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PubMed code 32944146

Compile data set for download or QSAR
Found 68 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50547324
PNG
(CHEMBL4754102)
Show SMILES COc1cccc2c(N3CCN(CC3)c3ccccc3F)c(cnc12)C#N
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UniChem
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 430n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of [3H]nisoxetine from recombinant human Dopamine transporter after 120 mins by scintillation counting analysis

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50547309
PNG
(CHEMBL4753189)
Show SMILES CC(C)Oc1cc(F)cc2c(N3CCN(CC3)c3ccccc3F)c(cnc12)C#N
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>1.00E+4n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of [3H]nisoxetine from recombinant human Dopamine transporter after 120 mins by scintillation counting analysis

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50547312
PNG
(CHEMBL4744634)
Show SMILES Fc1ccccc1N1CCN(CC1)c1c(cnc2c(OC3CCOC3)cccc12)C#N
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>1.00E+4n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of [3H]nisoxetine from recombinant human Dopamine transporter after 120 mins by scintillation counting analysis

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50547322
PNG
(CHEMBL4745777)
Show SMILES Fc1ccccc1N1CCN(CC1)c1c(cnc2c(cccc12)N1CCOCC1)C#N
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>1.00E+4n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of [3H]nisoxetine from recombinant human Dopamine transporter after 120 mins by scintillation counting analysis

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50547305
PNG
(CHEMBL4761695)
Show SMILES [2H]C([2H])([2H])Oc1cc(F)cc2c(N3CCN(CC3)c3ccccc3F)c(cnc12)C#N
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>1.00E+4n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of [3H]nisoxetine from recombinant human Dopamine transporter after 120 mins by scintillation counting analysis

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50547328
PNG
(CHEMBL4752850)
Show SMILES COc1c(F)c(F)cc2c(N3CCN(CC3)c3ccccc3F)c(cnc12)C#N
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n/an/a 2.20E+3n/an/an/an/an/an/a


TBA

Assay Description
Displacement of [3H]nisoxetine from recombinant human Dopamine transporter after 120 mins by scintillation counting analysis

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50547326
PNG
(CHEMBL4779613)
Show SMILES COc1c(F)ccc2c(N3CCN(CC3)c3ccccc3F)c(cnc12)C#N
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n/an/a 3.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Displacement of [3H]nisoxetine from recombinant human Dopamine transporter after 120 mins by scintillation counting analysis

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50547305
PNG
(CHEMBL4761695)
Show SMILES [2H]C([2H])([2H])Oc1cc(F)cc2c(N3CCN(CC3)c3ccccc3F)c(cnc12)C#N
PDB

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n/an/a 3.50E+3n/an/an/an/an/an/a


TBA

Assay Description
Displacement of [3H]-Pentazocine from human recombinant sigma 1 receptor incubated for 120 mins by scintillation counting analysis relative to contro...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50547325
PNG
(CHEMBL4752581)
Show SMILES COc1ccc(F)c2c(N3CCN(CC3)c3ccccc3F)c(cnc12)C#N
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n/an/a 4.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Displacement of [3H]nisoxetine from recombinant human Dopamine transporter after 120 mins by scintillation counting analysis

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50547327
PNG
(CHEMBL4781814)
Show SMILES COc1cc(F)cc2c(N3CCN(CC3)c3ccccc3F)c(cnc12)C#N
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n/an/a>1.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Displacement of [3H]nisoxetine from recombinant human Dopamine transporter after 120 mins by scintillation counting analysis

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens (Human))		BDBM50547329
PNG
(CHEMBL1527295)
Show SMILES CCOC(=O)c1cnc2c(OC)cccc2c1N1CCN(CC1)c1ccccc1F
PDB

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n/an/a>3.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Negative allosteric modulation of mGlu8 receptor (unknown origin)

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50547329
PNG
(CHEMBL1527295)
Show SMILES CCOC(=O)c1cnc2c(OC)cccc2c1N1CCN(CC1)c1ccccc1F
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n/an/a>3.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Negative allosteric modulation of mGlu4 receptor (unknown origin)

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM50547329
PNG
(CHEMBL1527295)
Show SMILES CCOC(=O)c1cnc2c(OC)cccc2c1N1CCN(CC1)c1ccccc1F
PDB

UniProtKB/SwissProt

antibodypedia
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UniChem
Article
PubMed
n/an/a>3.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Negative allosteric modulation of mGlu2 receptor (unknown origin)

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50547329
PNG
(CHEMBL1527295)
Show SMILES CCOC(=O)c1cnc2c(OC)cccc2c1N1CCN(CC1)c1ccccc1F
PDB
MMDB

KEGG

UniProtKB/SwissProt

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PC sid
UniChem
Article
PubMed
n/an/a>3.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Negative allosteric modulation of mGlu5 receptor (unknown origin)

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))		BDBM50547329
PNG
(CHEMBL1527295)
Show SMILES CCOC(=O)c1cnc2c(OC)cccc2c1N1CCN(CC1)c1ccccc1F
PDB

UniProtKB/SwissProt

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n/an/a>3.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Negative allosteric modulation of mGlu3 receptor (unknown origin)

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))		BDBM50547329
PNG
(CHEMBL1527295)
Show SMILES CCOC(=O)c1cnc2c(OC)cccc2c1N1CCN(CC1)c1ccccc1F
PDB

UniProtKB/SwissProt

antibodypedia
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UniChem
Article
PubMed
n/an/a>3.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Negative allosteric modulation of mGlu1 receptor (unknown origin)

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547312
PNG
(CHEMBL4744634)
Show SMILES Fc1ccccc1N1CCN(CC1)c1c(cnc2c(OC3CCOC3)cccc12)C#N
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n/an/an/an/a 1.02E+3n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 expressed in HEK293 cells co- expressing GIRK assessed as potentiation of L-AP4-induced thallium flux inc...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547324
PNG
(CHEMBL4754102)
Show SMILES COc1cccc2c(N3CCN(CC3)c3ccccc3F)c(cnc12)C#N
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UniProtKB/SwissProt

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n/an/an/an/a 871n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 expressed in HEK293 cells co- expressing GIRK assessed as potentiation of L-AP4-induced thallium flux inc...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens (Human))		BDBM50547305
PNG
(CHEMBL4761695)
Show SMILES [2H]C([2H])([2H])Oc1cc(F)cc2c(N3CCN(CC3)c3ccccc3F)c(cnc12)C#N
PDB

UniProtKB/SwissProt

antibodypedia
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PC sid
UniChem
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n/an/an/an/a>1.00E+4n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of mGlu8 receptor (unknown origin)

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547305
PNG
(CHEMBL4761695)
Show SMILES [2H]C([2H])([2H])Oc1cc(F)cc2c(N3CCN(CC3)c3ccccc3F)c(cnc12)C#N
PDB

UniProtKB/SwissProt

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n/an/an/an/a 1.10E+3n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547306
PNG
(CHEMBL4756772)
Show SMILES FC(F)Oc1cccc2c(N3CCN(CC3)c3ccccc3F)c(cnc12)C#N
PDB

UniProtKB/SwissProt

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n/an/an/an/a>1.00E+4n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547311
PNG
(CHEMBL4762020)
Show SMILES Fc1cc(OC2CCC2)c2ncc(C#N)c(N3CCN(CC3)c3ccccc3F)c2c1
PDB

UniProtKB/SwissProt

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n/an/an/an/a>1.00E+4n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547320
PNG
(CHEMBL4800018)
Show SMILES Fc1ccccc1N1CCN(CC1)c1c(cnc2c(cccc12)N1CCCCC1)C#N
PDB

UniProtKB/SwissProt

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n/an/an/an/a>1.00E+4n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547323
PNG
(CHEMBL4756462)
Show SMILES CC1CN(CCO1)c1cccc2c(N3CCN(CC3)c3ccccc3F)c(cnc12)C#N
PDB

UniProtKB/SwissProt

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n/an/an/an/a 7.10E+3n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547305
PNG
(CHEMBL4761695)
Show SMILES [2H]C([2H])([2H])Oc1cc(F)cc2c(N3CCN(CC3)c3ccccc3F)c(cnc12)C#N
PDB

UniProtKB/SwissProt

GoogleScholar
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PC sid
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n/an/an/an/a 1.00E+3n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 expressed in HEK293 cells co- expressing GIRK assessed as potentiation of L-AP4-induced thallium flux inc...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547312
PNG
(CHEMBL4744634)
Show SMILES Fc1ccccc1N1CCN(CC1)c1c(cnc2c(OC3CCOC3)cccc12)C#N
PDB

UniProtKB/SwissProt

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n/an/an/an/a 1.00E+3n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 expressed in HEK293 cells co- expressing GIRK assessed as potentiation of L-AP4-induced thallium flux inc...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM50547305
PNG
(CHEMBL4761695)
Show SMILES [2H]C([2H])([2H])Oc1cc(F)cc2c(N3CCN(CC3)c3ccccc3F)c(cnc12)C#N
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a>3.00E+4n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of mGlu2 receptor (unknown origin)

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50547305
PNG
(CHEMBL4761695)
Show SMILES [2H]C([2H])([2H])Oc1cc(F)cc2c(N3CCN(CC3)c3ccccc3F)c(cnc12)C#N
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
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PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a>3.00E+4n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of mGlu5 receptor (unknown origin)

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547304
PNG
(CHEMBL4776732)
Show SMILES [2H]C([2H])([2H])Oc1cccc2c(N3CCN(CC3)c3ccccc3F)c(cnc12)C#N
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 1.50E+3n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547308
PNG
(CHEMBL4759638)
Show SMILES CC(C)Oc1cccc2c(N3CCN(CC3)c3ccccc3F)c(cnc12)C#N
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 1.25E+3n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547312
PNG
(CHEMBL4744634)
Show SMILES Fc1ccccc1N1CCN(CC1)c1c(cnc2c(OC3CCOC3)cccc12)C#N
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 1.30E+3n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547312
PNG
(CHEMBL4744634)
Show SMILES Fc1ccccc1N1CCN(CC1)c1c(cnc2c(OC3CCOC3)cccc12)C#N
PDB

UniProtKB/SwissProt

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n/an/an/an/a 1.54E+3n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547314
PNG
(CHEMBL4745281)
Show SMILES Fc1ccccc1N1CCN(CC1)c1c(cnc2c(OCC3CCOC3)cccc12)C#N
PDB

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n/an/an/an/a 1.30E+3n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547315
PNG
(CHEMBL4751175)
Show SMILES Fc1cc(OCC2CCOC2)c2ncc(C#N)c(N3CCN(CC3)c3ccccc3F)c2c1
PDB

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n/an/an/an/a 650n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547316
PNG
(CHEMBL4776901)
Show SMILES Fc1ccccc1N1CCN(CC1)c1c(cnc2c(cccc12)-n1cccn1)C#N
PDB

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n/an/an/an/a>1.00E+4n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547318
PNG
(CHEMBL4760187)
Show SMILES Fc1ccccc1N1CCN(CC1)c1c(cnc2c(cccc12)-n1cncn1)C#N
PDB

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n/an/an/an/a>1.00E+4n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547322
PNG
(CHEMBL4745777)
Show SMILES Fc1ccccc1N1CCN(CC1)c1c(cnc2c(cccc12)N1CCOCC1)C#N
PDB

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n/an/an/an/a 1.29E+3n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547328
PNG
(CHEMBL4752850)
Show SMILES COc1c(F)c(F)cc2c(N3CCN(CC3)c3ccccc3F)c(cnc12)C#N
PDB

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n/an/an/an/a 1.10E+3n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547314
PNG
(CHEMBL4745281)
Show SMILES Fc1ccccc1N1CCN(CC1)c1c(cnc2c(OCC3CCOC3)cccc12)C#N
PDB

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n/an/an/an/a 1.30E+3n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547321
PNG
(CHEMBL4776529)
Show SMILES Fc1ccccc1N1CCN(CC1)c1c(cnc2c(cccc12)N1CCC(F)(F)CC1)C#N
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n/an/an/an/a>1.00E+4n/an/an/an/a


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Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547309
PNG
(CHEMBL4753189)
Show SMILES CC(C)Oc1cc(F)cc2c(N3CCN(CC3)c3ccccc3F)c(cnc12)C#N
PDB

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n/an/an/an/a 759n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 expressed in HEK293 cells co- expressing GIRK assessed as potentiation of L-AP4-induced thallium flux inc...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547324
PNG
(CHEMBL4754102)
Show SMILES COc1cccc2c(N3CCN(CC3)c3ccccc3F)c(cnc12)C#N
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n/an/an/an/a 879n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 expressed in HEK293 cells co- expressing GIRK assessed as potentiation of L-AP4-induced thallium flux inc...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547305
PNG
(CHEMBL4761695)
Show SMILES [2H]C([2H])([2H])Oc1cc(F)cc2c(N3CCN(CC3)c3ccccc3F)c(cnc12)C#N
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n/an/an/an/a 1.10E+3n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547327
PNG
(CHEMBL4781814)
Show SMILES COc1cc(F)cc2c(N3CCN(CC3)c3ccccc3F)c(cnc12)C#N
PDB

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n/an/an/an/a 1.40E+3n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547305
PNG
(CHEMBL4761695)
Show SMILES [2H]C([2H])([2H])Oc1cc(F)cc2c(N3CCN(CC3)c3ccccc3F)c(cnc12)C#N
PDB

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n/an/an/an/a 990n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 expressed in HEK293 cells co- expressing GIRK assessed as potentiation of L-AP4-induced thallium flux inc...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547309
PNG
(CHEMBL4753189)
Show SMILES CC(C)Oc1cc(F)cc2c(N3CCN(CC3)c3ccccc3F)c(cnc12)C#N
PDB

UniProtKB/SwissProt

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n/an/an/an/a 750n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 expressed in HEK293 cells co- expressing GIRK assessed as potentiation of L-AP4-induced thallium flux inc...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547322
PNG
(CHEMBL4745777)
Show SMILES Fc1ccccc1N1CCN(CC1)c1c(cnc2c(cccc12)N1CCOCC1)C#N
PDB

UniProtKB/SwissProt

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n/an/an/an/a 708n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 expressed in HEK293 cells co- expressing GIRK assessed as potentiation of L-AP4-induced thallium flux inc...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))		BDBM50547305
PNG
(CHEMBL4761695)
Show SMILES [2H]C([2H])([2H])Oc1cc(F)cc2c(N3CCN(CC3)c3ccccc3F)c(cnc12)C#N
PDB

UniProtKB/SwissProt

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n/an/an/an/a>3.00E+4n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of mGlu1 receptor (unknown origin)

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))		BDBM50547305
PNG
(CHEMBL4761695)
Show SMILES [2H]C([2H])([2H])Oc1cc(F)cc2c(N3CCN(CC3)c3ccccc3F)c(cnc12)C#N
PDB

UniProtKB/SwissProt

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n/an/an/an/a>3.00E+4n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of mGlu3 receptor (unknown origin)

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547312
PNG
(CHEMBL4744634)
Show SMILES Fc1ccccc1N1CCN(CC1)c1c(cnc2c(OC3CCOC3)cccc12)C#N
PDB

UniProtKB/SwissProt

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n/an/an/an/a 1.30E+3n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547322
PNG
(CHEMBL4745777)
Show SMILES Fc1ccccc1N1CCN(CC1)c1c(cnc2c(cccc12)N1CCOCC1)C#N
PDB

UniProtKB/SwissProt

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n/an/an/an/a 1.30E+3n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547324
PNG
(CHEMBL4754102)
Show SMILES COc1cccc2c(N3CCN(CC3)c3ccccc3F)c(cnc12)C#N
PDB

UniProtKB/SwissProt

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n/an/an/an/a 1.10E+3n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547307
PNG
(CHEMBL4782643)
Show SMILES FC(F)Oc1cc(F)cc2c(N3CCN(CC3)c3ccccc3F)c(cnc12)C#N
PDB

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n/an/an/an/a 3.80E+3n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547309
PNG
(CHEMBL4753189)
Show SMILES CC(C)Oc1cc(F)cc2c(N3CCN(CC3)c3ccccc3F)c(cnc12)C#N
PDB

UniProtKB/SwissProt

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n/an/an/an/a 690n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547309
PNG
(CHEMBL4753189)
Show SMILES CC(C)Oc1cc(F)cc2c(N3CCN(CC3)c3ccccc3F)c(cnc12)C#N
PDB

UniProtKB/SwissProt

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n/an/an/an/a 690n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547312
PNG
(CHEMBL4744634)
Show SMILES Fc1ccccc1N1CCN(CC1)c1c(cnc2c(OC3CCOC3)cccc12)C#N
PDB

UniProtKB/SwissProt

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n/an/an/an/a 1.54E+3n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547313
PNG
(CHEMBL4751110)
Show SMILES Fc1cc(OC2CCOC2)c2ncc(C#N)c(N3CCN(CC3)c3ccccc3F)c2c1
PDB

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n/an/an/an/a 510n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547314
PNG
(CHEMBL4745281)
Show SMILES Fc1ccccc1N1CCN(CC1)c1c(cnc2c(OCC3CCOC3)cccc12)C#N
PDB

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n/an/an/an/a 1.30E+3n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547325
PNG
(CHEMBL4752581)
Show SMILES COc1ccc(F)c2c(N3CCN(CC3)c3ccccc3F)c(cnc12)C#N
PDB

UniProtKB/SwissProt

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n/an/an/an/a>1.00E+4n/an/an/an/a


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Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547303
PNG
(CHEMBL4760168)
Show SMILES Oc1cc(F)cc2c(N3CCN(CC3)c3ccccc3F)c(cnc12)C#N
PDB

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n/an/an/an/a>1.00E+4n/an/an/an/a


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Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50547305
PNG
(CHEMBL4761695)
Show SMILES [2H]C([2H])([2H])Oc1cc(F)cc2c(N3CCN(CC3)c3ccccc3F)c(cnc12)C#N
PDB

UniProtKB/SwissProt

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n/an/an/an/a>3.00E+4n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of mGlu4 receptor (unknown origin)

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547322
PNG
(CHEMBL4745777)
Show SMILES Fc1ccccc1N1CCN(CC1)c1c(cnc2c(cccc12)N1CCOCC1)C#N
PDB

UniProtKB/SwissProt

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n/an/an/an/a 710n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 expressed in HEK293 cells co- expressing GIRK assessed as potentiation of L-AP4-induced thallium flux inc...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547324
PNG
(CHEMBL4754102)
Show SMILES COc1cccc2c(N3CCN(CC3)c3ccccc3F)c(cnc12)C#N
PDB

UniProtKB/SwissProt

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n/an/an/an/a 1.05E+3n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547319
PNG
(CHEMBL4785377)
Show SMILES Fc1ccccc1N1CCN(CC1)c1c(cnc2c(cccc12)N1CCCC1)C#N
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547317
PNG
(CHEMBL4759480)
Show SMILES Fc1ccccc1N1CCN(CC1)c1c(cnc2c(cccc12)-n1ccnc1)C#N
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 6.70E+3n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547326
PNG
(CHEMBL4779613)
Show SMILES COc1c(F)ccc2c(N3CCN(CC3)c3ccccc3F)c(cnc12)C#N
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 1.80E+3n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547302
PNG
(CHEMBL4778165)
Show SMILES Oc1cccc2c(N3CCN(CC3)c3ccccc3F)c(cnc12)C#N
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50547310
PNG
(CHEMBL4749059)
Show SMILES Fc1ccccc1N1CCN(CC1)c1c(cnc2c(OC3CCC3)cccc12)C#N
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 1.80E+3n/an/an/an/a


TBA

Assay Description
Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00432
BindingDB Entry DOI: 10.7270/Q2ZG6WTX
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%