Affinity Data by USPatent=US8580800

USPatent US8580800

Found 9 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Neutrophil elastase (Homo sapiens (Human))	BDBM105226 (US8580800, 2) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.4	37
Bayer Intellectual Property GmbH US Patent					Assay Description The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...				US Patent US8580800 (2013) BindingDB Entry DOI: 10.7270/Q2WM1C18
Bayer Intellectual Property GmbH US Patent					More data for this Ligand-Target Pair
Neutrophil elastase (Homo sapiens (Human))	BDBM105231 (US8580800, 23) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.4	37
Bayer Intellectual Property GmbH US Patent					Assay Description The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...				US Patent US8580800 (2013) BindingDB Entry DOI: 10.7270/Q2WM1C18
Bayer Intellectual Property GmbH US Patent					More data for this Ligand-Target Pair
Neutrophil elastase (Homo sapiens (Human))	BDBM105227 (US8580800, 4) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	7.4	37
Bayer Intellectual Property GmbH US Patent					Assay Description The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...				US Patent US8580800 (2013) BindingDB Entry DOI: 10.7270/Q2WM1C18
Bayer Intellectual Property GmbH US Patent					More data for this Ligand-Target Pair
Neutrophil elastase (Homo sapiens (Human))	BDBM105232 (US8580800, 27) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	7.4	37
Bayer Intellectual Property GmbH US Patent					Assay Description The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...				US Patent US8580800 (2013) BindingDB Entry DOI: 10.7270/Q2WM1C18
Bayer Intellectual Property GmbH US Patent					More data for this Ligand-Target Pair
Neutrophil elastase (Homo sapiens (Human))	BDBM105230 (US8580800, 17) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	7.4	37
Bayer Intellectual Property GmbH US Patent					Assay Description The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...				US Patent US8580800 (2013) BindingDB Entry DOI: 10.7270/Q2WM1C18
Bayer Intellectual Property GmbH US Patent					More data for this Ligand-Target Pair
Neutrophil elastase (Homo sapiens (Human))	BDBM105229 (US8580800, 9) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	23	n/a	n/a	n/a	n/a	7.4	37
Bayer Intellectual Property GmbH US Patent					Assay Description The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...				US Patent US8580800 (2013) BindingDB Entry DOI: 10.7270/Q2WM1C18
Bayer Intellectual Property GmbH US Patent					More data for this Ligand-Target Pair
Neutrophil elastase (Homo sapiens (Human))	BDBM105233 (US8580800, 31) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	28	n/a	n/a	n/a	n/a	7.4	37
Bayer Intellectual Property GmbH US Patent					Assay Description The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...				US Patent US8580800 (2013) BindingDB Entry DOI: 10.7270/Q2WM1C18
Bayer Intellectual Property GmbH US Patent					More data for this Ligand-Target Pair
Neutrophil elastase (Homo sapiens (Human))	BDBM105225 (US8580800, 1) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	28	n/a	n/a	n/a	n/a	7.4	37
Bayer Intellectual Property GmbH US Patent					Assay Description The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...				US Patent US8580800 (2013) BindingDB Entry DOI: 10.7270/Q2WM1C18
Bayer Intellectual Property GmbH US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
Neutrophil elastase (Homo sapiens (Human))	BDBM105228 (US8580800, 8) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	32	n/a	n/a	n/a	n/a	7.4	37
Bayer Intellectual Property GmbH US Patent					Assay Description The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...				US Patent US8580800 (2013) BindingDB Entry DOI: 10.7270/Q2WM1C18
Bayer Intellectual Property GmbH US Patent					More data for this Ligand-Target Pair

* indicates data uncertainty>20%