Found 31 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50133817
(4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic ...)Show SMILES CC(C)(C)c1ccc(NC(=O)N2CCN(CC2)c2ncccc2Cl)cc1 Show InChI InChI=1S/C20H25ClN4O/c1-20(2,3)15-6-8-16(9-7-15)23-19(26)25-13-11-24(12-14-25)18-17(21)5-4-10-22-18/h4-10H,11-14H2,1-3H3,(H,23,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Henan University
Curated by ChEMBL
| Assay Description
Antagonist activity at capsaicin-induced human recombinant TRPV1 expressed in CHO-K1 cells co-expressing aequorin incubated for 2.5 mins in presence ... |
Eur J Med Chem 178: 433-445 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.007
BindingDB Entry DOI: 10.7270/Q2765JPB |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50516352
(CHEMBL4444339)Show SMILES FC(F)(F)c1ccccc1-n1cc(CN2CCc3c(C2)[nH]c2ccccc32)nn1 Show InChI InChI=1S/C21H18F3N5/c22-21(23,24)17-6-2-4-8-20(17)29-12-14(26-27-29)11-28-10-9-16-15-5-1-3-7-18(15)25-19(16)13-28/h1-8,12,25H,9-11,13H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 75 | n/a | n/a | n/a | n/a | n/a | n/a |
Henan University
Curated by ChEMBL
| Assay Description
Antagonist activity at capsaicin-induced human recombinant TRPV1 expressed in CHO-K1 cells co-expressing aequorin incubated for 2.5 mins in presence ... |
Eur J Med Chem 178: 433-445 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.007
BindingDB Entry DOI: 10.7270/Q2765JPB |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50516359
(CHEMBL4436455)Show SMILES FC(F)(F)c1cccc(c1)-n1cc(CN2CCc3c(C2)[nH]c2ccccc32)nn1 Show InChI InChI=1S/C21H18F3N5/c22-21(23,24)14-4-3-5-16(10-14)29-12-15(26-27-29)11-28-9-8-18-17-6-1-2-7-19(17)25-20(18)13-28/h1-7,10,12,25H,8-9,11,13H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 89 | n/a | n/a | n/a | n/a | n/a | n/a |
Henan University
Curated by ChEMBL
| Assay Description
Antagonist activity at capsaicin-induced human recombinant TRPV1 expressed in CHO-K1 cells co-expressing aequorin incubated for 2.5 mins in presence ... |
Eur J Med Chem 178: 433-445 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.007
BindingDB Entry DOI: 10.7270/Q2765JPB |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50516360
(CHEMBL4475822)Show SMILES [O-][N+](=O)c1ccccc1-n1cc(CN2CCc3c(C2)[nH]c2ccccc32)nn1 Show InChI InChI=1S/C20H18N6O2/c27-26(28)20-8-4-3-7-19(20)25-12-14(22-23-25)11-24-10-9-16-15-5-1-2-6-17(15)21-18(16)13-24/h1-8,12,21H,9-11,13H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 108 | n/a | n/a | n/a | n/a | n/a | n/a |
Henan University
Curated by ChEMBL
| Assay Description
Antagonist activity at capsaicin-induced human recombinant TRPV1 expressed in CHO-K1 cells co-expressing aequorin incubated for 2.5 mins in presence ... |
Eur J Med Chem 178: 433-445 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.007
BindingDB Entry DOI: 10.7270/Q2765JPB |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50516367
(CHEMBL4461856)Show SMILES Clc1ccc(Cl)c(c1)-n1cc(CN2CCc3c(C2)[nH]c2ccccc32)nn1 Show InChI InChI=1S/C20H17Cl2N5/c21-13-5-6-17(22)20(9-13)27-11-14(24-25-27)10-26-8-7-16-15-3-1-2-4-18(15)23-19(16)12-26/h1-6,9,11,23H,7-8,10,12H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 112 | n/a | n/a | n/a | n/a | n/a | n/a |
Henan University
Curated by ChEMBL
| Assay Description
Antagonist activity at capsaicin-induced human recombinant TRPV1 expressed in CHO-K1 cells co-expressing aequorin incubated for 2.5 mins in presence ... |
Eur J Med Chem 178: 433-445 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.007
BindingDB Entry DOI: 10.7270/Q2765JPB |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50516377
(CHEMBL4556426)Show SMILES [O-][N+](=O)c1ccc(cc1)-n1cc(CN2CCc3c(C2)[nH]c2ccccc32)nn1 Show InChI InChI=1S/C20H18N6O2/c27-26(28)16-7-5-15(6-8-16)25-12-14(22-23-25)11-24-10-9-18-17-3-1-2-4-19(17)21-20(18)13-24/h1-8,12,21H,9-11,13H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 121 | n/a | n/a | n/a | n/a | n/a | n/a |
Henan University
Curated by ChEMBL
| Assay Description
Antagonist activity at capsaicin-induced human recombinant TRPV1 expressed in CHO-K1 cells co-expressing aequorin incubated for 2.5 mins in presence ... |
Eur J Med Chem 178: 433-445 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.007
BindingDB Entry DOI: 10.7270/Q2765JPB |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50516373
(CHEMBL4436645)Show SMILES FC(F)(F)c1ccc(cc1)-n1cc(CN2CCc3c(C2)[nH]c2ccccc32)nn1 Show InChI InChI=1S/C21H18F3N5/c22-21(23,24)14-5-7-16(8-6-14)29-12-15(26-27-29)11-28-10-9-18-17-3-1-2-4-19(17)25-20(18)13-28/h1-8,12,25H,9-11,13H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 204 | n/a | n/a | n/a | n/a | n/a | n/a |
Henan University
Curated by ChEMBL
| Assay Description
Antagonist activity at capsaicin-induced human recombinant TRPV1 expressed in CHO-K1 cells co-expressing aequorin incubated for 2.5 mins in presence ... |
Eur J Med Chem 178: 433-445 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.007
BindingDB Entry DOI: 10.7270/Q2765JPB |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50516357
(CHEMBL4438728)Show SMILES Fc1ccccc1-n1cc(CN2CCc3c(C2)[nH]c2ccccc32)nn1 Show InChI InChI=1S/C20H18FN5/c21-17-6-2-4-8-20(17)26-12-14(23-24-26)11-25-10-9-16-15-5-1-3-7-18(15)22-19(16)13-25/h1-8,12,22H,9-11,13H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 232 | n/a | n/a | n/a | n/a | n/a | n/a |
Henan University
Curated by ChEMBL
| Assay Description
Antagonist activity at capsaicin-induced human recombinant TRPV1 expressed in CHO-K1 cells co-expressing aequorin incubated for 2.5 mins in presence ... |
Eur J Med Chem 178: 433-445 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.007
BindingDB Entry DOI: 10.7270/Q2765JPB |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50516355
(CHEMBL4519573)Show SMILES Clc1ccccc1-n1cc(CN2CCc3c(C2)[nH]c2ccccc32)nn1 Show InChI InChI=1S/C20H18ClN5/c21-17-6-2-4-8-20(17)26-12-14(23-24-26)11-25-10-9-16-15-5-1-3-7-18(15)22-19(16)13-25/h1-8,12,22H,9-11,13H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 243 | n/a | n/a | n/a | n/a | n/a | n/a |
Henan University
Curated by ChEMBL
| Assay Description
Antagonist activity at capsaicin-induced human recombinant TRPV1 expressed in CHO-K1 cells co-expressing aequorin incubated for 2.5 mins in presence ... |
Eur J Med Chem 178: 433-445 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.007
BindingDB Entry DOI: 10.7270/Q2765JPB |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50516353
(CHEMBL4591413)Show SMILES C(N1CCc2c(C1)[nH]c1ccccc21)c1cn(nn1)-c1ccccc1 Show InChI InChI=1S/C20H19N5/c1-2-6-16(7-3-1)25-13-15(22-23-25)12-24-11-10-18-17-8-4-5-9-19(17)21-20(18)14-24/h1-9,13,21H,10-12,14H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 314 | n/a | n/a | n/a | n/a | n/a | n/a |
Henan University
Curated by ChEMBL
| Assay Description
Antagonist activity at capsaicin-induced human recombinant TRPV1 expressed in CHO-K1 cells co-expressing aequorin incubated for 2.5 mins in presence ... |
Eur J Med Chem 178: 433-445 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.007
BindingDB Entry DOI: 10.7270/Q2765JPB |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50516378
(CHEMBL4444567)Show SMILES Clc1ccc(cc1Cl)-n1cc(CN2CCc3c(C2)[nH]c2ccccc32)nn1 Show InChI InChI=1S/C20H17Cl2N5/c21-17-6-5-14(9-18(17)22)27-11-13(24-25-27)10-26-8-7-16-15-3-1-2-4-19(15)23-20(16)12-26/h1-6,9,11,23H,7-8,10,12H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 341 | n/a | n/a | n/a | n/a | n/a | n/a |
Henan University
Curated by ChEMBL
| Assay Description
Antagonist activity at capsaicin-induced human recombinant TRPV1 expressed in CHO-K1 cells co-expressing aequorin incubated for 2.5 mins in presence ... |
Eur J Med Chem 178: 433-445 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.007
BindingDB Entry DOI: 10.7270/Q2765JPB |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50516358
(CHEMBL4439917)Show SMILES Fc1cccc(c1)-n1cc(CN2CCc3c(C2)[nH]c2ccccc32)nn1 Show InChI InChI=1S/C20H18FN5/c21-14-4-3-5-16(10-14)26-12-15(23-24-26)11-25-9-8-18-17-6-1-2-7-19(17)22-20(18)13-25/h1-7,10,12,22H,8-9,11,13H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 385 | n/a | n/a | n/a | n/a | n/a | n/a |
Henan University
Curated by ChEMBL
| Assay Description
Antagonist activity at capsaicin-induced human recombinant TRPV1 expressed in CHO-K1 cells co-expressing aequorin incubated for 2.5 mins in presence ... |
Eur J Med Chem 178: 433-445 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.007
BindingDB Entry DOI: 10.7270/Q2765JPB |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50516365
(CHEMBL4464712)Show SMILES [O-][N+](=O)c1cc(Cl)ccc1-n1cc(CN2CCc3c(C2)[nH]c2ccccc32)nn1 Show InChI InChI=1S/C20H17ClN6O2/c21-13-5-6-19(20(9-13)27(28)29)26-11-14(23-24-26)10-25-8-7-16-15-3-1-2-4-17(15)22-18(16)12-25/h1-6,9,11,22H,7-8,10,12H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 394 | n/a | n/a | n/a | n/a | n/a | n/a |
Henan University
Curated by ChEMBL
| Assay Description
Antagonist activity at capsaicin-induced human recombinant TRPV1 expressed in CHO-K1 cells co-expressing aequorin incubated for 2.5 mins in presence ... |
Eur J Med Chem 178: 433-445 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.007
BindingDB Entry DOI: 10.7270/Q2765JPB |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50516374
(CHEMBL4556872)Show SMILES Clc1cccc(c1)-n1cc(CN2CCc3c(C2)[nH]c2ccccc32)nn1 Show InChI InChI=1S/C20H18ClN5/c21-14-4-3-5-16(10-14)26-12-15(23-24-26)11-25-9-8-18-17-6-1-2-7-19(17)22-20(18)13-25/h1-7,10,12,22H,8-9,11,13H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 416 | n/a | n/a | n/a | n/a | n/a | n/a |
Henan University
Curated by ChEMBL
| Assay Description
Antagonist activity at capsaicin-induced human recombinant TRPV1 expressed in CHO-K1 cells co-expressing aequorin incubated for 2.5 mins in presence ... |
Eur J Med Chem 178: 433-445 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.007
BindingDB Entry DOI: 10.7270/Q2765JPB |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50516375
(CHEMBL4474666)Show SMILES Fc1ccc(cc1)-n1cc(CN2CCc3c(C2)[nH]c2ccccc32)nn1 Show InChI InChI=1S/C20H18FN5/c21-14-5-7-16(8-6-14)26-12-15(23-24-26)11-25-10-9-18-17-3-1-2-4-19(17)22-20(18)13-25/h1-8,12,22H,9-11,13H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 494 | n/a | n/a | n/a | n/a | n/a | n/a |
Henan University
Curated by ChEMBL
| Assay Description
Antagonist activity at capsaicin-induced human recombinant TRPV1 expressed in CHO-K1 cells co-expressing aequorin incubated for 2.5 mins in presence ... |
Eur J Med Chem 178: 433-445 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.007
BindingDB Entry DOI: 10.7270/Q2765JPB |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50516356
(CHEMBL4442375)Show SMILES Clc1ccc(cc1)-n1cc(CN2CCc3c(C2)[nH]c2ccccc32)nn1 Show InChI InChI=1S/C20H18ClN5/c21-14-5-7-16(8-6-14)26-12-15(23-24-26)11-25-10-9-18-17-3-1-2-4-19(17)22-20(18)13-25/h1-8,12,22H,9-11,13H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 495 | n/a | n/a | n/a | n/a | n/a | n/a |
Henan University
Curated by ChEMBL
| Assay Description
Antagonist activity at capsaicin-induced human recombinant TRPV1 expressed in CHO-K1 cells co-expressing aequorin incubated for 2.5 mins in presence ... |
Eur J Med Chem 178: 433-445 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.007
BindingDB Entry DOI: 10.7270/Q2765JPB |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50516350
(CHEMBL4454610)Show SMILES Brc1ccc(cc1)-n1cc(CN2CCc3c(C2)[nH]c2ccccc32)nn1 Show InChI InChI=1S/C20H18BrN5/c21-14-5-7-16(8-6-14)26-12-15(23-24-26)11-25-10-9-18-17-3-1-2-4-19(17)22-20(18)13-25/h1-8,12,22H,9-11,13H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 788 | n/a | n/a | n/a | n/a | n/a | n/a |
Henan University
Curated by ChEMBL
| Assay Description
Antagonist activity at capsaicin-induced human recombinant TRPV1 expressed in CHO-K1 cells co-expressing aequorin incubated for 2.5 mins in presence ... |
Eur J Med Chem 178: 433-445 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.007
BindingDB Entry DOI: 10.7270/Q2765JPB |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50516366
(CHEMBL4445182)Show SMILES COc1ccc(cc1OC)-n1cc(CN2CCc3c(C2)[nH]c2ccccc32)nn1 Show InChI InChI=1S/C22H23N5O2/c1-28-21-8-7-16(11-22(21)29-2)27-13-15(24-25-27)12-26-10-9-18-17-5-3-4-6-19(17)23-20(18)14-26/h3-8,11,13,23H,9-10,12,14H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.12E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Henan University
Curated by ChEMBL
| Assay Description
Antagonist activity at capsaicin-induced human recombinant TRPV1 expressed in CHO-K1 cells co-expressing aequorin incubated for 2.5 mins in presence ... |
Eur J Med Chem 178: 433-445 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.007
BindingDB Entry DOI: 10.7270/Q2765JPB |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50516363
(CHEMBL4459131)Show SMILES COc1ccc(cc1)-n1cc(CN2CCc3c(C2)[nH]c2ccccc32)nn1 Show InChI InChI=1S/C21H21N5O/c1-27-17-8-6-16(7-9-17)26-13-15(23-24-26)12-25-11-10-19-18-4-2-3-5-20(18)22-21(19)14-25/h2-9,13,22H,10-12,14H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Henan University
Curated by ChEMBL
| Assay Description
Antagonist activity at capsaicin-induced human recombinant TRPV1 expressed in CHO-K1 cells co-expressing aequorin incubated for 2.5 mins in presence ... |
Eur J Med Chem 178: 433-445 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.007
BindingDB Entry DOI: 10.7270/Q2765JPB |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50516362
(CHEMBL4557946)Show SMILES CC(C)(C)c1ccc(cc1)-n1cc(CN2CCc3c(C2)[nH]c2ccccc32)nn1 Show InChI InChI=1S/C24H27N5/c1-24(2,3)17-8-10-19(11-9-17)29-15-18(26-27-29)14-28-13-12-21-20-6-4-5-7-22(20)25-23(21)16-28/h4-11,15,25H,12-14,16H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.22E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Henan University
Curated by ChEMBL
| Assay Description
Antagonist activity at capsaicin-induced human recombinant TRPV1 expressed in CHO-K1 cells co-expressing aequorin incubated for 2.5 mins in presence ... |
Eur J Med Chem 178: 433-445 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.007
BindingDB Entry DOI: 10.7270/Q2765JPB |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50516372
(CHEMBL4446753)Show SMILES Cc1ccc(C)c(c1)-n1cc(CN2CCc3c(C2)[nH]c2ccccc32)nn1 Show InChI InChI=1S/C22H23N5/c1-15-7-8-16(2)22(11-15)27-13-17(24-25-27)12-26-10-9-19-18-5-3-4-6-20(18)23-21(19)14-26/h3-8,11,13,23H,9-10,12,14H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.54E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Henan University
Curated by ChEMBL
| Assay Description
Antagonist activity at capsaicin-induced human recombinant TRPV1 expressed in CHO-K1 cells co-expressing aequorin incubated for 2.5 mins in presence ... |
Eur J Med Chem 178: 433-445 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.007
BindingDB Entry DOI: 10.7270/Q2765JPB |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50516364
(CHEMBL4438597)Show SMILES CC(C)c1cccc(c1)-n1cc(CN2CCc3c(C2)[nH]c2ccccc32)nn1 Show InChI InChI=1S/C23H25N5/c1-16(2)17-6-5-7-19(12-17)28-14-18(25-26-28)13-27-11-10-21-20-8-3-4-9-22(20)24-23(21)15-27/h3-9,12,14,16,24H,10-11,13,15H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.67E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Henan University
Curated by ChEMBL
| Assay Description
Antagonist activity at capsaicin-induced human recombinant TRPV1 expressed in CHO-K1 cells co-expressing aequorin incubated for 2.5 mins in presence ... |
Eur J Med Chem 178: 433-445 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.007
BindingDB Entry DOI: 10.7270/Q2765JPB |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50516361
(CHEMBL4468324)Show SMILES COc1ccccc1-n1cc(CN2CCc3c(C2)[nH]c2ccccc32)nn1 Show InChI InChI=1S/C21H21N5O/c1-27-21-9-5-4-8-20(21)26-13-15(23-24-26)12-25-11-10-17-16-6-2-3-7-18(16)22-19(17)14-25/h2-9,13,22H,10-12,14H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.88E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Henan University
Curated by ChEMBL
| Assay Description
Antagonist activity at capsaicin-induced human recombinant TRPV1 expressed in CHO-K1 cells co-expressing aequorin incubated for 2.5 mins in presence ... |
Eur J Med Chem 178: 433-445 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.007
BindingDB Entry DOI: 10.7270/Q2765JPB |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50516351
(CHEMBL4592679)Show SMILES C(N1CCc2c(C1)[nH]c1ccccc21)c1cn(nn1)-c1cccc2cnccc12 Show InChI InChI=1S/C23H20N6/c1-2-6-21-19(5-1)20-9-11-28(15-22(20)25-21)13-17-14-29(27-26-17)23-7-3-4-16-12-24-10-8-18(16)23/h1-8,10,12,14,25H,9,11,13,15H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Henan University
Curated by ChEMBL
| Assay Description
Antagonist activity at capsaicin-induced human recombinant TRPV1 expressed in CHO-K1 cells co-expressing aequorin incubated for 2.5 mins in presence ... |
Eur J Med Chem 178: 433-445 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.007
BindingDB Entry DOI: 10.7270/Q2765JPB |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50516376
(CHEMBL4535483)Show SMILES CC(C)c1ccccc1-n1cc(CN2CCc3c(C2)[nH]c2ccccc32)nn1 Show InChI InChI=1S/C23H25N5/c1-16(2)18-7-4-6-10-23(18)28-14-17(25-26-28)13-27-12-11-20-19-8-3-5-9-21(19)24-22(20)15-27/h3-10,14,16,24H,11-13,15H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.53E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Henan University
Curated by ChEMBL
| Assay Description
Antagonist activity at capsaicin-induced human recombinant TRPV1 expressed in CHO-K1 cells co-expressing aequorin incubated for 2.5 mins in presence ... |
Eur J Med Chem 178: 433-445 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.007
BindingDB Entry DOI: 10.7270/Q2765JPB |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50516354
(CHEMBL4530705)Show SMILES Clc1ncccc1-n1cc(CN2CCc3c(C2)[nH]c2ccccc32)nn1 Show InChI InChI=1S/C19H17ClN6/c20-19-18(6-3-8-21-19)26-11-13(23-24-26)10-25-9-7-15-14-4-1-2-5-16(14)22-17(15)12-25/h1-6,8,11,22H,7,9-10,12H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.49E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Henan University
Curated by ChEMBL
| Assay Description
Antagonist activity at capsaicin-induced human recombinant TRPV1 expressed in CHO-K1 cells co-expressing aequorin incubated for 2.5 mins in presence ... |
Eur J Med Chem 178: 433-445 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.007
BindingDB Entry DOI: 10.7270/Q2765JPB |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50516369
(CHEMBL4547919)Show InChI InChI=1S/C18H15F3N4/c19-18(20,21)15-6-2-4-8-17(15)25-12-14(22-23-25)11-24-10-9-13-5-1-3-7-16(13)24/h1-8,12H,9-11H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.95E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Henan University
Curated by ChEMBL
| Assay Description
Antagonist activity at capsaicin-induced human recombinant TRPV1 expressed in CHO-K1 cells co-expressing aequorin incubated for 2.5 mins in presence ... |
Eur J Med Chem 178: 433-445 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.007
BindingDB Entry DOI: 10.7270/Q2765JPB |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50516370
(CHEMBL4466908)Show InChI InChI=1S/C17H15ClN4/c18-14-5-7-16(8-6-14)22-12-15(19-20-22)11-21-10-9-13-3-1-2-4-17(13)21/h1-8,12H,9-11H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.26E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Henan University
Curated by ChEMBL
| Assay Description
Antagonist activity at capsaicin-induced human recombinant TRPV1 expressed in CHO-K1 cells co-expressing aequorin incubated for 2.5 mins in presence ... |
Eur J Med Chem 178: 433-445 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.007
BindingDB Entry DOI: 10.7270/Q2765JPB |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50516368
(CHEMBL4468624)Show InChI InChI=1S/C17H15FN4/c18-14-5-3-6-16(10-14)22-12-15(19-20-22)11-21-9-8-13-4-1-2-7-17(13)21/h1-7,10,12H,8-9,11H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.94E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Henan University
Curated by ChEMBL
| Assay Description
Antagonist activity at capsaicin-induced human recombinant TRPV1 expressed in CHO-K1 cells co-expressing aequorin incubated for 2.5 mins in presence ... |
Eur J Med Chem 178: 433-445 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.007
BindingDB Entry DOI: 10.7270/Q2765JPB |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50516379
(CHEMBL4437514)Show InChI InChI=1S/C21H24N4/c1-21(2,3)17-8-10-19(11-9-17)25-15-18(22-23-25)14-24-13-12-16-6-4-5-7-20(16)24/h4-11,15H,12-14H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.26E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Henan University
Curated by ChEMBL
| Assay Description
Antagonist activity at capsaicin-induced human recombinant TRPV1 expressed in CHO-K1 cells co-expressing aequorin incubated for 2.5 mins in presence ... |
Eur J Med Chem 178: 433-445 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.007
BindingDB Entry DOI: 10.7270/Q2765JPB |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50516371
(CHEMBL4446839)Show SMILES CC(C)(C)c1ccc(cc1)-n1cc(CN2CCc3cc(Cl)ccc23)nn1 Show InChI InChI=1S/C21H23ClN4/c1-21(2,3)16-4-7-19(8-5-16)26-14-18(23-24-26)13-25-11-10-15-12-17(22)6-9-20(15)25/h4-9,12,14H,10-11,13H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.71E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Henan University
Curated by ChEMBL
| Assay Description
Antagonist activity at capsaicin-induced human recombinant TRPV1 expressed in CHO-K1 cells co-expressing aequorin incubated for 2.5 mins in presence ... |
Eur J Med Chem 178: 433-445 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.007
BindingDB Entry DOI: 10.7270/Q2765JPB |
More data for this
Ligand-Target Pair | |
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