Found 9 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Transient receptor potential cation channel subfamily M member 2
(Homo sapiens (Human)) | BDBM50227083
(CHEMBL173443)Show InChI InChI=1S/C21H23NO3/c1-2-3-4-7-16-10-12-17(13-11-16)14-15-20(23)22-19-9-6-5-8-18(19)21(24)25/h5-6,8-15H,2-4,7H2,1H3,(H,22,23)(H,24,25)/b15-14+ | PDB
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CHEMBL
MCE
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description
Inhibition of human TRPM2 expressed in HEK293 cells assessed as reduction in ADPR-induced channel currents treated extracellularly after 60 secs by w... |
Eur J Med Chem 152: 235-252 (2018)
Article DOI: 10.1016/j.ejmech.2018.04.045
BindingDB Entry DOI: 10.7270/Q22J6FDS |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 2
(Homo sapiens (Human)) | BDBM50227083
(CHEMBL173443)Show InChI InChI=1S/C21H23NO3/c1-2-3-4-7-16-10-12-17(13-11-16)14-15-20(23)22-19-9-6-5-8-18(19)21(24)25/h5-6,8-15H,2-4,7H2,1H3,(H,22,23)(H,24,25)/b15-14+ | PDB
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CHEMBL
MCE
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description
Inhibition of human TRPM2 expressed in HEK293 cells assessed as reduction in H2O2-induced intracellular calcium flux after 30 mins by Fluo4-AM dye ba... |
Eur J Med Chem 152: 235-252 (2018)
Article DOI: 10.1016/j.ejmech.2018.04.045
BindingDB Entry DOI: 10.7270/Q22J6FDS |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 2
(Homo sapiens (Human)) | BDBM50227083
(CHEMBL173443)Show InChI InChI=1S/C21H23NO3/c1-2-3-4-7-16-10-12-17(13-11-16)14-15-20(23)22-19-9-6-5-8-18(19)21(24)25/h5-6,8-15H,2-4,7H2,1H3,(H,22,23)(H,24,25)/b15-14+ | PDB
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CHEMBL
MCE
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description
Inhibition of human TRPM2 expressed in HEK293 cells assessed as reduction in ADPR-induced channel currents by whole cell patch clamp electrophysiolog... |
Eur J Med Chem 152: 235-252 (2018)
Article DOI: 10.1016/j.ejmech.2018.04.045
BindingDB Entry DOI: 10.7270/Q22J6FDS |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 2
(Homo sapiens (Human)) | BDBM50405913
(CHEMBL4176916)Show SMILES Cc1cc(Br)cc2C(=O)NC(Nc12)c1c[nH]nc1-c1cccc2ccccc12 Show InChI InChI=1S/C19H31NO4S/c1-2-11-20-18(21)13-25-12-15-14(16-9-10-17(15)24-16)7-5-3-4-6-8-19(22)23/h3,5,14-17H,2,4,6-13H2,1H3,(H,20,21)(H,22,23)/b5-3- | PDB
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| PC cid
PC sid
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| Article
PubMed
| n/a | n/a | 3.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description
Inhibition of human TRPM2 expressed in HEK293 cells assessed as reduction in ADPR-induced channel currents treated extracellularly after 60 secs by w... |
Eur J Med Chem 152: 235-252 (2018)
Article DOI: 10.1016/j.ejmech.2018.04.045
BindingDB Entry DOI: 10.7270/Q22J6FDS |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50227083
(CHEMBL173443)Show InChI InChI=1S/C21H23NO3/c1-2-3-4-7-16-10-12-17(13-11-16)14-15-20(23)22-19-9-6-5-8-18(19)21(24)25/h5-6,8-15H,2-4,7H2,1H3,(H,22,23)(H,24,25)/b15-14+ | PDB
KEGG
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CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| n/a | n/a | 3.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description
Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in H2O2-induced intracellular calcium flux after 30 mins by Fluo4-AM dye ba... |
Eur J Med Chem 152: 235-252 (2018)
Article DOI: 10.1016/j.ejmech.2018.04.045
BindingDB Entry DOI: 10.7270/Q22J6FDS |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 2
(Homo sapiens (Human)) | BDBM50405912
(CHEMBL4159037)Show SMILES Cc1cc(Cl)cc2C(=O)NC(Nc12)c1c[nH]nc1-c1cccc2ccccc12 Show InChI InChI=1S/C20H26O3S/c21-20(22)11-7-2-1-6-10-16-17(19-13-12-18(16)23-19)14-24-15-8-4-3-5-9-15/h1,3-6,8-9,16-19H,2,7,10-14H2,(H,21,22)/b6-1- | PDB
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description
Inhibition of human TRPM2 expressed in HEK293 cells assessed as reduction in ADPR-induced channel currents treated extracellularly after 60 secs by w... |
Eur J Med Chem 152: 235-252 (2018)
Article DOI: 10.1016/j.ejmech.2018.04.045
BindingDB Entry DOI: 10.7270/Q22J6FDS |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 2
(Homo sapiens (Human)) | BDBM50405910
(CHEMBL4174768)Show SMILES Cc1cc(Br)cc2C(=O)NC(Nc12)c1c[nH]nc1-c1ccccc1 Show InChI InChI=1S/C20H34O3S/c1-2-3-4-7-10-15-24-20-16(17-13-14-18(20)23-17)11-8-5-6-9-12-19(21)22/h5,8,16-18,20H,2-4,6-7,9-15H2,1H3,(H,21,22)/b8-5- | PDB
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description
Inhibition of human TRPM2 expressed in HEK293 cells assessed as reduction in ADPR-induced channel currents treated extracellularly after 60 secs by w... |
Eur J Med Chem 152: 235-252 (2018)
Article DOI: 10.1016/j.ejmech.2018.04.045
BindingDB Entry DOI: 10.7270/Q22J6FDS |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 2
(Homo sapiens (Human)) | BDBM50405911
(CHEMBL4167784)Show SMILES Cc1cc(Cl)cc2C(=O)NC(Nc12)c1c[nH]nc1-c1ccccc1 Show InChI InChI=1S/C23H30O3S/c24-23(25)13-7-2-1-6-12-19-20(22-15-14-21(19)26-22)17-27-16-8-11-18-9-4-3-5-10-18/h1,3-6,8-11,19-22H,2,7,12-17H2,(H,24,25)/b6-1-,11-8+ | PDB
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description
Inhibition of human TRPM2 expressed in HEK293 cells assessed as reduction in ADPR-induced channel currents treated extracellularly after 60 secs by w... |
Eur J Med Chem 152: 235-252 (2018)
Article DOI: 10.1016/j.ejmech.2018.04.045
BindingDB Entry DOI: 10.7270/Q22J6FDS |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 2
(Homo sapiens (Human)) | BDBM18137
(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O Show InChI InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1 | PDB
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CHEMBL
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MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 7.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description
Inhibition of human TRPM2 assessed as reduction in ADPR-induced channel currents by whole cell patch clamp electrophysiology method |
Eur J Med Chem 152: 235-252 (2018)
Article DOI: 10.1016/j.ejmech.2018.04.045
BindingDB Entry DOI: 10.7270/Q22J6FDS |
More data for this
Ligand-Target Pair | |
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