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PubMed code 8289207

Compile data set for download or QSAR
Found 30 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50008735
PNG
((+)-3-(tert-butyl)-(3S,4aS,13bS)-2,3,4,4a,8,9,13b,...)
Show SMILES CC(C)(C)[C@]1(O)CCN2C[C@H]3c4ccccc4CCc4cccc([C@@H]2C1)c34
Show InChI InChI=1S/C25H31NO/c1-24(2,3)25(27)13-14-26-16-21-19-9-5-4-7-17(19)11-12-18-8-6-10-20(23(18)21)22(26)15-25/h4-10,21-22,27H,11-16H2,1-3H3/t21-,22-,25-/m0/s1
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n/an/a 0.5n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
Inhibition of binding of radioligand [3H]-spiroperidol to dopamine D2 receptor in rat striatal membranes

J Med Chem 37: 99-104 (1994)


BindingDB Entry DOI: 10.7270/Q2NP23GP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM21393
PNG
(7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-o...)
Show SMILES CCCN(CCC)C1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3
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Università di Bari

Curated by ChEMBL


Assay Description
In vitro ability of the compound to inhibit binding of radioligand [3H]-8-OH-DPAT to 5-hydroxytryptamine 1A receptor in rat cerebral cortex

J Med Chem 37: 99-104 (1994)


BindingDB Entry DOI: 10.7270/Q2NP23GP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50043891
PNG
(1-[3-(8-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1cccc2CCC=C(CCCN3CCN(CC3)c3ccccn3)c12 |t:9|
Show InChI InChI=1S/C23H29N3O/c1-27-21-11-5-9-19-7-4-8-20(23(19)21)10-6-14-25-15-17-26(18-16-25)22-12-2-3-13-24-22/h2-3,5,8-9,11-13H,4,6-7,10,14-18H2,1H3
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Università di Bari

Curated by ChEMBL


Assay Description
In vitro ability of the compound to inhibit binding of radioligand [3H]-8-OH-DPAT to 5-hydroxytryptamine 1A receptor in rat cerebral cortex

J Med Chem 37: 99-104 (1994)


BindingDB Entry DOI: 10.7270/Q2NP23GP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50043882
PNG
(1-[3-(6-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1ccc2C(CCCN3CCN(CC3)c3ccccc3OC)=CCCc2c1 |c:25|
Show InChI InChI=1S/C25H32N2O2/c1-28-22-12-13-23-20(7-5-8-21(23)19-22)9-6-14-26-15-17-27(18-16-26)24-10-3-4-11-25(24)29-2/h3-4,7,10-13,19H,5-6,8-9,14-18H2,1-2H3
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Università di Bari

Curated by ChEMBL


Assay Description
In vitro ability of the compound to inhibit binding of radioligand [3H]-8-OH-DPAT to 5-hydroxytryptamine 1A receptor in rat cerebral cortex

J Med Chem 37: 99-104 (1994)


BindingDB Entry DOI: 10.7270/Q2NP23GP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50043892
PNG
(1-[3-(8-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1ccccc1N1CCN(CCCC2=CCCc3cccc(OC)c23)CC1 |t:16|
Show InChI InChI=1S/C25H32N2O2/c1-28-23-13-4-3-12-22(23)27-18-16-26(17-19-27)15-7-11-21-9-5-8-20-10-6-14-24(29-2)25(20)21/h3-4,6,9-10,12-14H,5,7-8,11,15-19H2,1-2H3
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Università di Bari

Curated by ChEMBL


Assay Description
In vitro ability of the compound to inhibit binding of radioligand [3H]-8-OH-DPAT to 5-hydroxytryptamine 1A receptor in rat cerebral cortex

J Med Chem 37: 99-104 (1994)


BindingDB Entry DOI: 10.7270/Q2NP23GP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50001859
PNG
((buspirone) 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)...)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C21H31N5O2/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9H,1-4,6-7,10-17H2
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Università di Bari

Curated by ChEMBL


Assay Description
In vitro ability of the compound to inhibit binding of radioligand [3H]-8-OH-DPAT to 5-hydroxytryptamine 1A receptor in rat cerebral cortex

J Med Chem 37: 99-104 (1994)


BindingDB Entry DOI: 10.7270/Q2NP23GP
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50043884
PNG
(1-[3-(3,4-Dihydro-naphthalen-1-yl)-propyl]-4-(2-me...)
Show SMILES COc1ccccc1N1CCN(CCCC2=CCCc3ccccc23)CC1 |t:16|
Show InChI InChI=1S/C24H30N2O/c1-27-24-14-5-4-13-23(24)26-18-16-25(17-19-26)15-7-11-21-10-6-9-20-8-2-3-12-22(20)21/h2-5,8,10,12-14H,6-7,9,11,15-19H2,1H3
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Università di Bari

Curated by ChEMBL


Assay Description
Inhibition of binding of radioligand [3H]-spiroperidol to dopamine D2 receptor in rat striatal membranes

J Med Chem 37: 99-104 (1994)


BindingDB Entry DOI: 10.7270/Q2NP23GP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50043884
PNG
(1-[3-(3,4-Dihydro-naphthalen-1-yl)-propyl]-4-(2-me...)
Show SMILES COc1ccccc1N1CCN(CCCC2=CCCc3ccccc23)CC1 |t:16|
Show InChI InChI=1S/C24H30N2O/c1-27-24-14-5-4-13-23(24)26-18-16-25(17-19-26)15-7-11-21-10-6-9-20-8-2-3-12-22(20)21/h2-5,8,10,12-14H,6-7,9,11,15-19H2,1H3
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Università di Bari

Curated by ChEMBL


Assay Description
In vitro ability of the compound to inhibit binding of radioligand [3H]-8-OH-DPAT to 5-hydroxytryptamine 1A receptor in rat cerebral cortex

J Med Chem 37: 99-104 (1994)


BindingDB Entry DOI: 10.7270/Q2NP23GP
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50043892
PNG
(1-[3-(8-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1ccccc1N1CCN(CCCC2=CCCc3cccc(OC)c23)CC1 |t:16|
Show InChI InChI=1S/C25H32N2O2/c1-28-23-13-4-3-12-22(23)27-18-16-26(17-19-27)15-7-11-21-9-5-8-20-10-6-14-24(29-2)25(20)21/h3-4,6,9-10,12-14H,5,7-8,11,15-19H2,1-2H3
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Università di Bari

Curated by ChEMBL


Assay Description
Inhibition of binding of radioligand [3H]-spiroperidol to dopamine D2 receptor in rat striatal membranes

J Med Chem 37: 99-104 (1994)


BindingDB Entry DOI: 10.7270/Q2NP23GP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50043893
PNG
(1-[3-(8-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1cccc2CCC=C(CCCN3CCN(CC3)c3ccccc3)c12 |t:9|
Show InChI InChI=1S/C24H30N2O/c1-27-23-14-6-10-20-8-5-9-21(24(20)23)11-7-15-25-16-18-26(19-17-25)22-12-3-2-4-13-22/h2-4,6,9-10,12-14H,5,7-8,11,15-19H2,1H3
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Università di Bari

Curated by ChEMBL


Assay Description
In vitro ability of the compound to inhibit binding of radioligand [3H]-8-OH-DPAT to 5-hydroxytryptamine 1A receptor in rat cerebral cortex

J Med Chem 37: 99-104 (1994)


BindingDB Entry DOI: 10.7270/Q2NP23GP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50043886
PNG
(1-(3-Chloro-phenyl)-4-[3-(8-methoxy-3,4-dihydro-na...)
Show SMILES COc1cccc2CCC=C(CCCN3CCN(CC3)c3cccc(Cl)c3)c12 |t:9|
Show InChI InChI=1S/C24H29ClN2O/c1-28-23-12-3-8-19-6-2-7-20(24(19)23)9-5-13-26-14-16-27(17-15-26)22-11-4-10-21(25)18-22/h3-4,7-8,10-12,18H,2,5-6,9,13-17H2,1H3
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Università di Bari

Curated by ChEMBL


Assay Description
In vitro ability of the compound to inhibit binding of radioligand [3H]-8-OH-DPAT to 5-hydroxytryptamine 1A receptor in rat cerebral cortex

J Med Chem 37: 99-104 (1994)


BindingDB Entry DOI: 10.7270/Q2NP23GP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50043888
PNG
(1-[3-(8-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1cccc2CCC=C(CCCN3CCN(CC3)c3cccc(c3)C(F)(F)F)c12 |t:9|
Show InChI InChI=1S/C25H29F3N2O/c1-31-23-12-3-8-19-6-2-7-20(24(19)23)9-5-13-29-14-16-30(17-15-29)22-11-4-10-21(18-22)25(26,27)28/h3-4,7-8,10-12,18H,2,5-6,9,13-17H2,1H3
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Università di Bari

Curated by ChEMBL


Assay Description
In vitro ability of the compound to inhibit binding of radioligand [3H]-8-OH-DPAT to 5-hydroxytryptamine 1A receptor in rat cerebral cortex

J Med Chem 37: 99-104 (1994)


BindingDB Entry DOI: 10.7270/Q2NP23GP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50043881
PNG
(1-[3-(6-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1ccc2C(CCCN3CCN(CC3)c3ccccn3)=CCCc2c1 |c:23|
Show InChI InChI=1S/C23H29N3O/c1-27-21-10-11-22-19(6-4-7-20(22)18-21)8-5-13-25-14-16-26(17-15-25)23-9-2-3-12-24-23/h2-3,6,9-12,18H,4-5,7-8,13-17H2,1H3
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Università di Bari

Curated by ChEMBL


Assay Description
In vitro ability of the compound to inhibit binding of radioligand [3H]-8-OH-DPAT to 5-hydroxytryptamine 1A receptor in rat cerebral cortex

J Med Chem 37: 99-104 (1994)


BindingDB Entry DOI: 10.7270/Q2NP23GP
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50043882
PNG
(1-[3-(6-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1ccc2C(CCCN3CCN(CC3)c3ccccc3OC)=CCCc2c1 |c:25|
Show InChI InChI=1S/C25H32N2O2/c1-28-22-12-13-23-20(7-5-8-21(23)19-22)9-6-14-26-15-17-27(18-16-26)24-10-3-4-11-25(24)29-2/h3-4,7,10-13,19H,5-6,8-9,14-18H2,1-2H3
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Università di Bari

Curated by ChEMBL


Assay Description
Inhibition of binding of radioligand [3H]-spiroperidol to dopamine D2 receptor in rat striatal membranes

J Med Chem 37: 99-104 (1994)


BindingDB Entry DOI: 10.7270/Q2NP23GP
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50043891
PNG
(1-[3-(8-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1cccc2CCC=C(CCCN3CCN(CC3)c3ccccn3)c12 |t:9|
Show InChI InChI=1S/C23H29N3O/c1-27-21-11-5-9-19-7-4-8-20(23(19)21)10-6-14-25-15-17-26(18-16-25)22-12-2-3-13-24-22/h2-3,5,8-9,11-13H,4,6-7,10,14-18H2,1H3
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Università di Bari

Curated by ChEMBL


Assay Description
Inhibition of binding of radioligand [3H]-spiroperidol to dopamine D2 receptor in rat striatal membranes

J Med Chem 37: 99-104 (1994)


BindingDB Entry DOI: 10.7270/Q2NP23GP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50043885
PNG
(1-(3-Chloro-phenyl)-4-[3-(6-methoxy-3,4-dihydro-na...)
Show SMILES COc1ccc2C(CCCN3CCN(CC3)c3cccc(Cl)c3)=CCCc2c1 |c:24|
Show InChI InChI=1S/C24H29ClN2O/c1-28-23-10-11-24-19(5-2-6-20(24)17-23)7-4-12-26-13-15-27(16-14-26)22-9-3-8-21(25)18-22/h3,5,8-11,17-18H,2,4,6-7,12-16H2,1H3
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Università di Bari

Curated by ChEMBL


Assay Description
In vitro ability of the compound to inhibit binding of radioligand [3H]-8-OH-DPAT to 5-hydroxytryptamine 1A receptor in rat cerebral cortex

J Med Chem 37: 99-104 (1994)


BindingDB Entry DOI: 10.7270/Q2NP23GP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50043889
PNG
(1-[3-(6-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1ccc2C(CCCN3CCN(CC3)c3cccc(c3)C(F)(F)F)=CCCc2c1 |c:27|
Show InChI InChI=1S/C25H29F3N2O/c1-31-23-10-11-24-19(5-2-6-20(24)17-23)7-4-12-29-13-15-30(16-14-29)22-9-3-8-21(18-22)25(26,27)28/h3,5,8-11,17-18H,2,4,6-7,12-16H2,1H3
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Università di Bari

Curated by ChEMBL


Assay Description
In vitro ability of the compound to inhibit binding of radioligand [3H]-8-OH-DPAT to 5-hydroxytryptamine 1A receptor in rat cerebral cortex

J Med Chem 37: 99-104 (1994)


BindingDB Entry DOI: 10.7270/Q2NP23GP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50043887
PNG
(1-[3-(6-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1ccc2C(CCCN3CCN(CC3)c3ccccc3)=CCCc2c1 |c:23|
Show InChI InChI=1S/C24H30N2O/c1-27-23-12-13-24-20(7-5-8-21(24)19-23)9-6-14-25-15-17-26(18-16-25)22-10-3-2-4-11-22/h2-4,7,10-13,19H,5-6,8-9,14-18H2,1H3
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Curated by ChEMBL


Assay Description
In vitro ability of the compound to inhibit binding of radioligand [3H]-8-OH-DPAT to 5-hydroxytryptamine 1A receptor in rat cerebral cortex

J Med Chem 37: 99-104 (1994)


BindingDB Entry DOI: 10.7270/Q2NP23GP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50043883
PNG
(1-(2,5-Dimethoxy-phenyl)-4-[3-(6-methoxy-3,4-dihyd...)
Show SMILES COc1ccc2C(CCCN3CCN(CC3)c3cc(OC)ccc3OC)=CCCc2c1 |c:27|
Show InChI InChI=1S/C26H34N2O3/c1-29-22-9-11-24-20(6-4-7-21(24)18-22)8-5-13-27-14-16-28(17-15-27)25-19-23(30-2)10-12-26(25)31-3/h6,9-12,18-19H,4-5,7-8,13-17H2,1-3H3
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Assay Description
In vitro ability of the compound to inhibit binding of radioligand [3H]-8-OH-DPAT to 5-hydroxytryptamine 1A receptor in rat cerebral cortex

J Med Chem 37: 99-104 (1994)


BindingDB Entry DOI: 10.7270/Q2NP23GP
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50043883
PNG
(1-(2,5-Dimethoxy-phenyl)-4-[3-(6-methoxy-3,4-dihyd...)
Show SMILES COc1ccc2C(CCCN3CCN(CC3)c3cc(OC)ccc3OC)=CCCc2c1 |c:27|
Show InChI InChI=1S/C26H34N2O3/c1-29-22-9-11-24-20(6-4-7-21(24)18-22)8-5-13-27-14-16-28(17-15-27)25-19-23(30-2)10-12-26(25)31-3/h6,9-12,18-19H,4-5,7-8,13-17H2,1-3H3
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Curated by ChEMBL


Assay Description
Inhibition of binding of radioligand [3H]-spiroperidol to dopamine D2 receptor in rat striatal membranes

J Med Chem 37: 99-104 (1994)


BindingDB Entry DOI: 10.7270/Q2NP23GP
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50001859
PNG
((buspirone) 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)...)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C21H31N5O2/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9H,1-4,6-7,10-17H2
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n/an/a 222n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
Inhibition of binding of radioligand [3H]-spiroperidol to dopamine D2 receptor in rat striatal membranes

J Med Chem 37: 99-104 (1994)


BindingDB Entry DOI: 10.7270/Q2NP23GP
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50043893
PNG
(1-[3-(8-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1cccc2CCC=C(CCCN3CCN(CC3)c3ccccc3)c12 |t:9|
Show InChI InChI=1S/C24H30N2O/c1-27-23-14-6-10-20-8-5-9-21(24(20)23)11-7-15-25-16-18-26(19-17-25)22-12-3-2-4-13-22/h2-4,6,9-10,12-14H,5,7-8,11,15-19H2,1H3
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n/an/a 303n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
Inhibition of binding of radioligand [3H]-spiroperidol to dopamine D2 receptor in rat striatal membranes

J Med Chem 37: 99-104 (1994)


BindingDB Entry DOI: 10.7270/Q2NP23GP
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50043886
PNG
(1-(3-Chloro-phenyl)-4-[3-(8-methoxy-3,4-dihydro-na...)
Show SMILES COc1cccc2CCC=C(CCCN3CCN(CC3)c3cccc(Cl)c3)c12 |t:9|
Show InChI InChI=1S/C24H29ClN2O/c1-28-23-12-3-8-19-6-2-7-20(24(19)23)9-5-13-26-14-16-27(17-15-26)22-11-4-10-21(25)18-22/h3-4,7-8,10-12,18H,2,5-6,9,13-17H2,1H3
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n/an/a 484n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
Inhibition of binding of radioligand [3H]-spiroperidol to dopamine D2 receptor in rat striatal membranes

J Med Chem 37: 99-104 (1994)


BindingDB Entry DOI: 10.7270/Q2NP23GP
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50043888
PNG
(1-[3-(8-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1cccc2CCC=C(CCCN3CCN(CC3)c3cccc(c3)C(F)(F)F)c12 |t:9|
Show InChI InChI=1S/C25H29F3N2O/c1-31-23-12-3-8-19-6-2-7-20(24(19)23)9-5-13-29-14-16-30(17-15-29)22-11-4-10-21(18-22)25(26,27)28/h3-4,7-8,10-12,18H,2,5-6,9,13-17H2,1H3
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n/an/a 644n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
Inhibition of binding of radioligand [3H]-spiroperidol to dopamine D2 receptor in rat striatal membranes

J Med Chem 37: 99-104 (1994)


BindingDB Entry DOI: 10.7270/Q2NP23GP
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50043885
PNG
(1-(3-Chloro-phenyl)-4-[3-(6-methoxy-3,4-dihydro-na...)
Show SMILES COc1ccc2C(CCCN3CCN(CC3)c3cccc(Cl)c3)=CCCc2c1 |c:24|
Show InChI InChI=1S/C24H29ClN2O/c1-28-23-10-11-24-19(5-2-6-20(24)17-23)7-4-12-26-13-15-27(16-14-26)22-9-3-8-21(25)18-22/h3,5,8-11,17-18H,2,4,6-7,12-16H2,1H3
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n/an/a 768n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
Inhibition of binding of radioligand [3H]-spiroperidol to dopamine D2 receptor in rat striatal membranes

J Med Chem 37: 99-104 (1994)


BindingDB Entry DOI: 10.7270/Q2NP23GP
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50043887
PNG
(1-[3-(6-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1ccc2C(CCCN3CCN(CC3)c3ccccc3)=CCCc2c1 |c:23|
Show InChI InChI=1S/C24H30N2O/c1-27-23-12-13-24-20(7-5-8-21(24)19-23)9-6-14-25-15-17-26(18-16-25)22-10-3-2-4-11-22/h2-4,7,10-13,19H,5-6,8-9,14-18H2,1H3
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n/an/a 777n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
Inhibition of binding of radioligand [3H]-spiroperidol to dopamine D2 receptor in rat striatal membranes

J Med Chem 37: 99-104 (1994)


BindingDB Entry DOI: 10.7270/Q2NP23GP
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50043881
PNG
(1-[3-(6-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1ccc2C(CCCN3CCN(CC3)c3ccccn3)=CCCc2c1 |c:23|
Show InChI InChI=1S/C23H29N3O/c1-27-21-10-11-22-19(6-4-7-20(22)18-21)8-5-13-25-14-16-26(17-15-25)23-9-2-3-12-24-23/h2-3,6,9-12,18H,4-5,7-8,13-17H2,1H3
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n/an/a 778n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
Inhibition of binding of radioligand [3H]-spiroperidol to dopamine D2 receptor in rat striatal membranes

J Med Chem 37: 99-104 (1994)


BindingDB Entry DOI: 10.7270/Q2NP23GP
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50043889
PNG
(1-[3-(6-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1ccc2C(CCCN3CCN(CC3)c3cccc(c3)C(F)(F)F)=CCCc2c1 |c:27|
Show InChI InChI=1S/C25H29F3N2O/c1-31-23-10-11-24-19(5-2-6-20(24)17-23)7-4-12-29-13-15-30(16-14-29)22-9-3-8-21(18-22)25(26,27)28/h3,5,8-11,17-18H,2,4,6-7,12-16H2,1H3
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n/an/a 1.29E+3n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
Inhibition of binding of radioligand [3H]-spiroperidol to dopamine D2 receptor in rat striatal membranes

J Med Chem 37: 99-104 (1994)


BindingDB Entry DOI: 10.7270/Q2NP23GP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50043890
PNG
(1-[3-(6-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1ccc2C(CCCN3CCNCC3)=CCCc2c1 |c:16|
Show InChI InChI=1S/C18H26N2O/c1-21-17-7-8-18-15(4-2-5-16(18)14-17)6-3-11-20-12-9-19-10-13-20/h4,7-8,14,19H,2-3,5-6,9-13H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro ability of the compound to inhibit binding of radioligand [3H]-8-OH-DPAT to 5-hydroxytryptamine 1A receptor in rat cerebral cortex

J Med Chem 37: 99-104 (1994)


BindingDB Entry DOI: 10.7270/Q2NP23GP
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50043890
PNG
(1-[3-(6-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1ccc2C(CCCN3CCNCC3)=CCCc2c1 |c:16|
Show InChI InChI=1S/C18H26N2O/c1-21-17-7-8-18-15(4-2-5-16(18)14-17)6-3-11-20-12-9-19-10-13-20/h4,7-8,14,19H,2-3,5-6,9-13H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
Inhibition of binding of radioligand [3H]-spiroperidol to dopamine D2 receptor in rat striatal membranes

J Med Chem 37: 99-104 (1994)


BindingDB Entry DOI: 10.7270/Q2NP23GP
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%