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PubMed code 8759642

Compile data set for download or QSAR
Found 53 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50033857
PNG
(1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccc3)CCCc12
Show InChI InChI=1S/C24H32N2O/c1-27-24-14-6-12-22-20(8-5-13-23(22)24)9-7-15-25-16-18-26(19-17-25)21-10-3-2-4-11-21/h2-4,6,10-12,14,20H,5,7-9,13,15-19H2,1H3
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n/an/a 0.5n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against serotonin 5-hydroxytryptamine 1A receptor in rat hippocampus membrane using [3H]8-OH-DPAT as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50033852
PNG
(1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccn3)CCCc12
Show InChI InChI=1S/C23H31N3O/c1-27-22-11-5-9-20-19(7-4-10-21(20)22)8-6-14-25-15-17-26(18-16-25)23-12-2-3-13-24-23/h2-3,5,9,11-13,19H,4,6-8,10,14-18H2,1H3
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n/an/a 0.540n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against serotonin 5-hydroxytryptamine 1A receptor in rat hippocampus membrane using [3H]8-OH-DPAT as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50033839
PNG
(1-(2-Methoxy-phenyl)-4-[3-(5-methoxy-1,2,3,4-tetra...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccc3OC)CCCc12
Show InChI InChI=1S/C25H34N2O2/c1-28-24-14-6-10-21-20(8-5-11-22(21)24)9-7-15-26-16-18-27(19-17-26)23-12-3-4-13-25(23)29-2/h3-4,6,10,12-14,20H,5,7-9,11,15-19H2,1-2H3
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n/an/a 0.770n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against serotonin 5-hydroxytryptamine 1A receptor in rat hippocampus membrane using [3H]8-OH-DPAT as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50033835
PNG
(1-(2-Methoxy-phenyl)-4-[4-(5-methoxy-1,2,3,4-tetra...)
Show SMILES COc1cccc2C(CCCCN3CCN(CC3)c3ccccc3OC)CCCc12
Show InChI InChI=1S/C26H36N2O2/c1-29-25-15-8-11-22-21(10-7-12-23(22)25)9-5-6-16-27-17-19-28(20-18-27)24-13-3-4-14-26(24)30-2/h3-4,8,11,13-15,21H,5-7,9-10,12,16-20H2,1-2H3
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n/an/a 1.70n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against serotonin 5-hydroxytryptamine 1A receptor in rat hippocampus membrane using [3H]8-OH-DPAT as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM21393
PNG
(7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-o...)
Show SMILES CCCN(CCC)C1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3
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n/an/a 2.10n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against serotonin 5-hydroxytryptamine 1A receptor in rat hippocampus membrane using [3H]8-OH-DPAT as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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n/an/a 4.80n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity to rat Dopamine receptor D2 expressed in CHO cells was determined using [125 I ] iodosulpride as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM21393
PNG
(7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-o...)
Show SMILES CCCN(CCC)C1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3
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n/an/a 5.20n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity to rat Dopamine receptor D2 expressed in CHO cells was determined using [125 I ] iodosulpride as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50033847
PNG
(CHEMBL108241 | {2-[4-(2-Methoxy-phenyl)-piperazin-...)
Show SMILES COc1cccc2C(CCCc12)NCCN1CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C24H33N3O2/c1-28-23-12-6-7-19-20(23)8-5-9-21(19)25-13-14-26-15-17-27(18-16-26)22-10-3-4-11-24(22)29-2/h3-4,6-7,10-12,21,25H,5,8-9,13-18H2,1-2H3
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n/an/a 7.70n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat hippocampus membranes using [3H]8-OH-DPAT as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50052561
PNG
(CHEMBL326017 | {2-[4-(2-Methoxy-phenyl)-piperazin-...)
Show SMILES COc1cccc2C(CCCc12)N(C)CCN1CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C25H35N3O2/c1-26(22-11-6-9-21-20(22)8-7-13-24(21)29-2)14-15-27-16-18-28(19-17-27)23-10-4-5-12-25(23)30-3/h4-5,7-8,10,12-13,22H,6,9,11,14-19H2,1-3H3
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n/an/a 8.70n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat hippocampus membranes using [3H]8-OH-DPAT as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50052569
PNG
(CHEMBL107486 | {3-[4-(2-Methoxy-phenyl)-piperazin-...)
Show SMILES COc1cccc2C(CCCc12)NCCCN1CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C25H35N3O2/c1-29-24-13-6-8-20-21(24)9-5-10-22(20)26-14-7-15-27-16-18-28(19-17-27)23-11-3-4-12-25(23)30-2/h3-4,6,8,11-13,22,26H,5,7,9-10,14-19H2,1-2H3
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n/an/a 10n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat hippocampus membranes using [3H]8-OH-DPAT as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50033835
PNG
(1-(2-Methoxy-phenyl)-4-[4-(5-methoxy-1,2,3,4-tetra...)
Show SMILES COc1cccc2C(CCCCN3CCN(CC3)c3ccccc3OC)CCCc12
Show InChI InChI=1S/C26H36N2O2/c1-29-25-15-8-11-22-21(10-7-12-23(22)25)9-5-6-16-27-17-19-28(20-18-27)24-13-3-4-14-26(24)30-2/h3-4,8,11,13-15,21H,5-7,9-10,12,16-20H2,1-2H3
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n/an/a 15n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against Dopamine receptor D2 in rat striatal membrane using [3H]spiroperidol as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50052565
PNG
(5-Methoxy-1,2,3,4-tetrahydro-naphthalene-1-carboxy...)
Show SMILES COc1cccc2C(CCCc12)C(=O)NCCCN1CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C26H35N3O3/c1-31-24-13-6-8-20-21(24)9-5-10-22(20)26(30)27-14-7-15-28-16-18-29(19-17-28)23-11-3-4-12-25(23)32-2/h3-4,6,8,11-13,22H,5,7,9-10,14-19H2,1-2H3,(H,27,30)
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n/an/a 16n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against serotonin 5-hydroxytryptamine 1A receptor in rat hippocampus membrane using [3H]8-OH-DPAT as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50033839
PNG
(1-(2-Methoxy-phenyl)-4-[3-(5-methoxy-1,2,3,4-tetra...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccc3OC)CCCc12
Show InChI InChI=1S/C25H34N2O2/c1-28-24-14-6-10-21-20(8-5-11-22(21)24)9-7-15-26-16-18-27(19-17-26)23-12-3-4-13-25(23)29-2/h3-4,6,10,12-14,20H,5,7-9,11,15-19H2,1-2H3
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n/an/a 18n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity to rat Dopamine receptor D2 expressed in CHO cells was determined using [125 I ] iodosulpride as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50001859
PNG
((buspirone) 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)...)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C21H31N5O2/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9H,1-4,6-7,10-17H2
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n/an/a 30n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat hippocampus membranes using [3H]8-OH-DPAT as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50052573
PNG
(5-Methoxy-1,2,3,4-tetrahydro-naphthalene-1-carboxy...)
Show SMILES COc1cccc2C(CCCc12)C(=O)NCCN1CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C25H33N3O3/c1-30-23-12-6-7-19-20(23)8-5-9-21(19)25(29)26-13-14-27-15-17-28(18-16-27)22-10-3-4-11-24(22)31-2/h3-4,6-7,10-12,21H,5,8-9,13-18H2,1-2H3,(H,26,29)
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n/an/a 35n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against serotonin 5-hydroxytryptamine 1A receptor in rat hippocampus membrane using [3H]8-OH-DPAT as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50052563
PNG
(3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-N-(5-metho...)
Show SMILES COc1cccc2C(CCCc12)NC(=O)CCN1CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C25H33N3O3/c1-30-23-12-6-7-19-20(23)8-5-9-21(19)26-25(29)13-14-27-15-17-28(18-16-27)22-10-3-4-11-24(22)31-2/h3-4,6-7,10-12,21H,5,8-9,13-18H2,1-2H3,(H,26,29)
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n/an/a 38n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat hippocampus membranes using [3H]8-OH-DPAT as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50052559
PNG
((5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-[2-...)
Show SMILES COc1cccc2C(CCCc12)NCCN1CCN(CC1)c1ccccn1
Show InChI InChI=1S/C22H30N4O/c1-27-21-9-5-6-18-19(21)7-4-8-20(18)23-12-13-25-14-16-26(17-15-25)22-10-2-3-11-24-22/h2-3,5-6,9-11,20,23H,4,7-8,12-17H2,1H3
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n/an/a 49n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat hippocampus membranes using [3H]8-OH-DPAT as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50052567
PNG
((5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-[3-...)
Show SMILES COc1cccc2C(CCCc12)NCCCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C24H33N3O/c1-28-24-13-6-10-21-22(24)11-5-12-23(21)25-14-7-15-26-16-18-27(19-17-26)20-8-3-2-4-9-20/h2-4,6,8-10,13,23,25H,5,7,11-12,14-19H2,1H3
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n/an/a 53n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat hippocampus membranes using [3H]8-OH-DPAT as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50052564
PNG
(5-Methoxy-1,2,3,4-tetrahydro-naphthalene-1-carboxy...)
Show SMILES COc1cccc2C(CCCc12)C(=O)NCCCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C25H33N3O2/c1-30-24-13-6-10-21-22(24)11-5-12-23(21)25(29)26-14-7-15-27-16-18-28(19-17-27)20-8-3-2-4-9-20/h2-4,6,8-10,13,23H,5,7,11-12,14-19H2,1H3,(H,26,29)
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n/an/a 63n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against serotonin 5-hydroxytryptamine 1A receptor in rat hippocampus membrane using [3H]8-OH-DPAT as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50052561
PNG
(CHEMBL326017 | {2-[4-(2-Methoxy-phenyl)-piperazin-...)
Show SMILES COc1cccc2C(CCCc12)N(C)CCN1CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C25H35N3O2/c1-26(22-11-6-9-21-20(22)8-7-13-24(21)29-2)14-15-27-16-18-28(19-17-27)23-10-4-5-12-25(23)30-3/h4-5,7-8,10,12-13,22H,6,9,11,14-19H2,1-3H3
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n/an/a 73n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against Dopamine receptor D2 in rat striatal membrane using [3H]spiroperidol as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50052570
PNG
((5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-[2-...)
Show SMILES COc1cccc2C(CCCc12)NCCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C23H31N3O/c1-27-23-12-6-9-20-21(23)10-5-11-22(20)24-13-14-25-15-17-26(18-16-25)19-7-3-2-4-8-19/h2-4,6-9,12,22,24H,5,10-11,13-18H2,1H3
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n/an/a 92n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat hippocampus membranes using [3H]8-OH-DPAT as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50052560
PNG
(5-Methoxy-1,2,3,4-tetrahydro-naphthalene-1-carboxy...)
Show SMILES COc1cccc2C(CCCc12)C(=O)NCCCN1CCN(CC1)c1ccccn1
Show InChI InChI=1S/C24H32N4O2/c1-30-22-10-5-7-19-20(22)8-4-9-21(19)24(29)26-13-6-14-27-15-17-28(18-16-27)23-11-2-3-12-25-23/h2-3,5,7,10-12,21H,4,6,8-9,13-18H2,1H3,(H,26,29)
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n/an/a 95n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat hippocampus membranes using [3H]8-OH-DPAT as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50033857
PNG
(1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccc3)CCCc12
Show InChI InChI=1S/C24H32N2O/c1-27-24-14-6-12-22-20(8-5-13-23(22)24)9-7-15-25-16-18-26(19-17-25)21-10-3-2-4-11-21/h2-4,6,10-12,14,20H,5,7-9,13,15-19H2,1H3
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n/an/a 110n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity to rat Dopamine receptor D2 expressed in CHO cells was determined using [125 I ] iodosulpride as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50052565
PNG
(5-Methoxy-1,2,3,4-tetrahydro-naphthalene-1-carboxy...)
Show SMILES COc1cccc2C(CCCc12)C(=O)NCCCN1CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C26H35N3O3/c1-31-24-13-6-8-20-21(24)9-5-10-22(20)26(30)27-14-7-15-28-16-18-29(19-17-28)23-11-3-4-12-25(23)32-2/h3-4,6,8,11-13,22H,5,7,9-10,14-19H2,1-2H3,(H,27,30)
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n/an/a 116n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against Dopamine receptor D2 in rat striatal membrane using [3H]spiroperidol as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50052575
PNG
((5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-ylmethy...)
Show SMILES COc1cccc2C(CNCCN3CCN(CC3)c3ccccc3)CCCc12
Show InChI InChI=1S/C24H33N3O/c1-28-24-12-6-10-22-20(7-5-11-23(22)24)19-25-13-14-26-15-17-27(18-16-26)21-8-3-2-4-9-21/h2-4,6,8-10,12,20,25H,5,7,11,13-19H2,1H3
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n/an/a 116n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat hippocampus membranes using [3H]8-OH-DPAT as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50052562
PNG
(5-Methoxy-1,2,3,4-tetrahydro-naphthalene-1-carboxy...)
Show SMILES COc1cccc2C(CCCc12)C(=O)N(C)CCCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C26H35N3O2/c1-27(26(30)24-13-6-12-23-22(24)11-7-14-25(23)31-2)15-8-16-28-17-19-29(20-18-28)21-9-4-3-5-10-21/h3-5,7,9-11,14,24H,6,8,12-13,15-20H2,1-2H3
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n/an/a 134n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat hippocampus membranes using [3H]8-OH-DPAT as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50052556
PNG
(CHEMBL323242 | N-(5-Methoxy-1,2,3,4-tetrahydro-nap...)
Show SMILES COc1cccc2C(CCCc12)NC(=O)CCN1CCN(CC1)c1ccccn1
Show InChI InChI=1S/C23H30N4O2/c1-29-21-9-5-6-18-19(21)7-4-8-20(18)25-23(28)11-13-26-14-16-27(17-15-26)22-10-2-3-12-24-22/h2-3,5-6,9-10,12,20H,4,7-8,11,13-17H2,1H3,(H,25,28)
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n/an/a 135n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat hippocampus membranes using [3H]8-OH-DPAT as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50033852
PNG
(1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccn3)CCCc12
Show InChI InChI=1S/C23H31N3O/c1-27-22-11-5-9-20-19(7-4-10-21(20)22)8-6-14-25-15-17-26(18-16-25)23-12-2-3-13-24-23/h2-3,5,9,11-13,19H,4,6-8,10,14-18H2,1H3
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n/an/a 140n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity to rat Dopamine receptor D2 expressed in CHO cells was determined using [125 I ] iodosulpride as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50052557
PNG
(5-Methoxy-1,2,3,4-tetrahydro-naphthalene-1-carboxy...)
Show SMILES COc1cccc2C(CCCc12)C(=O)NCCN1CCN(CC1)c1ccccn1
Show InChI InChI=1S/C23H30N4O2/c1-29-21-9-5-6-18-19(21)7-4-8-20(18)23(28)25-12-13-26-14-16-27(17-15-26)22-10-2-3-11-24-22/h2-3,5-6,9-11,20H,4,7-8,12-17H2,1H3,(H,25,28)
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n/an/a 173n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against serotonin 5-hydroxytryptamine 1A receptor in rat hippocampus membrane using [3H]8-OH-DPAT as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50052566
PNG
(5-Methoxy-1,2,3,4-tetrahydro-naphthalene-1-carboxy...)
Show SMILES COc1cccc2C(CCCc12)C(=O)N(C)CCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C25H33N3O2/c1-26(14-15-27-16-18-28(19-17-27)20-8-4-3-5-9-20)25(29)23-12-6-11-22-21(23)10-7-13-24(22)30-2/h3-5,7-10,13,23H,6,11-12,14-19H2,1-2H3
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n/an/a 271n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat hippocampus membranes using [3H]8-OH-DPAT as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50001859
PNG
((buspirone) 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)...)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C21H31N5O2/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9H,1-4,6-7,10-17H2
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n/an/a 280n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against Dopamine receptor D2 in rat striatal membrane using [3H]spiroperidol as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50052558
PNG
(5-Methoxy-1,2,3,4-tetrahydro-naphthalene-1-carboxy...)
Show SMILES COc1ccccc1N1CCN(CCN(C)C(=O)C2CCCc3c(OC)cccc23)CC1
Show InChI InChI=1S/C26H35N3O3/c1-27(26(30)22-10-6-9-21-20(22)8-7-13-24(21)31-2)14-15-28-16-18-29(19-17-28)23-11-4-5-12-25(23)32-3/h4-5,7-8,11-13,22H,6,9-10,14-19H2,1-3H3
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n/an/a 307n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat hippocampus membranes using [3H]8-OH-DPAT as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50052574
PNG
(CHEMBL108858 | N-(5-Methoxy-1,2,3,4-tetrahydro-nap...)
Show SMILES COc1cccc2C(CCCc12)NC(=O)CCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C24H31N3O2/c1-29-23-12-6-9-20-21(23)10-5-11-22(20)25-24(28)13-14-26-15-17-27(18-16-26)19-7-3-2-4-8-19/h2-4,6-9,12,22H,5,10-11,13-18H2,1H3,(H,25,28)
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n/an/a 311n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat hippocampus membranes using [3H]8-OH-DPAT as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50052558
PNG
(5-Methoxy-1,2,3,4-tetrahydro-naphthalene-1-carboxy...)
Show SMILES COc1ccccc1N1CCN(CCN(C)C(=O)C2CCCc3c(OC)cccc23)CC1
Show InChI InChI=1S/C26H35N3O3/c1-27(26(30)22-10-6-9-21-20(22)8-7-13-24(21)31-2)14-15-28-16-18-29(19-17-28)23-11-4-5-12-25(23)32-3/h4-5,7-8,11-13,22H,6,9-10,14-19H2,1-3H3
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n/an/a 332n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against Dopamine receptor D2 in rat striatal membrane using [3H]spiroperidol as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50033847
PNG
(CHEMBL108241 | {2-[4-(2-Methoxy-phenyl)-piperazin-...)
Show SMILES COc1cccc2C(CCCc12)NCCN1CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C24H33N3O2/c1-28-23-12-6-7-19-20(23)8-5-9-21(19)25-13-14-26-15-17-27(18-16-26)22-10-3-4-11-24(22)29-2/h3-4,6-7,10-12,21,25H,5,8-9,13-18H2,1-2H3
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n/an/a 380n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Compound was evaluated for their affinity against Dopamine receptor D2 by displacing [3H]spiperone in rat striatal membrane

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50052572
PNG
(5-Methoxy-1,2,3,4-tetrahydro-naphthalene-1-carboxy...)
Show SMILES COc1cccc2C(CCCc12)C(=O)NCCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C24H31N3O2/c1-29-23-12-6-9-20-21(23)10-5-11-22(20)24(28)25-13-14-26-15-17-27(18-16-26)19-7-3-2-4-8-19/h2-4,6-9,12,22H,5,10-11,13-18H2,1H3,(H,25,28)
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n/an/a 416n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against serotonin 5-hydroxytryptamine 1A receptor in rat hippocampus membrane using [3H]8-OH-DPAT as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50052573
PNG
(5-Methoxy-1,2,3,4-tetrahydro-naphthalene-1-carboxy...)
Show SMILES COc1cccc2C(CCCc12)C(=O)NCCN1CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C25H33N3O3/c1-30-23-12-6-7-19-20(23)8-5-9-21(19)25(29)26-13-14-27-15-17-28(18-16-27)22-10-3-4-11-24(22)31-2/h3-4,6-7,10-12,21H,5,8-9,13-18H2,1-2H3,(H,26,29)
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n/an/a 448n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against Dopamine receptor D2 in rat striatal membrane using [3H]spiroperidol as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50052562
PNG
(5-Methoxy-1,2,3,4-tetrahydro-naphthalene-1-carboxy...)
Show SMILES COc1cccc2C(CCCc12)C(=O)N(C)CCCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C26H35N3O2/c1-27(26(30)24-13-6-12-23-22(24)11-7-14-25(23)31-2)15-8-16-28-17-19-29(20-18-28)21-9-4-3-5-10-21/h3-5,7,9-11,14,24H,6,8,12-13,15-20H2,1-2H3
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n/an/a 594n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against Dopamine receptor D2 in rat striatal membrane using [3H]spiroperidol as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50052563
PNG
(3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-N-(5-metho...)
Show SMILES COc1cccc2C(CCCc12)NC(=O)CCN1CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C25H33N3O3/c1-30-23-12-6-7-19-20(23)8-5-9-21(19)26-25(29)13-14-27-15-17-28(18-16-27)22-10-3-4-11-24(22)31-2/h3-4,6-7,10-12,21H,5,8-9,13-18H2,1-2H3,(H,26,29)
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n/an/a 761n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against Dopamine receptor D2 in rat striatal membrane using [3H]spiroperidol as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50052564
PNG
(5-Methoxy-1,2,3,4-tetrahydro-naphthalene-1-carboxy...)
Show SMILES COc1cccc2C(CCCc12)C(=O)NCCCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C25H33N3O2/c1-30-24-13-6-10-21-22(24)11-5-12-23(21)25(29)26-14-7-15-27-16-18-28(19-17-27)20-8-3-2-4-9-20/h2-4,6,8-10,13,23H,5,7,11-12,14-19H2,1H3,(H,26,29)
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n/an/a 783n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against Dopamine receptor D2 in rat striatal membrane using [3H]spiroperidol as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50052560
PNG
(5-Methoxy-1,2,3,4-tetrahydro-naphthalene-1-carboxy...)
Show SMILES COc1cccc2C(CCCc12)C(=O)NCCCN1CCN(CC1)c1ccccn1
Show InChI InChI=1S/C24H32N4O2/c1-30-22-10-5-7-19-20(22)8-4-9-21(19)24(29)26-13-6-14-27-15-17-28(18-16-27)23-11-2-3-12-25-23/h2-3,5,7,10-12,21H,4,6,8-9,13-18H2,1H3,(H,26,29)
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n/an/a 819n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against Dopamine receptor D2 in rat striatal membrane using [3H]spiroperidol as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50052566
PNG
(5-Methoxy-1,2,3,4-tetrahydro-naphthalene-1-carboxy...)
Show SMILES COc1cccc2C(CCCc12)C(=O)N(C)CCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C25H33N3O2/c1-26(14-15-27-16-18-28(19-17-27)20-8-4-3-5-9-20)25(29)23-12-6-11-22-21(23)10-7-13-24(22)30-2/h3-5,7-10,13,23H,6,11-12,14-19H2,1-2H3
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n/an/a 882n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against Dopamine receptor D2 in rat striatal membrane using [3H]spiroperidol as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50052569
PNG
(CHEMBL107486 | {3-[4-(2-Methoxy-phenyl)-piperazin-...)
Show SMILES COc1cccc2C(CCCc12)NCCCN1CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C25H35N3O2/c1-29-24-13-6-8-20-21(24)9-5-10-22(20)26-14-7-15-27-16-18-28(19-17-27)23-11-3-4-12-25(23)30-2/h3-4,6,8,11-13,22,26H,5,7,9-10,14-19H2,1-2H3
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n/an/a 1.06E+3n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against Dopamine receptor D2 in rat striatal membrane using [3H]spiroperidol as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50052575
PNG
((5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-ylmethy...)
Show SMILES COc1cccc2C(CNCCN3CCN(CC3)c3ccccc3)CCCc12
Show InChI InChI=1S/C24H33N3O/c1-28-24-12-6-10-22-20(7-5-11-23(22)24)19-25-13-14-26-15-17-27(18-16-26)21-8-3-2-4-9-21/h2-4,6,8-10,12,20,25H,5,7,11,13-19H2,1H3
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n/an/a 1.10E+3n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against Dopamine receptor D2 in rat striatal membrane using [3H]spiroperidol as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50052570
PNG
((5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-[2-...)
Show SMILES COc1cccc2C(CCCc12)NCCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C23H31N3O/c1-27-23-12-6-9-20-21(23)10-5-11-22(20)24-13-14-25-15-17-26(18-16-25)19-7-3-2-4-8-19/h2-4,6-9,12,22,24H,5,10-11,13-18H2,1H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against Dopamine receptor D2 in rat striatal membrane using [3H]spiroperidol as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50052559
PNG
((5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-[2-...)
Show SMILES COc1cccc2C(CCCc12)NCCN1CCN(CC1)c1ccccn1
Show InChI InChI=1S/C22H30N4O/c1-27-21-9-5-6-18-19(21)7-4-8-20(18)23-12-13-25-14-16-26(17-15-25)22-10-2-3-11-24-22/h2-3,5-6,9-11,20,23H,4,7-8,12-17H2,1H3
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n/an/a 1.85E+3n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against Dopamine receptor D2 in rat striatal membrane using [3H]spiroperidol as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50052556
PNG
(CHEMBL323242 | N-(5-Methoxy-1,2,3,4-tetrahydro-nap...)
Show SMILES COc1cccc2C(CCCc12)NC(=O)CCN1CCN(CC1)c1ccccn1
Show InChI InChI=1S/C23H30N4O2/c1-29-21-9-5-6-18-19(21)7-4-8-20(18)25-23(28)11-13-26-14-16-27(17-15-26)22-10-2-3-12-24-22/h2-3,5-6,9-10,12,20H,4,7-8,11,13-17H2,1H3,(H,25,28)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against Dopamine receptor D2 in rat striatal membrane using [3H]spiroperidol as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50052567
PNG
((5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-[3-...)
Show SMILES COc1cccc2C(CCCc12)NCCCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C24H33N3O/c1-28-24-13-6-10-21-22(24)11-5-12-23(21)25-14-7-15-26-16-18-27(19-17-26)20-8-3-2-4-9-20/h2-4,6,8-10,13,23,25H,5,7,11-12,14-19H2,1H3
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n/an/a 2.16E+3n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against Dopamine receptor D2 in rat striatal membrane using [3H]spiroperidol as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50052557
PNG
(5-Methoxy-1,2,3,4-tetrahydro-naphthalene-1-carboxy...)
Show SMILES COc1cccc2C(CCCc12)C(=O)NCCN1CCN(CC1)c1ccccn1
Show InChI InChI=1S/C23H30N4O2/c1-29-21-9-5-6-18-19(21)7-4-8-20(18)23(28)25-12-13-26-14-16-27(17-15-26)22-10-2-3-11-24-22/h2-3,5-6,9-11,20H,4,7-8,12-17H2,1H3,(H,25,28)
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n/an/a 2.44E+3n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against Dopamine receptor D2 in rat striatal membrane using [3H]spiroperidol as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50052574
PNG
(CHEMBL108858 | N-(5-Methoxy-1,2,3,4-tetrahydro-nap...)
Show SMILES COc1cccc2C(CCCc12)NC(=O)CCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C24H31N3O2/c1-29-23-12-6-9-20-21(23)10-5-11-22(20)25-24(28)13-14-26-15-17-27(18-16-26)19-7-3-2-4-8-19/h2-4,6-9,12,22H,5,10-11,13-18H2,1H3,(H,25,28)
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n/an/a 2.97E+3n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against Dopamine receptor D2 in rat striatal membrane using [3H]spiroperidol as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50052572
PNG
(5-Methoxy-1,2,3,4-tetrahydro-naphthalene-1-carboxy...)
Show SMILES COc1cccc2C(CCCc12)C(=O)NCCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C24H31N3O2/c1-29-23-12-6-9-20-21(23)10-5-11-22(20)24(28)25-13-14-26-15-17-27(18-16-26)19-7-3-2-4-8-19/h2-4,6-9,12,22H,5,10-11,13-18H2,1H3,(H,25,28)
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n/an/a 4.04E+3n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against Dopamine receptor D2 in rat striatal membrane using [3H]spiroperidol as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50052571
PNG
(CHEMBL109263 | N-(5-Methoxy-1,2,3,4-tetrahydro-nap...)
Show SMILES COc1cccc2C(CCCc12)NC(=O)CN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C23H29N3O2/c1-28-22-12-6-9-19-20(22)10-5-11-21(19)24-23(27)17-25-13-15-26(16-14-25)18-7-3-2-4-8-18/h2-4,6-9,12,21H,5,10-11,13-17H2,1H3,(H,24,27)
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n/an/a 5.31E+3n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat hippocampus membranes using [3H]8-OH-DPAT as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50052571
PNG
(CHEMBL109263 | N-(5-Methoxy-1,2,3,4-tetrahydro-nap...)
Show SMILES COc1cccc2C(CCCc12)NC(=O)CN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C23H29N3O2/c1-28-22-12-6-9-19-20(22)10-5-11-21(19)24-23(27)17-25-13-15-26(16-14-25)18-7-3-2-4-8-18/h2-4,6-9,12,21H,5,10-11,13-17H2,1H3,(H,24,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against Dopamine receptor D2 in rat striatal membrane using [3H]spiroperidol as radioligand

J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%