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PubMed code 8863806

Compile data set for download or QSAR
Found 68 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM82368
PNG
(CAS_121851 | CHEMBL11592 | CHEMBL301060 | NSC_1218...)
Show SMILES CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1
Show InChI InChI=1S/C26H38N2O4/c1-3-13-27(20-16-21-22(31-2)9-8-10-23(21)32-19-20)14-6-7-15-28-24(29)17-26(18-25(28)30)11-4-5-12-26/h8-10,20H,3-7,11-19H2,1-2H3
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n/an/a 0.300n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Binding affinity to 5-hydroxytryptamine 1A receptor in rat hippocampus membranes,3H-8-OH-DPAT and buspirone for nonspecific binding (NSB)

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM82368
PNG
(CAS_121851 | CHEMBL11592 | CHEMBL301060 | NSC_1218...)
Show SMILES CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1
Show InChI InChI=1S/C26H38N2O4/c1-3-13-27(20-16-21-22(31-2)9-8-10-23(21)32-19-20)14-6-7-15-28-24(29)17-26(18-25(28)30)11-4-5-12-26/h8-10,20H,3-7,11-19H2,1-2H3
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n/an/a 0.300n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Binding affinity to 5-hydroxytryptamine 1A receptor in rat hippocampus membranes,3H-8-OH-DPAT and buspirone for nonspecific binding (NSB)

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM21393
PNG
(7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-o...)
Show SMILES CCCN(CCC)C1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3
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n/an/a 2.40n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Binding affinity to 5-hydroxytryptamine 1A receptor in rat hippocampus membranes,3H-8-OH-DPAT and buspirone for nonspecific binding (NSB)

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50054143
PNG
((+) 8-{4-[5-methoxyspiro[3,4-dihydro-2H-chromene-3...)
Show SMILES COc1cccc2OCC3(CCCN3CCCCN3C(=O)CC4(CCCC4)CC3=O)Cc12
Show InChI InChI=1S/C26H36N2O4/c1-31-21-8-6-9-22-20(21)16-26(19-32-22)12-7-14-27(26)13-4-5-15-28-23(29)17-25(18-24(28)30)10-2-3-11-25/h6,8-9H,2-5,7,10-19H2,1H3
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n/an/a 6.72n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Binding affinity to 5-hydroxytryptamine 1A receptor in rat hippocampus membranes,3H-8-OH-DPAT and buspirone for nonspecific binding (NSB)

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50054147
PNG
(8-{4-[5-methoxyspiro[3,4-dihydro-2H-chromene-3,2'-...)
Show SMILES COc1cccc2OCC3(CCCCN3CCCCN3C(=O)CC4(CCCC4)CC3=O)Cc12
Show InChI InChI=1S/C27H38N2O4/c1-32-22-9-8-10-23-21(22)17-27(20-33-23)13-4-5-14-28(27)15-6-7-16-29-24(30)18-26(19-25(29)31)11-2-3-12-26/h8-10H,2-7,11-20H2,1H3
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n/an/a 8.81n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Binding affinity to 5-hydroxytryptamine 1A receptor in rat hippocampus membranes,3H-8-OH-DPAT and buspirone for nonspecific binding (NSB)

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50054143
PNG
((+) 8-{4-[5-methoxyspiro[3,4-dihydro-2H-chromene-3...)
Show SMILES COc1cccc2OCC3(CCCN3CCCCN3C(=O)CC4(CCCC4)CC3=O)Cc12
Show InChI InChI=1S/C26H36N2O4/c1-31-21-8-6-9-22-20(21)16-26(19-32-22)12-7-14-27(26)13-4-5-15-28-23(29)17-25(18-24(28)30)10-2-3-11-25/h6,8-9H,2-5,7,10-19H2,1H3
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n/an/a 10.6n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Binding affinity to 5-hydroxytryptamine 1A receptor in rat hippocampus membranes,3H-8-OH-DPAT and buspirone for nonspecific binding (NSB)

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM82368
PNG
(CAS_121851 | CHEMBL11592 | CHEMBL301060 | NSC_1218...)
Show SMILES CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1
Show InChI InChI=1S/C26H38N2O4/c1-3-13-27(20-16-21-22(31-2)9-8-10-23(21)32-19-20)14-6-7-15-28-24(29)17-26(18-25(28)30)11-4-5-12-26/h8-10,20H,3-7,11-19H2,1-2H3
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n/an/a 20n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Displacement of [3H]-SDZ-205-501 from Dopamine receptor D2 in calf caudate nucleus.

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM82368
PNG
(CAS_121851 | CHEMBL11592 | CHEMBL301060 | NSC_1218...)
Show SMILES CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1
Show InChI InChI=1S/C26H38N2O4/c1-3-13-27(20-16-21-22(31-2)9-8-10-23(21)32-19-20)14-6-7-15-28-24(29)17-26(18-25(28)30)11-4-5-12-26/h8-10,20H,3-7,11-19H2,1-2H3
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n/an/a 20n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Displacement of [3H]-SDZ-205-501 from Dopamine receptor D2 in calf caudate nucleus.

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50036862
PNG
((5-Methoxy-chroman-3-yl)-dipropyl-amine | CHEMBL28...)
Show SMILES CCCN(CCC)C1COc2cccc(OC)c2C1
Show InChI InChI=1S/C16H25NO2/c1-4-9-17(10-5-2)13-11-14-15(18-3)7-6-8-16(14)19-12-13/h6-8,13H,4-5,9-12H2,1-3H3
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n/an/a 20n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Binding affinity to 5-hydroxytryptamine 1A receptor in rat hippocampus membranes,3H-8-OH-DPAT and buspirone for nonspecific binding (NSB)

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50005127
PNG
(1,1-Dioxo-2-[4-(4-pyrimidin-2-yl-piperazin-1-yl)-b...)
Show SMILES O=C1N(CCCCN2CCN(CC2)c2ncccn2)S(=O)(=O)c2ccccc12
Show InChI InChI=1S/C19H23N5O3S/c25-18-16-6-1-2-7-17(16)28(26,27)24(18)11-4-3-10-22-12-14-23(15-13-22)19-20-8-5-9-21-19/h1-2,5-9H,3-4,10-15H2
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n/an/a 35n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Binding affinity to 5-hydroxytryptamine 1A receptor in rat hippocampus membranes,3H-8-OH-DPAT and buspirone for nonspecific binding (NSB)

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50054141
PNG
(1'-propylspiro[3,4-dihydro-2H-chromene-3,2'-(tetra...)
Show SMILES CCCN1CCCC11COc2cccc(O)c2C1
Show InChI InChI=1S/C15H21NO2/c1-2-8-16-9-4-7-15(16)10-12-13(17)5-3-6-14(12)18-11-15/h3,5-6,17H,2,4,7-11H2,1H3
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n/an/a 39n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity on 5-hydroxytryptamine 1A receptor in rat hippocampus membranes,3H-8-OH-DPAT and buspirone for nonspecifi...

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50036862
PNG
((5-Methoxy-chroman-3-yl)-dipropyl-amine | CHEMBL28...)
Show SMILES CCCN(CCC)C1COc2cccc(OC)c2C1
Show InChI InChI=1S/C16H25NO2/c1-4-9-17(10-5-2)13-11-14-15(18-3)7-6-8-16(14)19-12-13/h6-8,13H,4-5,9-12H2,1-3H3
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n/an/a 50n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Displacement of [3H]-SDZ-205-501 from Dopamine receptor D2 in calf caudate nucleus.

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50001859
PNG
((buspirone) 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)...)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C21H31N5O2/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9H,1-4,6-7,10-17H2
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n/an/a 60n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Binding affinity to 5-hydroxytryptamine 1A receptor in rat hippocampus membranes,3H-8-OH-DPAT and buspirone for nonspecific binding (NSB)

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50054149
PNG
(1'-[4-(4-fluorophenylcarboxamido)butyl]-5-methoxys...)
Show SMILES COc1cccc2OCC3(CCCCN3CCCCNC(=O)c3ccc(F)cc3)Cc12
Show InChI InChI=1S/C25H31FN2O3/c1-30-22-7-6-8-23-21(22)17-25(18-31-23)13-2-4-15-28(25)16-5-3-14-27-24(29)19-9-11-20(26)12-10-19/h6-12H,2-5,13-18H2,1H3,(H,27,29)
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n/an/a 62.8n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Binding affinity to 5-hydroxytryptamine 1A receptor in rat hippocampus membranes,3H-8-OH-DPAT and buspirone for nonspecific binding (NSB)

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50054142
PNG
(5-methoxy-1'-[4-(4-methylphenylsulfonamido)butyl]s...)
Show SMILES COc1cccc2OCC3(CCCCN3CCCCNS(=O)(=O)c3ccc(C)cc3)Cc12
Show InChI InChI=1S/C25H34N2O4S/c1-20-10-12-21(13-11-20)32(28,29)26-15-4-6-17-27-16-5-3-14-25(27)18-22-23(30-2)8-7-9-24(22)31-19-25/h7-13,26H,3-6,14-19H2,1-2H3
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Université d'Orléans

Curated by ChEMBL


Assay Description
Binding affinity to 5-hydroxytryptamine 1A receptor in rat hippocampus membranes,3H-8-OH-DPAT and buspirone for nonspecific binding (NSB)

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50054145
PNG
(5-methoxy-1'-propylspiro[3,4-dihydro-2H-chromene-3...)
Show SMILES CCCN1CCCC11COc2cccc(OC)c2C1
Show InChI InChI=1S/C16H23NO2/c1-3-9-17-10-5-8-16(17)11-13-14(18-2)6-4-7-15(13)19-12-16/h4,6-7H,3,5,8-12H2,1-2H3
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n/an/a 74.6n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Binding affinity to 5-hydroxytryptamine 1A receptor in rat hippocampus membranes,3H-8-OH-DPAT and buspirone for nonspecific binding (NSB)

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50054155
PNG
(8-{4-[1'-propylspiro[3,4-dihydro-2H-chromene-3,2'-...)
Show SMILES CCCN1CCCC11COc2cccc(OCCCCN3C(=O)CC4(CCCC4)CC3=O)c2C1
Show InChI InChI=1S/C28H40N2O4/c1-2-14-29-15-8-13-28(29)18-22-23(9-7-10-24(22)34-21-28)33-17-6-5-16-30-25(31)19-27(20-26(30)32)11-3-4-12-27/h7,9-10H,2-6,8,11-21H2,1H3
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n/an/a 101n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Binding affinity to 5-hydroxytryptamine 1A receptor in rat hippocampus membranes,3H-8-OH-DPAT and buspirone for nonspecific binding (NSB)

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50054154
PNG
(8-[4-spiro[3,4-dihydro-2H-chromene-3,2'-(tetrahydr...)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCCC11COc2ccccc2C1
Show InChI InChI=1S/C25H34N2O3/c28-22-17-24(10-3-4-11-24)18-23(29)27(22)15-6-5-13-26-14-7-12-25(26)16-20-8-1-2-9-21(20)30-19-25/h1-2,8-9H,3-7,10-19H2
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n/an/a 178n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Binding affinity to 5-hydroxytryptamine 1A receptor in rat hippocampus membranes,3H-8-OH-DPAT and buspirone for nonspecific binding (NSB)

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50054152
PNG
(5-methoxyspiro[3,4-dihydro-2H-chromene-3,2'-(tetra...)
Show SMILES COc1cccc2OCC3(CCCN3)Cc12
Show InChI InChI=1S/C13H17NO2/c1-15-11-4-2-5-12-10(11)8-13(9-16-12)6-3-7-14-13/h2,4-5,14H,3,6-9H2,1H3
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n/an/a 298n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Binding affinity to 5-hydroxytryptamine 1A receptor in rat hippocampus membranes,3H-8-OH-DPAT and buspirone for nonspecific binding (NSB)

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50054150
PNG
(5-methoxy-1'-propylspiro[3,4-dihydro-2H-chromene-3...)
Show SMILES CCCN1CCCCC11COc2cccc(OC)c2C1
Show InChI InChI=1S/C17H25NO2/c1-3-10-18-11-5-4-9-17(18)12-14-15(19-2)7-6-8-16(14)20-13-17/h6-8H,3-5,9-13H2,1-2H3
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Université d'Orléans

Curated by ChEMBL


Assay Description
Binding affinity to 5-hydroxytryptamine 1A receptor in rat hippocampus membranes,3H-8-OH-DPAT and buspirone for nonspecific binding (NSB)

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM21393
PNG
(7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-o...)
Show SMILES CCCN(CCC)C1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3
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n/an/a 800n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Compound was evaluated for the binding affinity towards Dopamine receptor D2 using [3H]-raclopride radioligand.

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50054144
PNG
(1'-propylspiro[3,4-dihydro-2H-chromene-3,2'-(tetra...)
Show SMILES CCCN1CCCC11COc2ccccc2C1
Show InChI InChI=1S/C15H21NO/c1-2-9-16-10-5-8-15(16)11-13-6-3-4-7-14(13)17-12-15/h3-4,6-7H,2,5,8-12H2,1H3
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n/an/a 1.30E+3n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Binding affinity to 5-hydroxytryptamine 1A receptor in rat hippocampus membranes,3H-8-OH-DPAT and buspirone for nonspecific binding (NSB)

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Rattus norvegicus (Rat))		BDBM50054143
PNG
((+) 8-{4-[5-methoxyspiro[3,4-dihydro-2H-chromene-3...)
Show SMILES COc1cccc2OCC3(CCCN3CCCCN3C(=O)CC4(CCCC4)CC3=O)Cc12
Show InChI InChI=1S/C26H36N2O4/c1-31-21-8-6-9-22-20(21)16-26(19-32-22)12-7-14-27(26)13-4-5-15-28-23(29)17-25(18-24(28)30)10-2-3-11-25/h6,8-9H,2-5,7,10-19H2,1H3
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n/an/a 1.30E+3n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSB

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Rattus norvegicus (Rat))		BDBM50054147
PNG
(8-{4-[5-methoxyspiro[3,4-dihydro-2H-chromene-3,2'-...)
Show SMILES COc1cccc2OCC3(CCCCN3CCCCN3C(=O)CC4(CCCC4)CC3=O)Cc12
Show InChI InChI=1S/C27H38N2O4/c1-32-22-9-8-10-23-21(22)17-27(20-33-23)13-4-5-14-28(27)15-6-7-16-29-24(30)18-26(19-25(29)31)11-2-3-12-26/h8-10H,2-7,11-20H2,1H3
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n/an/a 2.21E+3n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSB

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Rattus norvegicus (Rat))		BDBM50054155
PNG
(8-{4-[1'-propylspiro[3,4-dihydro-2H-chromene-3,2'-...)
Show SMILES CCCN1CCCC11COc2cccc(OCCCCN3C(=O)CC4(CCCC4)CC3=O)c2C1
Show InChI InChI=1S/C28H40N2O4/c1-2-14-29-15-8-13-28(29)18-22-23(9-7-10-24(22)34-21-28)33-17-6-5-16-30-25(31)19-27(20-26(30)32)11-3-4-12-27/h7,9-10H,2-6,8,11-21H2,1H3
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n/an/a 2.70E+3n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSB

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50054147
PNG
(8-{4-[5-methoxyspiro[3,4-dihydro-2H-chromene-3,2'-...)
Show SMILES COc1cccc2OCC3(CCCCN3CCCCN3C(=O)CC4(CCCC4)CC3=O)Cc12
Show InChI InChI=1S/C27H38N2O4/c1-32-22-9-8-10-23-21(22)17-27(20-33-23)13-4-5-14-28(27)15-6-7-16-29-24(30)18-26(19-25(29)31)11-2-3-12-26/h8-10H,2-7,11-20H2,1H3
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n/an/a 2.84E+3n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Displacement of [3H]-SDZ-205-501 from Dopamine receptor D2 in calf caudate nucleus.

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Rattus norvegicus (Rat))		BDBM50054143
PNG
((+) 8-{4-[5-methoxyspiro[3,4-dihydro-2H-chromene-3...)
Show SMILES COc1cccc2OCC3(CCCN3CCCCN3C(=O)CC4(CCCC4)CC3=O)Cc12
Show InChI InChI=1S/C26H36N2O4/c1-31-21-8-6-9-22-20(21)16-26(19-32-22)12-7-14-27(26)13-4-5-15-28-23(29)17-25(18-24(28)30)10-2-3-11-25/h6,8-9H,2-5,7,10-19H2,1H3
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n/an/a 3.80E+3n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSB

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Rattus norvegicus (Rat))		BDBM50054154
PNG
(8-[4-spiro[3,4-dihydro-2H-chromene-3,2'-(tetrahydr...)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCCC11COc2ccccc2C1
Show InChI InChI=1S/C25H34N2O3/c28-22-17-24(10-3-4-11-24)18-23(29)27(22)15-6-5-13-26-14-7-12-25(26)16-20-8-1-2-9-21(20)30-19-25/h1-2,8-9H,3-7,10-19H2
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n/an/a 3.80E+3n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSB

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50001859
PNG
((buspirone) 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)...)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C21H31N5O2/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9H,1-4,6-7,10-17H2
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n/an/a 4.00E+3n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Displacement of [3H]-SDZ-205-501 from Dopamine receptor D2 in calf caudate nucleus.

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50054142
PNG
(5-methoxy-1'-[4-(4-methylphenylsulfonamido)butyl]s...)
Show SMILES COc1cccc2OCC3(CCCCN3CCCCNS(=O)(=O)c3ccc(C)cc3)Cc12
Show InChI InChI=1S/C25H34N2O4S/c1-20-10-12-21(13-11-20)32(28,29)26-15-4-6-17-27-16-5-3-14-25(27)18-22-23(30-2)8-7-9-24(22)31-19-25/h7-13,26H,3-6,14-19H2,1-2H3
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n/an/a 4.22E+3n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Displacement of [3H]-SDZ-205-501 from Dopamine receptor D2 in calf caudate nucleus.

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50054149
PNG
(1'-[4-(4-fluorophenylcarboxamido)butyl]-5-methoxys...)
Show SMILES COc1cccc2OCC3(CCCCN3CCCCNC(=O)c3ccc(F)cc3)Cc12
Show InChI InChI=1S/C25H31FN2O3/c1-30-22-7-6-8-23-21(22)17-25(18-31-23)13-2-4-15-28(25)16-5-3-14-27-24(29)19-9-11-20(26)12-10-19/h6-12H,2-5,13-18H2,1H3,(H,27,29)
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n/an/a 4.30E+3n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Displacement of [3H]-SDZ-205-501 from Dopamine receptor D2 in calf caudate nucleus.

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50054148
PNG
(5-methoxyspiro[3,4-dihydro-2H-chromene-3,2'-(tetra...)
Show SMILES COc1cccc2OCC3(CCC(=O)N3)Cc12
Show InChI InChI=1S/C13H15NO3/c1-16-10-3-2-4-11-9(10)7-13(8-17-11)6-5-12(15)14-13/h2-4H,5-8H2,1H3,(H,14,15)
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n/an/a 4.37E+3n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Binding affinity to 5-hydroxytryptamine 1A receptor in rat hippocampus membranes,3H-8-OH-DPAT and buspirone for nonspecific binding (NSB)

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Rattus norvegicus (Rat))		BDBM50054152
PNG
(5-methoxyspiro[3,4-dihydro-2H-chromene-3,2'-(tetra...)
Show SMILES COc1cccc2OCC3(CCCN3)Cc12
Show InChI InChI=1S/C13H17NO2/c1-15-11-4-2-5-12-10(11)8-13(9-16-12)6-3-7-14-13/h2,4-5,14H,3,6-9H2,1H3
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n/an/a 4.40E+3n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSB

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50054145
PNG
(5-methoxy-1'-propylspiro[3,4-dihydro-2H-chromene-3...)
Show SMILES CCCN1CCCC11COc2cccc(OC)c2C1
Show InChI InChI=1S/C16H23NO2/c1-3-9-17-10-5-8-16(17)11-13-14(18-2)6-4-7-15(13)19-12-16/h4,6-7H,3,5,8-12H2,1-2H3
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n/an/a 6.55E+3n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Displacement of [3H]-SDZ-205-501 from Dopamine receptor D2 in calf caudate nucleus.

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Rattus norvegicus (Rat))		BDBM82368
PNG
(CAS_121851 | CHEMBL11592 | CHEMBL301060 | NSC_1218...)
Show SMILES CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1
Show InChI InChI=1S/C26H38N2O4/c1-3-13-27(20-16-21-22(31-2)9-8-10-23(21)32-19-20)14-6-7-15-28-24(29)17-26(18-25(28)30)11-4-5-12-26/h8-10,20H,3-7,11-19H2,1-2H3
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n/an/a 1.00E+4n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSB

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Rattus norvegicus (Rat))		BDBM82368
PNG
(CAS_121851 | CHEMBL11592 | CHEMBL301060 | NSC_1218...)
Show SMILES CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1
Show InChI InChI=1S/C26H38N2O4/c1-3-13-27(20-16-21-22(31-2)9-8-10-23(21)32-19-20)14-6-7-15-28-24(29)17-26(18-25(28)30)11-4-5-12-26/h8-10,20H,3-7,11-19H2,1-2H3
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n/an/a 1.00E+4n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSB

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Rattus norvegicus (Rat))		BDBM50054145
PNG
(5-methoxy-1'-propylspiro[3,4-dihydro-2H-chromene-3...)
Show SMILES CCCN1CCCC11COc2cccc(OC)c2C1
Show InChI InChI=1S/C16H23NO2/c1-3-9-17-10-5-8-16(17)11-13-14(18-2)6-4-7-15(13)19-12-16/h4,6-7H,3,5,8-12H2,1-2H3
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n/an/a 1.10E+4n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSB

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Rattus norvegicus (Rat))		BDBM50054149
PNG
(1'-[4-(4-fluorophenylcarboxamido)butyl]-5-methoxys...)
Show SMILES COc1cccc2OCC3(CCCCN3CCCCNC(=O)c3ccc(F)cc3)Cc12
Show InChI InChI=1S/C25H31FN2O3/c1-30-22-7-6-8-23-21(22)17-25(18-31-23)13-2-4-15-28(25)16-5-3-14-27-24(29)19-9-11-20(26)12-10-19/h6-12H,2-5,13-18H2,1H3,(H,27,29)
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n/an/a 1.12E+4n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity on 5-HT1B receptors using rat cortex+striatum+ globus pallidus,[ 3H]-5-OH-tryptamine, and serotonin for N...

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(BOVINE)		BDBM50005127
PNG
(1,1-Dioxo-2-[4-(4-pyrimidin-2-yl-piperazin-1-yl)-b...)
Show SMILES O=C1N(CCCCN2CCN(CC2)c2ncccn2)S(=O)(=O)c2ccccc12
Show InChI InChI=1S/C19H23N5O3S/c25-18-16-6-1-2-7-17(16)28(26,27)24(18)11-4-3-10-22-12-14-23(15-13-22)19-20-8-5-9-21-19/h1-2,5-9H,3-4,10-15H2
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n/an/a 1.20E+4n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Displacement of [3H]-raclopride from Dopamine receptor D1 of calf striatum

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50054143
PNG
((+) 8-{4-[5-methoxyspiro[3,4-dihydro-2H-chromene-3...)
Show SMILES COc1cccc2OCC3(CCCN3CCCCN3C(=O)CC4(CCCC4)CC3=O)Cc12
Show InChI InChI=1S/C26H36N2O4/c1-31-21-8-6-9-22-20(21)16-26(19-32-22)12-7-14-27(26)13-4-5-15-28-23(29)17-25(18-24(28)30)10-2-3-11-25/h6,8-9H,2-5,7,10-19H2,1H3
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n/an/a 1.31E+4n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Displacement of [3H]-SDZ-205-501 from Dopamine receptor D2 in calf caudate nucleus.

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50054143
PNG
((+) 8-{4-[5-methoxyspiro[3,4-dihydro-2H-chromene-3...)
Show SMILES COc1cccc2OCC3(CCCN3CCCCN3C(=O)CC4(CCCC4)CC3=O)Cc12
Show InChI InChI=1S/C26H36N2O4/c1-31-21-8-6-9-22-20(21)16-26(19-32-22)12-7-14-27(26)13-4-5-15-28-23(29)17-25(18-24(28)30)10-2-3-11-25/h6,8-9H,2-5,7,10-19H2,1H3
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n/an/a 1.31E+4n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Displacement of [3H]-SDZ-205-501 from Dopamine receptor D2 in calf caudate nucleus.

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50054151
PNG
(5-methoxy-1'-propylspiro[3,4-dihydro-2H-chromene-3...)
Show SMILES CCCN1C(=O)CCC11COc2cccc(OC)c2C1
Show InChI InChI=1S/C16H21NO3/c1-3-9-17-15(18)7-8-16(17)10-12-13(19-2)5-4-6-14(12)20-11-16/h4-6H,3,7-11H2,1-2H3
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n/an/a 1.42E+4n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Binding affinity to 5-hydroxytryptamine 1A receptor in rat hippocampus membranes,3H-8-OH-DPAT and buspirone for nonspecific binding (NSB)

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50054150
PNG
(5-methoxy-1'-propylspiro[3,4-dihydro-2H-chromene-3...)
Show SMILES CCCN1CCCCC11COc2cccc(OC)c2C1
Show InChI InChI=1S/C17H25NO2/c1-3-10-18-11-5-4-9-17(18)12-14-15(19-2)7-6-8-16(14)20-13-17/h6-8H,3-5,9-13H2,1-2H3
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n/an/a 1.47E+4n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Displacement of [3H]-SDZ-205-501 from Dopamine receptor D2 in calf caudate nucleus.

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Rattus norvegicus (Rat))		BDBM50036862
PNG
((5-Methoxy-chroman-3-yl)-dipropyl-amine | CHEMBL28...)
Show SMILES CCCN(CCC)C1COc2cccc(OC)c2C1
Show InChI InChI=1S/C16H25NO2/c1-4-9-17(10-5-2)13-11-14-15(18-3)7-6-8-16(14)19-12-13/h6-8,13H,4-5,9-12H2,1-3H3
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n/an/a 2.00E+4n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSB

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(BOVINE)		BDBM50054143
PNG
((+) 8-{4-[5-methoxyspiro[3,4-dihydro-2H-chromene-3...)
Show SMILES COc1cccc2OCC3(CCCN3CCCCN3C(=O)CC4(CCCC4)CC3=O)Cc12
Show InChI InChI=1S/C26H36N2O4/c1-31-21-8-6-9-22-20(21)16-26(19-32-22)12-7-14-27(26)13-4-5-15-28-23(29)17-25(18-24(28)30)10-2-3-11-25/h6,8-9H,2-5,7,10-19H2,1H3
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n/an/a 2.24E+4n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Displacement of [3H]-raclopride from Dopamine receptor D1 of calf striatum

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(BOVINE)		BDBM50054143
PNG
((+) 8-{4-[5-methoxyspiro[3,4-dihydro-2H-chromene-3...)
Show SMILES COc1cccc2OCC3(CCCN3CCCCN3C(=O)CC4(CCCC4)CC3=O)Cc12
Show InChI InChI=1S/C26H36N2O4/c1-31-21-8-6-9-22-20(21)16-26(19-32-22)12-7-14-27(26)13-4-5-15-28-23(29)17-25(18-24(28)30)10-2-3-11-25/h6,8-9H,2-5,7,10-19H2,1H3
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n/an/a 2.33E+4n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Displacement of [3H]-raclopride from Dopamine receptor D1 of calf striatum

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(BOVINE)		BDBM50054147
PNG
(8-{4-[5-methoxyspiro[3,4-dihydro-2H-chromene-3,2'-...)
Show SMILES COc1cccc2OCC3(CCCCN3CCCCN3C(=O)CC4(CCCC4)CC3=O)Cc12
Show InChI InChI=1S/C27H38N2O4/c1-32-22-9-8-10-23-21(22)17-27(20-33-23)13-4-5-14-28(27)15-6-7-16-29-24(30)18-26(19-25(29)31)11-2-3-12-26/h8-10H,2-7,11-20H2,1H3
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n/an/a 2.34E+4n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Displacement of [3H]-raclopride from Dopamine receptor D1 of calf striatum

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(BOVINE)		BDBM50054142
PNG
(5-methoxy-1'-[4-(4-methylphenylsulfonamido)butyl]s...)
Show SMILES COc1cccc2OCC3(CCCCN3CCCCNS(=O)(=O)c3ccc(C)cc3)Cc12
Show InChI InChI=1S/C25H34N2O4S/c1-20-10-12-21(13-11-20)32(28,29)26-15-4-6-17-27-16-5-3-14-25(27)18-22-23(30-2)8-7-9-24(22)31-19-25/h7-13,26H,3-6,14-19H2,1-2H3
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n/an/a 3.80E+4n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Displacement of [3H]-raclopride from Dopamine receptor D1 of calf striatum

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(BOVINE)		BDBM50054149
PNG
(1'-[4-(4-fluorophenylcarboxamido)butyl]-5-methoxys...)
Show SMILES COc1cccc2OCC3(CCCCN3CCCCNC(=O)c3ccc(F)cc3)Cc12
Show InChI InChI=1S/C25H31FN2O3/c1-30-22-7-6-8-23-21(22)17-25(18-31-23)13-2-4-15-28(25)16-5-3-14-27-24(29)19-9-11-20(26)12-10-19/h6-12H,2-5,13-18H2,1H3,(H,27,29)
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n/an/a 3.83E+4n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Displacement of [3H]-raclopride from Dopamine receptor D1 of calf striatum

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(BOVINE)		BDBM82368
PNG
(CAS_121851 | CHEMBL11592 | CHEMBL301060 | NSC_1218...)
Show SMILES CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1
Show InChI InChI=1S/C26H38N2O4/c1-3-13-27(20-16-21-22(31-2)9-8-10-23(21)32-19-20)14-6-7-15-28-24(29)17-26(18-25(28)30)11-4-5-12-26/h8-10,20H,3-7,11-19H2,1-2H3
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n/an/a 4.00E+4n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Displacement of [3H]-raclopride from Dopamine receptor D1 of calf striatum

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(BOVINE)		BDBM82368
PNG
(CAS_121851 | CHEMBL11592 | CHEMBL301060 | NSC_1218...)
Show SMILES CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1
Show InChI InChI=1S/C26H38N2O4/c1-3-13-27(20-16-21-22(31-2)9-8-10-23(21)32-19-20)14-6-7-15-28-24(29)17-26(18-25(28)30)11-4-5-12-26/h8-10,20H,3-7,11-19H2,1-2H3
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n/an/a 4.00E+4n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Displacement of [3H]-raclopride from Dopamine receptor D1 of calf striatum

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Rattus norvegicus (Rat))		BDBM50005127
PNG
(1,1-Dioxo-2-[4-(4-pyrimidin-2-yl-piperazin-1-yl)-b...)
Show SMILES O=C1N(CCCCN2CCN(CC2)c2ncccn2)S(=O)(=O)c2ccccc12
Show InChI InChI=1S/C19H23N5O3S/c25-18-16-6-1-2-7-17(16)28(26,27)24(18)11-4-3-10-22-12-14-23(15-13-22)19-20-8-5-9-21-19/h1-2,5-9H,3-4,10-15H2
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n/an/a 5.00E+4n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSB

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Rattus norvegicus (Rat))		BDBM50054142
PNG
(5-methoxy-1'-[4-(4-methylphenylsulfonamido)butyl]s...)
Show SMILES COc1cccc2OCC3(CCCCN3CCCCNS(=O)(=O)c3ccc(C)cc3)Cc12
Show InChI InChI=1S/C25H34N2O4S/c1-20-10-12-21(13-11-20)32(28,29)26-15-4-6-17-27-16-5-3-14-25(27)18-22-23(30-2)8-7-9-24(22)31-19-25/h7-13,26H,3-6,14-19H2,1-2H3
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n/an/a 5.11E+4n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSB

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Rattus norvegicus (Rat))		BDBM50054150
PNG
(5-methoxy-1'-propylspiro[3,4-dihydro-2H-chromene-3...)
Show SMILES CCCN1CCCCC11COc2cccc(OC)c2C1
Show InChI InChI=1S/C17H25NO2/c1-3-10-18-11-5-4-9-17(18)12-14-15(19-2)7-6-8-16(14)20-13-17/h6-8H,3-5,9-13H2,1-2H3
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n/an/a 6.91E+4n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSB

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50054141
PNG
(1'-propylspiro[3,4-dihydro-2H-chromene-3,2'-(tetra...)
Show SMILES CCCN1CCCC11COc2cccc(O)c2C1
Show InChI InChI=1S/C15H21NO2/c1-2-8-16-9-4-7-15(16)10-12-13(17)5-3-6-14(12)18-11-15/h3,5-6,17H,2,4,7-11H2,1H3
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n/an/a 7.14E+4n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Displacement of [3H]-SDZ-205-501 from Dopamine receptor D2 in calf caudate nucleus.

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50054153
PNG
(1-[5-methoxyspiro[3,4-dihydro-2H-chromene-3,2'-(te...)
Show SMILES COc1cccc2OCC3(CCCN3C(C)=O)Cc12
Show InChI InChI=1S/C15H19NO3/c1-11(17)16-8-4-7-15(16)9-12-13(18-2)5-3-6-14(12)19-10-15/h3,5-6H,4,7-10H2,1-2H3
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n/an/a 8.14E+4n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Binding affinity to 5-hydroxytryptamine 1A receptor in rat hippocampus membranes,3H-8-OH-DPAT and buspirone for nonspecific binding (NSB)

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(BOVINE)		BDBM50054150
PNG
(5-methoxy-1'-propylspiro[3,4-dihydro-2H-chromene-3...)
Show SMILES CCCN1CCCCC11COc2cccc(OC)c2C1
Show InChI InChI=1S/C17H25NO2/c1-3-10-18-11-5-4-9-17(18)12-14-15(19-2)7-6-8-16(14)20-13-17/h6-8H,3-5,9-13H2,1-2H3
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n/an/a 1.00E+5n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Displacement of [3H]-raclopride from Dopamine receptor D1 of calf striatum

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(BOVINE)		BDBM50036862
PNG
((5-Methoxy-chroman-3-yl)-dipropyl-amine | CHEMBL28...)
Show SMILES CCCN(CCC)C1COc2cccc(OC)c2C1
Show InChI InChI=1S/C16H25NO2/c1-4-9-17(10-5-2)13-11-14-15(18-3)7-6-8-16(14)19-12-13/h6-8,13H,4-5,9-12H2,1-3H3
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n/an/a 1.00E+5n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Displacement of [3H]-raclopride from Dopamine receptor D1 of calf striatum

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Rattus norvegicus (Rat))		BDBM50054141
PNG
(1'-propylspiro[3,4-dihydro-2H-chromene-3,2'-(tetra...)
Show SMILES CCCN1CCCC11COc2cccc(O)c2C1
Show InChI InChI=1S/C15H21NO2/c1-2-8-16-9-4-7-15(16)10-12-13(17)5-3-6-14(12)18-11-15/h3,5-6,17H,2,4,7-11H2,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSB

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Rattus norvegicus (Rat))		BDBM50054148
PNG
(5-methoxyspiro[3,4-dihydro-2H-chromene-3,2'-(tetra...)
Show SMILES COc1cccc2OCC3(CCC(=O)N3)Cc12
Show InChI InChI=1S/C13H15NO3/c1-16-10-3-2-4-11-9(10)7-13(8-17-11)6-5-12(15)14-13/h2-4H,5-8H2,1H3,(H,14,15)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSB

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(BOVINE)		BDBM50054145
PNG
(5-methoxy-1'-propylspiro[3,4-dihydro-2H-chromene-3...)
Show SMILES CCCN1CCCC11COc2cccc(OC)c2C1
Show InChI InChI=1S/C16H23NO2/c1-3-9-17-10-5-8-16(17)11-13-14(18-2)6-4-7-15(13)19-12-16/h4,6-7H,3,5,8-12H2,1-2H3
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n/an/a 1.20E+5n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Displacement of [3H]-raclopride from Dopamine receptor D1 of calf striatum

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Rattus norvegicus (Rat))		BDBM50054153
PNG
(1-[5-methoxyspiro[3,4-dihydro-2H-chromene-3,2'-(te...)
Show SMILES COc1cccc2OCC3(CCCN3C(C)=O)Cc12
Show InChI InChI=1S/C15H19NO3/c1-11(17)16-8-4-7-15(16)9-12-13(18-2)5-3-6-14(12)19-10-15/h3,5-6H,4,7-10H2,1-2H3
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n/an/a 2.46E+5n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSB

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(BOVINE)		BDBM50001859
PNG
((buspirone) 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)...)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C21H31N5O2/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9H,1-4,6-7,10-17H2
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n/an/a 2.70E+5n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Displacement of [3H]-raclopride from Dopamine receptor D1 of calf striatum

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50005127
PNG
(1,1-Dioxo-2-[4-(4-pyrimidin-2-yl-piperazin-1-yl)-b...)
Show SMILES O=C1N(CCCCN2CCN(CC2)c2ncccn2)S(=O)(=O)c2ccccc12
Show InChI InChI=1S/C19H23N5O3S/c25-18-16-6-1-2-7-17(16)28(26,27)24(18)11-4-3-10-22-12-14-23(15-13-22)19-20-8-5-9-21-19/h1-2,5-9H,3-4,10-15H2
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n/an/a>1.00E+6n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Displacement of [3H]-SDZ-205-501 from Dopamine receptor D2 in calf caudate nucleus.

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Rattus norvegicus (Rat))		BDBM50054151
PNG
(5-methoxy-1'-propylspiro[3,4-dihydro-2H-chromene-3...)
Show SMILES CCCN1C(=O)CCC11COc2cccc(OC)c2C1
Show InChI InChI=1S/C16H21NO3/c1-3-9-17-15(18)7-8-16(17)10-12-13(19-2)5-4-6-14(12)20-11-16/h4-6H,3,7-11H2,1-2H3
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n/an/a>1.00E+6n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSB

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(BOVINE)		BDBM50054141
PNG
(1'-propylspiro[3,4-dihydro-2H-chromene-3,2'-(tetra...)
Show SMILES CCCN1CCCC11COc2cccc(O)c2C1
Show InChI InChI=1S/C15H21NO2/c1-2-8-16-9-4-7-15(16)10-12-13(17)5-3-6-14(12)18-11-15/h3,5-6,17H,2,4,7-11H2,1H3
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n/an/a>1.00E+6n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Displacement of [3H]-raclopride from Dopamine receptor D1 of calf striatum

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Rattus norvegicus (Rat))		BDBM50054144
PNG
(1'-propylspiro[3,4-dihydro-2H-chromene-3,2'-(tetra...)
Show SMILES CCCN1CCCC11COc2ccccc2C1
Show InChI InChI=1S/C15H21NO/c1-2-9-16-10-5-8-15(16)11-13-6-3-4-7-14(13)17-12-15/h3-4,6-7H,2,5,8-12H2,1H3
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n/an/a>1.00E+6n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSB

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(BOVINE)		BDBM21393
PNG
(7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-o...)
Show SMILES CCCN(CCC)C1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3
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n/an/a>1.00E+6n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity on Dopamine receptor D1 using calf striatum

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%