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PubMed code 3735309

Compile data set for download or QSAR
Found 50 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50025079
PNG
(CHEMBL30344 | [4-(2-Amino-propyl)-3-methyl-phenyl]...)
Show SMILES CC(N)Cc1ccc(cc1C)N(C)C
Show InChI InChI=1S/C12H20N2/c1-9-7-12(14(3)4)6-5-11(9)8-10(2)13/h5-7,10H,8,13H2,1-4H3
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TBA

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibition of Serotonin transporter uptake at serotonin uptake site

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A/B


(Rattus norvegicus (rat))		BDBM50025082
PNG
(2-(4-Chloro-2,3-dihydro-1H-indol-5-yl)-1-methyl-et...)
Show SMILES CC(N)Cc1ccc2NCCc2c1Cl
Show InChI InChI=1S/C11H15ClN2/c1-7(13)6-8-2-3-10-9(11(8)12)4-5-14-10/h2-3,7,14H,4-6,13H2,1H3
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TBA

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibition of MAO by using [14C]5-HT as substrate in rat brain mitochondrial preparation

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50025080
PNG
(1-(4-Chloro-2,3-dihydro-1H-indol-5-ylmethyl)-propy...)
Show SMILES CCC(N)Cc1ccc2NCCc2c1Cl
Show InChI InChI=1S/C12H17ClN2/c1-2-9(14)7-8-3-4-11-10(12(8)13)5-6-15-11/h3-4,9,15H,2,5-7,14H2,1H3
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TBA

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibition of Serotonin transporter uptake at serotonin uptake site

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Transporter


(Rattus norvegicus)		BDBM50025082
PNG
(2-(4-Chloro-2,3-dihydro-1H-indol-5-yl)-1-methyl-et...)
Show SMILES CC(N)Cc1ccc2NCCc2c1Cl
Show InChI InChI=1S/C11H15ClN2/c1-7(13)6-8-2-3-10-9(11(8)12)4-5-14-10/h2-3,7,14H,4-6,13H2,1H3
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TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of NE uptake at NE uptake site

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A/B


(Rattus norvegicus (rat))		BDBM50025084
PNG
(2-(1-Ethyl-6-methyl-2,3-dihydro-1H-indol-5-yl)-1-m...)
Show SMILES CCN1CCc2cc(CC(C)N)c(C)cc12
Show InChI InChI=1S/C14H22N2/c1-4-16-6-5-12-9-13(8-11(3)15)10(2)7-14(12)16/h7,9,11H,4-6,8,15H2,1-3H3
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TBA

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibition of MAO by using [14C]5-HT as substrate in rat brain mitochondrial preparation

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50025082
PNG
(2-(4-Chloro-2,3-dihydro-1H-indol-5-yl)-1-methyl-et...)
Show SMILES CC(N)Cc1ccc2NCCc2c1Cl
Show InChI InChI=1S/C11H15ClN2/c1-7(13)6-8-2-3-10-9(11(8)12)4-5-14-10/h2-3,7,14H,4-6,13H2,1H3
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TBA

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibition of Serotonin transporter uptake at serotonin uptake site

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Transporter


(Rattus norvegicus)		BDBM50025081
PNG
(2-(2,3-Dihydro-1H-indol-5-yl)-1-methyl-ethylamine ...)
Show SMILES CC(N)Cc1ccc2NCCc2c1
Show InChI InChI=1S/C11H16N2/c1-8(12)6-9-2-3-11-10(7-9)4-5-13-11/h2-3,7-8,13H,4-6,12H2,1H3
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TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of NE uptake at NE uptake site

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50025086
PNG
(1-Methyl-2-(4-methyl-2,3-dihydro-1H-indol-5-yl)-et...)
Show SMILES CC(N)Cc1ccc2NCCc2c1C
Show InChI InChI=1S/C12H18N2/c1-8(13)7-10-3-4-12-11(9(10)2)5-6-14-12/h3-4,8,14H,5-7,13H2,1-2H3
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TBA

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibition of Serotonin transporter uptake at serotonin uptake site

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Transporter


(Rattus norvegicus)		BDBM50025077
PNG
(1-(2,3-Dihydro-1H-indol-5-ylmethyl)-propylamine | ...)
Show SMILES CCC(N)Cc1ccc2NCCc2c1
Show InChI InChI=1S/C12H18N2/c1-2-11(13)8-9-3-4-12-10(7-9)5-6-14-12/h3-4,7,11,14H,2,5-6,8,13H2,1H3
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TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of NE uptake at NE uptake site

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A/B


(Rattus norvegicus (rat))		BDBM50025080
PNG
(1-(4-Chloro-2,3-dihydro-1H-indol-5-ylmethyl)-propy...)
Show SMILES CCC(N)Cc1ccc2NCCc2c1Cl
Show InChI InChI=1S/C12H17ClN2/c1-2-9(14)7-8-3-4-11-10(12(8)13)5-6-15-11/h3-4,9,15H,2,5-7,14H2,1H3
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TBA

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibition of MAO by using [14C]5-HT as substrate in rat brain mitochondrial preparation

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Transporter


(Rattus norvegicus)		BDBM50025079
PNG
(CHEMBL30344 | [4-(2-Amino-propyl)-3-methyl-phenyl]...)
Show SMILES CC(N)Cc1ccc(cc1C)N(C)C
Show InChI InChI=1S/C12H20N2/c1-9-7-12(14(3)4)6-5-11(9)8-10(2)13/h5-7,10H,8,13H2,1-4H3
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TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of NE uptake at NE uptake site

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Transporter


(Rattus norvegicus)		BDBM50025086
PNG
(1-Methyl-2-(4-methyl-2,3-dihydro-1H-indol-5-yl)-et...)
Show SMILES CC(N)Cc1ccc2NCCc2c1C
Show InChI InChI=1S/C12H18N2/c1-8(13)7-10-3-4-12-11(9(10)2)5-6-14-12/h3-4,8,14H,5-7,13H2,1-2H3
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TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of NE uptake at NE uptake site

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A/B


(Rattus norvegicus (rat))		BDBM50025086
PNG
(1-Methyl-2-(4-methyl-2,3-dihydro-1H-indol-5-yl)-et...)
Show SMILES CC(N)Cc1ccc2NCCc2c1C
Show InChI InChI=1S/C12H18N2/c1-8(13)7-10-3-4-12-11(9(10)2)5-6-14-12/h3-4,8,14H,5-7,13H2,1-2H3
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TBA

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibition of MAO by using [14C]5-HT as substrate in rat brain mitochondrial preparation

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A/B


(Rattus norvegicus (rat))		BDBM50025079
PNG
(CHEMBL30344 | [4-(2-Amino-propyl)-3-methyl-phenyl]...)
Show SMILES CC(N)Cc1ccc(cc1C)N(C)C
Show InChI InChI=1S/C12H20N2/c1-9-7-12(14(3)4)6-5-11(9)8-10(2)13/h5-7,10H,8,13H2,1-4H3
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TBA

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibition of MAO by using [14C]5-HT as substrate in rat brain mitochondrial preparation

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A/B


(Rattus norvegicus (rat))		BDBM50025085
PNG
(2-(1-Ethyl-4-methyl-2,3-dihydro-1H-indol-5-yl)-1-m...)
Show SMILES CCN1CCc2c1ccc(CC(C)N)c2C
Show InChI InChI=1S/C14H22N2/c1-4-16-8-7-13-11(3)12(9-10(2)15)5-6-14(13)16/h5-6,10H,4,7-9,15H2,1-3H3
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n/an/a 1.10E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibition of MAO by using [14C]5-HT as substrate in rat brain mitochondrial preparation

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A/B


(Rattus norvegicus (rat))		BDBM50025080
PNG
(1-(4-Chloro-2,3-dihydro-1H-indol-5-ylmethyl)-propy...)
Show SMILES CCC(N)Cc1ccc2NCCc2c1Cl
Show InChI InChI=1S/C12H17ClN2/c1-2-9(14)7-8-3-4-11-10(12(8)13)5-6-15-11/h3-4,9,15H,2,5-7,14H2,1H3
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n/an/a 1.45E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibition of MAO by using [14C]phenylethylamine as substrate in rat brain mitochondrial preparation

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50025085
PNG
(2-(1-Ethyl-4-methyl-2,3-dihydro-1H-indol-5-yl)-1-m...)
Show SMILES CCN1CCc2c1ccc(CC(C)N)c2C
Show InChI InChI=1S/C14H22N2/c1-4-16-8-7-13-11(3)12(9-10(2)15)5-6-14(13)16/h5-6,10H,4,7-9,15H2,1-3H3
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n/an/a 1.50E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibition of Serotonin transporter uptake at serotonin uptake site

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Transporter


(Rattus norvegicus)		BDBM50025080
PNG
(1-(4-Chloro-2,3-dihydro-1H-indol-5-ylmethyl)-propy...)
Show SMILES CCC(N)Cc1ccc2NCCc2c1Cl
Show InChI InChI=1S/C12H17ClN2/c1-2-9(14)7-8-3-4-11-10(12(8)13)5-6-15-11/h3-4,9,15H,2,5-7,14H2,1H3
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n/an/a 1.60E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of NE uptake at NE uptake site

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50025081
PNG
(2-(2,3-Dihydro-1H-indol-5-yl)-1-methyl-ethylamine ...)
Show SMILES CC(N)Cc1ccc2NCCc2c1
Show InChI InChI=1S/C11H16N2/c1-8(12)6-9-2-3-11-10(7-9)4-5-13-11/h2-3,7-8,13H,4-6,12H2,1H3
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n/an/a 1.80E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibition of Serotonin transporter uptake at serotonin uptake site

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50025083
PNG
(2-(2,3-Dihydro-1H-indol-5-yl)-1,1-dimethyl-ethylam...)
Show SMILES CC(C)(N)Cc1ccc2NCCc2c1
Show InChI InChI=1S/C12H18N2/c1-12(2,13)8-9-3-4-11-10(7-9)5-6-14-11/h3-4,7,14H,5-6,8,13H2,1-2H3
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n/an/a 1.90E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibition of Serotonin transporter uptake at serotonin uptake site

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50025084
PNG
(2-(1-Ethyl-6-methyl-2,3-dihydro-1H-indol-5-yl)-1-m...)
Show SMILES CCN1CCc2cc(CC(C)N)c(C)cc12
Show InChI InChI=1S/C14H22N2/c1-4-16-6-5-12-9-13(8-11(3)15)10(2)7-14(12)16/h7,9,11H,4-6,8,15H2,1-3H3
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n/an/a 2.20E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibition of Serotonin transporter uptake at serotonin uptake site

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Transporter


(Rattus norvegicus)		BDBM50025084
PNG
(2-(1-Ethyl-6-methyl-2,3-dihydro-1H-indol-5-yl)-1-m...)
Show SMILES CCN1CCc2cc(CC(C)N)c(C)cc12
Show InChI InChI=1S/C14H22N2/c1-4-16-6-5-12-9-13(8-11(3)15)10(2)7-14(12)16/h7,9,11H,4-6,8,15H2,1-3H3
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n/an/a 2.50E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of NE uptake at NE uptake site

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Transporter


(Rattus norvegicus)		BDBM50025083
PNG
(2-(2,3-Dihydro-1H-indol-5-yl)-1,1-dimethyl-ethylam...)
Show SMILES CC(C)(N)Cc1ccc2NCCc2c1
Show InChI InChI=1S/C12H18N2/c1-12(2,13)8-9-3-4-11-10(7-9)5-6-14-11/h3-4,7,14H,5-6,8,13H2,1-2H3
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n/an/a 2.70E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of NE uptake at NE uptake site

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A/B


(Rattus norvegicus (rat))		BDBM50025083
PNG
(2-(2,3-Dihydro-1H-indol-5-yl)-1,1-dimethyl-ethylam...)
Show SMILES CC(C)(N)Cc1ccc2NCCc2c1
Show InChI InChI=1S/C12H18N2/c1-12(2,13)8-9-3-4-11-10(7-9)5-6-14-11/h3-4,7,14H,5-6,8,13H2,1-2H3
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n/an/a 2.80E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibition of MAO by using [14C]5-HT as substrate in rat brain mitochondrial preparation

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50025077
PNG
(1-(2,3-Dihydro-1H-indol-5-ylmethyl)-propylamine | ...)
Show SMILES CCC(N)Cc1ccc2NCCc2c1
Show InChI InChI=1S/C12H18N2/c1-2-11(13)8-9-3-4-12-10(7-9)5-6-14-12/h3-4,7,11,14H,2,5-6,8,13H2,1H3
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n/an/a 3.60E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibition of Serotonin transporter uptake at serotonin uptake site

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50025081
PNG
(2-(2,3-Dihydro-1H-indol-5-yl)-1-methyl-ethylamine ...)
Show SMILES CC(N)Cc1ccc2NCCc2c1
Show InChI InChI=1S/C11H16N2/c1-8(12)6-9-2-3-11-10(7-9)4-5-13-11/h2-3,7-8,13H,4-6,12H2,1H3
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n/an/a 3.80E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibition of DA uptake at dopamine uptake site

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A/B


(Rattus norvegicus (rat))		BDBM50025081
PNG
(2-(2,3-Dihydro-1H-indol-5-yl)-1-methyl-ethylamine ...)
Show SMILES CC(N)Cc1ccc2NCCc2c1
Show InChI InChI=1S/C11H16N2/c1-8(12)6-9-2-3-11-10(7-9)4-5-13-11/h2-3,7-8,13H,4-6,12H2,1H3
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n/an/a 5.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibition of MAO by using [14C]5-HT as substrate in rat brain mitochondrial preparation

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50025078
PNG
(1-Methyl-2-(6-methyl-2,3-dihydro-1H-indol-5-yl)-et...)
Show SMILES CC(N)Cc1cc2CCNc2cc1C
Show InChI InChI=1S/C12H18N2/c1-8-5-12-10(3-4-14-12)7-11(8)6-9(2)13/h5,7,9,14H,3-4,6,13H2,1-2H3
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n/an/a 6.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibition of DA uptake at dopamine uptake site

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Transporter


(Rattus norvegicus)		BDBM50025078
PNG
(1-Methyl-2-(6-methyl-2,3-dihydro-1H-indol-5-yl)-et...)
Show SMILES CC(N)Cc1cc2CCNc2cc1C
Show InChI InChI=1S/C12H18N2/c1-8-5-12-10(3-4-14-12)7-11(8)6-9(2)13/h5,7,9,14H,3-4,6,13H2,1-2H3
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n/an/a 6.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of NE uptake at NE uptake site

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Transporter


(Rattus norvegicus)		BDBM50025085
PNG
(2-(1-Ethyl-4-methyl-2,3-dihydro-1H-indol-5-yl)-1-m...)
Show SMILES CCN1CCc2c1ccc(CC(C)N)c2C
Show InChI InChI=1S/C14H22N2/c1-4-16-8-7-13-11(3)12(9-10(2)15)5-6-14(13)16/h5-6,10H,4,7-9,15H2,1-3H3
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n/an/a 7.50E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of NE uptake at NE uptake site

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50025086
PNG
(1-Methyl-2-(4-methyl-2,3-dihydro-1H-indol-5-yl)-et...)
Show SMILES CC(N)Cc1ccc2NCCc2c1C
Show InChI InChI=1S/C12H18N2/c1-8(13)7-10-3-4-12-11(9(10)2)5-6-14-12/h3-4,8,14H,5-7,13H2,1-2H3
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n/an/a 9.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibition of DA uptake at dopamine uptake site

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50025083
PNG
(2-(2,3-Dihydro-1H-indol-5-yl)-1,1-dimethyl-ethylam...)
Show SMILES CC(C)(N)Cc1ccc2NCCc2c1
Show InChI InChI=1S/C12H18N2/c1-12(2,13)8-9-3-4-11-10(7-9)5-6-14-11/h3-4,7,14H,5-6,8,13H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibition of DA uptake at dopamine uptake site

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50025082
PNG
(2-(4-Chloro-2,3-dihydro-1H-indol-5-yl)-1-methyl-et...)
Show SMILES CC(N)Cc1ccc2NCCc2c1Cl
Show InChI InChI=1S/C11H15ClN2/c1-7(13)6-8-2-3-10-9(11(8)12)4-5-14-10/h2-3,7,14H,4-6,13H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibition of DA uptake at dopamine uptake site

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50025085
PNG
(2-(1-Ethyl-4-methyl-2,3-dihydro-1H-indol-5-yl)-1-m...)
Show SMILES CCN1CCc2c1ccc(CC(C)N)c2C
Show InChI InChI=1S/C14H22N2/c1-4-16-8-7-13-11(3)12(9-10(2)15)5-6-14(13)16/h5-6,10H,4,7-9,15H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibition of DA uptake at dopamine uptake site

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50025080
PNG
(1-(4-Chloro-2,3-dihydro-1H-indol-5-ylmethyl)-propy...)
Show SMILES CCC(N)Cc1ccc2NCCc2c1Cl
Show InChI InChI=1S/C12H17ClN2/c1-2-9(14)7-8-3-4-11-10(12(8)13)5-6-15-11/h3-4,9,15H,2,5-7,14H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibition of DA uptake at dopamine uptake site

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50025077
PNG
(1-(2,3-Dihydro-1H-indol-5-ylmethyl)-propylamine | ...)
Show SMILES CCC(N)Cc1ccc2NCCc2c1
Show InChI InChI=1S/C12H18N2/c1-2-11(13)8-9-3-4-12-10(7-9)5-6-14-12/h3-4,7,11,14H,2,5-6,8,13H2,1H3
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n/an/a 1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibition of DA uptake at dopamine uptake site

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50025084
PNG
(2-(1-Ethyl-6-methyl-2,3-dihydro-1H-indol-5-yl)-1-m...)
Show SMILES CCN1CCc2cc(CC(C)N)c(C)cc12
Show InChI InChI=1S/C14H22N2/c1-4-16-6-5-12-9-13(8-11(3)15)10(2)7-14(12)16/h7,9,11H,4-6,8,15H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibition of DA uptake at dopamine uptake site

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50025079
PNG
(CHEMBL30344 | [4-(2-Amino-propyl)-3-methyl-phenyl]...)
Show SMILES CC(N)Cc1ccc(cc1C)N(C)C
Show InChI InChI=1S/C12H20N2/c1-9-7-12(14(3)4)6-5-11(9)8-10(2)13/h5-7,10H,8,13H2,1-4H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibition of DA uptake at dopamine uptake site

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A/B


(Rattus norvegicus (rat))		BDBM50025078
PNG
(1-Methyl-2-(6-methyl-2,3-dihydro-1H-indol-5-yl)-et...)
Show SMILES CC(N)Cc1cc2CCNc2cc1C
Show InChI InChI=1S/C12H18N2/c1-8-5-12-10(3-4-14-12)7-11(8)6-9(2)13/h5,7,9,14H,3-4,6,13H2,1-2H3
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n/an/a 1.30E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibition of MAO by using [14C]5-HT as substrate in rat brain mitochondrial preparation

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A/B


(Rattus norvegicus (rat))		BDBM50025077
PNG
(1-(2,3-Dihydro-1H-indol-5-ylmethyl)-propylamine | ...)
Show SMILES CCC(N)Cc1ccc2NCCc2c1
Show InChI InChI=1S/C12H18N2/c1-2-11(13)8-9-3-4-12-10(7-9)5-6-14-12/h3-4,7,11,14H,2,5-6,8,13H2,1H3
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n/an/a 1.40E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibition of Monoamino oxidase by using [14C]5-HT as substrate in rat brain mitochondrial preparation

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50025078
PNG
(1-Methyl-2-(6-methyl-2,3-dihydro-1H-indol-5-yl)-et...)
Show SMILES CC(N)Cc1cc2CCNc2cc1C
Show InChI InChI=1S/C12H18N2/c1-8-5-12-10(3-4-14-12)7-11(8)6-9(2)13/h5,7,9,14H,3-4,6,13H2,1-2H3
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n/an/a>1.60E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibition of Serotonin transporter uptake at serotonin uptake site

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A/B


(Rattus norvegicus (rat))		BDBM50025084
PNG
(2-(1-Ethyl-6-methyl-2,3-dihydro-1H-indol-5-yl)-1-m...)
Show SMILES CCN1CCc2cc(CC(C)N)c(C)cc12
Show InChI InChI=1S/C14H22N2/c1-4-16-6-5-12-9-13(8-11(3)15)10(2)7-14(12)16/h7,9,11H,4-6,8,15H2,1-3H3
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n/an/a 7.70E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibition of MAO by using [14C]phenylethylamine as substrate in rat brain mitochondrial preparation

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A/B


(Rattus norvegicus (rat))		BDBM50025081
PNG
(2-(2,3-Dihydro-1H-indol-5-yl)-1-methyl-ethylamine ...)
Show SMILES CC(N)Cc1ccc2NCCc2c1
Show InChI InChI=1S/C11H16N2/c1-8(12)6-9-2-3-11-10(7-9)4-5-13-11/h2-3,7-8,13H,4-6,12H2,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibition of MAO by using [14C]phenylethylamine as substrate in rat brain mitochondrial preparation

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A/B


(Rattus norvegicus (rat))		BDBM50025078
PNG
(1-Methyl-2-(6-methyl-2,3-dihydro-1H-indol-5-yl)-et...)
Show SMILES CC(N)Cc1cc2CCNc2cc1C
Show InChI InChI=1S/C12H18N2/c1-8-5-12-10(3-4-14-12)7-11(8)6-9(2)13/h5,7,9,14H,3-4,6,13H2,1-2H3
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n/an/a 1.70E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibition of MAO by using [14C]phenylethylamine as substrate in rat brain mitochondrial preparation

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A/B


(Rattus norvegicus (rat))		BDBM50025086
PNG
(1-Methyl-2-(4-methyl-2,3-dihydro-1H-indol-5-yl)-et...)
Show SMILES CC(N)Cc1ccc2NCCc2c1C
Show InChI InChI=1S/C12H18N2/c1-8(13)7-10-3-4-12-11(9(10)2)5-6-14-12/h3-4,8,14H,5-7,13H2,1-2H3
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n/an/a>5.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibition of MAO by using [14C]phenylethylamine as substrate in rat brain mitochondrial preparation

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A/B


(Rattus norvegicus (rat))		BDBM50025085
PNG
(2-(1-Ethyl-4-methyl-2,3-dihydro-1H-indol-5-yl)-1-m...)
Show SMILES CCN1CCc2c1ccc(CC(C)N)c2C
Show InChI InChI=1S/C14H22N2/c1-4-16-8-7-13-11(3)12(9-10(2)15)5-6-14(13)16/h5-6,10H,4,7-9,15H2,1-3H3
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TBA

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibition of MAO by using [14C]phenylethylamine as substrate in rat brain mitochondrial preparation

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A/B


(Rattus norvegicus (rat))		BDBM50025082
PNG
(2-(4-Chloro-2,3-dihydro-1H-indol-5-yl)-1-methyl-et...)
Show SMILES CC(N)Cc1ccc2NCCc2c1Cl
Show InChI InChI=1S/C11H15ClN2/c1-7(13)6-8-2-3-10-9(11(8)12)4-5-14-10/h2-3,7,14H,4-6,13H2,1H3
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n/an/a 8.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibition of MAO by using [14C]phenylethylamine as substrate in rat brain mitochondrial preparation

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A/B


(Rattus norvegicus (rat))		BDBM50025077
PNG
(1-(2,3-Dihydro-1H-indol-5-ylmethyl)-propylamine | ...)
Show SMILES CCC(N)Cc1ccc2NCCc2c1
Show InChI InChI=1S/C12H18N2/c1-2-11(13)8-9-3-4-12-10(7-9)5-6-14-12/h3-4,7,11,14H,2,5-6,8,13H2,1H3
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n/an/a 8.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibition of Monoamino oxidase by using [14C]phenylethylamine as substrate in rat brain mitochondrial preparation

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A/B


(Rattus norvegicus (rat))		BDBM50025079
PNG
(CHEMBL30344 | [4-(2-Amino-propyl)-3-methyl-phenyl]...)
Show SMILES CC(N)Cc1ccc(cc1C)N(C)C
Show InChI InChI=1S/C12H20N2/c1-9-7-12(14(3)4)6-5-11(9)8-10(2)13/h5-7,10H,8,13H2,1-4H3
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n/an/a>1.00E+6n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibition of MAO by using [14C]phenylethylamine as substrate in rat brain mitochondrial preparation

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A/B


(Rattus norvegicus (rat))		BDBM50025083
PNG
(2-(2,3-Dihydro-1H-indol-5-yl)-1,1-dimethyl-ethylam...)
Show SMILES CC(C)(N)Cc1ccc2NCCc2c1
Show InChI InChI=1S/C12H18N2/c1-12(2,13)8-9-3-4-11-10(7-9)5-6-14-11/h3-4,7,14H,5-6,8,13H2,1-2H3
PDB

UniProtKB/SwissProt

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PC cid
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UniChem

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PubMed
n/an/a 2.60E+6n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibition of MAO by using [14C]phenylethylamine as substrate in rat brain mitochondrial preparation

J Med Chem 29: 1406-12 (1986)


BindingDB Entry DOI: 10.7270/Q29022S9
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%