Affinity Data by PubMed id=32124607

PubMed code 32124607

Found 5 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Transthyretin (Homo sapiens (Human))	BDBM50527390 (CHEMBL1232738) Show SMILES OC(=O)c1cc(cc(I)c1O)-c1ccc(F)cc1F Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a
Institut de Qu??mica Avan£ada de Catalunya (I.Q.A.C.-C.S.I.C.) Curated by ChEMBL					Assay Description Stabilization of wild type human transthyretin expressed in Escherichia coli BL21(DE3) Star assessed as dissociation constant for TTR-amyloid beta (1...				J Med Chem 63: 3205-3214 (2020) Article DOI: 10.1021/acs.jmedchem.9b01970 BindingDB Entry DOI: 10.7270/Q2RJ4NW0
					More data for this Ligand-Target Pair				3D Structure (crystal)
Transthyretin (Homo sapiens (Human))	BDBM50197883 (CHEBI:78538 \| FX-1006 \| Tafamidis \| US10377729, Co...) Show SMILES OC(=O)c1ccc2nc(oc2c1)-c1cc(Cl)cc(Cl)c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a
Institut de Qu??mica Avan£ada de Catalunya (I.Q.A.C.-C.S.I.C.) Curated by ChEMBL					Assay Description Stabilization of wild type human transthyretin expressed in Escherichia coli BL21(DE3) Star assessed as dissociation constant for TTR-amyloid beta (1...				J Med Chem 63: 3205-3214 (2020) Article DOI: 10.1021/acs.jmedchem.9b01970 BindingDB Entry DOI: 10.7270/Q2RJ4NW0
					More data for this Ligand-Target Pair				3D Structure (crystal)
Transthyretin (Homo sapiens (Human))	BDBM50527390 (CHEMBL1232738) Show SMILES OC(=O)c1cc(cc(I)c1O)-c1ccc(F)cc1F Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	810	n/a	n/a	n/a	n/a	n/a
Institut de Qu??mica Avan£ada de Catalunya (I.Q.A.C.-C.S.I.C.) Curated by ChEMBL					Assay Description Stabilization of wild type human transthyretin expressed in Escherichia coli BL21(DE3) Star assessed as dissociation constant for TTR-amyloid beta (1...				J Med Chem 63: 3205-3214 (2020) Article DOI: 10.1021/acs.jmedchem.9b01970 BindingDB Entry DOI: 10.7270/Q2RJ4NW0
					More data for this Ligand-Target Pair				3D Structure (crystal)
Transthyretin (Homo sapiens (Human))	BDBM50240510 (CHEMBL898 \| DIFLUNISAL) Show SMILES OC(=O)c1cc(ccc1O)-c1ccc(F)cc1F Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents	DrugBank PDB Article PubMed	n/a	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a
Institut de Qu??mica Avan£ada de Catalunya (I.Q.A.C.-C.S.I.C.) Curated by ChEMBL					Assay Description Stabilization of wild type human transthyretin expressed in Escherichia coli BL21(DE3) Star assessed as dissociation constant for TTR-amyloid beta (1...				J Med Chem 63: 3205-3214 (2020) Article DOI: 10.1021/acs.jmedchem.9b01970 BindingDB Entry DOI: 10.7270/Q2RJ4NW0
					More data for this Ligand-Target Pair				3D Structure (crystal)
Transthyretin (Homo sapiens (Human))	BDBM50197883 (CHEBI:78538 \| FX-1006 \| Tafamidis \| US10377729, Co...) Show SMILES OC(=O)c1ccc2nc(oc2c1)-c1cc(Cl)cc(Cl)c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	1.05E+3	n/a	n/a	n/a	n/a	n/a
Institut de Qu??mica Avan£ada de Catalunya (I.Q.A.C.-C.S.I.C.) Curated by ChEMBL					Assay Description Stabilization of wild type human transthyretin expressed in Escherichia coli BL21(DE3) Star assessed as dissociation constant for TTR-amyloid beta (1...				J Med Chem 63: 3205-3214 (2020) Article DOI: 10.1021/acs.jmedchem.9b01970 BindingDB Entry DOI: 10.7270/Q2RJ4NW0
					More data for this Ligand-Target Pair				3D Structure (crystal)

* indicates data uncertainty>20%