Found 8 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Sodium- and chloride-dependent GABA transporter 1/GABA transporter 2/GABA transporter 3/betaine transporter
(Rattus norvegicus) | BDBM24183
(4-amino-n-[2,3-3H]butyric acid | 4-aminobutanoic a...)Show InChI InChI=1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
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CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro effect on GABA uptake in a crude preparation of synaptosomes from rat brain. |
J Med Chem 26: 895-900 (1983)
BindingDB Entry DOI: 10.7270/Q2P84CGX |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Gamma-aminobutyric acid receptor subunit gamma-1
(Rattus norvegicus) | BDBM50021262
(4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-5-ium-3-...)Show InChI InChI=1S/C6H8N2O2/c9-6-4-3-7-2-1-5(4)10-8-6/h7H,1-3H2,(H,8,9) | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 7.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro affinity for GABA binding sites on purified synaptic membranes from rat brain |
J Med Chem 26: 895-900 (1983)
BindingDB Entry DOI: 10.7270/Q2P84CGX |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent GABA transporter 1/GABA transporter 2/GABA transporter 3/betaine transporter
(Rattus norvegicus) | BDBM50021262
(4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-5-ium-3-...)Show InChI InChI=1S/C6H8N2O2/c9-6-4-3-7-2-1-5(4)10-8-6/h7H,1-3H2,(H,8,9) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.60E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro effect on GABA uptake in a crude preparation of synaptosomes from rat brain |
J Med Chem 26: 895-900 (1983)
BindingDB Entry DOI: 10.7270/Q2P84CGX |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent GABA transporter 1/GABA transporter 2/GABA transporter 3/betaine transporter
(Rattus norvegicus) | BDBM50224812
(CHEBI:35010 | CHEMBL170539)Show InChI InChI=1S/C6H8N2OS/c9-6-4-1-2-7-3-5(4)10-8-6/h7H,1-3H2,(H,8,9) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 2.20E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro effect on GABA uptake in a crude preparation of synaptosomes from rat brain. |
J Med Chem 26: 895-900 (1983)
BindingDB Entry DOI: 10.7270/Q2P84CGX |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent GABA transporter 1/GABA transporter 2/GABA transporter 3/betaine transporter
(Rattus norvegicus) | BDBM50224810
(CHEMBL171241)Show InChI InChI=1S/C6H8N2OS/c9-6-4-3-7-2-1-5(4)10-8-6/h7H,1-3H2,(H,8,9) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 2.30E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro effect on GABA uptake in a crude preparation of synaptosomes from rat brain. |
J Med Chem 26: 895-900 (1983)
BindingDB Entry DOI: 10.7270/Q2P84CGX |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent GABA transporter 1/GABA transporter 2/GABA transporter 3/betaine transporter
(Rattus norvegicus) | BDBM50224811
(CHEMBL170753)Show InChI InChI=1S/C7H10N2OS/c10-7-5-1-3-8-4-2-6(5)11-9-7/h8H,1-4H2,(H,9,10) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 4.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro effect on GABA uptake in a crude preparation of synaptosomes from rat brain. |
J Med Chem 26: 895-900 (1983)
BindingDB Entry DOI: 10.7270/Q2P84CGX |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent GABA transporter 1/GABA transporter 2/GABA transporter 3/betaine transporter
(Rattus norvegicus) | BDBM50224809
(CHEBI:34373 | Gaboxadol | LU-02030 | MK-0928)Show InChI InChI=1S/C6H8N2O2/c9-6-4-1-2-7-3-5(4)10-8-6/h7H,1-3H2,(H,8,9) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >5.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro effect on GABA uptake in a crude preparation of synaptosomes from rat brain. |
J Med Chem 26: 895-900 (1983)
BindingDB Entry DOI: 10.7270/Q2P84CGX |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent GABA transporter 1/GABA transporter 2/GABA transporter 3/betaine transporter
(Rattus norvegicus) | BDBM50224808
(CHEMBL309689)Show InChI InChI=1S/C7H10N2O2/c10-7-5-1-3-8-4-2-6(5)11-9-7/h8H,1-4H2,(H,9,10) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >5.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro effect on GABA uptake in a crude preparation of synaptosomes from rat brain. |
J Med Chem 26: 895-900 (1983)
BindingDB Entry DOI: 10.7270/Q2P84CGX |
More data for this
Ligand-Target Pair | |
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