Affinity Data by PubMed id=32223194

PubMed code 32223194

Found 5 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Exportin-1 (Homo sapiens (Human))	BDBM50527779 (CHEMBL4440028) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	151	n/a	n/a	n/a	n/a	n/a	n/a
Dalian University of Technology Curated by ChEMBL					Assay Description Inhibition of CRM1 in human HCT-15 cells assessed as reduction in cell viability incubated for 24 hrs				J Med Chem 63: 3881-3895 (2020) Article DOI: 10.1021/acs.jmedchem.9b01663 BindingDB Entry DOI: 10.7270/Q26H4MW8
Dalian University of Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Exportin-1 (Homo sapiens (Human))	BDBM50527777 (CHEMBL4458289) Show SMILES [O-][S+](\C=C\CCN=C=S)c1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Dalian University of Technology Curated by ChEMBL					Assay Description Inhibition of nuclear CRM1 (unknown origin) by cell based assay				J Med Chem 63: 3881-3895 (2020) Article DOI: 10.1021/acs.jmedchem.9b01663 BindingDB Entry DOI: 10.7270/Q26H4MW8
Dalian University of Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50527779 (CHEMBL4440028) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Dalian University of Technology Curated by ChEMBL					Assay Description Inhibition of human ERG expressed in human HEK293 cells by whole cell patch clamp assay				J Med Chem 63: 3881-3895 (2020) Article DOI: 10.1021/acs.jmedchem.9b01663 BindingDB Entry DOI: 10.7270/Q26H4MW8
Dalian University of Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Exportin-1 (Homo sapiens (Human))	BDBM50527778 (KPT-330 \| Selinexor \| Xpovio) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a
Dalian University of Technology Curated by ChEMBL					Assay Description Binding affinity to recombinant His-tagged CRM1 (unknown origin) by SPR analysis				J Med Chem 63: 3881-3895 (2020) Article DOI: 10.1021/acs.jmedchem.9b01663 BindingDB Entry DOI: 10.7270/Q26H4MW8
Dalian University of Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Exportin-1 (Homo sapiens (Human))	BDBM50527779 (CHEMBL4440028) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a
Dalian University of Technology Curated by ChEMBL					Assay Description Binding affinity to recombinant His-tagged CRM1 (unknown origin) by SPR analysis				J Med Chem 63: 3881-3895 (2020) Article DOI: 10.1021/acs.jmedchem.9b01663 BindingDB Entry DOI: 10.7270/Q26H4MW8
Dalian University of Technology Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%