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Articleid 50030008

Compile data set for download or QSAR
Found 32 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50290197
PNG
((2H-Benzo[1,4]oxazin-3-yl)-{3-[4-(2-methoxy-phenyl...)
Show SMILES COc1ccccc1N1CCN(CCCNC2=Nc3ccccc3OC2)CC1 |t:17|
Show InChI InChI=1S/C22H28N4O2/c1-27-21-10-5-3-8-19(21)26-15-13-25(14-16-26)12-6-11-23-22-17-28-20-9-4-2-7-18(20)24-22/h2-5,7-10H,6,11-17H2,1H3,(H,23,24)
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Article
 3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at cloned human D4 dopamine receptor in CHO cells using [3H]-YM 09151 as radioligand

Bioorg Med Chem Lett 7: 2399-2402 (1997)


Article DOI: 10.1016/S0960-894X(97)00442-3
BindingDB Entry DOI: 10.7270/Q29K4B6M
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50290196
PNG
((2H-Benzo[1,4]oxazin-3-yl)-[3-(4-phenyl-piperazin-...)
Show SMILES C(CNC1=Nc2ccccc2OC1)CN1CCN(CC1)c1ccccc1 |t:3|
Show InChI InChI=1S/C21H26N4O/c1-2-7-18(8-3-1)25-15-13-24(14-16-25)12-6-11-22-21-17-26-20-10-5-4-9-19(20)23-21/h1-5,7-10H,6,11-17H2,(H,22,23)
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Article
 18n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at cloned human D4 dopamine receptor in CHO cells using [3H]-YM 09151 as radioligand

Bioorg Med Chem Lett 7: 2399-2402 (1997)


Article DOI: 10.1016/S0960-894X(97)00442-3
BindingDB Entry DOI: 10.7270/Q29K4B6M
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50290195
PNG
((2H-Benzo[1,4]oxazin-3-yl)-[5-(4-pyrimidin-2-yl-pi...)
Show SMILES C(CCNC1=Nc2ccccc2OC1)CCN1CCN(CC1)c1ncccn1 |t:4|
Show InChI InChI=1S/C21H28N6O/c1(4-9-22-20-17-28-19-8-3-2-7-18(19)25-20)5-12-26-13-15-27(16-14-26)21-23-10-6-11-24-21/h2-3,6-8,10-11H,1,4-5,9,12-17H2,(H,22,25)
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 19n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of 333 nM dopamine stimulated GTP binding in CHO cells expressing human D4 receptor

Bioorg Med Chem Lett 7: 2399-2402 (1997)


Article DOI: 10.1016/S0960-894X(97)00442-3
BindingDB Entry DOI: 10.7270/Q29K4B6M
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50290205
PNG
((2H-Benzo[1,4]oxazin-3-yl)-[3-(4-pyridin-2-yl-pipe...)
Show SMILES C(CNC1=Nc2ccccc2OC1)CN1CCN(CC1)c1ccccn1 |t:3|
Show InChI InChI=1S/C20H25N5O/c1-2-7-18-17(6-1)23-19(16-26-18)21-10-5-11-24-12-14-25(15-13-24)20-8-3-4-9-22-20/h1-4,6-9H,5,10-16H2,(H,21,23)
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 21n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at cloned human D4 dopamine receptor in CHO cells using [3H]-YM 09151 as radioligand

Bioorg Med Chem Lett 7: 2399-2402 (1997)


Article DOI: 10.1016/S0960-894X(97)00442-3
BindingDB Entry DOI: 10.7270/Q29K4B6M
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50290200
PNG
((2H-Benzo[1,4]oxazin-3-yl)-[5-(4-pyridin-2-yl-pipe...)
Show SMILES C(CCNC1=Nc2ccccc2OC1)CCN1CCN(CC1)c1ccccn1 |t:4|
Show InChI InChI=1S/C22H29N5O/c1(5-11-23-21-18-28-20-9-3-2-8-19(20)25-21)7-13-26-14-16-27(17-15-26)22-10-4-6-12-24-22/h2-4,6,8-10,12H,1,5,7,11,13-18H2,(H,23,25)
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 50n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at cloned human D4 dopamine receptor in CHO cells using [3H]-YM 09151 as radioligand

Bioorg Med Chem Lett 7: 2399-2402 (1997)


Article DOI: 10.1016/S0960-894X(97)00442-3
BindingDB Entry DOI: 10.7270/Q29K4B6M
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50290198
PNG
((2H-Benzo[1,4]oxazin-3-yl)-[5-(4-phenyl-piperazin-...)
Show SMILES C(CCNC1=Nc2ccccc2OC1)CCN1CCN(CC1)c1ccccc1 |t:4|
Show InChI InChI=1S/C23H30N4O/c1-3-9-20(10-4-1)27-17-15-26(16-18-27)14-8-2-7-13-24-23-19-28-22-12-6-5-11-21(22)25-23/h1,3-6,9-12H,2,7-8,13-19H2,(H,24,25)
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 52n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at cloned human D4 dopamine receptor in CHO cells using [3H]-YM 09151 as radioligand

Bioorg Med Chem Lett 7: 2399-2402 (1997)


Article DOI: 10.1016/S0960-894X(97)00442-3
BindingDB Entry DOI: 10.7270/Q29K4B6M
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50290198
PNG
((2H-Benzo[1,4]oxazin-3-yl)-[5-(4-phenyl-piperazin-...)
Show SMILES C(CCNC1=Nc2ccccc2OC1)CCN1CCN(CC1)c1ccccc1 |t:4|
Show InChI InChI=1S/C23H30N4O/c1-3-9-20(10-4-1)27-17-15-26(16-18-27)14-8-2-7-13-24-23-19-28-22-12-6-5-11-21(22)25-23/h1,3-6,9-12H,2,7-8,13-19H2,(H,24,25)
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 94n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at cloned human D2 dopamine receptor in CHO cells using [3H]-YM 09151 as radioligand

Bioorg Med Chem Lett 7: 2399-2402 (1997)


Article DOI: 10.1016/S0960-894X(97)00442-3
BindingDB Entry DOI: 10.7270/Q29K4B6M
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50290199
PNG
((2H-Benzo[1,4]oxazin-3-yl)-[3-(4-pyrimidin-2-yl-pi...)
Show SMILES C(CNC1=Nc2ccccc2OC1)CN1CCN(CC1)c1ncccn1 |t:3|
Show InChI InChI=1S/C19H24N6O/c1-2-6-17-16(5-1)23-18(15-26-17)20-9-4-10-24-11-13-25(14-12-24)19-21-7-3-8-22-19/h1-3,5-8H,4,9-15H2,(H,20,23)
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 107n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at cloned human D4 dopamine receptor in CHO cells using [3H]-YM 09151 as radioligand

Bioorg Med Chem Lett 7: 2399-2402 (1997)


Article DOI: 10.1016/S0960-894X(97)00442-3
BindingDB Entry DOI: 10.7270/Q29K4B6M
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50290203
PNG
((2H-Benzo[1,4]oxazin-3-yl)-[5-(4-quinolin-2-yl-pip...)
Show SMILES C(CCNC1=Nc2ccccc2OC1)CCN1CCN(CC1)c1ccc2ccccc2n1 |t:4|
Show InChI InChI=1S/C26H31N5O/c1(6-14-27-25-20-32-24-11-5-4-10-23(24)28-25)7-15-30-16-18-31(19-17-30)26-13-12-21-8-2-3-9-22(21)29-26/h2-5,8-13H,1,6-7,14-20H2,(H,27,28)
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 125n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at cloned human D4 dopamine receptor in CHO cells using [3H]-YM 09151 as radioligand

Bioorg Med Chem Lett 7: 2399-2402 (1997)


Article DOI: 10.1016/S0960-894X(97)00442-3
BindingDB Entry DOI: 10.7270/Q29K4B6M
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50290201
PNG
((2H-Benzo[1,4]oxazin-3-yl)-[4-(4-pyrimidin-2-yl-pi...)
Show SMILES C(CCN1CCN(CC1)c1ncccn1)CNC1=Nc2ccccc2OC1 |t:19|
Show InChI InChI=1S/C20H26N6O/c1-2-7-18-17(6-1)24-19(16-27-18)21-8-3-4-11-25-12-14-26(15-13-25)20-22-9-5-10-23-20/h1-2,5-7,9-10H,3-4,8,11-16H2,(H,21,24)
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 161n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at cloned human D4 dopamine receptor in CHO cells using [3H]-YM 09151 as radioligand

Bioorg Med Chem Lett 7: 2399-2402 (1997)


Article DOI: 10.1016/S0960-894X(97)00442-3
BindingDB Entry DOI: 10.7270/Q29K4B6M
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50290198
PNG
((2H-Benzo[1,4]oxazin-3-yl)-[5-(4-phenyl-piperazin-...)
Show SMILES C(CCNC1=Nc2ccccc2OC1)CCN1CCN(CC1)c1ccccc1 |t:4|
Show InChI InChI=1S/C23H30N4O/c1-3-9-20(10-4-1)27-17-15-26(16-18-27)14-8-2-7-13-24-23-19-28-22-12-6-5-11-21(22)25-23/h1,3-6,9-12H,2,7-8,13-19H2,(H,24,25)
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 167n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at cloned human D3 dopamine receptor in CHO cells using [3H]-YM 09151 as radioligand

Bioorg Med Chem Lett 7: 2399-2402 (1997)


Article DOI: 10.1016/S0960-894X(97)00442-3
BindingDB Entry DOI: 10.7270/Q29K4B6M
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50290202
PNG
((2H-Benzo[1,4]oxazin-3-yl)-[4-(4-phenyl-piperazin-...)
Show SMILES C(CCN1CCN(CC1)c1ccccc1)CNC1=Nc2ccccc2OC1 |t:19|
Show InChI InChI=1S/C22H28N4O/c1-2-8-19(9-3-1)26-16-14-25(15-17-26)13-7-6-12-23-22-18-27-21-11-5-4-10-20(21)24-22/h1-5,8-11H,6-7,12-18H2,(H,23,24)
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 188n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at cloned human D4 dopamine receptor in CHO cells using [3H]-YM 09151 as radioligand

Bioorg Med Chem Lett 7: 2399-2402 (1997)


Article DOI: 10.1016/S0960-894X(97)00442-3
BindingDB Entry DOI: 10.7270/Q29K4B6M
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50290197
PNG
((2H-Benzo[1,4]oxazin-3-yl)-{3-[4-(2-methoxy-phenyl...)
Show SMILES COc1ccccc1N1CCN(CCCNC2=Nc3ccccc3OC2)CC1 |t:17|
Show InChI InChI=1S/C22H28N4O2/c1-27-21-10-5-3-8-19(21)26-15-13-25(14-16-26)12-6-11-23-22-17-28-20-9-4-2-7-18(20)24-22/h2-5,7-10H,6,11-17H2,1H3,(H,23,24)
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 280n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at cloned human D2 dopamine receptor in CHO cells using [3H]-YM 09151 as radioligand

Bioorg Med Chem Lett 7: 2399-2402 (1997)


Article DOI: 10.1016/S0960-894X(97)00442-3
BindingDB Entry DOI: 10.7270/Q29K4B6M
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50290200
PNG
((2H-Benzo[1,4]oxazin-3-yl)-[5-(4-pyridin-2-yl-pipe...)
Show SMILES C(CCNC1=Nc2ccccc2OC1)CCN1CCN(CC1)c1ccccn1 |t:4|
Show InChI InChI=1S/C22H29N5O/c1(5-11-23-21-18-28-20-9-3-2-8-19(20)25-21)7-13-26-14-16-27(17-15-26)22-10-4-6-12-24-22/h2-4,6,8-10,12H,1,5,7,11,13-18H2,(H,23,25)
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 408n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at cloned human D3 dopamine receptor in CHO cells using [3H]-YM 09151 as radioligand

Bioorg Med Chem Lett 7: 2399-2402 (1997)


Article DOI: 10.1016/S0960-894X(97)00442-3
BindingDB Entry DOI: 10.7270/Q29K4B6M
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50290200
PNG
((2H-Benzo[1,4]oxazin-3-yl)-[5-(4-pyridin-2-yl-pipe...)
Show SMILES C(CCNC1=Nc2ccccc2OC1)CCN1CCN(CC1)c1ccccn1 |t:4|
Show InChI InChI=1S/C22H29N5O/c1(5-11-23-21-18-28-20-9-3-2-8-19(20)25-21)7-13-26-14-16-27(17-15-26)22-10-4-6-12-24-22/h2-4,6,8-10,12H,1,5,7,11,13-18H2,(H,23,25)
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 543n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at cloned human D2 dopamine receptor in CHO cells using [3H]-YM 09151 as radioligand

Bioorg Med Chem Lett 7: 2399-2402 (1997)


Article DOI: 10.1016/S0960-894X(97)00442-3
BindingDB Entry DOI: 10.7270/Q29K4B6M
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50290204
PNG
((2H-Benzo[1,4]oxazin-3-yl)-methyl-[4-(4-pyrimidin-...)
Show SMILES CN(CCCCN1CCN(CC1)c1ncccn1)C1=Nc2ccccc2OC1 |t:20|
Show InChI InChI=1S/C21H28N6O/c1-25(20-17-28-19-8-3-2-7-18(19)24-20)11-4-5-12-26-13-15-27(16-14-26)21-22-9-6-10-23-21/h2-3,6-10H,4-5,11-17H2,1H3
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 558n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at cloned human D4 dopamine receptor in CHO cells using [3H]-YM 09151 as radioligand

Bioorg Med Chem Lett 7: 2399-2402 (1997)


Article DOI: 10.1016/S0960-894X(97)00442-3
BindingDB Entry DOI: 10.7270/Q29K4B6M
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50290197
PNG
((2H-Benzo[1,4]oxazin-3-yl)-{3-[4-(2-methoxy-phenyl...)
Show SMILES COc1ccccc1N1CCN(CCCNC2=Nc3ccccc3OC2)CC1 |t:17|
Show InChI InChI=1S/C22H28N4O2/c1-27-21-10-5-3-8-19(21)26-15-13-25(14-16-26)12-6-11-23-22-17-28-20-9-4-2-7-18(20)24-22/h2-5,7-10H,6,11-17H2,1H3,(H,23,24)
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>1.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at cloned human D3 dopamine receptor in CHO cells using [3H]-YM 09151 as radioligand

Bioorg Med Chem Lett 7: 2399-2402 (1997)


Article DOI: 10.1016/S0960-894X(97)00442-3
BindingDB Entry DOI: 10.7270/Q29K4B6M
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50290195
PNG
((2H-Benzo[1,4]oxazin-3-yl)-[5-(4-pyrimidin-2-yl-pi...)
Show SMILES C(CCNC1=Nc2ccccc2OC1)CCN1CCN(CC1)c1ncccn1 |t:4|
Show InChI InChI=1S/C21H28N6O/c1(4-9-22-20-17-28-19-8-3-2-7-18(19)25-20)5-12-26-13-15-27(16-14-26)21-23-10-6-11-24-21/h2-3,6-8,10-11H,1,4-5,9,12-17H2,(H,22,25)
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 1.81E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at cloned human D3 dopamine receptor in CHO cells using [3H]-YM 09151 as radioligand

Bioorg Med Chem Lett 7: 2399-2402 (1997)


Article DOI: 10.1016/S0960-894X(97)00442-3
BindingDB Entry DOI: 10.7270/Q29K4B6M
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50290196
PNG
((2H-Benzo[1,4]oxazin-3-yl)-[3-(4-phenyl-piperazin-...)
Show SMILES C(CNC1=Nc2ccccc2OC1)CN1CCN(CC1)c1ccccc1 |t:3|
Show InChI InChI=1S/C21H26N4O/c1-2-7-18(8-3-1)25-15-13-24(14-16-25)12-6-11-22-21-17-26-20-10-5-4-9-19(20)23-21/h1-5,7-10H,6,11-17H2,(H,22,23)
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 2.01E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at cloned human D2 dopamine receptor in CHO cells using [3H]-YM 09151 as radioligand

Bioorg Med Chem Lett 7: 2399-2402 (1997)


Article DOI: 10.1016/S0960-894X(97)00442-3
BindingDB Entry DOI: 10.7270/Q29K4B6M
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50290195
PNG
((2H-Benzo[1,4]oxazin-3-yl)-[5-(4-pyrimidin-2-yl-pi...)
Show SMILES C(CCNC1=Nc2ccccc2OC1)CCN1CCN(CC1)c1ncccn1 |t:4|
Show InChI InChI=1S/C21H28N6O/c1(4-9-22-20-17-28-19-8-3-2-7-18(19)25-20)5-12-26-13-15-27(16-14-26)21-23-10-6-11-24-21/h2-3,6-8,10-11H,1,4-5,9,12-17H2,(H,22,25)
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 2.54E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at cloned human D2 dopamine receptor in CHO cells using [3H]-YM 09151 as radioligand

Bioorg Med Chem Lett 7: 2399-2402 (1997)


Article DOI: 10.1016/S0960-894X(97)00442-3
BindingDB Entry DOI: 10.7270/Q29K4B6M
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50290202
PNG
((2H-Benzo[1,4]oxazin-3-yl)-[4-(4-phenyl-piperazin-...)
Show SMILES C(CCN1CCN(CC1)c1ccccc1)CNC1=Nc2ccccc2OC1 |t:19|
Show InChI InChI=1S/C22H28N4O/c1-2-8-19(9-3-1)26-16-14-25(15-17-26)13-7-6-12-23-22-18-27-21-11-5-4-10-20(21)24-22/h1-5,8-11H,6-7,12-18H2,(H,23,24)
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 2.75E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at cloned human D2 dopamine receptor in CHO cells using [3H]-YM 09151 as radioligand

Bioorg Med Chem Lett 7: 2399-2402 (1997)


Article DOI: 10.1016/S0960-894X(97)00442-3
BindingDB Entry DOI: 10.7270/Q29K4B6M
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50290196
PNG
((2H-Benzo[1,4]oxazin-3-yl)-[3-(4-phenyl-piperazin-...)
Show SMILES C(CNC1=Nc2ccccc2OC1)CN1CCN(CC1)c1ccccc1 |t:3|
Show InChI InChI=1S/C21H26N4O/c1-2-7-18(8-3-1)25-15-13-24(14-16-25)12-6-11-22-21-17-26-20-10-5-4-9-19(20)23-21/h1-5,7-10H,6,11-17H2,(H,22,23)
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 3.44E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at cloned human D3 dopamine receptor in CHO cells using [3H]-YM 09151 as radioligand

Bioorg Med Chem Lett 7: 2399-2402 (1997)


Article DOI: 10.1016/S0960-894X(97)00442-3
BindingDB Entry DOI: 10.7270/Q29K4B6M
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50290205
PNG
((2H-Benzo[1,4]oxazin-3-yl)-[3-(4-pyridin-2-yl-pipe...)
Show SMILES C(CNC1=Nc2ccccc2OC1)CN1CCN(CC1)c1ccccn1 |t:3|
Show InChI InChI=1S/C20H25N5O/c1-2-7-18-17(6-1)23-19(16-26-18)21-10-5-11-24-12-14-25(15-13-24)20-8-3-4-9-22-20/h1-4,6-9H,5,10-16H2,(H,21,23)
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>4.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at cloned human D2 dopamine receptor in CHO cells using [3H]-YM 09151 as radioligand

Bioorg Med Chem Lett 7: 2399-2402 (1997)


Article DOI: 10.1016/S0960-894X(97)00442-3
BindingDB Entry DOI: 10.7270/Q29K4B6M
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50290202
PNG
((2H-Benzo[1,4]oxazin-3-yl)-[4-(4-phenyl-piperazin-...)
Show SMILES C(CCN1CCN(CC1)c1ccccc1)CNC1=Nc2ccccc2OC1 |t:19|
Show InChI InChI=1S/C22H28N4O/c1-2-8-19(9-3-1)26-16-14-25(15-17-26)13-7-6-12-23-22-18-27-21-11-5-4-10-20(21)24-22/h1-5,8-11H,6-7,12-18H2,(H,23,24)
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>4.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at cloned human D3 dopamine receptor in CHO cells using [3H]-YM 09151 as radioligand

Bioorg Med Chem Lett 7: 2399-2402 (1997)


Article DOI: 10.1016/S0960-894X(97)00442-3
BindingDB Entry DOI: 10.7270/Q29K4B6M
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50290199
PNG
((2H-Benzo[1,4]oxazin-3-yl)-[3-(4-pyrimidin-2-yl-pi...)
Show SMILES C(CNC1=Nc2ccccc2OC1)CN1CCN(CC1)c1ncccn1 |t:3|
Show InChI InChI=1S/C19H24N6O/c1-2-6-17-16(5-1)23-18(15-26-17)20-9-4-10-24-11-13-25(14-12-24)19-21-7-3-8-22-19/h1-3,5-8H,4,9-15H2,(H,20,23)
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>4.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at cloned human D2 dopamine receptor in CHO cells using [3H]-YM 09151 as radioligand

Bioorg Med Chem Lett 7: 2399-2402 (1997)


Article DOI: 10.1016/S0960-894X(97)00442-3
BindingDB Entry DOI: 10.7270/Q29K4B6M
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50290201
PNG
((2H-Benzo[1,4]oxazin-3-yl)-[4-(4-pyrimidin-2-yl-pi...)
Show SMILES C(CCN1CCN(CC1)c1ncccn1)CNC1=Nc2ccccc2OC1 |t:19|
Show InChI InChI=1S/C20H26N6O/c1-2-7-18-17(6-1)24-19(16-27-18)21-8-3-4-11-25-12-14-26(15-13-25)20-22-9-5-10-23-20/h1-2,5-7,9-10H,3-4,8,11-16H2,(H,21,24)
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>4.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at cloned human D2 dopamine receptor in CHO cells using [3H]-YM 09151 as radioligand

Bioorg Med Chem Lett 7: 2399-2402 (1997)


Article DOI: 10.1016/S0960-894X(97)00442-3
BindingDB Entry DOI: 10.7270/Q29K4B6M
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50290205
PNG
((2H-Benzo[1,4]oxazin-3-yl)-[3-(4-pyridin-2-yl-pipe...)
Show SMILES C(CNC1=Nc2ccccc2OC1)CN1CCN(CC1)c1ccccn1 |t:3|
Show InChI InChI=1S/C20H25N5O/c1-2-7-18-17(6-1)23-19(16-26-18)21-10-5-11-24-12-14-25(15-13-24)20-8-3-4-9-22-20/h1-4,6-9H,5,10-16H2,(H,21,23)
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>7.90E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at cloned human D3 dopamine receptor in CHO cells using [3H]-YM 09151 as radioligand

Bioorg Med Chem Lett 7: 2399-2402 (1997)


Article DOI: 10.1016/S0960-894X(97)00442-3
BindingDB Entry DOI: 10.7270/Q29K4B6M
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50290201
PNG
((2H-Benzo[1,4]oxazin-3-yl)-[4-(4-pyrimidin-2-yl-pi...)
Show SMILES C(CCN1CCN(CC1)c1ncccn1)CNC1=Nc2ccccc2OC1 |t:19|
Show InChI InChI=1S/C20H26N6O/c1-2-7-18-17(6-1)24-19(16-27-18)21-8-3-4-11-25-12-14-26(15-13-25)20-22-9-5-10-23-20/h1-2,5-7,9-10H,3-4,8,11-16H2,(H,21,24)
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>7.90E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at cloned human D3 dopamine receptor in CHO cells using [3H]-YM 09151 as radioligand

Bioorg Med Chem Lett 7: 2399-2402 (1997)


Article DOI: 10.1016/S0960-894X(97)00442-3
BindingDB Entry DOI: 10.7270/Q29K4B6M
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50290199
PNG
((2H-Benzo[1,4]oxazin-3-yl)-[3-(4-pyrimidin-2-yl-pi...)
Show SMILES C(CNC1=Nc2ccccc2OC1)CN1CCN(CC1)c1ncccn1 |t:3|
Show InChI InChI=1S/C19H24N6O/c1-2-6-17-16(5-1)23-18(15-26-17)20-9-4-10-24-11-13-25(14-12-24)19-21-7-3-8-22-19/h1-3,5-8H,4,9-15H2,(H,20,23)
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>7.90E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at cloned human D3 dopamine receptor in CHO cells using [3H]-YM 09151 as radioligand

Bioorg Med Chem Lett 7: 2399-2402 (1997)


Article DOI: 10.1016/S0960-894X(97)00442-3
BindingDB Entry DOI: 10.7270/Q29K4B6M
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50290205
PNG
((2H-Benzo[1,4]oxazin-3-yl)-[3-(4-pyridin-2-yl-pipe...)
Show SMILES C(CNC1=Nc2ccccc2OC1)CN1CCN(CC1)c1ccccn1 |t:3|
Show InChI InChI=1S/C20H25N5O/c1-2-7-18-17(6-1)23-19(16-26-18)21-10-5-11-24-12-14-25(15-13-24)20-8-3-4-9-22-20/h1-4,6-9H,5,10-16H2,(H,21,23)
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n/an/a 27n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at cloned human D4 dopamine receptor in CHO cells using [3H]-YM 09151 as radioligand

Bioorg Med Chem Lett 7: 2399-2402 (1997)


Article DOI: 10.1016/S0960-894X(97)00442-3
BindingDB Entry DOI: 10.7270/Q29K4B6M
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50290195
PNG
((2H-Benzo[1,4]oxazin-3-yl)-[5-(4-pyrimidin-2-yl-pi...)
Show SMILES C(CCNC1=Nc2ccccc2OC1)CCN1CCN(CC1)c1ncccn1 |t:4|
Show InChI InChI=1S/C21H28N6O/c1(4-9-22-20-17-28-19-8-3-2-7-18(19)25-20)5-12-26-13-15-27(16-14-26)21-23-10-6-11-24-21/h2-3,6-8,10-11H,1,4-5,9,12-17H2,(H,22,25)
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n/an/a 95n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of 333 nM dopamine stimulated GTP binding in CHO cells expressing human D4 receptor

Bioorg Med Chem Lett 7: 2399-2402 (1997)


Article DOI: 10.1016/S0960-894X(97)00442-3
BindingDB Entry DOI: 10.7270/Q29K4B6M
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50290196
PNG
((2H-Benzo[1,4]oxazin-3-yl)-[3-(4-phenyl-piperazin-...)
Show SMILES C(CNC1=Nc2ccccc2OC1)CN1CCN(CC1)c1ccccc1 |t:3|
Show InChI InChI=1S/C21H26N4O/c1-2-7-18(8-3-1)25-15-13-24(14-16-25)12-6-11-22-21-17-26-20-10-5-4-9-19(20)23-21/h1-5,7-10H,6,11-17H2,(H,22,23)
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n/an/a 95n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of 333 nM dopamine stimulated GTP binding in CHO cells expressing human D4 receptor

Bioorg Med Chem Lett 7: 2399-2402 (1997)


Article DOI: 10.1016/S0960-894X(97)00442-3
BindingDB Entry DOI: 10.7270/Q29K4B6M
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%