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PubMed code 31345748

Compile data set for download or QSAR
Found 37 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM50524779
PNG
(CHEMBL4447079)
Show SMILES Fc1ccc(cc1)S(=O)(=O)Oc1ccc(cc1)-c1ccc2occc2c1
Show InChI InChI=1S/C20H13FO4S/c21-17-4-8-19(9-5-17)26(22,23)25-18-6-1-14(2-7-18)15-3-10-20-16(13-15)11-12-24-20/h1-13H
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n/an/a 140n/an/an/an/an/an/a



University of Sharjah

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-HA-tagged carbonic anhydrase 2 expressed in HEK293T cells using p-nitrophenyl acetate as substrate measured after 3...


Bioorg Med Chem 27: 3889-3901 (2019)


Article DOI: 10.1016/j.bmc.2019.07.026
BindingDB Entry DOI: 10.7270/Q2GX4G0K
More data for this
Ligand-Target Pair
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM50524777
PNG
(CHEMBL4452931)
Show SMILES O=S(=O)(Oc1ccc(cc1)-c1ccc2occc2c1)C1CCCCC1
Show InChI InChI=1S/C20H20O4S/c21-25(22,19-4-2-1-3-5-19)24-18-9-6-15(7-10-18)16-8-11-20-17(14-16)12-13-23-20/h6-14,19H,1-5H2
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n/an/a 170n/an/an/an/an/an/a



University of Sharjah

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-HA--tagged carbonic anhydrase 12 expressed in HEK293T cells using p-nitrophenyl acetate as substrate measured after...


Bioorg Med Chem 27: 3889-3901 (2019)


Article DOI: 10.1016/j.bmc.2019.07.026
BindingDB Entry DOI: 10.7270/Q2GX4G0K
More data for this
Ligand-Target Pair
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM50524773
PNG
(CHEMBL4533978)
Show SMILES CN(C)S(=O)(=O)Oc1ccc(cc1)-c1ccc2occc2c1
Show InChI InChI=1S/C16H15NO4S/c1-17(2)22(18,19)21-15-6-3-12(4-7-15)13-5-8-16-14(11-13)9-10-20-16/h3-11H,1-2H3
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n/an/a 170n/an/an/an/an/an/a



University of Sharjah

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-HA--tagged carbonic anhydrase 12 expressed in HEK293T cells using p-nitrophenyl acetate as substrate measured after...


Bioorg Med Chem 27: 3889-3901 (2019)


Article DOI: 10.1016/j.bmc.2019.07.026
BindingDB Entry DOI: 10.7270/Q2GX4G0K
More data for this
Ligand-Target Pair
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM50524780
PNG
(CHEMBL4540118)
Show SMILES O=S(=O)(Oc1ccc(cc1)-c1ccc2sccc2c1)c1ccccc1
Show InChI InChI=1S/C20H14O3S2/c21-25(22,19-4-2-1-3-5-19)23-18-9-6-15(7-10-18)16-8-11-20-17(14-16)12-13-24-20/h1-14H
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n/an/a 250n/an/an/an/an/an/a



University of Sharjah

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-HA--tagged carbonic anhydrase 12 expressed in HEK293T cells using p-nitrophenyl acetate as substrate measured after...


Bioorg Med Chem 27: 3889-3901 (2019)


Article DOI: 10.1016/j.bmc.2019.07.026
BindingDB Entry DOI: 10.7270/Q2GX4G0K
More data for this
Ligand-Target Pair
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM50524779
PNG
(CHEMBL4447079)
Show SMILES Fc1ccc(cc1)S(=O)(=O)Oc1ccc(cc1)-c1ccc2occc2c1
Show InChI InChI=1S/C20H13FO4S/c21-17-4-8-19(9-5-17)26(22,23)25-18-6-1-14(2-7-18)15-3-10-20-16(13-15)11-12-24-20/h1-13H
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n/an/a 270n/an/an/an/an/an/a



University of Sharjah

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-HA--tagged carbonic anhydrase 12 expressed in HEK293T cells using p-nitrophenyl acetate as substrate measured after...


Bioorg Med Chem 27: 3889-3901 (2019)


Article DOI: 10.1016/j.bmc.2019.07.026
BindingDB Entry DOI: 10.7270/Q2GX4G0K
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM50524768
PNG
(CHEMBL4469527)
Show SMILES CCCS(=O)(=O)Oc1ccc(cc1)-c1ccc2sccc2c1
Show InChI InChI=1S/C17H16O3S2/c1-2-11-22(18,19)20-16-6-3-13(4-7-16)14-5-8-17-15(12-14)9-10-21-17/h3-10,12H,2,11H2,1H3
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n/an/a 310n/an/an/an/an/an/a



University of Sharjah

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-HA-tagged carbonic anhydrase 2 expressed in HEK293T cells using p-nitrophenyl acetate as substrate measured after 3...


Bioorg Med Chem 27: 3889-3901 (2019)


Article DOI: 10.1016/j.bmc.2019.07.026
BindingDB Entry DOI: 10.7270/Q2GX4G0K
More data for this
Ligand-Target Pair
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM50524768
PNG
(CHEMBL4469527)
Show SMILES CCCS(=O)(=O)Oc1ccc(cc1)-c1ccc2sccc2c1
Show InChI InChI=1S/C17H16O3S2/c1-2-11-22(18,19)20-16-6-3-13(4-7-16)14-5-8-17-15(12-14)9-10-21-17/h3-10,12H,2,11H2,1H3
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n/an/a 310n/an/an/an/an/an/a



University of Sharjah

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-HA--tagged carbonic anhydrase 12 expressed in HEK293T cells using p-nitrophenyl acetate as substrate measured after...


Bioorg Med Chem 27: 3889-3901 (2019)


Article DOI: 10.1016/j.bmc.2019.07.026
BindingDB Entry DOI: 10.7270/Q2GX4G0K
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM50524770
PNG
(CHEMBL4554647)
Show SMILES O=S(=O)(Oc1ccc(cc1)-c1ccc2occc2c1)c1ccccc1
Show InChI InChI=1S/C20H14O4S/c21-25(22,19-4-2-1-3-5-19)24-18-9-6-15(7-10-18)16-8-11-20-17(14-16)12-13-23-20/h1-14H
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n/an/a 410n/an/an/an/an/an/a



University of Sharjah

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-HA-tagged carbonic anhydrase 2 expressed in HEK293T cells using p-nitrophenyl acetate as substrate measured after 3...


Bioorg Med Chem 27: 3889-3901 (2019)


Article DOI: 10.1016/j.bmc.2019.07.026
BindingDB Entry DOI: 10.7270/Q2GX4G0K
More data for this
Ligand-Target Pair
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM50524770
PNG
(CHEMBL4554647)
Show SMILES O=S(=O)(Oc1ccc(cc1)-c1ccc2occc2c1)c1ccccc1
Show InChI InChI=1S/C20H14O4S/c21-25(22,19-4-2-1-3-5-19)24-18-9-6-15(7-10-18)16-8-11-20-17(14-16)12-13-23-20/h1-14H
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n/an/a 490n/an/an/an/an/an/a



University of Sharjah

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-HA--tagged carbonic anhydrase 12 expressed in HEK293T cells using p-nitrophenyl acetate as substrate measured after...


Bioorg Med Chem 27: 3889-3901 (2019)


Article DOI: 10.1016/j.bmc.2019.07.026
BindingDB Entry DOI: 10.7270/Q2GX4G0K
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM50524771
PNG
(CHEMBL4517453)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Oc1ccc(cc1)-c1ccc2occc2c1
Show InChI InChI=1S/C21H16O4S/c1-15-2-9-20(10-3-15)26(22,23)25-19-7-4-16(5-8-19)17-6-11-21-18(14-17)12-13-24-21/h2-14H,1H3
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n/an/a 500n/an/an/an/an/an/a



University of Sharjah

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-HA-tagged carbonic anhydrase 2 expressed in HEK293T cells using p-nitrophenyl acetate as substrate measured after 3...


Bioorg Med Chem 27: 3889-3901 (2019)


Article DOI: 10.1016/j.bmc.2019.07.026
BindingDB Entry DOI: 10.7270/Q2GX4G0K
More data for this
Ligand-Target Pair
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM50524769
PNG
(CHEMBL4592008)
Show SMILES CS(=O)(=O)Oc1ccc(cc1)-c1ccc2occc2c1
Show InChI InChI=1S/C15H12O4S/c1-20(16,17)19-14-5-2-11(3-6-14)12-4-7-15-13(10-12)8-9-18-15/h2-10H,1H3
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n/an/a 540n/an/an/an/an/an/a



University of Sharjah

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-HA--tagged carbonic anhydrase 12 expressed in HEK293T cells using p-nitrophenyl acetate as substrate measured after...


Bioorg Med Chem 27: 3889-3901 (2019)


Article DOI: 10.1016/j.bmc.2019.07.026
BindingDB Entry DOI: 10.7270/Q2GX4G0K
More data for this
Ligand-Target Pair
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM50524767
PNG
(CHEMBL4591628)
Show SMILES CS(=O)(=O)Oc1ccc(cc1)-c1ccc2sccc2c1
Show InChI InChI=1S/C15H12O3S2/c1-20(16,17)18-14-5-2-11(3-6-14)12-4-7-15-13(10-12)8-9-19-15/h2-10H,1H3
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n/an/a 870n/an/an/an/an/an/a



University of Sharjah

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-HA--tagged carbonic anhydrase 12 expressed in HEK293T cells using p-nitrophenyl acetate as substrate measured after...


Bioorg Med Chem 27: 3889-3901 (2019)


Article DOI: 10.1016/j.bmc.2019.07.026
BindingDB Entry DOI: 10.7270/Q2GX4G0K
More data for this
Ligand-Target Pair
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM50524784
PNG
(CHEMBL4576825)
Show SMILES CCS(=O)(=O)Oc1ccc(cc1)-c1ccc2sccc2c1
Show InChI InChI=1S/C16H14O3S2/c1-2-21(17,18)19-15-6-3-12(4-7-15)13-5-8-16-14(11-13)9-10-20-16/h3-11H,2H2,1H3
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n/an/a 920n/an/an/an/an/an/a



University of Sharjah

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-HA--tagged carbonic anhydrase 12 expressed in HEK293T cells using p-nitrophenyl acetate as substrate measured after...


Bioorg Med Chem 27: 3889-3901 (2019)


Article DOI: 10.1016/j.bmc.2019.07.026
BindingDB Entry DOI: 10.7270/Q2GX4G0K
More data for this
Ligand-Target Pair
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM50524778
PNG
(CHEMBL4591260)
Show SMILES O=S(=O)(Oc1ccc(cc1)-c1ccc2sccc2c1)C1CCCCC1
Show InChI InChI=1S/C20H20O3S2/c21-25(22,19-4-2-1-3-5-19)23-18-9-6-15(7-10-18)16-8-11-20-17(14-16)12-13-24-20/h6-14,19H,1-5H2
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n/an/a 970n/an/an/an/an/an/a



University of Sharjah

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-HA--tagged carbonic anhydrase 12 expressed in HEK293T cells using p-nitrophenyl acetate as substrate measured after...


Bioorg Med Chem 27: 3889-3901 (2019)


Article DOI: 10.1016/j.bmc.2019.07.026
BindingDB Entry DOI: 10.7270/Q2GX4G0K
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM50524772
PNG
(CHEMBL4557523)
Show SMILES CNS(=O)(=O)Oc1ccc(cc1)-c1ccc2occc2c1
Show InChI InChI=1S/C15H13NO4S/c1-16-21(17,18)20-14-5-2-11(3-6-14)12-4-7-15-13(10-12)8-9-19-15/h2-10,16H,1H3
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n/an/a 1.04E+3n/an/an/an/an/an/a



University of Sharjah

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-HA-tagged carbonic anhydrase 2 expressed in HEK293T cells using p-nitrophenyl acetate as substrate measured after 3...


Bioorg Med Chem 27: 3889-3901 (2019)


Article DOI: 10.1016/j.bmc.2019.07.026
BindingDB Entry DOI: 10.7270/Q2GX4G0K
More data for this
Ligand-Target Pair
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM50524771
PNG
(CHEMBL4517453)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Oc1ccc(cc1)-c1ccc2occc2c1
Show InChI InChI=1S/C21H16O4S/c1-15-2-9-20(10-3-15)26(22,23)25-19-7-4-16(5-8-19)17-6-11-21-18(14-17)12-13-24-21/h2-14H,1H3
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n/an/a 1.13E+3n/an/an/an/an/an/a



University of Sharjah

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-HA--tagged carbonic anhydrase 12 expressed in HEK293T cells using p-nitrophenyl acetate as substrate measured after...


Bioorg Med Chem 27: 3889-3901 (2019)


Article DOI: 10.1016/j.bmc.2019.07.026
BindingDB Entry DOI: 10.7270/Q2GX4G0K
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM10880
PNG
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O
Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
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n/an/a 1.19E+3n/an/an/an/an/an/a



University of Sharjah

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-HA-tagged carbonic anhydrase 2 expressed in HEK293T cells using p-nitrophenyl acetate as substrate measured after 3...


Bioorg Med Chem 27: 3889-3901 (2019)


Article DOI: 10.1016/j.bmc.2019.07.026
BindingDB Entry DOI: 10.7270/Q2GX4G0K
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM50524785
PNG
(CHEMBL4532237)
Show SMILES CNS(=O)(=O)Oc1ccc(cc1)-c1ccc2sccc2c1
Show InChI InChI=1S/C15H13NO3S2/c1-16-21(17,18)19-14-5-2-11(3-6-14)12-4-7-15-13(10-12)8-9-20-15/h2-10,16H,1H3
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n/an/a 1.21E+3n/an/an/an/an/an/a



University of Sharjah

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-HA-tagged carbonic anhydrase 2 expressed in HEK293T cells using p-nitrophenyl acetate as substrate measured after 3...


Bioorg Med Chem 27: 3889-3901 (2019)


Article DOI: 10.1016/j.bmc.2019.07.026
BindingDB Entry DOI: 10.7270/Q2GX4G0K
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM50524773
PNG
(CHEMBL4533978)
Show SMILES CN(C)S(=O)(=O)Oc1ccc(cc1)-c1ccc2occc2c1
Show InChI InChI=1S/C16H15NO4S/c1-17(2)22(18,19)21-15-6-3-12(4-7-15)13-5-8-16-14(11-13)9-10-20-16/h3-11H,1-2H3
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n/an/a 1.23E+3n/an/an/an/an/an/a



University of Sharjah

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-HA-tagged carbonic anhydrase 2 expressed in HEK293T cells using p-nitrophenyl acetate as substrate measured after 3...


Bioorg Med Chem 27: 3889-3901 (2019)


Article DOI: 10.1016/j.bmc.2019.07.026
BindingDB Entry DOI: 10.7270/Q2GX4G0K
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM50524784
PNG
(CHEMBL4576825)
Show SMILES CCS(=O)(=O)Oc1ccc(cc1)-c1ccc2sccc2c1
Show InChI InChI=1S/C16H14O3S2/c1-2-21(17,18)19-15-6-3-12(4-7-15)13-5-8-16-14(11-13)9-10-20-16/h3-11H,2H2,1H3
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n/an/a 1.30E+3n/an/an/an/an/an/a



University of Sharjah

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-HA-tagged carbonic anhydrase 2 expressed in HEK293T cells using p-nitrophenyl acetate as substrate measured after 3...


Bioorg Med Chem 27: 3889-3901 (2019)


Article DOI: 10.1016/j.bmc.2019.07.026
BindingDB Entry DOI: 10.7270/Q2GX4G0K
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM50524775
PNG
(CHEMBL4476741)
Show SMILES NS(=O)(=O)Oc1ccc(cc1)-c1ccc2sccc2c1
Show InChI InChI=1S/C14H11NO3S2/c15-20(16,17)18-13-4-1-10(2-5-13)11-3-6-14-12(9-11)7-8-19-14/h1-9H,(H2,15,16,17)
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n/an/a 1.32E+3n/an/an/an/an/an/a



University of Sharjah

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-HA-tagged carbonic anhydrase 2 expressed in HEK293T cells using p-nitrophenyl acetate as substrate measured after 3...


Bioorg Med Chem 27: 3889-3901 (2019)


Article DOI: 10.1016/j.bmc.2019.07.026
BindingDB Entry DOI: 10.7270/Q2GX4G0K
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM50524780
PNG
(CHEMBL4540118)
Show SMILES O=S(=O)(Oc1ccc(cc1)-c1ccc2sccc2c1)c1ccccc1
Show InChI InChI=1S/C20H14O3S2/c21-25(22,19-4-2-1-3-5-19)23-18-9-6-15(7-10-18)16-8-11-20-17(14-16)12-13-24-20/h1-14H
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n/an/a 1.49E+3n/an/an/an/an/an/a



University of Sharjah

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-HA-tagged carbonic anhydrase 2 expressed in HEK293T cells using p-nitrophenyl acetate as substrate measured after 3...


Bioorg Med Chem 27: 3889-3901 (2019)


Article DOI: 10.1016/j.bmc.2019.07.026
BindingDB Entry DOI: 10.7270/Q2GX4G0K
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM50524767
PNG
(CHEMBL4591628)
Show SMILES CS(=O)(=O)Oc1ccc(cc1)-c1ccc2sccc2c1
Show InChI InChI=1S/C15H12O3S2/c1-20(16,17)18-14-5-2-11(3-6-14)12-4-7-15-13(10-12)8-9-19-15/h2-10H,1H3
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n/an/a 1.50E+3n/an/an/an/an/an/a



University of Sharjah

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-HA-tagged carbonic anhydrase 2 expressed in HEK293T cells using p-nitrophenyl acetate as substrate measured after 3...


Bioorg Med Chem 27: 3889-3901 (2019)


Article DOI: 10.1016/j.bmc.2019.07.026
BindingDB Entry DOI: 10.7270/Q2GX4G0K
More data for this
Ligand-Target Pair
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM10880
PNG
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O
Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
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PubMed
n/an/a 1.55E+3n/an/an/an/an/an/a



University of Sharjah

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-HA--tagged carbonic anhydrase 12 expressed in HEK293T cells using p-nitrophenyl acetate as substrate measured after...


Bioorg Med Chem 27: 3889-3901 (2019)


Article DOI: 10.1016/j.bmc.2019.07.026
BindingDB Entry DOI: 10.7270/Q2GX4G0K
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM50524775
PNG
(CHEMBL4476741)
Show SMILES NS(=O)(=O)Oc1ccc(cc1)-c1ccc2sccc2c1
Show InChI InChI=1S/C14H11NO3S2/c15-20(16,17)18-13-4-1-10(2-5-13)11-3-6-14-12(9-11)7-8-19-14/h1-9H,(H2,15,16,17)
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n/an/a 1.60E+3n/an/an/an/an/an/a



University of Sharjah

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-HA--tagged carbonic anhydrase 12 expressed in HEK293T cells using p-nitrophenyl acetate as substrate measured after...


Bioorg Med Chem 27: 3889-3901 (2019)


Article DOI: 10.1016/j.bmc.2019.07.026
BindingDB Entry DOI: 10.7270/Q2GX4G0K
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM50524782
PNG
(CHEMBL4561046)
Show SMILES CCS(=O)(=O)Oc1ccc(cc1)-c1ccc2occc2c1
Show InChI InChI=1S/C16H14O4S/c1-2-21(17,18)20-15-6-3-12(4-7-15)13-5-8-16-14(11-13)9-10-19-16/h3-11H,2H2,1H3
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n/an/a 1.60E+3n/an/an/an/an/an/a



University of Sharjah

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-HA-tagged carbonic anhydrase 2 expressed in HEK293T cells using p-nitrophenyl acetate as substrate measured after 3...


Bioorg Med Chem 27: 3889-3901 (2019)


Article DOI: 10.1016/j.bmc.2019.07.026
BindingDB Entry DOI: 10.7270/Q2GX4G0K
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM50524766
PNG
(CHEMBL4448898)
Show SMILES CCCS(=O)(=O)Oc1ccc(cc1)-c1ccc2occc2c1
Show InChI InChI=1S/C17H16O4S/c1-2-11-22(18,19)21-16-6-3-13(4-7-16)14-5-8-17-15(12-14)9-10-20-17/h3-10,12H,2,11H2,1H3
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n/an/a 1.62E+3n/an/an/an/an/an/a



University of Sharjah

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-HA-tagged carbonic anhydrase 2 expressed in HEK293T cells using p-nitrophenyl acetate as substrate measured after 3...


Bioorg Med Chem 27: 3889-3901 (2019)


Article DOI: 10.1016/j.bmc.2019.07.026
BindingDB Entry DOI: 10.7270/Q2GX4G0K
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM50524781
PNG
(CHEMBL4528023)
Show SMILES Fc1ccc(cc1)S(=O)(=O)Oc1ccc(cc1)-c1ccc2sccc2c1
Show InChI InChI=1S/C20H13FO3S2/c21-17-4-8-19(9-5-17)26(22,23)24-18-6-1-14(2-7-18)15-3-10-20-16(13-15)11-12-25-20/h1-13H
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n/an/a 2.10E+3n/an/an/an/an/an/a



University of Sharjah

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-HA-tagged carbonic anhydrase 2 expressed in HEK293T cells using p-nitrophenyl acetate as substrate measured after 3...


Bioorg Med Chem 27: 3889-3901 (2019)


Article DOI: 10.1016/j.bmc.2019.07.026
BindingDB Entry DOI: 10.7270/Q2GX4G0K
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM50524769
PNG
(CHEMBL4592008)
Show SMILES CS(=O)(=O)Oc1ccc(cc1)-c1ccc2occc2c1
Show InChI InChI=1S/C15H12O4S/c1-20(16,17)19-14-5-2-11(3-6-14)12-4-7-15-13(10-12)8-9-18-15/h2-10H,1H3
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n/an/a 2.13E+3n/an/an/an/an/an/a



University of Sharjah

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-HA-tagged carbonic anhydrase 2 expressed in HEK293T cells using p-nitrophenyl acetate as substrate measured after 3...


Bioorg Med Chem 27: 3889-3901 (2019)


Article DOI: 10.1016/j.bmc.2019.07.026
BindingDB Entry DOI: 10.7270/Q2GX4G0K
More data for this
Ligand-Target Pair
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM50524772
PNG
(CHEMBL4557523)
Show SMILES CNS(=O)(=O)Oc1ccc(cc1)-c1ccc2occc2c1
Show InChI InChI=1S/C15H13NO4S/c1-16-21(17,18)20-14-5-2-11(3-6-14)12-4-7-15-13(10-12)8-9-19-15/h2-10,16H,1H3
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n/an/a 2.23E+3n/an/an/an/an/an/a



University of Sharjah

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-HA--tagged carbonic anhydrase 12 expressed in HEK293T cells using p-nitrophenyl acetate as substrate measured after...


Bioorg Med Chem 27: 3889-3901 (2019)


Article DOI: 10.1016/j.bmc.2019.07.026
BindingDB Entry DOI: 10.7270/Q2GX4G0K
More data for this
Ligand-Target Pair
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM50524776
PNG
(CHEMBL4463041)
Show SMILES CN(C)S(=O)(=O)Oc1ccc(cc1)-c1ccc2sccc2c1
Show InChI InChI=1S/C16H15NO3S2/c1-17(2)22(18,19)20-15-6-3-12(4-7-15)13-5-8-16-14(11-13)9-10-21-16/h3-11H,1-2H3
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n/an/a 2.33E+3n/an/an/an/an/an/a



University of Sharjah

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-HA--tagged carbonic anhydrase 12 expressed in HEK293T cells using p-nitrophenyl acetate as substrate measured after...


Bioorg Med Chem 27: 3889-3901 (2019)


Article DOI: 10.1016/j.bmc.2019.07.026
BindingDB Entry DOI: 10.7270/Q2GX4G0K
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM50524783
PNG
(CHEMBL4441746)
Show SMILES NS(=O)(=O)Oc1ccc(cc1)-c1ccc2occc2c1
Show InChI InChI=1S/C14H11NO4S/c15-20(16,17)19-13-4-1-10(2-5-13)11-3-6-14-12(9-11)7-8-18-14/h1-9H,(H2,15,16,17)
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n/an/a 2.60E+3n/an/an/an/an/an/a



University of Sharjah

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-HA-tagged carbonic anhydrase 2 expressed in HEK293T cells using p-nitrophenyl acetate as substrate measured after 3...


Bioorg Med Chem 27: 3889-3901 (2019)


Article DOI: 10.1016/j.bmc.2019.07.026
BindingDB Entry DOI: 10.7270/Q2GX4G0K
More data for this
Ligand-Target Pair
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM50524781
PNG
(CHEMBL4528023)
Show SMILES Fc1ccc(cc1)S(=O)(=O)Oc1ccc(cc1)-c1ccc2sccc2c1
Show InChI InChI=1S/C20H13FO3S2/c21-17-4-8-19(9-5-17)26(22,23)24-18-6-1-14(2-7-18)15-3-10-20-16(13-15)11-12-25-20/h1-13H
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n/an/a 2.87E+3n/an/an/an/an/an/a



University of Sharjah

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-HA--tagged carbonic anhydrase 12 expressed in HEK293T cells using p-nitrophenyl acetate as substrate measured after...


Bioorg Med Chem 27: 3889-3901 (2019)


Article DOI: 10.1016/j.bmc.2019.07.026
BindingDB Entry DOI: 10.7270/Q2GX4G0K
More data for this
Ligand-Target Pair
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM50524774
PNG
(CHEMBL4467499)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Oc1ccc(cc1)-c1ccc2sccc2c1
Show InChI InChI=1S/C21H16O3S2/c1-15-2-9-20(10-3-15)26(22,23)24-19-7-4-16(5-8-19)17-6-11-21-18(14-17)12-13-25-21/h2-14H,1H3
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n/an/a 2.89E+3n/an/an/an/an/an/a



University of Sharjah

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-HA--tagged carbonic anhydrase 12 expressed in HEK293T cells using p-nitrophenyl acetate as substrate measured after...


Bioorg Med Chem 27: 3889-3901 (2019)


Article DOI: 10.1016/j.bmc.2019.07.026
BindingDB Entry DOI: 10.7270/Q2GX4G0K
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM50524774
PNG
(CHEMBL4467499)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Oc1ccc(cc1)-c1ccc2sccc2c1
Show InChI InChI=1S/C21H16O3S2/c1-15-2-9-20(10-3-15)26(22,23)24-19-7-4-16(5-8-19)17-6-11-21-18(14-17)12-13-25-21/h2-14H,1H3
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n/an/a 3.30E+3n/an/an/an/an/an/a



University of Sharjah

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-HA-tagged carbonic anhydrase 2 expressed in HEK293T cells using p-nitrophenyl acetate as substrate measured after 3...


Bioorg Med Chem 27: 3889-3901 (2019)


Article DOI: 10.1016/j.bmc.2019.07.026
BindingDB Entry DOI: 10.7270/Q2GX4G0K
More data for this
Ligand-Target Pair
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM50524766
PNG
(CHEMBL4448898)
Show SMILES CCCS(=O)(=O)Oc1ccc(cc1)-c1ccc2occc2c1
Show InChI InChI=1S/C17H16O4S/c1-2-11-22(18,19)21-16-6-3-13(4-7-16)14-5-8-17-15(12-14)9-10-20-17/h3-10,12H,2,11H2,1H3
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n/an/a 3.70E+3n/an/an/an/an/an/a



University of Sharjah

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-HA--tagged carbonic anhydrase 12 expressed in HEK293T cells using p-nitrophenyl acetate as substrate measured after...


Bioorg Med Chem 27: 3889-3901 (2019)


Article DOI: 10.1016/j.bmc.2019.07.026
BindingDB Entry DOI: 10.7270/Q2GX4G0K
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM50524776
PNG
(CHEMBL4463041)
Show SMILES CN(C)S(=O)(=O)Oc1ccc(cc1)-c1ccc2sccc2c1
Show InChI InChI=1S/C16H15NO3S2/c1-17(2)22(18,19)20-15-6-3-12(4-7-15)13-5-8-16-14(11-13)9-10-21-16/h3-11H,1-2H3
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n/an/a 5.82E+3n/an/an/an/an/an/a



University of Sharjah

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-HA-tagged carbonic anhydrase 2 expressed in HEK293T cells using p-nitrophenyl acetate as substrate measured after 3...


Bioorg Med Chem 27: 3889-3901 (2019)


Article DOI: 10.1016/j.bmc.2019.07.026
BindingDB Entry DOI: 10.7270/Q2GX4G0K
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%