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PubMed code 7608910

Compile data set for download or QSAR
Found 1 hit of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neutrophil elastase


(Homo sapiens (Human))		BDBM50031664
PNG
(4-((2R,3R)-1-Benzylcarbamoyl-3-methyl-4-oxo-3-prop...)
Show SMILES CCC[C@]1(C)[C@@H](Oc2ccc(cc2)C(O)=O)N(C(=O)NCc2ccccc2)C1=O
Show InChI InChI=1S/C22H24N2O5/c1-3-13-22(2)19(27)24(21(28)23-14-15-7-5-4-6-8-15)20(22)29-17-11-9-16(10-12-17)18(25)26/h4-12,20H,3,13-14H2,1-2H3,(H,23,28)(H,25,26)/t20-,22+/m1/s1
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Similars
PubMed
 5.10E+4n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated in vitro for the human leukocyte elastase (HLE) inhibition, and the Kobs[I] is the second-order rate constant for the time dep...

J Med Chem 38: 2449-62 (1995)


BindingDB Entry DOI: 10.7270/Q24B30BX
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%