Found 6 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Glutamine--tRNA ligase
(Homo sapiens (Human)) | BDBM50290175
(4-ammonio-5-{[(2R,4S,6S)-4-hydroxy-6-(hydroxymethy...)Show SMILES [NH3+]C(CCC([O-])=O)C(=O)OC[C@H]1C[C@@H](O)C[C@@H](CO)N1 Show InChI InChI=1S/C12H22N2O6/c13-10(1-2-11(17)18)12(19)20-6-8-4-9(16)3-7(5-15)14-8/h7-10,14-16H,1-6,13H2,(H,17,18)/t7-,8+,9-,10?/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
| 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound was tested for the inhibition of Escherichia coli glutamyl-t-RNA synthetase |
Bioorg Med Chem Lett 7: 2363-2366 (1997)
Article DOI: 10.1016/S0960-894X(97)00434-4
BindingDB Entry DOI: 10.7270/Q2CN74D8 |
More data for this
Ligand-Target Pair | |
Tyrosine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM20461
((6E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methy...)Show InChI InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
KEGG
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
| 4.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound was tested for the inhibition of aminoacyl tRNA Synthetase |
Bioorg Med Chem Lett 7: 2363-2366 (1997)
Article DOI: 10.1016/S0960-894X(97)00434-4
BindingDB Entry DOI: 10.7270/Q2CN74D8 |
More data for this
Ligand-Target Pair | |
Glutamine--tRNA ligase
(Homo sapiens (Human)) | BDBM50290174
(4-ammonio-5-{[(2R,6S)-6-(hydroxymethyl)piperidin-2...)Show SMILES [NH3+]C(CCC([O-])=O)C(=O)OC[C@H]1CCC[C@@H](CO)N1 Show InChI InChI=1S/C12H22N2O5/c13-10(4-5-11(16)17)12(18)19-7-9-3-1-2-8(6-15)14-9/h8-10,14-15H,1-7,13H2,(H,16,17)/t8-,9+,10?/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
| 2.30E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound was tested for the inhibition of Escherichia coli glutamyl-t-RNA synthetase |
Bioorg Med Chem Lett 7: 2363-2366 (1997)
Article DOI: 10.1016/S0960-894X(97)00434-4
BindingDB Entry DOI: 10.7270/Q2CN74D8 |
More data for this
Ligand-Target Pair | |
Glutamine--tRNA ligase
(Homo sapiens (Human)) | BDBM50403640
(CHEMBL2115178)Show InChI InChI=1S/C10H18N2O4/c11-8(3-4-9(13)14)10(15)16-6-7-2-1-5-12-7/h7-8,12H,1-6,11H2,(H,13,14)/t7-,8?/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
| 3.80E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound was tested for the inhibition of Escherichia coli glutamyl-t-RNA synthetase |
Bioorg Med Chem Lett 7: 2363-2366 (1997)
Article DOI: 10.1016/S0960-894X(97)00434-4
BindingDB Entry DOI: 10.7270/Q2CN74D8 |
More data for this
Ligand-Target Pair | |
Glutamine--tRNA ligase
(Homo sapiens (Human)) | BDBM50366478
(CHEMBL609498)Show SMILES NC(CCC(O)=O)C(=O)OC[C@H]1OC(O)[C@H](O)[C@@H]1O |r| Show InChI InChI=1S/C10H17NO8/c11-4(1-2-6(12)13)9(16)18-3-5-7(14)8(15)10(17)19-5/h4-5,7-8,10,14-15,17H,1-3,11H2,(H,12,13)/t4?,5-,7-,8-,10?/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
| 5.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound was tested for the inhibition of Escherichia coli glutamyl-t-RNA synthetase |
Bioorg Med Chem Lett 7: 2363-2366 (1997)
Article DOI: 10.1016/S0960-894X(97)00434-4
BindingDB Entry DOI: 10.7270/Q2CN74D8 |
More data for this
Ligand-Target Pair | |
Glutamine--tRNA ligase
(Homo sapiens (Human)) | BDBM50403639
(CHEMBL2114154)Show InChI InChI=1S/C10H18N2O4/c11-8(3-4-9(13)14)10(15)16-6-7-2-1-5-12-7/h7-8,12H,1-6,11H2,(H,13,14)/t7-,8?/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
| 1.14E+7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound was tested for the inhibition of Escherichia coli glutamyl-t-RNA synthetase |
Bioorg Med Chem Lett 7: 2363-2366 (1997)
Article DOI: 10.1016/S0960-894X(97)00434-4
BindingDB Entry DOI: 10.7270/Q2CN74D8 |
More data for this
Ligand-Target Pair | |
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