-3-4-14-10(7)12(17)18;/h1-2,5,7,10,14H,3-4H2,(H,15,16)(H,17,18);1H/t7-,10+;/m1./s1
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 1.10E+4n/an/an/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Displacement of [3H]-KA from recombinant homomeric rat GluK3a receptor expressed in baculovirus infected Sf9 insect cell membranes by scintillation c...

J Med Chem 60: 9885-9904 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01624
BindingDB Entry DOI: 10.7270/Q21R6SXD
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1


(RAT)		BDBM50246919
PNG
(CHEMBL4099104)
Show SMILES Cl.OC(=O)[C@H]1NCC[C@@H]1c1ccc(F)c(c1)C(O)=O |r|
Show InChI InChI=1S/C12H12FNO4.ClH/c13-9-2-1-6(5-8(9)11(15)16)7-3-4-14-10(7)12(17)18;/h1-2,5,7,10,14H,3-4H2,(H,15,16)(H,17,18);1H/t7-,10+;/m1./s1
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 1.20E+4n/an/an/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Displacement of [3H]-SYM2081 from recombinant homomeric rat GluK1 (Q)1b receptor expressed in baculovirus infected Sf9 insect cell membranes by scint...

J Med Chem 60: 9885-9904 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01624
BindingDB Entry DOI: 10.7270/Q21R6SXD
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2D


(RAT-Rattus norvegicus (Rat))		BDBM81977
PNG
(CAS_79055-68-8 | CB3371309 | D-AP5 | D-APV)
Show SMILES N[C@H](CCCP(O)(O)=O)C(O)=O |r|
Show InChI InChI=1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)/t4-/m1/s1
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 2.10E+4n/an/an/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat GluN1a/GluN2D expressed in Xenopus laevis oocytes assessed as inhibition of glycine/glutamate-mediated current...

J Med Chem 60: 9885-9904 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01624
BindingDB Entry DOI: 10.7270/Q21R6SXD
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50246910
PNG
(CHEMBL4084540)
Show SMILES Cl.OC(=O)[C@H]1NCC[C@@H]1c1ccc(Cl)c(c1)C(O)=O |r|
Show InChI InChI=1S/C12H12ClNO4.ClH/c13-9-2-1-6(5-8(9)11(15)16)7-3-4-14-10(7)12(17)18;/h1-2,5,7,10,14H,3-4H2,(H,15,16)(H,17,18);1H/t7-,10+;/m1./s1
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 2.40E+4n/an/an/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat GluN1a/GluN2C expressed in Xenopus laevis oocytes assessed as inhibition of glycine/glutamate-mediated current...

J Med Chem 60: 9885-9904 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01624
BindingDB Entry DOI: 10.7270/Q21R6SXD
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2D


(RAT-Rattus norvegicus (Rat))		BDBM50246910
PNG
(CHEMBL4084540)
Show SMILES Cl.OC(=O)[C@H]1NCC[C@@H]1c1ccc(Cl)c(c1)C(O)=O |r|
Show InChI InChI=1S/C12H12ClNO4.ClH/c13-9-2-1-6(5-8(9)11(15)16)7-3-4-14-10(7)12(17)18;/h1-2,5,7,10,14H,3-4H2,(H,15,16)(H,17,18);1H/t7-,10+;/m1./s1
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 4.10E+4n/an/an/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat GluN1a/GluN2D expressed in Xenopus laevis oocytes assessed as inhibition of glycine/glutamate-mediated current...

J Med Chem 60: 9885-9904 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01624
BindingDB Entry DOI: 10.7270/Q21R6SXD
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Rattus norvegicus)		BDBM50246914
PNG
(CHEMBL4088958)
Show SMILES Cl.NC(=O)c1cccc(c1)[C@H]1CCN[C@@H]1C(O)=O |r|
Show InChI InChI=1S/C12H14N2O3.ClH/c13-11(15)8-3-1-2-7(6-8)9-4-5-14-10(9)12(16)17;/h1-3,6,9-10,14H,4-5H2,(H2,13,15)(H,16,17);1H/t9-,10+;/m1./s1
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Displacement of [3H]-KA from recombinant homomeric rat GluK2 (V,C,R)a receptor expressed in baculovirus infected Sf9 insect cell membranes by scintil...

J Med Chem 60: 9885-9904 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01624
BindingDB Entry DOI: 10.7270/Q21R6SXD
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 3


(Rattus norvegicus)		BDBM50246916
PNG
(CHEMBL4102488)
Show SMILES Cl.Cc1ccc(cc1C(O)=O)[C@H]1CCN[C@@H]1C(O)=O |r|
Show InChI InChI=1S/C13H15NO4.ClH/c1-7-2-3-8(6-10(7)12(15)16)9-4-5-14-11(9)13(17)18;/h2-3,6,9,11,14H,4-5H2,1H3,(H,15,16)(H,17,18);1H/t9-,11+;/m1./s1
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Displacement of [3H]-KA from recombinant homomeric rat GluK3a receptor expressed in baculovirus infected Sf9 insect cell membranes by scintillation c...

J Med Chem 60: 9885-9904 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01624
BindingDB Entry DOI: 10.7270/Q21R6SXD
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1


(RAT)		BDBM50246916
PNG
(CHEMBL4102488)
Show SMILES Cl.Cc1ccc(cc1C(O)=O)[C@H]1CCN[C@@H]1C(O)=O |r|
Show InChI InChI=1S/C13H15NO4.ClH/c1-7-2-3-8(6-10(7)12(15)16)9-4-5-14-11(9)13(17)18;/h2-3,6,9,11,14H,4-5H2,1H3,(H,15,16)(H,17,18);1H/t9-,11+;/m1./s1
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Displacement of [3H]-SYM2081 from recombinant homomeric rat GluK1 (Q)1b receptor expressed in baculovirus infected Sf9 insect cell membranes by scint...

J Med Chem 60: 9885-9904 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01624
BindingDB Entry DOI: 10.7270/Q21R6SXD
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 3


(Rattus norvegicus)		BDBM50246914
PNG
(CHEMBL4088958)
Show SMILES Cl.NC(=O)c1cccc(c1)[C@H]1CCN[C@@H]1C(O)=O |r|
Show InChI InChI=1S/C12H14N2O3.ClH/c13-11(15)8-3-1-2-7(6-8)9-4-5-14-10(9)12(16)17;/h1-3,6,9-10,14H,4-5H2,(H2,13,15)(H,16,17);1H/t9-,10+;/m1./s1
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Displacement of [3H]-KA from recombinant homomeric rat GluK3a receptor expressed in baculovirus infected Sf9 insect cell membranes by scintillation c...

J Med Chem 60: 9885-9904 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01624
BindingDB Entry DOI: 10.7270/Q21R6SXD
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Rattus norvegicus)		BDBM50246918
PNG
(CHEMBL4091369)
Show SMILES Cl.OC(=O)[C@H]1NCC[C@@H]1c1cccc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C12H12F3NO2.ClH/c13-12(14,15)8-3-1-2-7(6-8)9-4-5-16-10(9)11(17)18;/h1-3,6,9-10,16H,4-5H2,(H,17,18);1H/t9-,10+;/m1./s1
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Displacement of [3H]-KA from recombinant homomeric rat GluK2 (V,C,R)a receptor expressed in baculovirus infected Sf9 insect cell membranes by scintil...

J Med Chem 60: 9885-9904 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01624
BindingDB Entry DOI: 10.7270/Q21R6SXD
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 3


(Rattus norvegicus)		BDBM50246917
PNG
(CHEMBL4068651)
Show SMILES Cl.OC(=O)[C@H]1NCC[C@@H]1c1ccc(Br)c(c1)C(O)=O |r|
Show InChI InChI=1S/C12H12BrNO4.ClH/c13-9-2-1-6(5-8(9)11(15)16)7-3-4-14-10(7)12(17)18;/h1-2,5,7,10,14H,3-4H2,(H,15,16)(H,17,18);1H/t7-,10+;/m1./s1
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Displacement of [3H]-KA from recombinant homomeric rat GluK3a receptor expressed in baculovirus infected Sf9 insect cell membranes by scintillation c...

J Med Chem 60: 9885-9904 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01624
BindingDB Entry DOI: 10.7270/Q21R6SXD
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Rattus norvegicus)		BDBM50246911
PNG
(CHEMBL4076785)
Show SMILES Cl.OC(=O)[C@H]1NCC[C@@H]1c1cccc(Cl)c1 |r|
Show InChI InChI=1S/C11H12ClNO2.ClH/c12-8-3-1-2-7(6-8)9-4-5-13-10(9)11(14)15;/h1-3,6,9-10,13H,4-5H2,(H,14,15);1H/t9-,10+;/m1./s1
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Displacement of [3H]-KA from recombinant homomeric rat GluK2 (V,C,R)a receptor expressed in baculovirus infected Sf9 insect cell membranes by scintil...

J Med Chem 60: 9885-9904 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01624
BindingDB Entry DOI: 10.7270/Q21R6SXD
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 3


(Rattus norvegicus)		BDBM50246911
PNG
(CHEMBL4076785)
Show SMILES Cl.OC(=O)[C@H]1NCC[C@@H]1c1cccc(Cl)c1 |r|
Show InChI InChI=1S/C11H12ClNO2.ClH/c12-8-3-1-2-7(6-8)9-4-5-13-10(9)11(14)15;/h1-3,6,9-10,13H,4-5H2,(H,14,15);1H/t9-,10+;/m1./s1
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Displacement of [3H]-KA from recombinant homomeric rat GluK3a receptor expressed in baculovirus infected Sf9 insect cell membranes by scintillation c...

J Med Chem 60: 9885-9904 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01624
BindingDB Entry DOI: 10.7270/Q21R6SXD
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Rattus norvegicus)		BDBM50246919
PNG
(CHEMBL4099104)
Show SMILES Cl.OC(=O)[C@H]1NCC[C@@H]1c1ccc(F)c(c1)C(O)=O |r|
Show InChI InChI=1S/C12H12FNO4.ClH/c13-9-2-1-6(5-8(9)11(15)16)7-3-4-14-10(7)12(17)18;/h1-2,5,7,10,14H,3-4H2,(H,15,16)(H,17,18);1H/t7-,10+;/m1./s1
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Displacement of [3H]-KA from recombinant homomeric rat GluK2 (V,C,R)a receptor expressed in baculovirus infected Sf9 insect cell membranes by scintil...

J Med Chem 60: 9885-9904 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01624
BindingDB Entry DOI: 10.7270/Q21R6SXD
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 3


(Rattus norvegicus)		BDBM50246915
PNG
(CHEMBL4060745)
Show SMILES Cl.OB(O)c1cccc(c1)[C@H]1CCN[C@@H]1C(O)=O |r|
Show InChI InChI=1S/C11H14BNO4.ClH/c14-11(15)10-9(4-5-13-10)7-2-1-3-8(6-7)12(16)17;/h1-3,6,9-10,13,16-17H,4-5H2,(H,14,15);1H/t9-,10+;/m1./s1
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Displacement of [3H]-KA from recombinant homomeric rat GluK3a receptor expressed in baculovirus infected Sf9 insect cell membranes by scintillation c...

J Med Chem 60: 9885-9904 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01624
BindingDB Entry DOI: 10.7270/Q21R6SXD
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1


(RAT)		BDBM50246917
PNG
(CHEMBL4068651)
Show SMILES Cl.OC(=O)[C@H]1NCC[C@@H]1c1ccc(Br)c(c1)C(O)=O |r|
Show InChI InChI=1S/C12H12BrNO4.ClH/c13-9-2-1-6(5-8(9)11(15)16)7-3-4-14-10(7)12(17)18;/h1-2,5,7,10,14H,3-4H2,(H,15,16)(H,17,18);1H/t7-,10+;/m1./s1
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Displacement of [3H]-SYM2081 from recombinant homomeric rat GluK1 (Q)1b receptor expressed in baculovirus infected Sf9 insect cell membranes by scint...

J Med Chem 60: 9885-9904 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01624
BindingDB Entry DOI: 10.7270/Q21R6SXD
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Rattus norvegicus)		BDBM50246910
PNG
(CHEMBL4084540)
Show SMILES Cl.OC(=O)[C@H]1NCC[C@@H]1c1ccc(Cl)c(c1)C(O)=O |r|
Show InChI InChI=1S/C12H12ClNO4.ClH/c13-9-2-1-6(5-8(9)11(15)16)7-3-4-14-10(7)12(17)18;/h1-2,5,7,10,14H,3-4H2,(H,15,16)(H,17,18);1H/t7-,10+;/m1./s1
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Displacement of [3H]-KA from recombinant homomeric rat GluK2 (V,C,R)a receptor expressed in baculovirus infected Sf9 insect cell membranes by scintil...

J Med Chem 60: 9885-9904 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01624
BindingDB Entry DOI: 10.7270/Q21R6SXD
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1


(RAT)		BDBM50246918
PNG
(CHEMBL4091369)
Show SMILES Cl.OC(=O)[C@H]1NCC[C@@H]1c1cccc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C12H12F3NO2.ClH/c13-12(14,15)8-3-1-2-7(6-8)9-4-5-16-10(9)11(17)18;/h1-3,6,9-10,16H,4-5H2,(H,17,18);1H/t9-,10+;/m1./s1
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Displacement of [3H]-SYM2081 from recombinant homomeric rat GluK1 (Q)1b receptor expressed in baculovirus infected Sf9 insect cell membranes by scint...

J Med Chem 60: 9885-9904 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01624
BindingDB Entry DOI: 10.7270/Q21R6SXD
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Rattus norvegicus)		BDBM50246917
PNG
(CHEMBL4068651)
Show SMILES Cl.OC(=O)[C@H]1NCC[C@@H]1c1ccc(Br)c(c1)C(O)=O |r|
Show InChI InChI=1S/C12H12BrNO4.ClH/c13-9-2-1-6(5-8(9)11(15)16)7-3-4-14-10(7)12(17)18;/h1-2,5,7,10,14H,3-4H2,(H,15,16)(H,17,18);1H/t7-,10+;/m1./s1
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Displacement of [3H]-KA from recombinant homomeric rat GluK2 (V,C,R)a receptor expressed in baculovirus infected Sf9 insect cell membranes by scintil...

J Med Chem 60: 9885-9904 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01624
BindingDB Entry DOI: 10.7270/Q21R6SXD
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1


(RAT)		BDBM50246911
PNG
(CHEMBL4076785)
Show SMILES Cl.OC(=O)[C@H]1NCC[C@@H]1c1cccc(Cl)c1 |r|
Show InChI InChI=1S/C11H12ClNO2.ClH/c12-8-3-1-2-7(6-8)9-4-5-13-10(9)11(14)15;/h1-3,6,9-10,13H,4-5H2,(H,14,15);1H/t9-,10+;/m1./s1
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Displacement of [3H]-SYM2081 from recombinant homomeric rat GluK1 (Q)1b receptor expressed in baculovirus infected Sf9 insect cell membranes by scint...

J Med Chem 60: 9885-9904 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01624
BindingDB Entry DOI: 10.7270/Q21R6SXD
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1


(RAT)		BDBM50246914
PNG
(CHEMBL4088958)
Show SMILES Cl.NC(=O)c1cccc(c1)[C@H]1CCN[C@@H]1C(O)=O |r|
Show InChI InChI=1S/C12H14N2O3.ClH/c13-11(15)8-3-1-2-7(6-8)9-4-5-14-10(9)12(16)17;/h1-3,6,9-10,14H,4-5H2,(H2,13,15)(H,16,17);1H/t9-,10+;/m1./s1
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Displacement of [3H]-SYM2081 from recombinant homomeric rat GluK1 (Q)1b receptor expressed in baculovirus infected Sf9 insect cell membranes by scint...

J Med Chem 60: 9885-9904 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01624
BindingDB Entry DOI: 10.7270/Q21R6SXD
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 3


(Rattus norvegicus)		BDBM50246918
PNG
(CHEMBL4091369)
Show SMILES Cl.OC(=O)[C@H]1NCC[C@@H]1c1cccc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C12H12F3NO2.ClH/c13-12(14,15)8-3-1-2-7(6-8)9-4-5-16-10(9)11(17)18;/h1-3,6,9-10,16H,4-5H2,(H,17,18);1H/t9-,10+;/m1./s1
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Displacement of [3H]-KA from recombinant homomeric rat GluK3a receptor expressed in baculovirus infected Sf9 insect cell membranes by scintillation c...

J Med Chem 60: 9885-9904 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01624
BindingDB Entry DOI: 10.7270/Q21R6SXD
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Rattus norvegicus)		BDBM50246916
PNG
(CHEMBL4102488)
Show SMILES Cl.Cc1ccc(cc1C(O)=O)[C@H]1CCN[C@@H]1C(O)=O |r|
Show InChI InChI=1S/C13H15NO4.ClH/c1-7-2-3-8(6-10(7)12(15)16)9-4-5-14-11(9)13(17)18;/h2-3,6,9,11,14H,4-5H2,1H3,(H,15,16)(H,17,18);1H/t9-,11+;/m1./s1
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Displacement of [3H]-KA from recombinant homomeric rat GluK2 (V,C,R)a receptor expressed in baculovirus infected Sf9 insect cell membranes by scintil...

J Med Chem 60: 9885-9904 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01624
BindingDB Entry DOI: 10.7270/Q21R6SXD
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 3


(Rattus norvegicus)		BDBM50246910
PNG
(CHEMBL4084540)
Show SMILES Cl.OC(=O)[C@H]1NCC[C@@H]1c1ccc(Cl)c(c1)C(O)=O |r|
Show InChI InChI=1S/C12H12ClNO4.ClH/c13-9-2-1-6(5-8(9)11(15)16)7-3-4-14-10(7)12(17)18;/h1-2,5,7,10,14H,3-4H2,(H,15,16)(H,17,18);1H/t7-,10+;/m1./s1
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 1.31E+5n/an/an/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Displacement of [3H]-KA from recombinant homomeric rat GluK3a receptor expressed in baculovirus infected Sf9 insect cell membranes by scintillation c...

J Med Chem 60: 9885-9904 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01624
BindingDB Entry DOI: 10.7270/Q21R6SXD
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1


(RAT)		BDBM50246910
PNG
(CHEMBL4084540)
Show SMILES Cl.OC(=O)[C@H]1NCC[C@@H]1c1ccc(Cl)c(c1)C(O)=O |r|
Show InChI InChI=1S/C12H12ClNO4.ClH/c13-9-2-1-6(5-8(9)11(15)16)7-3-4-14-10(7)12(17)18;/h1-2,5,7,10,14H,3-4H2,(H,15,16)(H,17,18);1H/t7-,10+;/m1./s1
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 1.54E+5n/an/an/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Displacement of [3H]-SYM2081 from recombinant homomeric rat GluK1 (Q)1b receptor expressed in baculovirus infected Sf9 insect cell membranes by scint...

J Med Chem 60: 9885-9904 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01624
BindingDB Entry DOI: 10.7270/Q21R6SXD
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Rattus norvegicus)		BDBM50246913
PNG
(CHEMBL4083586)
Show SMILES Cl.OC(=O)[C@H]1NCC[C@@H]1c1cccc(c1)C#N |r|
Show InChI InChI=1S/C12H12N2O2.ClH/c13-7-8-2-1-3-9(6-8)10-4-5-14-11(10)12(15)16;/h1-3,6,10-11,14H,4-5H2,(H,15,16);1H/t10-,11+;/m1./s1
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>1.00E+6n/an/an/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Displacement of [3H]-KA from recombinant homomeric rat GluK2 (V,C,R)a receptor expressed in baculovirus infected Sf9 insect cell membranes by scintil...

J Med Chem 60: 9885-9904 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01624
BindingDB Entry DOI: 10.7270/Q21R6SXD
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Rattus norvegicus)		BDBM50246915
PNG
(CHEMBL4060745)
Show SMILES Cl.OB(O)c1cccc(c1)[C@H]1CCN[C@@H]1C(O)=O |r|
Show InChI InChI=1S/C11H14BNO4.ClH/c14-11(15)10-9(4-5-13-10)7-2-1-3-8(6-7)12(16)17;/h1-3,6,9-10,13,16-17H,4-5H2,(H,14,15);1H/t9-,10+;/m1./s1
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>1.00E+6n/an/an/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Displacement of [3H]-KA from recombinant homomeric rat GluK2 (V,C,R)a receptor expressed in baculovirus infected Sf9 insect cell membranes by scintil...

J Med Chem 60: 9885-9904 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01624
BindingDB Entry DOI: 10.7270/Q21R6SXD
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 3


(Rattus norvegicus)		BDBM50246913
PNG
(CHEMBL4083586)
Show SMILES Cl.OC(=O)[C@H]1NCC[C@@H]1c1cccc(c1)C#N |r|
Show InChI InChI=1S/C12H12N2O2.ClH/c13-7-8-2-1-3-9(6-8)10-4-5-14-11(10)12(15)16;/h1-3,6,10-11,14H,4-5H2,(H,15,16);1H/t10-,11+;/m1./s1
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>1.00E+6n/an/an/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Displacement of [3H]-KA from recombinant homomeric rat GluK3a receptor expressed in baculovirus infected Sf9 insect cell membranes by scintillation c...

J Med Chem 60: 9885-9904 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01624
BindingDB Entry DOI: 10.7270/Q21R6SXD
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1


(RAT)		BDBM50246915
PNG
(CHEMBL4060745)
Show SMILES Cl.OB(O)c1cccc(c1)[C@H]1CCN[C@@H]1C(O)=O |r|
Show InChI InChI=1S/C11H14BNO4.ClH/c14-11(15)10-9(4-5-13-10)7-2-1-3-8(6-7)12(16)17;/h1-3,6,9-10,13,16-17H,4-5H2,(H,14,15);1H/t9-,10+;/m1./s1
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>1.00E+6n/an/an/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Displacement of [3H]-SYM2081 from recombinant homomeric rat GluK1 (Q)1b receptor expressed in baculovirus infected Sf9 insect cell membranes by scint...

J Med Chem 60: 9885-9904 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01624
BindingDB Entry DOI: 10.7270/Q21R6SXD
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1


(RAT)		BDBM50246913
PNG
(CHEMBL4083586)
Show SMILES Cl.OC(=O)[C@H]1NCC[C@@H]1c1cccc(c1)C#N |r|
Show InChI InChI=1S/C12H12N2O2.ClH/c13-7-8-2-1-3-9(6-8)10-4-5-14-11(10)12(15)16;/h1-3,6,10-11,14H,4-5H2,(H,15,16);1H/t10-,11+;/m1./s1
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>1.00E+6n/an/an/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Displacement of [3H]-SYM2081 from recombinant homomeric rat GluK1 (Q)1b receptor expressed in baculovirus infected Sf9 insect cell membranes by scint...

J Med Chem 60: 9885-9904 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01624
BindingDB Entry DOI: 10.7270/Q21R6SXD
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A


(Rattus norvegicus (Rat)-RAT)		BDBM50246910
PNG
(CHEMBL4084540)
Show SMILES Cl.OC(=O)[C@H]1NCC[C@@H]1c1ccc(Cl)c(c1)C(O)=O |r|
Show InChI InChI=1S/C12H12ClNO4.ClH/c13-9-2-1-6(5-8(9)11(15)16)7-3-4-14-10(7)12(17)18;/h1-2,5,7,10,14H,3-4H2,(H,15,16)(H,17,18);1H/t7-,10+;/m1./s1
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n/an/a 1.50E+4n/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat GluN1a/GluN2A expressed in Xenopus laevis oocytes assessed as inhibition of glycine/glutamate-mediated current...

J Med Chem 60: 9885-9904 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01624
BindingDB Entry DOI: 10.7270/Q21R6SXD
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50246910
PNG
(CHEMBL4084540)
Show SMILES Cl.OC(=O)[C@H]1NCC[C@@H]1c1ccc(Cl)c(c1)C(O)=O |r|
Show InChI InChI=1S/C12H12ClNO4.ClH/c13-9-2-1-6(5-8(9)11(15)16)7-3-4-14-10(7)12(17)18;/h1-2,5,7,10,14H,3-4H2,(H,15,16)(H,17,18);1H/t7-,10+;/m1./s1
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n/an/a 2.90E+4n/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat GluN1a/GluN2B expressed in Xenopus laevis oocytes assessed as inhibition of glycine/glutamate-mediated current...

J Med Chem 60: 9885-9904 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01624
BindingDB Entry DOI: 10.7270/Q21R6SXD
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50246910
PNG
(CHEMBL4084540)
Show SMILES Cl.OC(=O)[C@H]1NCC[C@@H]1c1ccc(Cl)c(c1)C(O)=O |r|
Show InChI InChI=1S/C12H12ClNO4.ClH/c13-9-2-1-6(5-8(9)11(15)16)7-3-4-14-10(7)12(17)18;/h1-2,5,7,10,14H,3-4H2,(H,15,16)(H,17,18);1H/t7-,10+;/m1./s1
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n/an/a 1.10E+5n/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat GluN1a/GluN2C expressed in Xenopus laevis oocytes assessed as inhibition of glycine/glutamate-mediated current...

J Med Chem 60: 9885-9904 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01624
BindingDB Entry DOI: 10.7270/Q21R6SXD
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2D


(RAT-Rattus norvegicus (Rat))		BDBM50246910
PNG
(CHEMBL4084540)
Show SMILES Cl.OC(=O)[C@H]1NCC[C@@H]1c1ccc(Cl)c(c1)C(O)=O |r|
Show InChI InChI=1S/C12H12ClNO4.ClH/c13-9-2-1-6(5-8(9)11(15)16)7-3-4-14-10(7)12(17)18;/h1-2,5,7,10,14H,3-4H2,(H,15,16)(H,17,18);1H/t7-,10+;/m1./s1
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n/an/a 1.70E+5n/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat GluN1a/GluN2D expressed in Xenopus laevis oocytes assessed as inhibition of glycine/glutamate-mediated current...

J Med Chem 60: 9885-9904 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01624
BindingDB Entry DOI: 10.7270/Q21R6SXD
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%