Found 24 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Endothelin receptor type B
(Homo sapiens (Human)) | BDBM50286614
(CHEMBL155943 | CHEMBL3143473 | Sodium; 2-[2-{2-[(2...)Show SMILES [Na+].CCCC[C@@H](NC(=O)[C@@H](Cc1cn(COC)c2ccccc12)NC(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C([O-])=O |r| Show InChI InChI=1S/C34H53N5O6/c1-8-9-16-26(32(42)43)35-30(40)27(18-24-20-38(21-45-7)29-17-11-10-15-25(24)29)36-31(41)28(19-34(4,5)6)37-33(44)39-22(2)13-12-14-23(39)3/h10-11,15,17,20,22-23,26-28H,8-9,12-14,16,18-19,21H2,1-7H3,(H,35,40)(H,36,41)(H,37,44)(H,42,43)/p-1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Antagonistic activity against endothelin B (ETB) receptor using human girardi heart cells. |
Bioorg Med Chem Lett 5: 621-626 (1995)
Article DOI: 10.1016/0960-894X(95)00084-7
BindingDB Entry DOI: 10.7270/Q27081DM |
More data for this
Ligand-Target Pair | |
Endothelin-1 receptor
(Homo sapiens (Human)) | BDBM50286622
(Ac-W-F-F-N-Y-Y-W | CHEMBL405677)Show SMILES CC(=O)[C@@H](Cc1c[nH]c2ccccc12)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C63H65N9O11/c1-37(73)50(32-42-35-65-48-18-10-8-16-46(42)48)67-51(28-38-12-4-2-5-13-38)58(77)68-52(29-39-14-6-3-7-15-39)60(79)71-55(34-57(64)76)62(81)70-53(30-40-20-24-44(74)25-21-40)59(78)69-54(31-41-22-26-45(75)27-23-41)61(80)72-56(63(82)83)33-43-36-66-49-19-11-9-17-47(43)49/h2-27,35-36,50-56,65-67,74-75H,28-34H2,1H3,(H2,64,76)(H,68,77)(H,69,78)(H,70,81)(H,71,79)(H,72,80)(H,82,83)/t50-,51+,52+,53+,54+,55+,56+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity in LtK cells stably transfected with human endothelin A (ETA) receptor |
Bioorg Med Chem Lett 5: 621-626 (1995)
Article DOI: 10.1016/0960-894X(95)00084-7
BindingDB Entry DOI: 10.7270/Q27081DM |
More data for this
Ligand-Target Pair | |
Endothelin-1 receptor
(Homo sapiens (Human)) | BDBM50286614
(CHEMBL155943 | CHEMBL3143473 | Sodium; 2-[2-{2-[(2...)Show SMILES [Na+].CCCC[C@@H](NC(=O)[C@@H](Cc1cn(COC)c2ccccc12)NC(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C([O-])=O |r| Show InChI InChI=1S/C34H53N5O6/c1-8-9-16-26(32(42)43)35-30(40)27(18-24-20-38(21-45-7)29-17-11-10-15-25(24)29)36-31(41)28(19-34(4,5)6)37-33(44)39-22(2)13-12-14-23(39)3/h10-11,15,17,20,22-23,26-28H,8-9,12-14,16,18-19,21H2,1-7H3,(H,35,40)(H,36,41)(H,37,44)(H,42,43)/p-1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Antagonistic activity against endothelin A (ETA) receptor using human neuroblastoma cell line. |
Bioorg Med Chem Lett 5: 621-626 (1995)
Article DOI: 10.1016/0960-894X(95)00084-7
BindingDB Entry DOI: 10.7270/Q27081DM |
More data for this
Ligand-Target Pair | |
Endothelin-1 receptor
(Homo sapiens (Human)) | BDBM50286619
(Ac-bhg-F-N-Y-Y-W | CHEMBL385405)Show SMILES CC(=O)N[C@@H](C1c2ccccc2CCc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C61H62N8O11/c1-35(70)64-55(54-45-16-7-5-13-39(45)23-24-40-14-6-8-17-46(40)54)60(78)68-50(29-36-11-3-2-4-12-36)57(75)67-51(33-53(62)73)59(77)66-48(30-37-19-25-42(71)26-20-37)56(74)65-49(31-38-21-27-43(72)28-22-38)58(76)69-52(61(79)80)32-41-34-63-47-18-10-9-15-44(41)47/h2-22,25-28,34,48-52,54-55,63,71-72H,23-24,29-33H2,1H3,(H2,62,73)(H,64,70)(H,65,74)(H,66,77)(H,67,75)(H,68,78)(H,69,76)(H,79,80)/t48-,49-,50-,51-,52-,55-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity in LtK cells stably transfected with human endothelin A (ETA) receptor |
Bioorg Med Chem Lett 5: 621-626 (1995)
Article DOI: 10.1016/0960-894X(95)00084-7
BindingDB Entry DOI: 10.7270/Q27081DM |
More data for this
Ligand-Target Pair | |
Endothelin-1 receptor
(Homo sapiens (Human)) | BDBM50286618
(CHEMBL413880 | W-F-F-N--Y-Y-W)Show SMILES NC(=O)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C62H63N9O12/c63-55(74)33-52(70-58(77)49(28-37-13-5-2-6-14-37)67-56(75)48(27-36-11-3-1-4-12-36)66-53(61(80)81)31-40-34-64-46-17-9-7-15-44(40)46)60(79)69-50(29-38-19-23-42(72)24-20-38)57(76)68-51(30-39-21-25-43(73)26-22-39)59(78)71-54(62(82)83)32-41-35-65-47-18-10-8-16-45(41)47/h1-26,34-35,48-54,64-66,72-73H,27-33H2,(H2,63,74)(H,67,75)(H,68,76)(H,69,79)(H,70,77)(H,71,78)(H,80,81)(H,82,83)/t48-,49-,50-,51-,52-,53+,54-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity in LtK cells stably transfected with human endothelin A (ETA) receptor |
Bioorg Med Chem Lett 5: 621-626 (1995)
Article DOI: 10.1016/0960-894X(95)00084-7
BindingDB Entry DOI: 10.7270/Q27081DM |
More data for this
Ligand-Target Pair | |
Endothelin-1 receptor
(Homo sapiens (Human)) | BDBM50286616
(CHEMBL267610 | G-N-W-H-G-T-A-P-D-W-F-F-N-Y-Y-W)Show SMILES C[C@@H](O)[C@H](NC(=O)CNC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)CN)C(=O)N[C@@H](C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C103H117N23O24/c1-54(113-101(147)89(55(2)127)125-87(133)52-111-90(136)78(43-63-51-107-53-112-63)121-96(142)77(41-61-49-109-70-24-13-10-21-67(61)70)119-97(143)79(44-84(105)130)114-86(132)47-104)102(148)126-35-15-26-83(126)100(146)123-81(46-88(134)135)99(145)120-76(40-60-48-108-69-23-12-9-20-66(60)69)95(141)117-72(36-56-16-5-3-6-17-56)91(137)115-73(37-57-18-7-4-8-19-57)93(139)122-80(45-85(106)131)98(144)118-74(38-58-27-31-64(128)32-28-58)92(138)116-75(39-59-29-33-65(129)34-30-59)94(140)124-82(103(149)150)42-62-50-110-71-25-14-11-22-68(62)71/h3-14,16-25,27-34,48-51,53-55,72-83,89,108-110,127-129H,15,26,35-47,52,104H2,1-2H3,(H2,105,130)(H2,106,131)(H,107,112)(H,111,136)(H,113,147)(H,114,132)(H,115,137)(H,116,138)(H,117,141)(H,118,144)(H,119,143)(H,120,145)(H,121,142)(H,122,139)(H,123,146)(H,124,140)(H,125,133)(H,134,135)(H,149,150)/t54-,55+,72-,73-,74-,75-,76-,77-,78-,79-,80-,81+,82-,83+,89-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | >2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity in LtK cells stably transfected with human endothelin A (ETA) receptor |
Bioorg Med Chem Lett 5: 621-626 (1995)
Article DOI: 10.1016/0960-894X(95)00084-7
BindingDB Entry DOI: 10.7270/Q27081DM |
More data for this
Ligand-Target Pair | |
Endothelin receptor type B
(Homo sapiens (Human)) | BDBM50286620
(CHEMBL415614 | W-H-G-T-A-P-D-W-F-F-N-Y-Y-W)Show SMILES C[C@@H](O)[C@H](NC(=O)CNC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C97H108N20O21/c1-52(106-95(135)84(53(2)118)116-82(122)50-104-86(126)76(43-61-49-100-51-105-61)107-85(125)67(98)40-58-46-101-68-23-12-9-20-64(58)68)96(136)117-35-15-26-80(117)94(134)114-78(45-83(123)124)93(133)112-75(41-59-47-102-69-24-13-10-21-65(59)69)91(131)110-71(36-54-16-5-3-6-17-54)87(127)108-72(37-55-18-7-4-8-19-55)89(129)113-77(44-81(99)121)92(132)111-73(38-56-27-31-62(119)32-28-56)88(128)109-74(39-57-29-33-63(120)34-30-57)90(130)115-79(97(137)138)42-60-48-103-70-25-14-11-22-66(60)70/h3-14,16-25,27-34,46-49,51-53,67,71-80,84,101-103,118-120H,15,26,35-45,50,98H2,1-2H3,(H2,99,121)(H,100,105)(H,104,126)(H,106,135)(H,107,125)(H,108,127)(H,109,128)(H,110,131)(H,111,132)(H,112,133)(H,113,129)(H,114,134)(H,115,130)(H,116,122)(H,123,124)(H,137,138)/t52-,53+,67-,71-,72-,73-,74-,75-,76-,77-,78+,79-,80+,84-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | >2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity in Chinese hamster ovary (CHO) cells stably transfected with human endothelin B (ETB) receptor |
Bioorg Med Chem Lett 5: 621-626 (1995)
Article DOI: 10.1016/0960-894X(95)00084-7
BindingDB Entry DOI: 10.7270/Q27081DM |
More data for this
Ligand-Target Pair | |
Endothelin-1 receptor
(Homo sapiens (Human)) | BDBM50286620
(CHEMBL415614 | W-H-G-T-A-P-D-W-F-F-N-Y-Y-W)Show SMILES C[C@@H](O)[C@H](NC(=O)CNC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C97H108N20O21/c1-52(106-95(135)84(53(2)118)116-82(122)50-104-86(126)76(43-61-49-100-51-105-61)107-85(125)67(98)40-58-46-101-68-23-12-9-20-64(58)68)96(136)117-35-15-26-80(117)94(134)114-78(45-83(123)124)93(133)112-75(41-59-47-102-69-24-13-10-21-65(59)69)91(131)110-71(36-54-16-5-3-6-17-54)87(127)108-72(37-55-18-7-4-8-19-55)89(129)113-77(44-81(99)121)92(132)111-73(38-56-27-31-62(119)32-28-56)88(128)109-74(39-57-29-33-63(120)34-30-57)90(130)115-79(97(137)138)42-60-48-103-70-25-14-11-22-66(60)70/h3-14,16-25,27-34,46-49,51-53,67,71-80,84,101-103,118-120H,15,26,35-45,50,98H2,1-2H3,(H2,99,121)(H,100,105)(H,104,126)(H,106,135)(H,107,125)(H,108,127)(H,109,128)(H,110,131)(H,111,132)(H,112,133)(H,113,129)(H,114,134)(H,115,130)(H,116,122)(H,123,124)(H,137,138)/t52-,53+,67-,71-,72-,73-,74-,75-,76-,77-,78+,79-,80+,84-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | >2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity in LtK cells stably transfected with human endothelin A (ETA) receptor |
Bioorg Med Chem Lett 5: 621-626 (1995)
Article DOI: 10.1016/0960-894X(95)00084-7
BindingDB Entry DOI: 10.7270/Q27081DM |
More data for this
Ligand-Target Pair | |
Endothelin receptor type B
(Homo sapiens (Human)) | BDBM50286616
(CHEMBL267610 | G-N-W-H-G-T-A-P-D-W-F-F-N-Y-Y-W)Show SMILES C[C@@H](O)[C@H](NC(=O)CNC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)CN)C(=O)N[C@@H](C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C103H117N23O24/c1-54(113-101(147)89(55(2)127)125-87(133)52-111-90(136)78(43-63-51-107-53-112-63)121-96(142)77(41-61-49-109-70-24-13-10-21-67(61)70)119-97(143)79(44-84(105)130)114-86(132)47-104)102(148)126-35-15-26-83(126)100(146)123-81(46-88(134)135)99(145)120-76(40-60-48-108-69-23-12-9-20-66(60)69)95(141)117-72(36-56-16-5-3-6-17-56)91(137)115-73(37-57-18-7-4-8-19-57)93(139)122-80(45-85(106)131)98(144)118-74(38-58-27-31-64(128)32-28-58)92(138)116-75(39-59-29-33-65(129)34-30-59)94(140)124-82(103(149)150)42-62-50-110-71-25-14-11-22-68(62)71/h3-14,16-25,27-34,48-51,53-55,72-83,89,108-110,127-129H,15,26,35-47,52,104H2,1-2H3,(H2,105,130)(H2,106,131)(H,107,112)(H,111,136)(H,113,147)(H,114,132)(H,115,137)(H,116,138)(H,117,141)(H,118,144)(H,119,143)(H,120,145)(H,121,142)(H,122,139)(H,123,146)(H,124,140)(H,125,133)(H,134,135)(H,149,150)/t54-,55+,72-,73-,74-,75-,76-,77-,78-,79-,80-,81+,82-,83+,89-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
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UniChem
Similars
| Article
| n/a | n/a | >2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity in Chinese hamster ovary (CHO) cells stably transfected with human endothelin B (ETB) receptor |
Bioorg Med Chem Lett 5: 621-626 (1995)
Article DOI: 10.1016/0960-894X(95)00084-7
BindingDB Entry DOI: 10.7270/Q27081DM |
More data for this
Ligand-Target Pair | |
Endothelin receptor type B
(Homo sapiens (Human)) | BDBM50286619
(Ac-bhg-F-N-Y-Y-W | CHEMBL385405)Show SMILES CC(=O)N[C@@H](C1c2ccccc2CCc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C61H62N8O11/c1-35(70)64-55(54-45-16-7-5-13-39(45)23-24-40-14-6-8-17-46(40)54)60(78)68-50(29-36-11-3-2-4-12-36)57(75)67-51(33-53(62)73)59(77)66-48(30-37-19-25-42(71)26-20-37)56(74)65-49(31-38-21-27-43(72)28-22-38)58(76)69-52(61(79)80)32-41-34-63-47-18-10-9-15-44(41)47/h2-22,25-28,34,48-52,54-55,63,71-72H,23-24,29-33H2,1H3,(H2,62,73)(H,64,70)(H,65,74)(H,66,77)(H,67,75)(H,68,78)(H,69,76)(H,79,80)/t48-,49-,50-,51-,52-,55-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
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UniChem
Similars
| Article
| n/a | n/a | 4.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity in Chinese hamster ovary (CHO) cells stably transfected with human endothelin B (ETB) receptor |
Bioorg Med Chem Lett 5: 621-626 (1995)
Article DOI: 10.1016/0960-894X(95)00084-7
BindingDB Entry DOI: 10.7270/Q27081DM |
More data for this
Ligand-Target Pair | |
Endothelin-1 receptor
(Homo sapiens (Human)) | BDBM50286613
(CHEMBL413825 | Cyclic (Gly1-Asp9) (Gly-Asn-Trp-His...)Show SMILES C[C@@H](O)[C@H]1NC(=O)CNC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(O)=O)NC(=O)[C@H]2CCCN2C(=O)[C@H](C)NC1=O Show InChI InChI=1S/C103H115N23O23/c1-54-102(147)126-35-15-26-83(126)100(145)123-81(91(136)110-51-87(133)115-79(44-84(104)130)98(143)120-77(41-61-48-108-70-24-13-10-21-67(61)70)97(142)121-78(43-63-50-106-53-112-63)90(135)111-52-88(134)125-89(55(2)127)101(146)113-54)46-86(132)114-76(40-60-47-107-69-23-12-9-20-66(60)69)96(141)118-72(36-56-16-5-3-6-17-56)92(137)116-73(37-57-18-7-4-8-19-57)94(139)122-80(45-85(105)131)99(144)119-74(38-58-27-31-64(128)32-28-58)93(138)117-75(39-59-29-33-65(129)34-30-59)95(140)124-82(103(148)149)42-62-49-109-71-25-14-11-22-68(62)71/h3-14,16-25,27-34,47-50,53-55,72-83,89,107-109,127-129H,15,26,35-46,51-52H2,1-2H3,(H2,104,130)(H2,105,131)(H,106,112)(H,110,136)(H,111,135)(H,113,146)(H,114,132)(H,115,133)(H,116,137)(H,117,138)(H,118,141)(H,119,144)(H,120,143)(H,121,142)(H,122,139)(H,123,145)(H,124,140)(H,125,134)(H,148,149)/t54-,55+,72-,73-,74-,75-,76-,77-,78+,79+,80-,81-,82-,83+,89+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
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| CHEMBL
PC cid
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UniChem
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| Article
| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Ability to block endothelin-1 (ET-1) stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells (AARA) expressing recombinant r... |
Bioorg Med Chem Lett 5: 621-626 (1995)
Article DOI: 10.1016/0960-894X(95)00084-7
BindingDB Entry DOI: 10.7270/Q27081DM |
More data for this
Ligand-Target Pair | |
Endothelin receptor type B
(Homo sapiens (Human)) | BDBM50286613
(CHEMBL413825 | Cyclic (Gly1-Asp9) (Gly-Asn-Trp-His...)Show SMILES C[C@@H](O)[C@H]1NC(=O)CNC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(O)=O)NC(=O)[C@H]2CCCN2C(=O)[C@H](C)NC1=O Show InChI InChI=1S/C103H115N23O23/c1-54-102(147)126-35-15-26-83(126)100(145)123-81(91(136)110-51-87(133)115-79(44-84(104)130)98(143)120-77(41-61-48-108-70-24-13-10-21-67(61)70)97(142)121-78(43-63-50-106-53-112-63)90(135)111-52-88(134)125-89(55(2)127)101(146)113-54)46-86(132)114-76(40-60-47-107-69-23-12-9-20-66(60)69)96(141)118-72(36-56-16-5-3-6-17-56)92(137)116-73(37-57-18-7-4-8-19-57)94(139)122-80(45-85(105)131)99(144)119-74(38-58-27-31-64(128)32-28-58)93(138)117-75(39-59-29-33-65(129)34-30-59)95(140)124-82(103(148)149)42-62-49-109-71-25-14-11-22-68(62)71/h3-14,16-25,27-34,47-50,53-55,72-83,89,107-109,127-129H,15,26,35-46,51-52H2,1-2H3,(H2,104,130)(H2,105,131)(H,106,112)(H,110,136)(H,111,135)(H,113,146)(H,114,132)(H,115,133)(H,116,137)(H,117,138)(H,118,141)(H,119,144)(H,120,143)(H,121,142)(H,122,139)(H,123,145)(H,124,140)(H,125,134)(H,148,149)/t54-,55+,72-,73-,74-,75-,76-,77-,78+,79+,80-,81-,82-,83+,89+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
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UniChem
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| Article
| n/a | n/a | 6.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity in Chinese hamster ovary (CHO) cells stably transfected with human endothelin B (ETB) receptor |
Bioorg Med Chem Lett 5: 621-626 (1995)
Article DOI: 10.1016/0960-894X(95)00084-7
BindingDB Entry DOI: 10.7270/Q27081DM |
More data for this
Ligand-Target Pair | |
Endothelin receptor type B
(Homo sapiens (Human)) | BDBM50286613
(CHEMBL413825 | Cyclic (Gly1-Asp9) (Gly-Asn-Trp-His...)Show SMILES C[C@@H](O)[C@H]1NC(=O)CNC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(O)=O)NC(=O)[C@H]2CCCN2C(=O)[C@H](C)NC1=O Show InChI InChI=1S/C103H115N23O23/c1-54-102(147)126-35-15-26-83(126)100(145)123-81(91(136)110-51-87(133)115-79(44-84(104)130)98(143)120-77(41-61-48-108-70-24-13-10-21-67(61)70)97(142)121-78(43-63-50-106-53-112-63)90(135)111-52-88(134)125-89(55(2)127)101(146)113-54)46-86(132)114-76(40-60-47-107-69-23-12-9-20-66(60)69)96(141)118-72(36-56-16-5-3-6-17-56)92(137)116-73(37-57-18-7-4-8-19-57)94(139)122-80(45-85(105)131)99(144)119-74(38-58-27-31-64(128)32-28-58)93(138)117-75(39-59-29-33-65(129)34-30-59)95(140)124-82(103(148)149)42-62-49-109-71-25-14-11-22-68(62)71/h3-14,16-25,27-34,47-50,53-55,72-83,89,107-109,127-129H,15,26,35-46,51-52H2,1-2H3,(H2,104,130)(H2,105,131)(H,106,112)(H,110,136)(H,111,135)(H,113,146)(H,114,132)(H,115,133)(H,116,137)(H,117,138)(H,118,141)(H,119,144)(H,120,143)(H,121,142)(H,122,139)(H,123,145)(H,124,140)(H,125,134)(H,148,149)/t54-,55+,72-,73-,74-,75-,76-,77-,78+,79+,80-,81-,82-,83+,89+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
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UniChem
Similars
| Article
| n/a | n/a | 6.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity in Chinese hamster ovary (CHO) cells stably transfected with human endothelin B (ETB) receptor |
Bioorg Med Chem Lett 5: 621-626 (1995)
Article DOI: 10.1016/0960-894X(95)00084-7
BindingDB Entry DOI: 10.7270/Q27081DM |
More data for this
Ligand-Target Pair | |
Endothelin receptor type B
(Homo sapiens (Human)) | BDBM50286613
(CHEMBL413825 | Cyclic (Gly1-Asp9) (Gly-Asn-Trp-His...)Show SMILES C[C@@H](O)[C@H]1NC(=O)CNC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(O)=O)NC(=O)[C@H]2CCCN2C(=O)[C@H](C)NC1=O Show InChI InChI=1S/C103H115N23O23/c1-54-102(147)126-35-15-26-83(126)100(145)123-81(91(136)110-51-87(133)115-79(44-84(104)130)98(143)120-77(41-61-48-108-70-24-13-10-21-67(61)70)97(142)121-78(43-63-50-106-53-112-63)90(135)111-52-88(134)125-89(55(2)127)101(146)113-54)46-86(132)114-76(40-60-47-107-69-23-12-9-20-66(60)69)96(141)118-72(36-56-16-5-3-6-17-56)92(137)116-73(37-57-18-7-4-8-19-57)94(139)122-80(45-85(105)131)99(144)119-74(38-58-27-31-64(128)32-28-58)93(138)117-75(39-59-29-33-65(129)34-30-59)95(140)124-82(103(148)149)42-62-49-109-71-25-14-11-22-68(62)71/h3-14,16-25,27-34,47-50,53-55,72-83,89,107-109,127-129H,15,26,35-46,51-52H2,1-2H3,(H2,104,130)(H2,105,131)(H,106,112)(H,110,136)(H,111,135)(H,113,146)(H,114,132)(H,115,133)(H,116,137)(H,117,138)(H,118,141)(H,119,144)(H,120,143)(H,121,142)(H,122,139)(H,123,145)(H,124,140)(H,125,134)(H,148,149)/t54-,55+,72-,73-,74-,75-,76-,77-,78+,79+,80-,81-,82-,83+,89+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 7.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity in LtK cells stably transfected with human endothelin A (ETA) receptor |
Bioorg Med Chem Lett 5: 621-626 (1995)
Article DOI: 10.1016/0960-894X(95)00084-7
BindingDB Entry DOI: 10.7270/Q27081DM |
More data for this
Ligand-Target Pair | |
Endothelin receptor type B
(Homo sapiens (Human)) | BDBM50286622
(Ac-W-F-F-N-Y-Y-W | CHEMBL405677)Show SMILES CC(=O)[C@@H](Cc1c[nH]c2ccccc12)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C63H65N9O11/c1-37(73)50(32-42-35-65-48-18-10-8-16-46(42)48)67-51(28-38-12-4-2-5-13-38)58(77)68-52(29-39-14-6-3-7-15-39)60(79)71-55(34-57(64)76)62(81)70-53(30-40-20-24-44(74)25-21-40)59(78)69-54(31-41-22-26-45(75)27-23-41)61(80)72-56(63(82)83)33-43-36-66-49-19-11-9-17-47(43)49/h2-27,35-36,50-56,65-67,74-75H,28-34H2,1H3,(H2,64,76)(H,68,77)(H,69,78)(H,70,81)(H,71,79)(H,72,80)(H,82,83)/t50-,51+,52+,53+,54+,55+,56+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
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UniChem
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| n/a | n/a | 7.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity in Chinese hamster ovary (CHO) cells stably transfected with human endothelin B (ETB) receptor |
Bioorg Med Chem Lett 5: 621-626 (1995)
Article DOI: 10.1016/0960-894X(95)00084-7
BindingDB Entry DOI: 10.7270/Q27081DM |
More data for this
Ligand-Target Pair | |
Endothelin-1 receptor
(Homo sapiens (Human)) | BDBM50286613
(CHEMBL413825 | Cyclic (Gly1-Asp9) (Gly-Asn-Trp-His...)Show SMILES C[C@@H](O)[C@H]1NC(=O)CNC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(O)=O)NC(=O)[C@H]2CCCN2C(=O)[C@H](C)NC1=O Show InChI InChI=1S/C103H115N23O23/c1-54-102(147)126-35-15-26-83(126)100(145)123-81(91(136)110-51-87(133)115-79(44-84(104)130)98(143)120-77(41-61-48-108-70-24-13-10-21-67(61)70)97(142)121-78(43-63-50-106-53-112-63)90(135)111-52-88(134)125-89(55(2)127)101(146)113-54)46-86(132)114-76(40-60-47-107-69-23-12-9-20-66(60)69)96(141)118-72(36-56-16-5-3-6-17-56)92(137)116-73(37-57-18-7-4-8-19-57)94(139)122-80(45-85(105)131)99(144)119-74(38-58-27-31-64(128)32-28-58)93(138)117-75(39-59-29-33-65(129)34-30-59)95(140)124-82(103(148)149)42-62-49-109-71-25-14-11-22-68(62)71/h3-14,16-25,27-34,47-50,53-55,72-83,89,107-109,127-129H,15,26,35-46,51-52H2,1-2H3,(H2,104,130)(H2,105,131)(H,106,112)(H,110,136)(H,111,135)(H,113,146)(H,114,132)(H,115,133)(H,116,137)(H,117,138)(H,118,141)(H,119,144)(H,120,143)(H,121,142)(H,122,139)(H,123,145)(H,124,140)(H,125,134)(H,148,149)/t54-,55+,72-,73-,74-,75-,76-,77-,78+,79+,80-,81-,82-,83+,89+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 7.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity in LtK cells stably transfected with human endothelin A (ETA) receptor |
Bioorg Med Chem Lett 5: 621-626 (1995)
Article DOI: 10.1016/0960-894X(95)00084-7
BindingDB Entry DOI: 10.7270/Q27081DM |
More data for this
Ligand-Target Pair | |
Endothelin-1 receptor
(Homo sapiens (Human)) | BDBM50286615
(Ac-w-F-F-N-Y-Y-W | CHEMBL441006)Show SMILES CC(=O)[C@H](Cc1c[nH]c2ccccc12)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C63H65N9O11/c1-37(73)50(32-42-35-65-48-18-10-8-16-46(42)48)67-51(28-38-12-4-2-5-13-38)58(77)68-52(29-39-14-6-3-7-15-39)60(79)71-55(34-57(64)76)62(81)70-53(30-40-20-24-44(74)25-21-40)59(78)69-54(31-41-22-26-45(75)27-23-41)61(80)72-56(63(82)83)33-43-36-66-49-19-11-9-17-47(43)49/h2-27,35-36,50-56,65-67,74-75H,28-34H2,1H3,(H2,64,76)(H,68,77)(H,69,78)(H,70,81)(H,71,79)(H,72,80)(H,82,83)/t50-,51-,52-,53-,54-,55-,56-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 8.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity in LtK cells stably transfected with human endothelin A (ETA) receptor |
Bioorg Med Chem Lett 5: 621-626 (1995)
Article DOI: 10.1016/0960-894X(95)00084-7
BindingDB Entry DOI: 10.7270/Q27081DM |
More data for this
Ligand-Target Pair | |
Endothelin-1 receptor
(Homo sapiens (Human)) | BDBM50286617
(CHEMBL414917 | bhg-F-N-Y-Y-W)Show SMILES N[C@@H](C1c2ccccc2CCc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C59H60N8O10/c60-51(70)32-49(65-55(72)48(28-34-10-2-1-3-11-34)66-58(75)53(61)52-43-15-6-4-12-37(43)22-23-38-13-5-7-16-44(38)52)57(74)64-46(29-35-18-24-40(68)25-19-35)54(71)63-47(30-36-20-26-41(69)27-21-36)56(73)67-50(59(76)77)31-39-33-62-45-17-9-8-14-42(39)45/h1-21,24-27,33,46-50,52-53,62,68-69H,22-23,28-32,61H2,(H2,60,70)(H,63,71)(H,64,74)(H,65,72)(H,66,75)(H,67,73)(H,76,77)/t46-,47-,48-,49-,50-,53-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 9.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity in LtK cells stably transfected with human endothelin A (ETA) receptor |
Bioorg Med Chem Lett 5: 621-626 (1995)
Article DOI: 10.1016/0960-894X(95)00084-7
BindingDB Entry DOI: 10.7270/Q27081DM |
More data for this
Ligand-Target Pair | |
Endothelin receptor type B
(Homo sapiens (Human)) | BDBM50286617
(CHEMBL414917 | bhg-F-N-Y-Y-W)Show SMILES N[C@@H](C1c2ccccc2CCc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C59H60N8O10/c60-51(70)32-49(65-55(72)48(28-34-10-2-1-3-11-34)66-58(75)53(61)52-43-15-6-4-12-37(43)22-23-38-13-5-7-16-44(38)52)57(74)64-46(29-35-18-24-40(68)25-19-35)54(71)63-47(30-36-20-26-41(69)27-21-36)56(73)67-50(59(76)77)31-39-33-62-45-17-9-8-14-42(39)45/h1-21,24-27,33,46-50,52-53,62,68-69H,22-23,28-32,61H2,(H2,60,70)(H,63,71)(H,64,74)(H,65,72)(H,66,75)(H,67,73)(H,76,77)/t46-,47-,48-,49-,50-,53-/m0/s1 | PDB
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| n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity in Chinese hamster ovary (CHO) cells stably transfected with human endothelin B (ETB) receptor |
Bioorg Med Chem Lett 5: 621-626 (1995)
Article DOI: 10.1016/0960-894X(95)00084-7
BindingDB Entry DOI: 10.7270/Q27081DM |
More data for this
Ligand-Target Pair | |
Endothelin receptor type B
(Homo sapiens (Human)) | BDBM50286615
(Ac-w-F-F-N-Y-Y-W | CHEMBL441006)Show SMILES CC(=O)[C@H](Cc1c[nH]c2ccccc12)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C63H65N9O11/c1-37(73)50(32-42-35-65-48-18-10-8-16-46(42)48)67-51(28-38-12-4-2-5-13-38)58(77)68-52(29-39-14-6-3-7-15-39)60(79)71-55(34-57(64)76)62(81)70-53(30-40-20-24-44(74)25-21-40)59(78)69-54(31-41-22-26-45(75)27-23-41)61(80)72-56(63(82)83)33-43-36-66-49-19-11-9-17-47(43)49/h2-27,35-36,50-56,65-67,74-75H,28-34H2,1H3,(H2,64,76)(H,68,77)(H,69,78)(H,70,81)(H,71,79)(H,72,80)(H,82,83)/t50-,51-,52-,53-,54-,55-,56-/m0/s1 | PDB
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| n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity in Chinese hamster ovary (CHO) cells stably transfected with human endothelin B (ETB) receptor |
Bioorg Med Chem Lett 5: 621-626 (1995)
Article DOI: 10.1016/0960-894X(95)00084-7
BindingDB Entry DOI: 10.7270/Q27081DM |
More data for this
Ligand-Target Pair | |
Endothelin receptor type B
(Homo sapiens (Human)) | BDBM50286618
(CHEMBL413880 | W-F-F-N--Y-Y-W)Show SMILES NC(=O)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C62H63N9O12/c63-55(74)33-52(70-58(77)49(28-37-13-5-2-6-14-37)67-56(75)48(27-36-11-3-1-4-12-36)66-53(61(80)81)31-40-34-64-46-17-9-7-15-44(40)46)60(79)69-50(29-38-19-23-42(72)24-20-38)57(76)68-51(30-39-21-25-43(73)26-22-39)59(78)71-54(62(82)83)32-41-35-65-47-18-10-8-16-45(41)47/h1-26,34-35,48-54,64-66,72-73H,27-33H2,(H2,63,74)(H,67,75)(H,68,76)(H,69,79)(H,70,77)(H,71,78)(H,80,81)(H,82,83)/t48-,49-,50-,51-,52-,53+,54-/m0/s1 | PDB
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| n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity in Chinese hamster ovary (CHO) cells stably transfected with human endothelin B (ETB) receptor |
Bioorg Med Chem Lett 5: 621-626 (1995)
Article DOI: 10.1016/0960-894X(95)00084-7
BindingDB Entry DOI: 10.7270/Q27081DM |
More data for this
Ligand-Target Pair | |
Endothelin receptor type B
(Homo sapiens (Human)) | BDBM50286613
(CHEMBL413825 | Cyclic (Gly1-Asp9) (Gly-Asn-Trp-His...)Show SMILES C[C@@H](O)[C@H]1NC(=O)CNC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(O)=O)NC(=O)[C@H]2CCCN2C(=O)[C@H](C)NC1=O Show InChI InChI=1S/C103H115N23O23/c1-54-102(147)126-35-15-26-83(126)100(145)123-81(91(136)110-51-87(133)115-79(44-84(104)130)98(143)120-77(41-61-48-108-70-24-13-10-21-67(61)70)97(142)121-78(43-63-50-106-53-112-63)90(135)111-52-88(134)125-89(55(2)127)101(146)113-54)46-86(132)114-76(40-60-47-107-69-23-12-9-20-66(60)69)96(141)118-72(36-56-16-5-3-6-17-56)92(137)116-73(37-57-18-7-4-8-19-57)94(139)122-80(45-85(105)131)99(144)119-74(38-58-27-31-64(128)32-28-58)93(138)117-75(39-59-29-33-65(129)34-30-59)95(140)124-82(103(148)149)42-62-49-109-71-25-14-11-22-68(62)71/h3-14,16-25,27-34,47-50,53-55,72-83,89,107-109,127-129H,15,26,35-46,51-52H2,1-2H3,(H2,104,130)(H2,105,131)(H,106,112)(H,110,136)(H,111,135)(H,113,146)(H,114,132)(H,115,133)(H,116,137)(H,117,138)(H,118,141)(H,119,144)(H,120,143)(H,121,142)(H,122,139)(H,123,145)(H,124,140)(H,125,134)(H,148,149)/t54-,55+,72-,73-,74-,75-,76-,77-,78+,79+,80-,81-,82-,83+,89+/m0/s1 | PDB
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| n/a | n/a | 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Ability to block sarafotoxin-6c (SRTX-6c) stimulated arachidonic acid release in chinese hamster ovary (CHO) cells expressing recombinant rat endothe... |
Bioorg Med Chem Lett 5: 621-626 (1995)
Article DOI: 10.1016/0960-894X(95)00084-7
BindingDB Entry DOI: 10.7270/Q27081DM |
More data for this
Ligand-Target Pair | |
Endothelin-1 receptor
(Homo sapiens (Human)) | BDBM50286621
(CHEMBL264253 | F-F-N-Y-YW)Show SMILES N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C51H54N8O10/c52-38(23-30-9-3-1-4-10-30)46(63)55-40(24-31-11-5-2-6-12-31)47(64)58-43(28-45(53)62)50(67)57-41(25-32-15-19-35(60)20-16-32)48(65)56-42(26-33-17-21-36(61)22-18-33)49(66)59-44(51(68)69)27-34-29-54-39-14-8-7-13-37(34)39/h1-22,29,38,40-44,54,60-61H,23-28,52H2,(H2,53,62)(H,55,63)(H,56,65)(H,57,67)(H,58,64)(H,59,66)(H,68,69)/t38-,40-,41-,42-,43-,44-/m0/s1 | PDB
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| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity in LtK cells stably transfected with human endothelin A (ETA) receptor |
Bioorg Med Chem Lett 5: 621-626 (1995)
Article DOI: 10.1016/0960-894X(95)00084-7
BindingDB Entry DOI: 10.7270/Q27081DM |
More data for this
Ligand-Target Pair | |
Endothelin receptor type B
(Homo sapiens (Human)) | BDBM50286621
(CHEMBL264253 | F-F-N-Y-YW)Show SMILES N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C51H54N8O10/c52-38(23-30-9-3-1-4-10-30)46(63)55-40(24-31-11-5-2-6-12-31)47(64)58-43(28-45(53)62)50(67)57-41(25-32-15-19-35(60)20-16-32)48(65)56-42(26-33-17-21-36(61)22-18-33)49(66)59-44(51(68)69)27-34-29-54-39-14-8-7-13-37(34)39/h1-22,29,38,40-44,54,60-61H,23-28,52H2,(H2,53,62)(H,55,63)(H,56,65)(H,57,67)(H,58,64)(H,59,66)(H,68,69)/t38-,40-,41-,42-,43-,44-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
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PC cid
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| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity in Chinese hamster ovary (CHO) cells stably transfected with human endothelin B (ETB) receptor |
Bioorg Med Chem Lett 5: 621-626 (1995)
Article DOI: 10.1016/0960-894X(95)00084-7
BindingDB Entry DOI: 10.7270/Q27081DM |
More data for this
Ligand-Target Pair | |
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