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PubMed code 592342

Compile data set for download or QSAR
Found 45 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50009725
PNG
(CHEMBL3246892)
Show SMILES CC(CCc1ccc(cc1)-c1ccccc1)CC(O)=O
Show InChI InChI=1S/C18H20O2/c1-14(13-18(19)20)7-8-15-9-11-17(12-10-15)16-5-3-2-4-6-16/h2-6,9-12,14H,7-8,13H2,1H3,(H,19,20)
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n/an/a 2.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of nonsaponifiable lipid synthesis using [2-14C]ac...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50009739
PNG
(CHEMBL3246905)
Show SMILES CC(CCc1ccc2CCc3ccccc3-c2c1)CC(O)=O
Show InChI InChI=1S/C20H22O2/c1-14(12-20(21)22)6-7-15-8-9-17-11-10-16-4-2-3-5-18(16)19(17)13-15/h2-5,8-9,13-14H,6-7,10-12H2,1H3,(H,21,22)
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n/an/a 1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of nonsaponifiable lipid synthesis using [2-14C]ac...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50009733
PNG
(CHEMBL3246899)
Show SMILES CC(CCc1ccc(Oc2ccccc2)cc1)CC(O)=O
Show InChI InChI=1S/C18H20O3/c1-14(13-18(19)20)7-8-15-9-11-17(12-10-15)21-16-5-3-2-4-6-16/h2-6,9-12,14H,7-8,13H2,1H3,(H,19,20)
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n/an/a 2.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of nonsaponifiable lipid synthesis using [2-14C]ac...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50009725
PNG
(CHEMBL3246892)
Show SMILES CC(CCc1ccc(cc1)-c1ccccc1)CC(O)=O
Show InChI InChI=1S/C18H20O2/c1-14(13-18(19)20)7-8-15-9-11-17(12-10-15)16-5-3-2-4-6-16/h2-6,9-12,14H,7-8,13H2,1H3,(H,19,20)
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n/an/a 2.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of total lipid synthesis using [2-14C]acetate as s...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50009734
PNG
(CHEMBL3246900)
Show SMILES CC(CCc1ccc(Sc2ccccc2)cc1)CC(O)=O
Show InChI InChI=1S/C18H20O2S/c1-14(13-18(19)20)7-8-15-9-11-17(12-10-15)21-16-5-3-2-4-6-16/h2-6,9-12,14H,7-8,13H2,1H3,(H,19,20)
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n/an/a 2.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of nonsaponifiable lipid synthesis using [2-14C]ac...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50009738
PNG
(CHEMBL3246904)
Show SMILES CC(CCc1ccc2c(c1)-c1ccccc1S2(=O)=O)CC(O)=O
Show InChI InChI=1S/C18H18O4S/c1-12(10-18(19)20)6-7-13-8-9-17-15(11-13)14-4-2-3-5-16(14)23(17,21)22/h2-5,8-9,11-12H,6-7,10H2,1H3,(H,19,20)
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n/an/a 3.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of fatty acid synthesis using [2-14C]acetate as su...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50009739
PNG
(CHEMBL3246905)
Show SMILES CC(CCc1ccc2CCc3ccccc3-c2c1)CC(O)=O
Show InChI InChI=1S/C20H22O2/c1-14(12-20(21)22)6-7-15-8-9-17-11-10-16-4-2-3-5-18(16)19(17)13-15/h2-5,8-9,13-14H,6-7,10-12H2,1H3,(H,21,22)
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n/an/a 3.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of total lipid synthesis using [2-14C]acetate as s...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50009732
PNG
(CHEMBL3246898)
Show SMILES CC(CC(O)=O)CC(=O)c1ccc2CCc3ccccc3-c2c1
Show InChI InChI=1S/C20H20O3/c1-13(11-20(22)23)10-19(21)16-9-8-15-7-6-14-4-2-3-5-17(14)18(15)12-16/h2-5,8-9,12-13H,6-7,10-11H2,1H3,(H,22,23)
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n/an/a 3.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of nonsaponifiable lipid synthesis using [2-14C]ac...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50009733
PNG
(CHEMBL3246899)
Show SMILES CC(CCc1ccc(Oc2ccccc2)cc1)CC(O)=O
Show InChI InChI=1S/C18H20O3/c1-14(13-18(19)20)7-8-15-9-11-17(12-10-15)21-16-5-3-2-4-6-16/h2-6,9-12,14H,7-8,13H2,1H3,(H,19,20)
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n/an/a 3.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of total lipid synthesis using [2-14C]acetate as s...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50009735
PNG
(CHEMBL3246901)
Show SMILES CC(CCc1ccc(cc1)S(=O)(=O)c1ccccc1)CC(O)=O
Show InChI InChI=1S/C18H20O4S/c1-14(13-18(19)20)7-8-15-9-11-17(12-10-15)23(21,22)16-5-3-2-4-6-16/h2-6,9-12,14H,7-8,13H2,1H3,(H,19,20)
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n/an/a 4.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of nonsaponifiable lipid synthesis using [2-14C]ac...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50009734
PNG
(CHEMBL3246900)
Show SMILES CC(CCc1ccc(Sc2ccccc2)cc1)CC(O)=O
Show InChI InChI=1S/C18H20O2S/c1-14(13-18(19)20)7-8-15-9-11-17(12-10-15)21-16-5-3-2-4-6-16/h2-6,9-12,14H,7-8,13H2,1H3,(H,19,20)
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n/an/a 4.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of total lipid synthesis using [2-14C]acetate as s...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50009738
PNG
(CHEMBL3246904)
Show SMILES CC(CCc1ccc2c(c1)-c1ccccc1S2(=O)=O)CC(O)=O
Show InChI InChI=1S/C18H18O4S/c1-12(10-18(19)20)6-7-13-8-9-17-15(11-13)14-4-2-3-5-16(14)23(17,21)22/h2-5,8-9,11-12H,6-7,10H2,1H3,(H,19,20)
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n/an/a 5.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of total lipid synthesis using [2-14C]acetate as s...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50009732
PNG
(CHEMBL3246898)
Show SMILES CC(CC(O)=O)CC(=O)c1ccc2CCc3ccccc3-c2c1
Show InChI InChI=1S/C20H20O3/c1-13(11-20(22)23)10-19(21)16-9-8-15-7-6-14-4-2-3-5-17(14)18(15)12-16/h2-5,8-9,12-13H,6-7,10-11H2,1H3,(H,22,23)
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n/an/a 6.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of total lipid synthesis using [2-14C]acetate as s...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50009726
PNG
(CHEMBL3246893)
Show SMILES CC(CC(O)=O)CC(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C18H18O3/c1-13(12-18(20)21)11-17(19)16-9-7-15(8-10-16)14-5-3-2-4-6-14/h2-10,13H,11-12H2,1H3,(H,20,21)
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n/an/a 7.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of nonsaponifiable lipid synthesis using [2-14C]ac...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50009737
PNG
(CHEMBL3246903)
Show SMILES CC(CCc1ccc2sc3ccccc3c2c1)CC(O)=O
Show InChI InChI=1S/C18H18O2S/c1-12(10-18(19)20)6-7-13-8-9-17-15(11-13)14-4-2-3-5-16(14)21-17/h2-5,8-9,11-12H,6-7,10H2,1H3,(H,19,20)
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n/an/a 7.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of nonsaponifiable lipid synthesis using [2-14C]ac...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50009735
PNG
(CHEMBL3246901)
Show SMILES CC(CCc1ccc(cc1)S(=O)(=O)c1ccccc1)CC(O)=O
Show InChI InChI=1S/C18H20O4S/c1-14(13-18(19)20)7-8-15-9-11-17(12-10-15)23(21,22)16-5-3-2-4-6-16/h2-6,9-12,14H,7-8,13H2,1H3,(H,19,20)
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n/an/a 7.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of total lipid synthesis using [2-14C]acetate as s...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50009738
PNG
(CHEMBL3246904)
Show SMILES CC(CCc1ccc2c(c1)-c1ccccc1S2(=O)=O)CC(O)=O
Show InChI InChI=1S/C18H18O4S/c1-12(10-18(19)20)6-7-13-8-9-17-15(11-13)14-4-2-3-5-16(14)23(17,21)22/h2-5,8-9,11-12H,6-7,10H2,1H3,(H,19,20)
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n/an/a 8.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of nonsaponifiable lipid synthesis using [2-14C]ac...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50009735
PNG
(CHEMBL3246901)
Show SMILES CC(CCc1ccc(cc1)S(=O)(=O)c1ccccc1)CC(O)=O
Show InChI InChI=1S/C18H20O4S/c1-14(13-18(19)20)7-8-15-9-11-17(12-10-15)23(21,22)16-5-3-2-4-6-16/h2-6,9-12,14H,7-8,13H2,1H3,(H,19,20)
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n/an/a 8.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of fatty acid synthesis using [2-14C]acetate as su...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50009733
PNG
(CHEMBL3246899)
Show SMILES CC(CCc1ccc(Oc2ccccc2)cc1)CC(O)=O
Show InChI InChI=1S/C18H20O3/c1-14(13-18(19)20)7-8-15-9-11-17(12-10-15)21-16-5-3-2-4-6-16/h2-6,9-12,14H,7-8,13H2,1H3,(H,19,20)
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n/an/a 8.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of fatty acid synthesis using [2-14C]acetate as su...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50009725
PNG
(CHEMBL3246892)
Show SMILES CC(CCc1ccc(cc1)-c1ccccc1)CC(O)=O
Show InChI InChI=1S/C18H20O2/c1-14(13-18(19)20)7-8-15-9-11-17(12-10-15)16-5-3-2-4-6-16/h2-6,9-12,14H,7-8,13H2,1H3,(H,19,20)
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n/an/a 8.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of fatty acid synthesis using [2-14C]acetate as su...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50009732
PNG
(CHEMBL3246898)
Show SMILES CC(CC(O)=O)CC(=O)c1ccc2CCc3ccccc3-c2c1
Show InChI InChI=1S/C20H20O3/c1-13(11-20(22)23)10-19(21)16-9-8-15-7-6-14-4-2-3-5-17(14)18(15)12-16/h2-5,8-9,12-13H,6-7,10-11H2,1H3,(H,22,23)
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n/an/a 9.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of fatty acid synthesis using [2-14C]acetate as su...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50009734
PNG
(CHEMBL3246900)
Show SMILES CC(CCc1ccc(Sc2ccccc2)cc1)CC(O)=O
Show InChI InChI=1S/C18H20O2S/c1-14(13-18(19)20)7-8-15-9-11-17(12-10-15)21-16-5-3-2-4-6-16/h2-6,9-12,14H,7-8,13H2,1H3,(H,19,20)
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n/an/a 1.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of fatty acid synthesis using [2-14C]acetate as su...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50009729
PNG
(CHEMBL3246896)
Show SMILES CC(CC(O)=O)CC(=O)c1ccc2oc3ccccc3c2c1
Show InChI InChI=1S/C18H16O4/c1-11(9-18(20)21)8-15(19)12-6-7-17-14(10-12)13-4-2-3-5-16(13)22-17/h2-7,10-11H,8-9H2,1H3,(H,20,21)
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n/an/a 1.10E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of nonsaponifiable lipid synthesis using [2-14C]ac...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50009731
PNG
(CHEMBL3246897)
Show SMILES CC(CC(O)=O)CC(=O)c1ccc2sc3ccccc3c2c1
Show InChI InChI=1S/C18H16O3S/c1-11(9-18(20)21)8-15(19)12-6-7-17-14(10-12)13-4-2-3-5-16(13)22-17/h2-7,10-11H,8-9H2,1H3,(H,20,21)
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n/an/a 1.60E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of nonsaponifiable lipid synthesis using [2-14C]ac...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50009726
PNG
(CHEMBL3246893)
Show SMILES CC(CC(O)=O)CC(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C18H18O3/c1-13(12-18(20)21)11-17(19)16-9-7-15(8-10-16)14-5-3-2-4-6-14/h2-10,13H,11-12H2,1H3,(H,20,21)
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n/an/a 1.80E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of total lipid synthesis using [2-14C]acetate as s...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50009737
PNG
(CHEMBL3246903)
Show SMILES CC(CCc1ccc2sc3ccccc3c2c1)CC(O)=O
Show InChI InChI=1S/C18H18O2S/c1-12(10-18(19)20)6-7-13-8-9-17-15(11-13)14-4-2-3-5-16(14)21-17/h2-5,8-9,11-12H,6-7,10H2,1H3,(H,19,20)
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n/an/a 1.90E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of total lipid synthesis using [2-14C]acetate as s...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50009728
PNG
(CHEMBL3246895)
Show SMILES CC(CC(O)=O)CC(=O)c1ccc(Sc2ccccc2)cc1
Show InChI InChI=1S/C18H18O3S/c1-13(12-18(20)21)11-17(19)14-7-9-16(10-8-14)22-15-5-3-2-4-6-15/h2-10,13H,11-12H2,1H3,(H,20,21)
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n/an/a 2.40E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of nonsaponifiable lipid synthesis using [2-14C]ac...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50009729
PNG
(CHEMBL3246896)
Show SMILES CC(CC(O)=O)CC(=O)c1ccc2oc3ccccc3c2c1
Show InChI InChI=1S/C18H16O4/c1-11(9-18(20)21)8-15(19)12-6-7-17-14(10-12)13-4-2-3-5-16(13)22-17/h2-7,10-11H,8-9H2,1H3,(H,20,21)
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n/an/a 2.60E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of total lipid synthesis using [2-14C]acetate as s...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50009739
PNG
(CHEMBL3246905)
Show SMILES CC(CCc1ccc2CCc3ccccc3-c2c1)CC(O)=O
Show InChI InChI=1S/C20H22O2/c1-14(12-20(21)22)6-7-15-8-9-17-11-10-16-4-2-3-5-18(16)19(17)13-15/h2-5,8-9,13-14H,6-7,10-12H2,1H3,(H,21,22)
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n/an/a 2.70E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of fatty acid synthesis using [2-14C]acetate as su...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50009727
PNG
(CHEMBL3246894)
Show SMILES CC(CC(O)=O)CC(=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C18H18O4/c1-13(12-18(20)21)11-17(19)14-7-9-16(10-8-14)22-15-5-3-2-4-6-15/h2-10,13H,11-12H2,1H3,(H,20,21)
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n/an/a 2.90E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of nonsaponifiable lipid synthesis using [2-14C]ac...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50009731
PNG
(CHEMBL3246897)
Show SMILES CC(CC(O)=O)CC(=O)c1ccc2sc3ccccc3c2c1
Show InChI InChI=1S/C18H16O3S/c1-11(9-18(20)21)8-15(19)12-6-7-17-14(10-12)13-4-2-3-5-16(13)22-17/h2-7,10-11H,8-9H2,1H3,(H,20,21)
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n/an/a 3.10E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of total lipid synthesis using [2-14C]acetate as s...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50009736
PNG
(CHEMBL3246902)
Show SMILES CC(CCc1ccc2oc3ccccc3c2c1)CC(O)=O
Show InChI InChI=1S/C18H18O3/c1-12(10-18(19)20)6-7-13-8-9-17-15(11-13)14-4-2-3-5-16(14)21-17/h2-5,8-9,11-12H,6-7,10H2,1H3,(H,19,20)
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n/an/a 3.60E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of nonsaponifiable lipid synthesis using [2-14C]ac...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50009729
PNG
(CHEMBL3246896)
Show SMILES CC(CC(O)=O)CC(=O)c1ccc2oc3ccccc3c2c1
Show InChI InChI=1S/C18H16O4/c1-11(9-18(20)21)8-15(19)12-6-7-17-14(10-12)13-4-2-3-5-16(13)22-17/h2-7,10-11H,8-9H2,1H3,(H,20,21)
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n/an/a 4.30E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of fatty acid synthesis using [2-14C]acetate as su...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50085047
PNG
(2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl e...)
Show SMILES CCOC(=O)C(C)(C)Oc1ccc(Cl)cc1
Show InChI InChI=1S/C12H15ClO3/c1-4-15-11(14)12(2,3)16-10-7-5-9(13)6-8-10/h5-8H,4H2,1-3H3
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n/an/a 4.40E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of fatty acid synthesis using [2-14C]acetate as su...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50009728
PNG
(CHEMBL3246895)
Show SMILES CC(CC(O)=O)CC(=O)c1ccc(Sc2ccccc2)cc1
Show InChI InChI=1S/C18H18O3S/c1-13(12-18(20)21)11-17(19)14-7-9-16(10-8-14)22-15-5-3-2-4-6-15/h2-10,13H,11-12H2,1H3,(H,20,21)
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n/an/a 5.70E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of total lipid synthesis using [2-14C]acetate as s...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50085047
PNG
(2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl e...)
Show SMILES CCOC(=O)C(C)(C)Oc1ccc(Cl)cc1
Show InChI InChI=1S/C12H15ClO3/c1-4-15-11(14)12(2,3)16-10-7-5-9(13)6-8-10/h5-8H,4H2,1-3H3
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n/an/a 6.30E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of total lipid synthesis using [2-14C]acetate as s...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50009728
PNG
(CHEMBL3246895)
Show SMILES CC(CC(O)=O)CC(=O)c1ccc(Sc2ccccc2)cc1
Show InChI InChI=1S/C18H18O3S/c1-13(12-18(20)21)11-17(19)14-7-9-16(10-8-14)22-15-5-3-2-4-6-15/h2-10,13H,11-12H2,1H3,(H,20,21)
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n/an/a 7.80E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of fatty acid synthesis using [2-14C]acetate as su...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50009736
PNG
(CHEMBL3246902)
Show SMILES CC(CCc1ccc2oc3ccccc3c2c1)CC(O)=O
Show InChI InChI=1S/C18H18O3/c1-12(10-18(19)20)6-7-13-8-9-17-15(11-13)14-4-2-3-5-16(14)21-17/h2-5,8-9,11-12H,6-7,10H2,1H3,(H,19,20)
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n/an/a 8.10E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of total lipid synthesis using [2-14C]acetate as s...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50009727
PNG
(CHEMBL3246894)
Show SMILES CC(CC(O)=O)CC(=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C18H18O4/c1-13(12-18(20)21)11-17(19)14-7-9-16(10-8-14)22-15-5-3-2-4-6-15/h2-10,13H,11-12H2,1H3,(H,20,21)
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n/an/a 8.50E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of total lipid synthesis using [2-14C]acetate as s...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50009737
PNG
(CHEMBL3246903)
Show SMILES CC(CCc1ccc2sc3ccccc3c2c1)CC(O)=O
Show InChI InChI=1S/C18H18O2S/c1-12(10-18(19)20)6-7-13-8-9-17-15(11-13)14-4-2-3-5-16(14)21-17/h2-5,8-9,11-12H,6-7,10H2,1H3,(H,19,20)
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n/an/a 8.60E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of fatty acid synthesis using [2-14C]acetate as su...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50085047
PNG
(2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl e...)
Show SMILES CCOC(=O)C(C)(C)Oc1ccc(Cl)cc1
Show InChI InChI=1S/C12H15ClO3/c1-4-15-11(14)12(2,3)16-10-7-5-9(13)6-8-10/h5-8H,4H2,1-3H3
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n/an/a 8.60E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of nonsaponifiable lipid synthesis using [2-14C]ac...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50009731
PNG
(CHEMBL3246897)
Show SMILES CC(CC(O)=O)CC(=O)c1ccc2sc3ccccc3c2c1
Show InChI InChI=1S/C18H16O3S/c1-11(9-18(20)21)8-15(19)12-6-7-17-14(10-12)13-4-2-3-5-16(13)22-17/h2-7,10-11H,8-9H2,1H3,(H,20,21)
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n/an/a 9.30E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of fatty acid synthesis using [2-14C]acetate as su...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50009726
PNG
(CHEMBL3246893)
Show SMILES CC(CC(O)=O)CC(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C18H18O3/c1-13(12-18(20)21)11-17(19)16-9-7-15(8-10-16)14-5-3-2-4-6-14/h2-10,13H,11-12H2,1H3,(H,20,21)
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CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 1.20E+6n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of fatty acid synthesis using [2-14C]acetate as su...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50009736
PNG
(CHEMBL3246902)
Show SMILES CC(CCc1ccc2oc3ccccc3c2c1)CC(O)=O
Show InChI InChI=1S/C18H18O3/c1-12(10-18(19)20)6-7-13-8-9-17-15(11-13)14-4-2-3-5-16(14)21-17/h2-5,8-9,11-12H,6-7,10H2,1H3,(H,19,20)
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PC cid
PC sid
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n/an/a 1.60E+6n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of fatty acid synthesis using [2-14C]acetate as su...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50009727
PNG
(CHEMBL3246894)
Show SMILES CC(CC(O)=O)CC(=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C18H18O4/c1-13(12-18(20)21)11-17(19)14-7-9-16(10-8-14)22-15-5-3-2-4-6-15/h2-10,13H,11-12H2,1H3,(H,20,21)
PDB
MMDB

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CHEMBL
PC cid
PC sid
UniChem

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PubMed
n/an/a 2.10E+6n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of fatty acid synthesis using [2-14C]acetate as su...

J Med Chem 20: 1705-8 (1978)


BindingDB Entry DOI: 10.7270/Q2GH9KGV
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%