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Articleid 50029696

Compile data set for download or QSAR
Found 48 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50029600
PNG
(5-Bromo-2-(4-fluoro-phenyl)-3-(4-methanesulfonyl-p...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cc(Br)sc1-c1ccc(F)cc1
Show InChI InChI=1S/C17H12BrFO2S2/c1-23(20,21)14-8-4-11(5-9-14)15-10-16(18)22-17(15)12-2-6-13(19)7-3-12/h2-10H,1H3
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n/an/a 7n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 2 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50286048
PNG
(2-Bromo-3-(4-fluoro-phenyl)-4-(4-methanesulfonyl-p...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1csc(Br)c1-c1ccc(F)cc1
Show InChI InChI=1S/C17H12BrFO2S2/c1-23(20,21)14-8-4-11(5-9-14)15-10-22-17(18)16(15)12-2-6-13(19)7-3-12/h2-10H,1H3
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n/an/a 30n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 2 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50029614
PNG
((SC-57666)1-[2-(4-fluorophenyl)-1-cyclopentenyl]-4...)
Show SMILES CS(=O)(=O)c1ccc(cc1)C1=C(CCC1)c1ccc(F)cc1 |t:11|
Show InChI InChI=1S/C18H17FO2S/c1-22(20,21)16-11-7-14(8-12-16)18-4-2-3-17(18)13-5-9-15(19)10-6-13/h5-12H,2-4H2,1H3
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n/an/a 160n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 2 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50029616
PNG
(5-(4-Fluoro-phenyl)-1-(4-methanesulfonyl-phenyl)-3...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-n1nc(cc1-c1ccc(F)cc1)C(F)(F)F
Show InChI InChI=1S/C17H12F4N2O2S/c1-26(24,25)14-8-6-13(7-9-14)23-15(10-16(22-23)17(19,20)21)11-2-4-12(18)5-3-11/h2-10H,1H3
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n/an/a 200n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 2 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50076857
PNG
(5-(4-Fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-2...)
Show SMILES Cc1nc(c(s1)-c1ccc(F)cc1)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C17H14FNO2S2/c1-11-19-16(12-5-9-15(10-6-12)23(2,20)21)17(22-11)13-3-7-14(18)8-4-13/h3-10H,1-2H3
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n/an/a 310n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 2 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50076875
PNG
(4-(4-Fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-2...)
Show SMILES Cc1nc(c(s1)-c1ccc(cc1)S(C)(=O)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C17H14FNO2S2/c1-11-19-16(12-3-7-14(18)8-4-12)17(22-11)13-5-9-15(10-6-13)23(2,20)21/h3-10H,1-2H3
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n/an/a 310n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 2 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50286046
PNG
(3-(4-Fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-t...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cscc1-c1ccc(F)cc1
Show InChI InChI=1S/C17H13FO2S2/c1-22(19,20)15-8-4-13(5-9-15)17-11-21-10-16(17)12-2-6-14(18)7-3-12/h2-11H,1H3
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n/an/a 470n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 2 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))		BDBM50029600
PNG
(5-Bromo-2-(4-fluoro-phenyl)-3-(4-methanesulfonyl-p...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cc(Br)sc1-c1ccc(F)cc1
Show InChI InChI=1S/C17H12BrFO2S2/c1-23(20,21)14-8-4-11(5-9-14)15-10-16(18)22-17(15)12-2-6-13(19)7-3-12/h2-10H,1H3
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n/an/a 600n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 1 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))		BDBM50286946
PNG
(1-(4-Fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-3...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cc(nn1-c1ccc(F)cc1)C(F)(F)F
Show InChI InChI=1S/C17H12F4N2O2S/c1-26(24,25)14-8-2-11(3-9-14)15-10-16(17(19,20)21)22-23(15)13-6-4-12(18)5-7-13/h2-10H,1H3
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n/an/a>1.10E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 1 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50286946
PNG
(1-(4-Fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-3...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cc(nn1-c1ccc(F)cc1)C(F)(F)F
Show InChI InChI=1S/C17H12F4N2O2S/c1-26(24,25)14-8-2-11(3-9-14)15-10-16(17(19,20)21)22-23(15)13-6-4-12(18)5-7-13/h2-10H,1H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 2 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))		BDBM50286048
PNG
(2-Bromo-3-(4-fluoro-phenyl)-4-(4-methanesulfonyl-p...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1csc(Br)c1-c1ccc(F)cc1
Show InChI InChI=1S/C17H12BrFO2S2/c1-23(20,21)14-8-4-11(5-9-14)15-10-22-17(18)16(15)12-2-6-13(19)7-3-12/h2-10H,1H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 1 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50286940
PNG
(5-(4-Fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-i...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cnsc1-c1ccc(F)cc1
Show InChI InChI=1S/C16H12FNO2S2/c1-22(19,20)14-8-4-11(5-9-14)15-10-18-21-16(15)12-2-6-13(17)7-3-12/h2-10H,1H3
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n/an/a 2.10E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 2 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50240911
PNG
(4-(4-Fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-i...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1sncc1-c1ccc(F)cc1
Show InChI InChI=1S/C16H12FNO2S2/c1-22(19,20)14-8-4-12(5-9-14)16-15(10-18-21-16)11-2-6-13(17)7-3-11/h2-10H,1H3
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n/an/a 5.10E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 2 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50286953
PNG
(2-[3-(4-Fluoro-phenyl)-4-(4-methanesulfonyl-phenyl...)
Show SMILES CC(C)(O)c1scc(c1-c1ccc(F)cc1)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C20H19FO3S2/c1-20(2,22)19-18(14-4-8-15(21)9-5-14)17(12-25-19)13-6-10-16(11-7-13)26(3,23)24/h4-12,22H,1-3H3
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n/an/a 5.90E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 2 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50286952
PNG
(4-(4-Fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-[...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1snnc1-c1ccc(F)cc1
Show InChI InChI=1S/C15H11FN2O2S2/c1-22(19,20)13-8-4-11(5-9-13)15-14(17-18-21-15)10-2-6-12(16)7-3-10/h2-9H,1H3
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n/an/a 6.50E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 2 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50286949
PNG
(CHEMBL174009 | [4-(4-Fluoro-phenyl)-3-(4-methanesu...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1c(CC(O)=O)scc1-c1ccc(F)cc1
Show InChI InChI=1S/C19H15FO4S2/c1-26(23,24)15-8-4-13(5-9-15)19-16(11-25-17(19)10-18(21)22)12-2-6-14(20)7-3-12/h2-9,11H,10H2,1H3,(H,21,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 2 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50286947
PNG
(CHEMBL355781 | [3-(4-Fluoro-phenyl)-4-(4-methanesu...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1csc(CC(O)=O)c1-c1ccc(F)cc1
Show InChI InChI=1S/C19H15FO4S2/c1-26(23,24)15-8-4-12(5-9-15)16-11-25-17(10-18(21)22)19(16)13-2-6-14(20)7-3-13/h2-9,11H,10H2,1H3,(H,21,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 2 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50286950
PNG
(4-(4-Fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-o...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1ocnc1-c1ccc(F)cc1
Show InChI InChI=1S/C16H12FNO3S/c1-22(19,20)14-8-4-12(5-9-14)16-15(18-10-21-16)11-2-6-13(17)7-3-11/h2-10H,1H3
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n/an/a>3.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 2 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50286945
PNG
(4-(4-Methanesulfonyl-phenyl)-5-phenyl-1H-[1,2,3]tr...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1[nH]nnc1-c1ccccc1
Show InChI InChI=1S/C15H13N3O2S/c1-21(19,20)13-9-7-12(8-10-13)15-14(16-18-17-15)11-5-3-2-4-6-11/h2-10H,1H3,(H,16,17,18)
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n/an/a>3.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 2 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50286942
PNG
(5-(4-Fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-o...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1ncoc1-c1ccc(F)cc1
Show InChI InChI=1S/C16H12FNO3S/c1-22(19,20)14-8-4-11(5-9-14)15-16(21-10-18-15)12-2-6-13(17)7-3-12/h2-10H,1H3
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n/an/a>3.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 2 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50286941
PNG
(5-(3,4-Difluoro-phenyl)-1-(4-methanesulfonyl-pheny...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-n1nnnc1-c1ccc(F)c(F)c1
Show InChI InChI=1S/C14H10F2N4O2S/c1-23(21,22)11-5-3-10(4-6-11)20-14(17-18-19-20)9-2-7-12(15)13(16)8-9/h2-8H,1H3
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 2 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50286944
PNG
(2-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-b...)
Show SMILES CS(=O)(=O)c1ccc(cc1)C1=C(C2CCC1C2)c1ccc(F)cc1 |t:11,TLB:17:11:16:14.13,THB:7:10:16:14.13|
Show InChI InChI=1S/C20H19FO2S/c1-24(22,23)18-10-6-14(7-11-18)20-16-3-2-15(12-16)19(20)13-4-8-17(21)9-5-13/h4-11,15-16H,2-3,12H2,1H3
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n/an/a 3.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 2 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50286939
PNG
(1-(3,4-Difluoro-phenyl)-5-(4-methanesulfonyl-pheny...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1nnnn1-c1ccc(F)c(F)c1
Show InChI InChI=1S/C14H10F2N4O2S/c1-23(21,22)11-5-2-9(3-6-11)14-17-18-19-20(14)10-4-7-12(15)13(16)8-10/h2-8H,1H3
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 2 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50286951
PNG
(4-(4-Fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-1...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1[nH]cnc1-c1ccc(F)cc1
Show InChI InChI=1S/C16H13FN2O2S/c1-22(20,21)14-8-4-12(5-9-14)16-15(18-10-19-16)11-2-6-13(17)7-3-11/h2-10H,1H3,(H,18,19)
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 2 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50286943
PNG
(2-[4-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl...)
Show SMILES CC(C)(O)c1scc(c1-c1ccc(cc1)S(C)(=O)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C20H19FO3S2/c1-20(2,22)19-18(14-6-10-16(11-7-14)26(3,23)24)17(12-25-19)13-4-8-15(21)9-5-13/h4-12,22H,1-3H3
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 2 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50286049
PNG
(2-Bromo-4-(4-fluoro-phenyl)-3-(4-methanesulfonyl-p...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1c(Br)scc1-c1ccc(F)cc1
Show InChI InChI=1S/C17H12BrFO2S2/c1-23(20,21)14-8-4-12(5-9-14)16-15(10-22-17(16)18)11-2-6-13(19)7-3-11/h2-10H,1H3
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 2 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50286948
PNG
(4-(4-Methanesulfonyl-phenyl)-5-phenyl-[1,3]dioxol-...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1oc(=O)oc1-c1ccccc1
Show InChI InChI=1S/C16H12O5S/c1-22(18,19)13-9-7-12(8-10-13)15-14(20-16(17)21-15)11-5-3-2-4-6-11/h2-10H,1H3
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 2 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))		BDBM50286049
PNG
(2-Bromo-4-(4-fluoro-phenyl)-3-(4-methanesulfonyl-p...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1c(Br)scc1-c1ccc(F)cc1
Show InChI InChI=1S/C17H12BrFO2S2/c1-23(20,21)14-8-4-12(5-9-14)16-15(10-22-17(16)18)11-2-6-13(19)7-3-11/h2-10H,1H3
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 1 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))		BDBM50286953
PNG
(2-[3-(4-Fluoro-phenyl)-4-(4-methanesulfonyl-phenyl...)
Show SMILES CC(C)(O)c1scc(c1-c1ccc(F)cc1)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C20H19FO3S2/c1-20(2,22)19-18(14-4-8-15(21)9-5-14)17(12-25-19)13-6-10-16(11-7-13)26(3,23)24/h4-12,22H,1-3H3
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 1 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))		BDBM50286948
PNG
(4-(4-Methanesulfonyl-phenyl)-5-phenyl-[1,3]dioxol-...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1oc(=O)oc1-c1ccccc1
Show InChI InChI=1S/C16H12O5S/c1-22(18,19)13-9-7-12(8-10-13)15-14(20-16(17)21-15)11-5-3-2-4-6-11/h2-10H,1H3
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 1 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))		BDBM50286939
PNG
(1-(3,4-Difluoro-phenyl)-5-(4-methanesulfonyl-pheny...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1nnnn1-c1ccc(F)c(F)c1
Show InChI InChI=1S/C14H10F2N4O2S/c1-23(21,22)11-5-2-9(3-6-11)14-17-18-19-20(14)10-4-7-12(15)13(16)8-10/h2-8H,1H3
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 1 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))		BDBM50286947
PNG
(CHEMBL355781 | [3-(4-Fluoro-phenyl)-4-(4-methanesu...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1csc(CC(O)=O)c1-c1ccc(F)cc1
Show InChI InChI=1S/C19H15FO4S2/c1-26(23,24)15-8-4-12(5-9-15)16-11-25-17(10-18(21)22)19(16)13-2-6-14(20)7-3-13/h2-9,11H,10H2,1H3,(H,21,22)
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 1 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))		BDBM50029614
PNG
((SC-57666)1-[2-(4-fluorophenyl)-1-cyclopentenyl]-4...)
Show SMILES CS(=O)(=O)c1ccc(cc1)C1=C(CCC1)c1ccc(F)cc1 |t:11|
Show InChI InChI=1S/C18H17FO2S/c1-22(20,21)16-11-7-14(8-12-16)18-4-2-3-17(18)13-5-9-15(19)10-6-13/h5-12H,2-4H2,1H3
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 1 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))		BDBM50029616
PNG
(5-(4-Fluoro-phenyl)-1-(4-methanesulfonyl-phenyl)-3...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-n1nc(cc1-c1ccc(F)cc1)C(F)(F)F
Show InChI InChI=1S/C17H12F4N2O2S/c1-26(24,25)14-8-6-13(7-9-14)23-15(10-16(22-23)17(19,20)21)11-2-4-12(18)5-3-11/h2-10H,1H3
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 1 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))		BDBM50286949
PNG
(CHEMBL174009 | [4-(4-Fluoro-phenyl)-3-(4-methanesu...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1c(CC(O)=O)scc1-c1ccc(F)cc1
Show InChI InChI=1S/C19H15FO4S2/c1-26(23,24)15-8-4-13(5-9-15)19-16(11-25-17(19)10-18(21)22)12-2-6-14(20)7-3-12/h2-9,11H,10H2,1H3,(H,21,22)
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 1 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))		BDBM50286945
PNG
(4-(4-Methanesulfonyl-phenyl)-5-phenyl-1H-[1,2,3]tr...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1[nH]nnc1-c1ccccc1
Show InChI InChI=1S/C15H13N3O2S/c1-21(19,20)13-9-7-12(8-10-13)15-14(16-18-17-15)11-5-3-2-4-6-11/h2-10H,1H3,(H,16,17,18)
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 1 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))		BDBM50286943
PNG
(2-[4-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl...)
Show SMILES CC(C)(O)c1scc(c1-c1ccc(cc1)S(C)(=O)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C20H19FO3S2/c1-20(2,22)19-18(14-6-10-16(11-7-14)26(3,23)24)17(12-25-19)13-4-8-15(21)9-5-13/h4-12,22H,1-3H3
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 1 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))		BDBM50286944
PNG
(2-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-b...)
Show SMILES CS(=O)(=O)c1ccc(cc1)C1=C(C2CCC1C2)c1ccc(F)cc1 |t:11,TLB:17:11:16:14.13,THB:7:10:16:14.13|
Show InChI InChI=1S/C20H19FO2S/c1-24(22,23)18-10-6-14(7-11-18)20-16-3-2-15(12-16)19(20)13-4-8-17(21)9-5-13/h4-11,15-16H,2-3,12H2,1H3
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 1 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))		BDBM50286046
PNG
(3-(4-Fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-t...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cscc1-c1ccc(F)cc1
Show InChI InChI=1S/C17H13FO2S2/c1-22(19,20)15-8-4-13(5-9-15)17-11-21-10-16(17)12-2-6-14(18)7-3-12/h2-11H,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 1 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))		BDBM50286942
PNG
(5-(4-Fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-o...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1ncoc1-c1ccc(F)cc1
Show InChI InChI=1S/C16H12FNO3S/c1-22(19,20)14-8-4-11(5-9-14)15-16(21-10-18-15)12-2-6-13(17)7-3-12/h2-10H,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 1 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))		BDBM50076875
PNG
(4-(4-Fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-2...)
Show SMILES Cc1nc(c(s1)-c1ccc(cc1)S(C)(=O)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C17H14FNO2S2/c1-11-19-16(12-3-7-14(18)8-4-12)17(22-11)13-5-9-15(10-6-13)23(2,20)21/h3-10H,1-2H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 1 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))		BDBM50076857
PNG
(5-(4-Fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-2...)
Show SMILES Cc1nc(c(s1)-c1ccc(F)cc1)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C17H14FNO2S2/c1-11-19-16(12-5-9-15(10-6-12)23(2,20)21)17(22-11)13-3-7-14(18)8-4-13/h3-10H,1-2H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 1 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))		BDBM50286950
PNG
(4-(4-Fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-o...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1ocnc1-c1ccc(F)cc1
Show InChI InChI=1S/C16H12FNO3S/c1-22(19,20)14-8-4-12(5-9-14)16-15(18-10-21-16)11-2-6-13(17)7-3-11/h2-10H,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 1 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))		BDBM50286940
PNG
(5-(4-Fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-i...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cnsc1-c1ccc(F)cc1
Show InChI InChI=1S/C16H12FNO2S2/c1-22(19,20)14-8-4-11(5-9-14)15-10-18-21-16(15)12-2-6-13(17)7-3-12/h2-10H,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 1 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))		BDBM50240911
PNG
(4-(4-Fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-i...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1sncc1-c1ccc(F)cc1
Show InChI InChI=1S/C16H12FNO2S2/c1-22(19,20)14-8-4-12(5-9-14)16-15(10-18-21-16)11-2-6-13(17)7-3-11/h2-10H,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 1 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))		BDBM50286951
PNG
(4-(4-Fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-1...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1[nH]cnc1-c1ccc(F)cc1
Show InChI InChI=1S/C16H13FN2O2S/c1-22(20,21)14-8-4-12(5-9-14)16-15(18-10-19-16)11-2-6-13(17)7-3-11/h2-10H,1H3,(H,18,19)
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n/an/a>1.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 1 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))		BDBM50286941
PNG
(5-(3,4-Difluoro-phenyl)-1-(4-methanesulfonyl-pheny...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-n1nnnc1-c1ccc(F)c(F)c1
Show InChI InChI=1S/C14H10F2N4O2S/c1-23(21,22)11-5-3-10(4-6-11)20-14(17-18-19-20)9-2-7-12(15)13(16)8-9/h2-8H,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 1 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Homo sapiens (Human))		BDBM50286952
PNG
(4-(4-Fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-[...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1snnc1-c1ccc(F)cc1
Show InChI InChI=1S/C15H11FN2O2S2/c1-22(19,20)13-8-4-11(5-9-13)15-14(17-18-21-15)10-2-6-12(16)7-3-10/h2-9H,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 1 expressed in microsomes taken from baculovirus infected Sf...

Bioorg Med Chem Lett 6: 87-92 (1996)


Article DOI: 10.1016/0960-894X(95)00564-A
BindingDB Entry DOI: 10.7270/Q20C4VR4
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%