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PubMed code 29456108

Compile data set for download or QSAR
Found 40 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Free fatty acid receptor 4


(Homo sapiens (Human))		BDBM50455223
PNG
(CHEMBL4205035)
Show SMILES Cc1c(C)c(OCc2c(Cl)ccn2-c2ccc(Cl)cc2)ccc1CCC(O)=O
Show InChI InChI=1S/C22H21Cl2NO3/c1-14-15(2)21(9-3-16(14)4-10-22(26)27)28-13-20-19(24)11-12-25(20)18-7-5-17(23)6-8-18/h3,5-9,11-12H,4,10,13H2,1-2H3,(H,26,27)
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n/an/an/an/a 173n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at ...

Bioorg Med Chem Lett 28: 841-846 (2018)


Article DOI: 10.1016/j.bmcl.2018.02.013
BindingDB Entry DOI: 10.7270/Q21Z471F
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Rattus norvegicus)		BDBM50455227
PNG
(CHEMBL4208325)
Show SMILES OC(=O)CCc1cc(F)c(OCc2c(ccn2-c2ccc(Cl)cc2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C21H15ClF5NO3/c22-13-2-4-14(5-3-13)28-8-7-15(21(25,26)27)18(28)11-31-20-16(23)9-12(10-17(20)24)1-6-19(29)30/h2-5,7-10H,1,6,11H2,(H,29,30)
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n/an/an/an/a 713n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at recombinant rat GPR120 expressed in HEK293 cells

Bioorg Med Chem Lett 28: 841-846 (2018)


Article DOI: 10.1016/j.bmcl.2018.02.013
BindingDB Entry DOI: 10.7270/Q21Z471F
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))		BDBM50455236
PNG
(CHEMBL4203774)
Show SMILES Cc1cc(CCC(O)=O)ccc1OCc1c(ccn1-c1ccc(F)cc1)C(F)(F)F
Show InChI InChI=1S/C22H19F4NO3/c1-14-12-15(3-9-21(28)29)2-8-20(14)30-13-19-18(22(24,25)26)10-11-27(19)17-6-4-16(23)5-7-17/h2,4-8,10-12H,3,9,13H2,1H3,(H,28,29)
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n/an/an/an/a 280n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at ...

Bioorg Med Chem Lett 28: 841-846 (2018)


Article DOI: 10.1016/j.bmcl.2018.02.013
BindingDB Entry DOI: 10.7270/Q21Z471F
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))		BDBM50455227
PNG
(CHEMBL4208325)
Show SMILES OC(=O)CCc1cc(F)c(OCc2c(ccn2-c2ccc(Cl)cc2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C21H15ClF5NO3/c22-13-2-4-14(5-3-13)28-8-7-15(21(25,26)27)18(28)11-31-20-16(23)9-12(10-17(20)24)1-6-19(29)30/h2-5,7-10H,1,6,11H2,(H,29,30)
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n/an/an/an/a 3.34E+3n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40

Bioorg Med Chem Lett 28: 841-846 (2018)


Article DOI: 10.1016/j.bmcl.2018.02.013
BindingDB Entry DOI: 10.7270/Q21Z471F
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))		BDBM50455250
PNG
(CHEMBL4212281)
Show SMILES OC(=O)CCc1ccc(OCc2c(Br)ccn2-c2ccc(Cl)cc2)c(F)c1F
Show InChI InChI=1S/C20H15BrClF2NO3/c21-15-9-10-25(14-5-3-13(22)4-6-14)16(15)11-28-17-7-1-12(2-8-18(26)27)19(23)20(17)24/h1,3-7,9-10H,2,8,11H2,(H,26,27)
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n/an/an/an/a 161n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at ...

Bioorg Med Chem Lett 28: 841-846 (2018)


Article DOI: 10.1016/j.bmcl.2018.02.013
BindingDB Entry DOI: 10.7270/Q21Z471F
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))		BDBM50455252
PNG
(CHEMBL4214224)
Show SMILES COc1ccc(cn1)-n1ccc(c1COc1c(F)cc(CCC(O)=O)cc1F)C(F)(F)F
Show InChI InChI=1S/C21H17F5N2O4/c1-31-18-4-3-13(10-27-18)28-7-6-14(21(24,25)26)17(28)11-32-20-15(22)8-12(9-16(20)23)2-5-19(29)30/h3-4,6-10H,2,5,11H2,1H3,(H,29,30)
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n/an/an/an/a 197n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at ...

Bioorg Med Chem Lett 28: 841-846 (2018)


Article DOI: 10.1016/j.bmcl.2018.02.013
BindingDB Entry DOI: 10.7270/Q21Z471F
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))		BDBM50455219
PNG
(CHEMBL4204928)
Show SMILES CCc1ccc(cc1)-n1ccc(c1COc1c(F)cc(CCC(O)=O)cc1F)C(F)(F)F
Show InChI InChI=1S/C23H20F5NO3/c1-2-14-3-6-16(7-4-14)29-10-9-17(23(26,27)28)20(29)13-32-22-18(24)11-15(12-19(22)25)5-8-21(30)31/h3-4,6-7,9-12H,2,5,8,13H2,1H3,(H,30,31)
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n/an/an/an/a 117n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at ...

Bioorg Med Chem Lett 28: 841-846 (2018)


Article DOI: 10.1016/j.bmcl.2018.02.013
BindingDB Entry DOI: 10.7270/Q21Z471F
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))		BDBM50455221
PNG
(CHEMBL4209308)
Show SMILES OCCCc1cc(F)c(OCc2c(ccn2-c2ccc(Cl)cc2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C21H17ClF5NO2/c22-14-3-5-15(6-4-14)28-8-7-16(21(25,26)27)19(28)12-30-20-17(23)10-13(2-1-9-29)11-18(20)24/h3-8,10-11,29H,1-2,9,12H2
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n/an/an/an/a 43n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at ...

Bioorg Med Chem Lett 28: 841-846 (2018)


Article DOI: 10.1016/j.bmcl.2018.02.013
BindingDB Entry DOI: 10.7270/Q21Z471F
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))		BDBM50455226
PNG
(CHEMBL4205429)
Show SMILES Cc1ccc(cc1)-n1ccc(c1COc1c(F)cc(CCC(O)=O)cc1F)C(F)(F)F
Show InChI InChI=1S/C22H18F5NO3/c1-13-2-5-15(6-3-13)28-9-8-16(22(25,26)27)19(28)12-31-21-17(23)10-14(11-18(21)24)4-7-20(29)30/h2-3,5-6,8-11H,4,7,12H2,1H3,(H,29,30)
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n/an/an/an/a 50n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at ...

Bioorg Med Chem Lett 28: 841-846 (2018)


Article DOI: 10.1016/j.bmcl.2018.02.013
BindingDB Entry DOI: 10.7270/Q21Z471F
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Mus musculus)		BDBM50455227
PNG
(CHEMBL4208325)
Show SMILES OC(=O)CCc1cc(F)c(OCc2c(ccn2-c2ccc(Cl)cc2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C21H15ClF5NO3/c22-13-2-4-14(5-3-13)28-8-7-15(21(25,26)27)18(28)11-31-20-16(23)9-12(10-17(20)24)1-6-19(29)30/h2-5,7-10H,1,6,11H2,(H,29,30)
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n/an/an/an/a 193n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at recombinant mouse GPR120 expressed in HEK293 cells

Bioorg Med Chem Lett 28: 841-846 (2018)


Article DOI: 10.1016/j.bmcl.2018.02.013
BindingDB Entry DOI: 10.7270/Q21Z471F
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))		BDBM50455249
PNG
(CHEMBL4216937)
Show SMILES OC(=O)CCc1ccc(OCc2c(ccn2-c2ccc(F)cc2)C(F)(F)F)cc1C(F)(F)F
Show InChI InChI=1S/C22H16F7NO3/c23-14-3-5-15(6-4-14)30-10-9-17(21(24,25)26)19(30)12-33-16-7-1-13(2-8-20(31)32)18(11-16)22(27,28)29/h1,3-7,9-11H,2,8,12H2,(H,31,32)
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n/an/an/an/a 834n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at ...

Bioorg Med Chem Lett 28: 841-846 (2018)


Article DOI: 10.1016/j.bmcl.2018.02.013
BindingDB Entry DOI: 10.7270/Q21Z471F
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))		BDBM50455231
PNG
(CHEMBL4204946)
Show SMILES Cc1ccc(c(F)c1)-n1ccc(c1COc1c(F)cc(CCC(O)=O)cc1F)C(F)(F)F
Show InChI InChI=1S/C22H17F6NO3/c1-12-2-4-18(15(23)8-12)29-7-6-14(22(26,27)28)19(29)11-32-21-16(24)9-13(10-17(21)25)3-5-20(30)31/h2,4,6-10H,3,5,11H2,1H3,(H,30,31)
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n/an/an/an/a 118n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at ...

Bioorg Med Chem Lett 28: 841-846 (2018)


Article DOI: 10.1016/j.bmcl.2018.02.013
BindingDB Entry DOI: 10.7270/Q21Z471F
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))		BDBM50455234
PNG
(CHEMBL4210752)
Show SMILES Cc1c(C)c(OCc2c(ccn2-c2ccc(Cl)cc2)C(F)(F)F)ccc1CCCO
Show InChI InChI=1S/C23H23ClF3NO2/c1-15-16(2)22(10-5-17(15)4-3-13-29)30-14-21-20(23(25,26)27)11-12-28(21)19-8-6-18(24)7-9-19/h5-12,29H,3-4,13-14H2,1-2H3
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n/an/an/an/a 533n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at ...

Bioorg Med Chem Lett 28: 841-846 (2018)


Article DOI: 10.1016/j.bmcl.2018.02.013
BindingDB Entry DOI: 10.7270/Q21Z471F
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))		BDBM50455241
PNG
(CHEMBL4217669)
Show SMILES OC(=O)CCc1cc(F)c(OCc2c(ccn2-c2cccc(F)c2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C21H15F6NO3/c22-13-2-1-3-14(10-13)28-7-6-15(21(25,26)27)18(28)11-31-20-16(23)8-12(9-17(20)24)4-5-19(29)30/h1-3,6-10H,4-5,11H2,(H,29,30)
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n/an/an/an/a 448n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at ...

Bioorg Med Chem Lett 28: 841-846 (2018)


Article DOI: 10.1016/j.bmcl.2018.02.013
BindingDB Entry DOI: 10.7270/Q21Z471F
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))		BDBM50455243
PNG
(CHEMBL4212409)
Show SMILES CCc1ccc(cc1)-n1ccc(c1COc1ccc(CCC(O)=O)c(F)c1F)C(F)(F)F
Show InChI InChI=1S/C23H20F5NO3/c1-2-14-3-7-16(8-4-14)29-12-11-17(23(26,27)28)18(29)13-32-19-9-5-15(6-10-20(30)31)21(24)22(19)25/h3-5,7-9,11-12H,2,6,10,13H2,1H3,(H,30,31)
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n/an/an/an/a 40n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at ...

Bioorg Med Chem Lett 28: 841-846 (2018)


Article DOI: 10.1016/j.bmcl.2018.02.013
BindingDB Entry DOI: 10.7270/Q21Z471F
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))		BDBM50455248
PNG
(CHEMBL4215446)
Show SMILES CC(Cc1cc(F)c(OCc2c(ccn2-c2ccc(F)cc2)C(F)(F)F)c(F)c1)C(O)=O
Show InChI InChI=1S/C22H17F6NO3/c1-12(21(30)31)8-13-9-17(24)20(18(25)10-13)32-11-19-16(22(26,27)28)6-7-29(19)15-4-2-14(23)3-5-15/h2-7,9-10,12H,8,11H2,1H3,(H,30,31)
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n/an/an/an/a 547n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at ...

Bioorg Med Chem Lett 28: 841-846 (2018)


Article DOI: 10.1016/j.bmcl.2018.02.013
BindingDB Entry DOI: 10.7270/Q21Z471F
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))		BDBM50455232
PNG
(CHEMBL4203544)
Show SMILES OC(=O)CCc1cc(F)c(OCc2c(ccn2-c2ccc(F)cc2F)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C21H14F7NO3/c22-12-2-3-17(14(23)9-12)29-6-5-13(21(26,27)28)18(29)10-32-20-15(24)7-11(8-16(20)25)1-4-19(30)31/h2-3,5-9H,1,4,10H2,(H,30,31)
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n/an/an/an/a 156n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at ...

Bioorg Med Chem Lett 28: 841-846 (2018)


Article DOI: 10.1016/j.bmcl.2018.02.013
BindingDB Entry DOI: 10.7270/Q21Z471F
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))		BDBM50455235
PNG
(CHEMBL4205879)
Show SMILES OCCCc1ccc(OCc2c(ccn2-c2ccc(Cl)cc2)C(F)(F)F)c(F)c1F
Show InChI InChI=1S/C21H17ClF5NO2/c22-14-4-6-15(7-5-14)28-10-9-16(21(25,26)27)17(28)12-30-18-8-3-13(2-1-11-29)19(23)20(18)24/h3-10,29H,1-2,11-12H2
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n/an/an/an/a 162n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at ...

Bioorg Med Chem Lett 28: 841-846 (2018)


Article DOI: 10.1016/j.bmcl.2018.02.013
BindingDB Entry DOI: 10.7270/Q21Z471F
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))		BDBM50455237
PNG
(CHEMBL4211967)
Show SMILES Cc1c(C)c(OCc2c(ccn2-c2ccc(F)cc2)C(F)(F)F)ccc1CCC(O)=O
Show InChI InChI=1S/C23H21F4NO3/c1-14-15(2)21(9-3-16(14)4-10-22(29)30)31-13-20-19(23(25,26)27)11-12-28(20)18-7-5-17(24)6-8-18/h3,5-9,11-12H,4,10,13H2,1-2H3,(H,29,30)
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n/an/an/an/a 346n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at ...

Bioorg Med Chem Lett 28: 841-846 (2018)


Article DOI: 10.1016/j.bmcl.2018.02.013
BindingDB Entry DOI: 10.7270/Q21Z471F
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))		BDBM50455238
PNG
(CHEMBL4207603)
Show SMILES OC(=O)CCc1ccc(OCc2c(ccn2-c2ccc(F)cc2)C(F)(F)F)cc1Cl
Show InChI InChI=1S/C21H16ClF4NO3/c22-18-11-16(7-1-13(18)2-8-20(28)29)30-12-19-17(21(24,25)26)9-10-27(19)15-5-3-14(23)4-6-15/h1,3-7,9-11H,2,8,12H2,(H,28,29)
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n/an/an/an/a 923n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at ...

Bioorg Med Chem Lett 28: 841-846 (2018)


Article DOI: 10.1016/j.bmcl.2018.02.013
BindingDB Entry DOI: 10.7270/Q21Z471F
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))		BDBM50455225
PNG
(CHEMBL4217143)
Show SMILES OC(=O)CCc1cc(F)c(OCc2c(ccn2-c2ccccc2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C21H16F5NO3/c22-16-10-13(6-7-19(28)29)11-17(23)20(16)30-12-18-15(21(24,25)26)8-9-27(18)14-4-2-1-3-5-14/h1-5,8-11H,6-7,12H2,(H,28,29)
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n/an/an/an/a 100n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at ...

Bioorg Med Chem Lett 28: 841-846 (2018)


Article DOI: 10.1016/j.bmcl.2018.02.013
BindingDB Entry DOI: 10.7270/Q21Z471F
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))		BDBM50455227
PNG
(CHEMBL4208325)
Show SMILES OC(=O)CCc1cc(F)c(OCc2c(ccn2-c2ccc(Cl)cc2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C21H15ClF5NO3/c22-13-2-4-14(5-3-13)28-8-7-15(21(25,26)27)18(28)11-31-20-16(23)9-12(10-17(20)24)1-6-19(29)30/h2-5,7-10H,1,6,11H2,(H,29,30)
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n/an/an/an/a 69n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human PK-tagged GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-g...

Bioorg Med Chem Lett 28: 841-846 (2018)


Article DOI: 10.1016/j.bmcl.2018.02.013
BindingDB Entry DOI: 10.7270/Q21Z471F
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))		BDBM50455240
PNG
(CHEMBL4203559)
Show SMILES OC(=O)CCc1ccc(OCc2c(ccn2-c2ccc(Cl)cc2)C(F)(F)F)c(F)c1F
Show InChI InChI=1S/C21H15ClF5NO3/c22-13-3-5-14(6-4-13)28-10-9-15(21(25,26)27)16(28)11-31-17-7-1-12(2-8-18(29)30)19(23)20(17)24/h1,3-7,9-10H,2,8,11H2,(H,29,30)
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n/an/an/an/a 91n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at ...

Bioorg Med Chem Lett 28: 841-846 (2018)


Article DOI: 10.1016/j.bmcl.2018.02.013
BindingDB Entry DOI: 10.7270/Q21Z471F
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))		BDBM50455220
PNG
(CHEMBL4212717)
Show SMILES COc1ccc(cc1)-n1ccc(c1COc1c(F)cc(CCC(O)=O)cc1F)C(F)(F)F
Show InChI InChI=1S/C22H18F5NO4/c1-31-15-5-3-14(4-6-15)28-9-8-16(22(25,26)27)19(28)12-32-21-17(23)10-13(11-18(21)24)2-7-20(29)30/h3-6,8-11H,2,7,12H2,1H3,(H,29,30)
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n/an/an/an/a 184n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at ...

Bioorg Med Chem Lett 28: 841-846 (2018)


Article DOI: 10.1016/j.bmcl.2018.02.013
BindingDB Entry DOI: 10.7270/Q21Z471F
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))		BDBM50455222
PNG
(CHEMBL4217252)
Show SMILES Cc1c(C)c(OCc2cccn2-c2ccc(Br)cc2)ccc1CCC(O)=O
Show InChI InChI=1S/C22H22BrNO3/c1-15-16(2)21(11-5-17(15)6-12-22(25)26)27-14-20-4-3-13-24(20)19-9-7-18(23)8-10-19/h3-5,7-11,13H,6,12,14H2,1-2H3,(H,25,26)
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n/an/an/an/a 164n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at ...

Bioorg Med Chem Lett 28: 841-846 (2018)


Article DOI: 10.1016/j.bmcl.2018.02.013
BindingDB Entry DOI: 10.7270/Q21Z471F
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))		BDBM50455227
PNG
(CHEMBL4208325)
Show SMILES OC(=O)CCc1cc(F)c(OCc2c(ccn2-c2ccc(Cl)cc2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C21H15ClF5NO3/c22-13-2-4-14(5-3-13)28-8-7-15(21(25,26)27)18(28)11-31-20-16(23)9-12(10-17(20)24)1-6-19(29)30/h2-5,7-10H,1,6,11H2,(H,29,30)
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n/an/an/an/a 80n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at ...

Bioorg Med Chem Lett 28: 841-846 (2018)


Article DOI: 10.1016/j.bmcl.2018.02.013
BindingDB Entry DOI: 10.7270/Q21Z471F
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))		BDBM50455228
PNG
(CHEMBL4206168)
Show SMILES OC(=O)CCc1cc(F)c(OCc2c(ccn2-c2ccc(F)cc2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C21H15F6NO3/c22-13-2-4-14(5-3-13)28-8-7-15(21(25,26)27)18(28)11-31-20-16(23)9-12(10-17(20)24)1-6-19(29)30/h2-5,7-10H,1,6,11H2,(H,29,30)
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n/an/an/an/a 134n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at ...

Bioorg Med Chem Lett 28: 841-846 (2018)


Article DOI: 10.1016/j.bmcl.2018.02.013
BindingDB Entry DOI: 10.7270/Q21Z471F
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))		BDBM50455242
PNG
(CHEMBL4211144)
Show SMILES Cc1ccc(cn1)-n1ccc(c1COc1c(F)cc(CCC(O)=O)cc1F)C(F)(F)F
Show InChI InChI=1S/C21H17F5N2O3/c1-12-2-4-14(10-27-12)28-7-6-15(21(24,25)26)18(28)11-31-20-16(22)8-13(9-17(20)23)3-5-19(29)30/h2,4,6-10H,3,5,11H2,1H3,(H,29,30)
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n/an/an/an/a 289n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at ...

Bioorg Med Chem Lett 28: 841-846 (2018)


Article DOI: 10.1016/j.bmcl.2018.02.013
BindingDB Entry DOI: 10.7270/Q21Z471F
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))		BDBM50455245
PNG
(CHEMBL4213709)
Show SMILES OC(=O)CCc1cc(F)c(OCc2c(ccn2-c2ccc(Br)cc2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C21H15BrF5NO3/c22-13-2-4-14(5-3-13)28-8-7-15(21(25,26)27)18(28)11-31-20-16(23)9-12(10-17(20)24)1-6-19(29)30/h2-5,7-10H,1,6,11H2,(H,29,30)
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n/an/an/an/a 112n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at ...

Bioorg Med Chem Lett 28: 841-846 (2018)


Article DOI: 10.1016/j.bmcl.2018.02.013
BindingDB Entry DOI: 10.7270/Q21Z471F
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))		BDBM50455246
PNG
(CHEMBL4206369)
Show SMILES Cc1ccc(cc1F)-n1ccc(c1COc1c(F)cc(CCC(O)=O)cc1F)C(F)(F)F
Show InChI InChI=1S/C22H17F6NO3/c1-12-2-4-14(10-16(12)23)29-7-6-15(22(26,27)28)19(29)11-32-21-17(24)8-13(9-18(21)25)3-5-20(30)31/h2,4,6-10H,3,5,11H2,1H3,(H,30,31)
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n/an/an/an/a 262n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at ...

Bioorg Med Chem Lett 28: 841-846 (2018)


Article DOI: 10.1016/j.bmcl.2018.02.013
BindingDB Entry DOI: 10.7270/Q21Z471F
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))		BDBM50455229
PNG
(CHEMBL4218078)
Show SMILES OC(=O)CCc1cc(F)c(OCc2c(ccn2-c2ccc(Cl)c(F)c2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C21H14ClF6NO3/c22-14-3-2-12(9-15(14)23)29-6-5-13(21(26,27)28)18(29)10-32-20-16(24)7-11(8-17(20)25)1-4-19(30)31/h2-3,5-9H,1,4,10H2,(H,30,31)
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n/an/an/an/a 368n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at ...

Bioorg Med Chem Lett 28: 841-846 (2018)


Article DOI: 10.1016/j.bmcl.2018.02.013
BindingDB Entry DOI: 10.7270/Q21Z471F
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Mus musculus)		BDBM50455227
PNG
(CHEMBL4208325)
Show SMILES OC(=O)CCc1cc(F)c(OCc2c(ccn2-c2ccc(Cl)cc2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C21H15ClF5NO3/c22-13-2-4-14(5-3-13)28-8-7-15(21(25,26)27)18(28)11-31-20-16(23)9-12(10-17(20)24)1-6-19(29)30/h2-5,7-10H,1,6,11H2,(H,29,30)
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n/an/an/an/a 3.52E+3n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR40

Bioorg Med Chem Lett 28: 841-846 (2018)


Article DOI: 10.1016/j.bmcl.2018.02.013
BindingDB Entry DOI: 10.7270/Q21Z471F
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))		BDBM50455247
PNG
(CHEMBL4217161)
Show SMILES OC(=O)CCc1cc(F)c(OCc2c(ccn2-c2ccc(F)c(F)c2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C21H14F7NO3/c22-14-3-2-12(9-15(14)23)29-6-5-13(21(26,27)28)18(29)10-32-20-16(24)7-11(8-17(20)25)1-4-19(30)31/h2-3,5-9H,1,4,10H2,(H,30,31)
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n/an/an/an/a 175n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at ...

Bioorg Med Chem Lett 28: 841-846 (2018)


Article DOI: 10.1016/j.bmcl.2018.02.013
BindingDB Entry DOI: 10.7270/Q21Z471F
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))		BDBM50455227
PNG
(CHEMBL4208325)
Show SMILES OC(=O)CCc1cc(F)c(OCc2c(ccn2-c2ccc(Cl)cc2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C21H15ClF5NO3/c22-13-2-4-14(5-3-13)28-8-7-15(21(25,26)27)18(28)11-31-20-16(23)9-12(10-17(20)24)1-6-19(29)30/h2-5,7-10H,1,6,11H2,(H,29,30)
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n/an/an/an/a 137n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at GPR120 in human HT-29 cells assessed as intracellular calcium flux

Bioorg Med Chem Lett 28: 841-846 (2018)


Article DOI: 10.1016/j.bmcl.2018.02.013
BindingDB Entry DOI: 10.7270/Q21Z471F
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))		BDBM50455224
PNG
(CHEMBL4216721)
Show SMILES OC(=O)CCc1ccc(OCc2c(ccn2-c2ccc(Cl)cc2)C#N)c(F)c1F
Show InChI InChI=1S/C21H15ClF2N2O3/c22-15-3-5-16(6-4-15)26-10-9-14(11-25)17(26)12-29-18-7-1-13(2-8-19(27)28)20(23)21(18)24/h1,3-7,9-10H,2,8,12H2,(H,27,28)
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n/an/an/an/a 1.37E+3n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at ...

Bioorg Med Chem Lett 28: 841-846 (2018)


Article DOI: 10.1016/j.bmcl.2018.02.013
BindingDB Entry DOI: 10.7270/Q21Z471F
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))		BDBM50455233
PNG
(CHEMBL4213710)
Show SMILES CCc1ccc(cn1)-n1ccc(c1COc1c(F)cc(CCC(O)=O)cc1F)C(F)(F)F
Show InChI InChI=1S/C22H19F5N2O3/c1-2-14-4-5-15(11-28-14)29-8-7-16(22(25,26)27)19(29)12-32-21-17(23)9-13(10-18(21)24)3-6-20(30)31/h4-5,7-11H,2-3,6,12H2,1H3,(H,30,31)
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n/an/an/an/a 877n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at ...

Bioorg Med Chem Lett 28: 841-846 (2018)


Article DOI: 10.1016/j.bmcl.2018.02.013
BindingDB Entry DOI: 10.7270/Q21Z471F
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))		BDBM50455239
PNG
(CHEMBL4212510)
Show SMILES COC(=O)CCc1cc(F)c(OCc2c(ccn2-c2ccc(Cl)cc2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C22H17ClF5NO3/c1-31-20(30)7-2-13-10-17(24)21(18(25)11-13)32-12-19-16(22(26,27)28)8-9-29(19)15-5-3-14(23)4-6-15/h3-6,8-11H,2,7,12H2,1H3
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n/an/an/an/a>5.00E+3n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at ...

Bioorg Med Chem Lett 28: 841-846 (2018)


Article DOI: 10.1016/j.bmcl.2018.02.013
BindingDB Entry DOI: 10.7270/Q21Z471F
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))		BDBM50455244
PNG
(CHEMBL4208442)
Show SMILES Cc1c(C)c(OCc2c(ccn2-c2ccc(Cl)cc2)C(F)(F)F)ccc1CCC(O)=O
Show InChI InChI=1S/C23H21ClF3NO3/c1-14-15(2)21(9-3-16(14)4-10-22(29)30)31-13-20-19(23(25,26)27)11-12-28(20)18-7-5-17(24)6-8-18/h3,5-9,11-12H,4,10,13H2,1-2H3,(H,29,30)
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n/an/an/an/a 88n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at ...

Bioorg Med Chem Lett 28: 841-846 (2018)


Article DOI: 10.1016/j.bmcl.2018.02.013
BindingDB Entry DOI: 10.7270/Q21Z471F
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))		BDBM50455251
PNG
(CHEMBL4214698)
Show SMILES CC(Cc1cc(F)c(OCc2c(ccn2-c2ccc(Cl)cc2)C(F)(F)F)c(F)c1)C(O)=O
Show InChI InChI=1S/C22H17ClF5NO3/c1-12(21(30)31)8-13-9-17(24)20(18(25)10-13)32-11-19-16(22(26,27)28)6-7-29(19)15-4-2-14(23)3-5-15/h2-7,9-10,12H,8,11H2,1H3,(H,30,31)
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n/an/an/an/a 290n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at ...

Bioorg Med Chem Lett 28: 841-846 (2018)


Article DOI: 10.1016/j.bmcl.2018.02.013
BindingDB Entry DOI: 10.7270/Q21Z471F
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens (Human))		BDBM50455230
PNG
(CHEMBL4209823)
Show SMILES OC(=O)CCc1cc(F)c(OCc2c(ccn2-c2ccc(Cl)cc2F)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C21H14ClF6NO3/c22-12-2-3-17(14(23)9-12)29-6-5-13(21(26,27)28)18(29)10-32-20-15(24)7-11(8-16(20)25)1-4-19(30)31/h2-3,5-9H,1,4,10H2,(H,30,31)
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n/an/an/an/a 179n/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at ...

Bioorg Med Chem Lett 28: 841-846 (2018)


Article DOI: 10.1016/j.bmcl.2018.02.013
BindingDB Entry DOI: 10.7270/Q21Z471F
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%