Found 11 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Type-1 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50049186
((S)-3-Methyl-2-{pentanoyl-[2'-(1H-tetrazol-5-yl)-b...)Show SMILES CCCCC(=O)N(Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)[C@@H](C(C)C)C(O)=O Show InChI InChI=1S/C24H29N5O3/c1-4-5-10-21(30)29(22(16(2)3)24(31)32)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)23-25-27-28-26-23/h6-9,11-14,16,22H,4-5,10,15H2,1-3H3,(H,31,32)(H,25,26,27,28)/t22-/m0/s1 | PDB
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| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA) |
Bioorg Med Chem Lett 4: 29-34 (1994)
Article DOI: 10.1016/S0960-894X(01)81117-3
BindingDB Entry DOI: 10.7270/Q25Q4W14 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50282368
(CHEMBL116298 | Pentanoic acid ((S)-1-carbamoyl-2-m...)Show SMILES CCCCC(=O)N(Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)[C@@H](C(C)C)C(N)=O Show InChI InChI=1S/C24H30N6O2/c1-4-5-10-21(31)30(22(16(2)3)23(25)32)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)24-26-28-29-27-24/h6-9,11-14,16,22H,4-5,10,15H2,1-3H3,(H2,25,32)(H,26,27,28,29)/t22-/m0/s1 | PDB
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| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA) |
Bioorg Med Chem Lett 4: 29-34 (1994)
Article DOI: 10.1016/S0960-894X(01)81117-3
BindingDB Entry DOI: 10.7270/Q25Q4W14 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50009714
(CHEMBL191 | {2-Butyl-5-chloro-3-[2'-(2H-tetrazol-5...)Show SMILES CCCCC1=NC(Cl)C(CO)N1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1 |t:4| Show InChI InChI=1S/C22H25ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,19,21,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28) | PDB
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| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA) |
Bioorg Med Chem Lett 4: 29-34 (1994)
Article DOI: 10.1016/S0960-894X(01)81117-3
BindingDB Entry DOI: 10.7270/Q25Q4W14 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50282372
((S)-2-{Pentanoyl-[2'-(1H-tetrazol-5-yl)-biphenyl-4...)Show SMILES CCCCC(=O)N(Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)[C@@H](C)C(O)=O Show InChI InChI=1S/C22H25N5O3/c1-3-4-9-20(28)27(15(2)22(29)30)14-16-10-12-17(13-11-16)18-7-5-6-8-19(18)21-23-25-26-24-21/h5-8,10-13,15H,3-4,9,14H2,1-2H3,(H,29,30)(H,23,24,25,26)/t15-/m0/s1 | PDB
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| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA) |
Bioorg Med Chem Lett 4: 29-34 (1994)
Article DOI: 10.1016/S0960-894X(01)81117-3
BindingDB Entry DOI: 10.7270/Q25Q4W14 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50282364
(3-(4-Fluoro-phenyl)-2-{pentanoyl-[2'-(1H-tetrazol-...)Show SMILES CCCCC(=O)N(Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)C(Cc1ccc(F)cc1)C(O)=O Show InChI InChI=1S/C28H28FN5O3/c1-2-3-8-26(35)34(25(28(36)37)17-19-11-15-22(29)16-12-19)18-20-9-13-21(14-10-20)23-6-4-5-7-24(23)27-30-32-33-31-27/h4-7,9-16,25H,2-3,8,17-18H2,1H3,(H,36,37)(H,30,31,32,33) | PDB
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TBA
Curated by ChEMBL
| Assay Description
Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA) |
Bioorg Med Chem Lett 4: 29-34 (1994)
Article DOI: 10.1016/S0960-894X(01)81117-3
BindingDB Entry DOI: 10.7270/Q25Q4W14 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50282370
((S)-3-Cyclohexyl-2-{pentanoyl-[2'-(1H-tetrazol-5-y...)Show SMILES CCCCC(=O)N(Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)[C@@H](CC1CCCCC1)C(O)=O Show InChI InChI=1S/C28H35N5O3/c1-2-3-13-26(34)33(25(28(35)36)18-20-9-5-4-6-10-20)19-21-14-16-22(17-15-21)23-11-7-8-12-24(23)27-29-31-32-30-27/h7-8,11-12,14-17,20,25H,2-6,9-10,13,18-19H2,1H3,(H,35,36)(H,29,30,31,32)/t25-/m0/s1 | PDB
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| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA) |
Bioorg Med Chem Lett 4: 29-34 (1994)
Article DOI: 10.1016/S0960-894X(01)81117-3
BindingDB Entry DOI: 10.7270/Q25Q4W14 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50282365
((S)-3-Methyl-2-{pentanoyl-[2'-(1H-tetrazol-5-yl)-b...)Show SMILES CCCCC(=O)N(Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)[C@@H](C(C)C)C(=O)OC Show InChI InChI=1S/C25H31N5O3/c1-5-6-11-22(31)30(23(17(2)3)25(32)33-4)16-18-12-14-19(15-13-18)20-9-7-8-10-21(20)24-26-28-29-27-24/h7-10,12-15,17,23H,5-6,11,16H2,1-4H3,(H,26,27,28,29)/t23-/m0/s1 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA) |
Bioorg Med Chem Lett 4: 29-34 (1994)
Article DOI: 10.1016/S0960-894X(01)81117-3
BindingDB Entry DOI: 10.7270/Q25Q4W14 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50282367
((R)-2-{Pentanoyl-[2'-(1H-tetrazol-5-yl)-biphenyl-4...)Show SMILES CCCCC(=O)N(Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)[C@H](C)C(O)=O Show InChI InChI=1S/C22H25N5O3/c1-3-4-9-20(28)27(15(2)22(29)30)14-16-10-12-17(13-11-16)18-7-5-6-8-19(18)21-23-25-26-24-21/h5-8,10-13,15H,3-4,9,14H2,1-2H3,(H,29,30)(H,23,24,25,26)/t15-/m1/s1 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA) |
Bioorg Med Chem Lett 4: 29-34 (1994)
Article DOI: 10.1016/S0960-894X(01)81117-3
BindingDB Entry DOI: 10.7270/Q25Q4W14 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50282369
(CHEMBL323911 | Pentanoic acid ((S)-1-hydroxymethyl...)Show SMILES CCCCC(=O)N(Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)[C@H](CO)C(C)C Show InChI InChI=1S/C24H31N5O2/c1-4-5-10-23(31)29(22(16-30)17(2)3)15-18-11-13-19(14-12-18)20-8-6-7-9-21(20)24-25-27-28-26-24/h6-9,11-14,17,22,30H,4-5,10,15-16H2,1-3H3,(H,25,26,27,28)/t22-/m1/s1 | PDB
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| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA) |
Bioorg Med Chem Lett 4: 29-34 (1994)
Article DOI: 10.1016/S0960-894X(01)81117-3
BindingDB Entry DOI: 10.7270/Q25Q4W14 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50282371
((R)-3-Methyl-2-{pentanoyl-[2'-(1H-tetrazol-5-yl)-b...)Show SMILES CCCCC(=O)N(Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)[C@H](C(C)C)C(O)=O Show InChI InChI=1S/C24H29N5O3/c1-4-5-10-21(30)29(22(16(2)3)24(31)32)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)23-25-27-28-26-23/h6-9,11-14,16,22H,4-5,10,15H2,1-3H3,(H,31,32)(H,25,26,27,28)/t22-/m1/s1 | PDB
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| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA) |
Bioorg Med Chem Lett 4: 29-34 (1994)
Article DOI: 10.1016/S0960-894X(01)81117-3
BindingDB Entry DOI: 10.7270/Q25Q4W14 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50282366
(CHEMBL326140 | {Pentanoyl-[2'-(1H-tetrazol-5-yl)-b...)Show SMILES CCCCC(=O)N(CC(O)=O)Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1 Show InChI InChI=1S/C21H23N5O3/c1-2-3-8-19(27)26(14-20(28)29)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)21-22-24-25-23-21/h4-7,9-12H,2-3,8,13-14H2,1H3,(H,28,29)(H,22,23,24,25) | PDB
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| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA) |
Bioorg Med Chem Lett 4: 29-34 (1994)
Article DOI: 10.1016/S0960-894X(01)81117-3
BindingDB Entry DOI: 10.7270/Q25Q4W14 |
More data for this
Ligand-Target Pair | |
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