BindingDB logo
myBDB logout

USPatent US8940720

Compile data set for download or QSAR
Found 77 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Coagulation factor XI


(Homo sapiens (Human))		BDBM47108
PNG
(US10487086, Example 10 | US11136327, Example 10 | ...)
Show SMILES COC(=O)Nc1ccc2-c3c[nH]c(n3)[C@H](CCCCC(=O)Nc2c1)NC(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1 |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
PDB
UniChem

Similars
PDB
US Patent
<5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Coagulation factor XI


(Homo sapiens (Human))		BDBM142896
PNG
(US10487086, Example 61 | US8940720, 61 | US9802939...)
Show SMILES COC(=O)Nc1ccc2-c3c[nH]c(n3)[C@H](CCC(C)CCC(=O)Nc2c1)NC(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1 |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
<5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142910
PNG
(US10487086, Example I-80 | US11136327, Example I-8...)
Show SMILES COC(=O)Nc1ccc2-c3c[nH]c(n3)[C@H](CCCC[C@@H](Nc2c1)C(=O)N1CCCC1)NC(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1 |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
<5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142927
PNG
(US11136327, Example II-13 | US8940720, II-13 | US9...)
Show SMILES COC(=O)Nc1ccc-2c(NC(CCCC[C@H](NC(=O)C3CC[C@H](CN)CC3)c3cc-2ccn3)C(F)(F)F)c1 |r,wU:16.16,wD:23.23,(11.38,-1.36,;10.29,-.28,;8.8,-.67,;8.41,-2.16,;7.72,.42,;6.23,.02,;5.83,-1.47,;4.34,-1.87,;3.25,-.78,;3.65,.71,;1.96,2.31,;1.96,3.85,;.62,4.62,;-.71,3.85,;-.71,2.31,;-2.05,1.54,;-2.05,,;-3.38,-.77,;-4.71,,;-4.71,1.54,;-6.05,-.77,;-6.05,-2.31,;-7.38,-3.08,;-8.71,-2.31,;-10.05,-3.08,;-10.05,-4.62,;-8.71,-.77,;-7.38,0,;-.71,-.77,;.78,-.37,;1.86,-1.46,;1.47,-2.95,;-.02,-3.35,;-1.11,-2.26,;3.29,4.62,;4.62,3.85,;3.29,6.16,;4.62,5.39,;5.14,1.11,)|
Show InChI InChI=1S/C28H36F3N5O3/c1-39-27(38)34-20-10-11-21-19-12-13-33-24(14-19)22(36-26(37)18-8-6-17(16-32)7-9-18)4-2-3-5-25(28(29,30)31)35-23(21)15-20/h10-15,17-18,22,25,35H,2-9,16,32H2,1H3,(H,34,38)(H,36,37)/t17-,18?,22-,25?/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
<5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142864
PNG
(US10487086, Example 90 | US11136327, Example 90 | ...)
Show SMILES COC(=O)Nc1ccc-2c(NC(=O)CC\C=C\C[C@H](NC(=O)[C@H]3CC[C@H](CN)CC3)c3cc-2ccn3)c1 |r,wU:22.21,18.18,wD:25.25,t:15,(11.34,.5,;10,1.27,;8.67,.5,;8.67,-1.04,;7.34,1.27,;6,.5,;6,-1.04,;4.67,-1.81,;3.33,-1.04,;3.33,.5,;2,1.27,;2,2.81,;3.45,3.34,;.91,3.9,;-.62,4.12,;-1.71,3.03,;-1.31,1.54,;-2.4,.45,;-2,-1.04,;-3.33,-1.81,;-4.67,-1.04,;-4.67,.5,;-6,-1.81,;-6,-3.35,;-7.34,-4.12,;-8.67,-3.35,;-10,-4.12,;-11.34,-3.35,;-8.67,-1.81,;-7.34,-1.04,;-.67,-1.81,;.67,-1.04,;2,-1.81,;2,-3.35,;.67,-4.12,;-.67,-3.35,;4.67,1.27,)|
Show InChI InChI=1S/C28H35N5O4/c1-37-28(36)31-21-11-12-22-20-13-14-30-25(15-20)23(5-3-2-4-6-26(34)32-24(22)16-21)33-27(35)19-9-7-18(17-29)8-10-19/h2-3,11-16,18-19,23H,4-10,17,29H2,1H3,(H,31,36)(H,32,34)(H,33,35)/b3-2+/t18-,19-,23-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
<5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142873
PNG
(US10487086, Example I-77 | US11136327, Example I-7...)
Show SMILES COC(=O)Nc1ccc2-c3c[nH]c(n3)[C@H](CCCC[C@H](CO)Nc2c1)NC(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1 |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
<5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142920
PNG
(US8940720, I-151)
Show SMILES COC(=O)Nc1ccc2-c3c[nH]c(n3)[C@H](C\C=C\CC(=O)Nc2c1)NC(=O)c1ccc2CNCCc2c1 |r,t:17|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
<5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142890
PNG
(US10487086, Example II-3 | US11136327, Example II-...)
Show SMILES COC(=O)Nc1ccc-2c(NC(=O)CC\C=C\C[C@H](NC(=O)c3ccc(cc3)C(N)=N)c3cc-2ccn3)c1 |r,t:15|
Show InChI InChI=1S/C28H28N6O4/c1-38-28(37)32-20-11-12-21-19-13-14-31-24(15-19)22(5-3-2-4-6-25(35)33-23(21)16-20)34-27(36)18-9-7-17(8-10-18)26(29)30/h2-3,7-16,22H,4-6H2,1H3,(H3,29,30)(H,32,37)(H,33,35)(H,34,36)/b3-2+/t22-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
<5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142930
PNG
(US10487086, Example II-35 | US11136327, Example II...)
Show SMILES COC(=O)Nc1ccc-2c(N[C@H](CCCC[C@H](NC(=O)\C=C\c3cc(Cl)ccc3-n3cnnn3)c3cc-2ccn3)C(=O)N2CCN(C)CC2)c1 |r|
Show InChI InChI=1S/C35H39ClN10O4/c1-44-15-17-45(18-16-44)34(48)29-6-4-3-5-28(41-33(47)12-7-24-19-25(36)8-11-32(24)46-22-38-42-43-46)31-20-23(13-14-37-31)27-10-9-26(21-30(27)40-29)39-35(49)50-2/h7-14,19-22,28-29,40H,3-6,15-18H2,1-2H3,(H,39,49)(H,41,47)/b12-7+/t28-,29+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
<5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142895
PNG
(US10487086, Example II-62 | US11136327, Example II...)
Show SMILES CCOC(=O)C1CCCCC(NC(=O)\C=C\c2cc(Cl)ccc2-n2cnnn2)c2cc(cc(=O)[nH]2)-c2ccc(NC(=O)OC)cc2N1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
<5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142917
PNG
(US10487086, Example I-115 | US11136327, Example I-...)
Show SMILES COC(=O)Nc1ccc2-c3nc([nH]c3C#N)[C@H](CCCCCNc2c1)NC(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1 |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
<5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142897
PNG
(US10487086, Example I-4 | US11136327, Example I-4 ...)
Show SMILES COC(=O)Nc1ccc2-c3c[nH]c(n3)[C@H](CCCCC(=O)Nc2c1)NC(=O)c1ccc(cc1)C(N)=N |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
<5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142924
PNG
(US10487086, Example I-251 | US11136327, Example I-...)
Show SMILES CCOC(=O)[C@H]1CCCC[C@H](NC(=O)\C=C\c2cc(Cl)ccc2-n2cnnn2)c2nc(c([nH]2)C#N)-c2ccc(NC(=O)OC)cc2N1 |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
<5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142889
PNG
(US10487086, Example I-311 | US11136327, Example I-...)
Show SMILES COC(=O)Nc1ccc2-c3nc([nH]c3Cl)[C@H](C\C=C\CCC(=O)Nc2c1)NC(=O)\C=C\c1c(F)c(Cl)ccc1C(F)(F)F |r,t:18|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
<5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142866
PNG
(US10487086, Example 121 | US11136327, Example 121 ...)
Show SMILES Clc1[nH]c2nc1-c1ccccc1NC(=O)OC\C=C\C[C@@H]2NC(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1 |r,t:19|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
<5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142904
PNG
(US11136327, Example I-21 | US8940720, I-21)
Show SMILES COC(=O)Nc1ccc2-c3nc([nH]c3F)[C@H](CCCCC(=O)Nc2c1)NC(=O)c1c(F)cc2n(C)cnc2c1F |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
<5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142919
PNG
(BDBM420091 | US11136327, Example I-124 | US8940720...)
Show SMILES Clc1ccc(c(\C=C\C(=O)N[C@H]2CCCCCNc3cc(NC(=O)OC[C@H]4CCCO4)ccc3-c3c[nH]c2n3)c1)-n1cnnn1 |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
<5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142898
PNG
(US10487086, Example I-5 | US11136327, Example I-5 ...)
Show SMILES COC(=O)Nc1ccc2-c3c[nH]c(n3)[C@H](CCCCC(=O)Nc2c1)NC(=O)\C=C\c1cc(Cl)ccc1-n1ccnn1 |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
<5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142865
PNG
(US10487086, Example 93 | US11136327, Example 93 | ...)
Show SMILES COC(=O)Nc1ccc-2c(NC(=O)CC\C=C\CC(NC(=O)\C=C\c3cc(Cl)ccc3-n3cnnn3)c3cccc-2c3)c1 |t:15|
Show InChI InChI=1S/C31H28ClN7O4/c1-43-31(42)34-24-12-13-25-20-6-5-7-21(16-20)26(8-3-2-4-9-29(40)36-27(25)18-24)35-30(41)15-10-22-17-23(32)11-14-28(22)39-19-33-37-38-39/h2-3,5-7,10-19,26H,4,8-9H2,1H3,(H,34,42)(H,35,41)(H,36,40)/b3-2+,15-10+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142906
PNG
(US10487086, Example I-59 | US8940720, I-59)
Show SMILES COC(=O)Nc1ccc2-c3nc([nH]c3Cl)[C@H](CCCC(C)C(=O)Nc2c1)NC(=O)c1c(F)cc2n(C)ccc2c1F |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
<5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142880
PNG
(US10487086, Example I-227 | US11136327, Example I-...)
Show SMILES Fc1ccc2NC(=O)CC\C=C\C[C@H](NC(=O)\C=C\c3cc(Cl)ccc3-n3cnnn3)c3nc(c(Cl)[nH]3)-c2c1 |r,t:10|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
<5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142885
PNG
(US10487086, Example I-278 | US11136327, Example I-...)
Show SMILES COCCOC(=O)Nc1ccc2-c3nc([nH]c3C#N)[C@H](CCCC[C@@H](Nc2c1)C(=O)OC)NC(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1 |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
<5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142876
PNG
(US10487086, Example I-134 | US11136327, Example I-...)
Show SMILES COC(=O)Nc1ccc2-c3cnc(o3)[C@H](CCCCC(=O)Nc2c1)NC(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1 |r|
Show InChI InChI=1S/C27H25ClN8O5/c1-40-27(39)31-18-8-9-19-21(13-18)33-24(37)5-3-2-4-20(26-29-14-23(19)41-26)32-25(38)11-6-16-12-17(28)7-10-22(16)36-15-30-34-35-36/h6-15,20H,2-5H2,1H3,(H,31,39)(H,32,38)(H,33,37)/b11-6+/t20-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142860
PNG
(US10487086, Example 11 | US11136327, Example 11 | ...)
Show SMILES COC(=O)Nc1ccc2-c3c[nH]c(n3)[C@H](CCCCCNc2c1)NC(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1 |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 6n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142905
PNG
(US8940720, I-57)
Show SMILES COC(=O)Nc1ccc2-c3nc([nH]c3Cl)[C@H](CCCC(C)C(=O)Nc2c1)NC(=O)c1c(F)cc2n(C)cnc2c1F |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 6.60n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142883
PNG
(US10487086, Example I-268 | US11136327, Example I-...)
Show SMILES COC(=O)Nc1ccc2-c3nc([nH]c3C#N)[C@H](CCCCCNc2c1)NC(=O)\C=C\c1cc(C)ccc1-n1cnnn1 |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 9n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142888
PNG
(US10487086, Example I-309 | US11136327, Example I-...)
Show SMILES COC(=O)Nc1ccc2-c3nc([nH]c3Cl)[C@H](C\C=C\CCC(=O)Nc2c1)NC(=O)\C=C\c1cccc(Cl)c1 |r,t:18|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 9n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142887
PNG
(US10487086, Example I-299 | US11136327, Example I-...)
Show SMILES COC(=O)Nc1ccc2-c3nc([nH]c3C(=O)N(C)C)[C@H](CCCCCNc2c1)NC(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1 |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 19n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142870
PNG
(US10487086, Example 138 | US11136327, Example 138 ...)
Show SMILES Clc1ccc(c(\C=C\C(=O)N[C@H]2CCCCC(=O)Nc3cnccc3-c3ccnc2c3)c1)-n1cnnn1 |r|
Show InChI InChI=1S/C26H23ClN8O2/c27-19-6-7-24(35-16-30-33-34-35)18(13-19)5-8-26(37)31-21-3-1-2-4-25(36)32-23-15-28-11-10-20(23)17-9-12-29-22(21)14-17/h5-16,21H,1-4H2,(H,31,37)(H,32,36)/b8-5+/t21-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 20n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142894
PNG
(US10487086, Example II-58 | US8940720, II-58 | US9...)
Show SMILES COC(=O)Nc1ccc-2c(N[C@H](CCCC[C@H](NC(=O)\C=C\c3cc(Cl)ccc3-n3cnnn3)c3cncc-2c3)C(=O)NCc2ccccn2)c1 |r|
Show InChI InChI=1S/C36H35ClN10O4/c1-51-36(50)42-27-11-12-29-24-16-25(20-38-19-24)30(44-34(48)14-9-23-17-26(37)10-13-33(23)47-22-41-45-46-47)7-2-3-8-31(43-32(29)18-27)35(49)40-21-28-6-4-5-15-39-28/h4-6,9-20,22,30-31,43H,2-3,7-8,21H2,1H3,(H,40,49)(H,42,50)(H,44,48)/b14-9+/t30-,31+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 21n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142921
PNG
(US8940720, I-152)
Show SMILES COC(=O)Nc1ccc2-c3c[nH]c(n3)[C@H](C\C=C\CC(=O)Nc2c1)NC(=O)c1ccc2[C@H](N)CCCc2c1 |r,t:17|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 21n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142892
PNG
(US10487086, Example II-10 | US11136327, Example II...)
Show SMILES COC(=O)Nc1ccc-2c(NC(=O)CCCCC(NC(=O)\C=C\c3cc(Cl)ccc3-n3cnnn3)c3cc-2nc(C)n3)c1
Show InChI InChI=1S/C29H28ClN9O4/c1-17-32-24-15-25(33-17)22(35-28(41)12-7-18-13-19(30)8-11-26(18)39-16-31-37-38-39)5-3-4-6-27(40)36-23-14-20(9-10-21(23)24)34-29(42)43-2/h7-16,22H,3-6H2,1-2H3,(H,34,42)(H,35,41)(H,36,40)/b12-7+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 23n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142874
PNG
(US10487086, Example I-106 | US8940720, I-106)
Show SMILES COC(=O)Nc1ccc2-c3c[nH]c(n3)[C@H](CCC=CC(=O)Nc2c1)NC(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1 |r,w:17.17|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 24n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142867
PNG
(US8940720, 122)
Show SMILES Clc1ccc(c(\C=C\C(=O)N[C@H]2C\C=C\CCC(=O)Nc3ccccc3-c3nnc2o3)c1)-n1cnnn1 |r,w:15.14,t:13|
Show InChI InChI=1S/C25H21ClN8O3/c26-17-11-12-21(34-15-27-32-33-34)16(14-17)10-13-23(36)29-20-8-2-1-3-9-22(35)28-19-7-5-4-6-18(19)24-30-31-25(20)37-24/h1-2,4-7,10-15,20H,3,8-9H2,(H,28,35)(H,29,36)/b2-1+,13-10+/t20-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
 25n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142875
PNG
(US10487086, Example I-107 | US11136327, Example I-...)
Show SMILES COC(=O)Nc1ccc2-c3nc([nH]c3F)[C@H](CCCC\C=N\c2c1)NC(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1 |r,t:21|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 29n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142858
PNG
(US10487086, Example 6 | US11136327, Example 6 | US...)
Show SMILES COC(=O)Nc1ccc2-c3c[nH]c(n3)[C@H](CCCCCCc2c1)NC(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1 |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 34n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142861
PNG
(US10487086, Example 19 | US11136327, Example 19 | ...)
Show SMILES COC(=O)Nc1ccc2-c3c[nH]c(n3)[C@H](C\C=C/CS(=O)(=O)Nc2c1)NC(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1 |r,c:17|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
 96n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142886
PNG
(US10487086, Example I-284 | US11136327, Example I-...)
Show SMILES COC(=O)c1ccc2NC(=O)CC\C=C\C[C@H](NC(=O)\C=C\c3cc(Cl)ccc3-n3cnnn3)c3nc(c[nH]3)-c2c1 |r,t:13|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
 102n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142891
PNG
(US10487086, Example II-4 | US11136327, Example II-...)
Show SMILES COC(=O)Nc1ccc-2c(NC(=O)CCCC[C@H](NC(=O)c3c(F)cc(C)cc3F)c3cc-2ccn3)c1 |r|
Show InChI InChI=1S/C27H26F2N4O4/c1-15-11-19(28)25(20(29)12-15)26(35)33-21-5-3-4-6-24(34)32-22-14-17(31-27(36)37-2)7-8-18(22)16-9-10-30-23(21)13-16/h7-14,21H,3-6H2,1-2H3,(H,31,36)(H,32,34)(H,33,35)/t21-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
 111n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142882
PNG
(US10487086, Example I-265 | US11136327, Example I-...)
Show SMILES COC(=O)Nc1ccc2-c3nc([nH]c3C#N)[C@H](CCCCCNc2c1)NC(=O)\C=C\c1c(F)c(Cl)ccc1C(C)=O |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
 133n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142871
PNG
(US10487086, Example 167 | US11136327, Example 167 ...)
Show SMILES COC(=O)Nc1ccc-2c(NC(=O)C\C=C\CC(NC(=O)\C=C\c3cc(Cl)ccc3-n3cnnn3)c3cc-2nc(C)n3)c1 |t:14|
Show InChI InChI=1S/C29H26ClN9O4/c1-17-32-24-15-25(33-17)22(35-28(41)12-7-18-13-19(30)8-11-26(18)39-16-31-37-38-39)5-3-4-6-27(40)36-23-14-20(9-10-21(23)24)34-29(42)43-2/h3-4,7-16,22H,5-6H2,1-2H3,(H,34,42)(H,35,41)(H,36,40)/b4-3+,12-7+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 157n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142877
PNG
(US8940720, I-136)
Show SMILES Clc1ccc(c(\C=C\C(=O)N[C@H]2CCCCC(=O)Nc3cc4[nH]ncc4cc3-c3c[nH]c2n3)c1)-n1cnnn1 |r|
Show InChI InChI=1S/C26H21ClN10O2/c27-17-6-7-23(37-14-30-35-36-37)15(9-17)5-8-25(39)31-19-3-1-2-4-24(38)32-21-11-20-16(12-29-34-20)10-18(21)22-13-28-26(19)33-22/h5-14,19H,1-4H2,(H,31,39)(H,32,38)/b8-5+,22-18-/t19-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 183n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142869
PNG
(US10487086, Example 137 | US11136327, Example 137 ...)
Show SMILES COC(=O)Nc1ccc2-c3c[nH]c(n3)[C@H](CC(O)C(O)CC(=O)Nc2c1)NC(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1 |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 192n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142872
PNG
(US8940720, I-67)
Show SMILES CCOC(=O)[C@H]1CCCC[C@H](NC(=O)\C=C\c2cc(Cl)ccc2-n2cnnn2)c2nc(c[nH]2)-c2ccc(NC(=O)OC)cc2N1 |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
PDB
UniChem

Similars
PDB
US Patent
 203n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Coagulation factor XI


(Homo sapiens (Human))		BDBM142900
PNG
(US10208068, Example 52 | US10487086, Example I-10 ...)
Show SMILES COC(=O)Nc1ccc2-c3c[nH]c(n3)[C@H](CCCCC(=O)Nc2c1)NC(=O)c1cn(nn1)-c1cccc(Cl)c1 |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
 217n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142859
PNG
(US10487086, Example 9 | US11136327, Example 9 | US...)
Show SMILES COC(=O)Nc1ccc2-c3nc([nH]c3Cl)[C@H](CCCCCOc2c1)NC(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1 |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
 249n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142908
PNG
(US8940720, I-70)
Show SMILES COC(=O)Nc1ccc2-c3nc([nH]c3C)[C@H](CCCCC(Nc2c1)C(F)(F)F)NC(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1 |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 270n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142909
PNG
(US8940720, I-72)
Show SMILES COC(=O)Nc1ccc2-c3c[nH]c(n3)[C@H](CCCCC(Nc2c1)C(F)F)NC(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1 |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 289n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142916
PNG
(US10487086, Example I-114 | US11136327, Example I-...)
Show SMILES COC(=O)Nc1ccc2-c3c[nH]c(n3)[C@H](CCCC(C)C(Nc2c1)C(N)=O)NC(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1 |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 296n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142901
PNG
(US10487086, Example I-13 | US8940720, I-13)
Show SMILES COC(=O)Nc1ccc2-c3c[nH]c(n3)[C@H](CCCCC(=O)Nc2c1)NC(=O)c1ccc2NCCCc2c1 |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 311n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142903
PNG
(US10487086, Example I-17 | US11136327, Example I-1...)
Show SMILES COC(=O)Nc1ccc2-c3c[nH]c(n3)[C@H](CCCCC(=O)Nc2c1)NC(=O)c1cccc2ccccc12 |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 351n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142914
PNG
(US8940720, I-104)
Show SMILES COC(=O)Nc1ccc2-c3c[nH]c(n3)[C@H](CCCCC(Nc2c1)(C(=O)OC)C(F)(F)F)NC(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1 |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 435n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142881
PNG
(US10487086, Example I-242 | US11136327, Example I-...)
Show SMILES CCOC(=O)[C@@H]1CCCC[C@H](NC(=O)\C=C\c2cc(Cl)ccc2-n2cnnn2)c2nc(c(C)[nH]2)-c2ccc(NC(=O)OC)cc2N1 |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 456n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142929
PNG
(US8940720, II-18)
Show SMILES CCOC(=O)C1CCCC[C@H](NC(=O)\C=C\c2cc(Cl)ccc2-n2cnnn2)c2cc(ccn2)-c2ccc(NC(=O)OC)cc2N1 |r|
Show InChI InChI=1S/C32H33ClN8O5/c1-3-46-31(43)26-7-5-4-6-25(38-30(42)13-8-21-16-22(33)9-12-29(21)41-19-35-39-40-41)28-17-20(14-15-34-28)24-11-10-23(18-27(24)37-26)36-32(44)45-2/h8-19,25-26,37H,3-7H2,1-2H3,(H,36,44)(H,38,42)/b13-8+/t25-,26?/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 572n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142911
PNG
(US11136327, Example I-84 | US8940720, I-84)
Show SMILES COC(=O)Nc1ccc2-c3c[nH]c(n3)[C@H](CCCC[C@H](Nc2c1)C(O)=O)NC(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1 |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 580n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142907
PNG
(US8940720, I-60)
Show SMILES COC(=O)Nc1ccc2-c3nc([nH]c3Cl)[C@H](CCCCC(Nc2c1)C(F)(F)F)NC(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1 |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 616n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142857
PNG
(US10487086, Example 4 | US11136327, Example 4 | US...)
Show SMILES COC(=O)Nc1ccc2-c3c[nH]c(n3)[C@H](C\C=C\CCCc2c1)NC(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1 |r,t:17|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 636n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142926
PNG
(US10487086, Example I-262 | US11136327, Example I-...)
Show SMILES COC(=O)Nc1ccc2-c3c[nH]c(n3)[C@H](CCCCC(=O)Nc2c1)NC(=O)c1ccc2cccnc2c1 |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 675n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142918
PNG
(US8940720, I-121)
Show SMILES CCC(=O)CN1CCCC[C@H](NC(=O)\C=C\c2cc(Cl)ccc2-n2cnnn2)c2nc(c[nH]2)-c2ccc(NC(=O)OC)cc2C1 |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 736n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142893
PNG
(US10487086, Example II-43 | US11136327, Example II...)
Show SMILES CCOC(=O)[C@@H]1CCCC[C@H](NC(=O)\C=C\c2c(F)c(Cl)ccc2-n2cnnn2)c2cc(ccn2)-c2ccc(NC(=O)OCCOC)cc2N1 |r|
Show InChI InChI=1S/C34H36ClFN8O6/c1-3-49-33(46)27-7-5-4-6-26(41-31(45)13-10-24-30(44-20-38-42-43-44)12-11-25(35)32(24)36)29-18-21(14-15-37-29)23-9-8-22(19-28(23)40-27)39-34(47)50-17-16-48-2/h8-15,18-20,26-27,40H,3-7,16-17H2,1-2H3,(H,39,47)(H,41,45)/b13-10+/t26-,27-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 938n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142925
PNG
(US8940720, I-258)
Show SMILES COC(=O)Nc1ccc2-c3c[nH]c(n3)[C@H](CCCCC(Cc2c1)C(=O)N(C)C)NC(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1 |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 947n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142868
PNG
(US10487086, Example 136 | US11136327, Example 136 ...)
Show SMILES COC(=O)Nc1ccc2-c3nc([nH]c3Cl)[C@H](C\C=C\CCC(=O)Nc2c1)NC(=O)c1ccc(cc1)C#N |r,t:18|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 962n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142863
PNG
(US10487086, Example 89 | US8940720, 89 | US9802939...)
Show SMILES COC(=O)Nc1ccc-2c(NC(=O)CC\C=C\CC(NC(=O)\C=C\c3cc(Cl)ccc3-n3cnnn3)c3cc(Cl)nnc-23)c1 |t:15|
Show InChI InChI=1S/C29H25Cl2N9O4/c1-44-29(43)33-19-9-10-20-23(14-19)35-26(41)6-4-2-3-5-22(21-15-25(31)36-37-28(20)21)34-27(42)12-7-17-13-18(30)8-11-24(17)40-16-32-38-39-40/h2-3,7-16,22H,4-6H2,1H3,(H,33,43)(H,34,42)(H,35,41)/b3-2+,12-7+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
 1.06E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142913
PNG
(US11136327, Example I-99 | US8940720, I-99)
Show SMILES COC(=O)Nc1ccc2-c3c[nH]c(n3)[C@H](CCCCC(Nc2c1)C1(C)COC1)NC(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1 |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 1.32E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142922
PNG
(US8940720, I-153)
Show SMILES COC(=O)Nc1ccc2-c3c[nH]c(n3)[C@H](C\C=C\CC(=O)Nc2c1)NC(=O)c1ccc2[C@@H](N)CCCc2c1 |r,t:17|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 1.65E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142884
PNG
(US10487086, Example I-270 | US11136327, Example I-...)
Show SMILES COC(=O)Nc1ccc2-c3c[nH]c(n3)[C@H](CCCCC(F)(F)C(=O)c2c1)NC(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1 |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 1.75E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142899
PNG
(US10487086, Example I-9 | US11136327, Example I-9 ...)
Show SMILES COC(=O)Nc1ccc2-c3c[nH]c(n3)[C@H](CCCCC(=O)Nc2c1)NC(=O)c1cc(no1)-c1cccc(Cl)c1 |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
 1.87E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142923
PNG
(US11136327, Example I-211 | US8940720, I-211)
Show SMILES COC(=O)Nc1ccc2-c3c[nH]c(n3)[C@H](C\C=C\CCC(Nc2c1)C(F)(F)F)NC(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1 |r,t:17|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 2.17E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142902
PNG
(US10487086, Example I-14 | US11136327, Example I-1...)
Show SMILES COC(=O)Nc1ccc2-c3c[nH]c(n3)[C@H](CCCCC(=O)Nc2c1)NC(=O)c1ccc2ncccc2c1 |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 2.92E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142878
PNG
(US10487086, Example I-137 | US11136327, Example I-...)
Show SMILES COC(=O)Nc1cc2NC(=O)[C@@H](C)CCC[C@H](NC(=O)c3c(F)cc4n(C)ncc4c3F)c3nc(c(Cl)[nH]3)-c2cc1Cl |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 2.98E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142931
PNG
(US8940720, 1)
Show SMILES Clc1ccc(c(\C=C\C(=O)N[C@H]2C\C=C\CCOc3ccccc3-n3cnc2n3)c1)-n1cnnn1 |r,t:13|
Show InChI InChI=1S/C24H21ClN8O2/c25-18-10-11-20(33-16-27-30-31-33)17(14-18)9-12-23(34)28-19-6-2-1-5-13-35-22-8-4-3-7-21(22)32-15-26-24(19)29-32/h1-4,7-12,14-16,19H,5-6,13H2,(H,28,34)/b2-1+,12-9+/t19-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
 2.98E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142912
PNG
(US8940720, I-94)
Show SMILES COC(=O)Nc1ccc2-c3c[nH]c(n3)[C@H](CCCC[C@H](Nc2c1)c1nn(N)cc1Cl)NC(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1 |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
 3.85E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142915
PNG
(US11136327, Example I-108 | US8940720, I-108)
Show SMILES COC(=O)Nc1ccc2-c3c[nH]c(n3)[C@H](CCCCCN(C(=O)OC)c2c1)NC(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1 |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 3.87E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142928
PNG
(US10487086, Example II-15 | US11136327, Example II...)
Show SMILES COC(=O)Nc1ccc-2c(NC(CCCC[C@H](NC(=O)c3ccc(cc3)C(N)=N)c3cc-2ccn3)C(F)(F)F)c1 |r|
Show InChI InChI=1S/C28H29F3N6O3/c1-40-27(39)35-19-10-11-20-18-12-13-34-23(14-18)21(37-26(38)17-8-6-16(7-9-17)25(32)33)4-2-3-5-24(28(29,30)31)36-22(20)15-19/h6-15,21,24,36H,2-5H2,1H3,(H3,32,33)(H,35,39)(H,37,38)/t21-,24?/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 4.16E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142862
PNG
(US10487086, Example 21 | US11136327, Example 21 | ...)
Show SMILES COC(=O)Nc1ccc2-c3c[nH]c(n3)[C@H](CNC(=O)C(F)(F)CNc2c1)NC(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1 |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 4.52E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142879
PNG
(US10487086, Example I-183 | US11136327, Example I-...)
Show SMILES CN(C)CCOC(=O)Nc1ccc2-c3nc([nH]c3Cl)[C@H](C\C=C\CCC(=O)Nc2c1)NC(=O)c1c(F)cc(C)cc1F |r,t:22|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 4.95E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))		BDBM142856
PNG
(US10487086, Example 3 | US11136327, Example 3 | US...)
Show SMILES NC[C@H]1CC[C@@H](CC1)C(=O)N[C@H]1C\C=C\CCCc2ccccc2-c2c[nH]c1n2 |r,wU:5.8,11.11,wD:2.1,t:14,(-8.52,-2.85,;-7.19,-3.62,;-5.85,-2.85,;-4.52,-3.62,;-3.19,-2.85,;-3.19,-1.31,;-4.52,-.54,;-5.85,-1.31,;-1.85,-.54,;-1.85,1,;-.52,-1.31,;.82,-.54,;.82,1,;2.15,1.77,;2.15,3.31,;3.43,3.62,;4.52,2.54,;4.52,1,;5.85,.23,;7.19,1,;8.52,.23,;8.52,-1.31,;7.19,-2.08,;5.85,-1.31,;4.52,-2.08,;3.61,-3.33,;2.15,-2.85,;2.15,-1.31,;3.61,-.84,)|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
 6.17E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...

US Patent US8940720 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B20
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%