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USPatent US9023354

Compile data set for download or QSAR
Found 43 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM156655
PNG
(US9023354, AD4-10315)
Show SMILES Oc1c(ccc2cccnc12)C(Nc1cccnc1)c1cccs1
Show InChI InChI=1S/C19H15N3OS/c23-19-15(8-7-13-4-1-10-21-17(13)19)18(16-6-3-11-24-16)22-14-5-2-9-20-12-14/h1-12,18,22-23H
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US Patent
n/an/a 1.50E+3n/an/an/an/an/a25



TBA

US Patent


Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM156660
PNG
(US9023354, AD4-10963)
Show SMILES Cc1ccsc1C(Nc1cc(C)ccn1)c1ccc2cccnc2c1O
Show InChI InChI=1S/C21H19N3OS/c1-13-7-10-22-17(12-13)24-19(21-14(2)8-11-26-21)16-6-5-15-4-3-9-23-18(15)20(16)25/h3-12,19,25H,1-2H3,(H,22,24)
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n/an/a 2.00E+3n/an/an/an/an/a25



TBA

US Patent


Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM50447144
PNG
(CHEMBL3112895 | US9023354, AD4-12917)
Show SMILES Cc1ccnc(NC(c2ccc(Cl)c(Cl)c2)c2ccc3cccnc3c2O)c1
Show InChI InChI=1S/C22H17Cl2N3O/c1-13-8-10-25-19(11-13)27-20(15-5-7-17(23)18(24)12-15)16-6-4-14-3-2-9-26-21(14)22(16)28/h2-12,20,28H,1H3,(H,25,27)
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n/an/a 3.60E+3n/an/an/an/an/a25



TBA

US Patent


Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM47305
PNG
(BDBM156659 | US9023354, AD4-10483)
Show SMILES Cc1cccc(NC(c2ccc(cc2)C(F)(F)F)c2ccc3cccnc3c2O)n1
Show InChI InChI=1S/C23H18F3N3O/c1-14-4-2-6-19(28-14)29-20(16-7-10-17(11-8-16)23(24,25)26)18-12-9-15-5-3-13-27-21(15)22(18)30/h2-13,20,30H,1H3,(H,28,29)
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US Patent


Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM156414
PNG
(US9023354, AD4-1505)
Show SMILES COc1ccc(cc1O)C(Nc1cc(C)ccn1)c1ccc2cccnc2c1O
Show InChI InChI=1S/C23H21N3O3/c1-14-9-11-24-20(12-14)26-21(16-6-8-19(29-2)18(27)13-16)17-7-5-15-4-3-10-25-22(15)23(17)28/h3-13,21,27-28H,1-2H3,(H,24,26)
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n/an/a 4.20E+3n/an/an/an/an/a25



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US Patent


Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM156422
PNG
(US9023354, AD4-12909)
Show SMILES COc1ccc(cc1O)C(Nc1cccc(C)n1)c1ccc2cccnc2c1O
Show InChI InChI=1S/C23H21N3O3/c1-14-5-3-7-20(25-14)26-21(16-9-11-19(29-2)18(27)13-16)17-10-8-15-6-4-12-24-22(15)23(17)28/h3-13,21,27-28H,1-2H3,(H,25,26)
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US Patent


Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM156419
PNG
(US9023354, AD4-12906)
Show SMILES Cc1ccnc(NC(c2cccc(Cl)c2Cl)c2ccc3cccnc3c2O)c1
Show InChI InChI=1S/C22H17Cl2N3O/c1-13-9-11-25-18(12-13)27-21(15-5-2-6-17(23)19(15)24)16-8-7-14-4-3-10-26-20(14)22(16)28/h2-12,21,28H,1H3,(H,25,27)
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US Patent


Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM47305
PNG
(BDBM156659 | US9023354, AD4-10483)
Show SMILES Cc1cccc(NC(c2ccc(cc2)C(F)(F)F)c2ccc3cccnc3c2O)n1
Show InChI InChI=1S/C23H18F3N3O/c1-14-4-2-6-19(28-14)29-20(16-7-10-17(11-8-16)23(24,25)26)18-12-9-15-5-3-13-27-21(15)22(18)30/h2-13,20,30H,1H3,(H,28,29)
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US Patent


Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM156430
PNG
(US9023354, AD4-12918)
Show SMILES Cc1cccc(NC(c2ccc3cccnc3c2O)c2c(F)c(F)cc(F)c2F)n1
Show InChI InChI=1S/C22H15F4N3O/c1-11-4-2-6-16(28-11)29-21(17-18(25)14(23)10-15(24)19(17)26)13-8-7-12-5-3-9-27-20(12)22(13)30/h2-10,21,30H,1H3,(H,28,29)
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US Patent


Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM156506
PNG
(US9023354, AD4-13080)
Show SMILES Cc1cccc(NC(c2ccc(Cl)c(Cl)c2)c2ccc3ccc(C)nc3c2O)n1
Show InChI InChI=1S/C23H19Cl2N3O/c1-13-4-3-5-20(26-13)28-21(16-9-11-18(24)19(25)12-16)17-10-8-15-7-6-14(2)27-22(15)23(17)29/h3-12,21,29H,1-2H3,(H,26,28)
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US Patent


Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM156654
PNG
(US9023354, AD4-10484)
Show SMILES Oc1c(ccc2cccnc12)C(Nc1ccccn1)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C21H15Cl2N3O/c22-14-7-9-15(17(23)12-14)20(26-18-5-1-2-10-24-18)16-8-6-13-4-3-11-25-19(13)21(16)27/h1-12,20,27H,(H,24,26)
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US Patent


Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM156423
PNG
(US9023354, AD4-12910)
Show SMILES Oc1c(ccc2cccnc12)C(Nc1ccccn1)c1cc(Cl)ccc1Cl
Show InChI InChI=1S/C21H15Cl2N3O/c22-14-7-9-17(23)16(12-14)20(26-18-5-1-2-10-24-18)15-8-6-13-4-3-11-25-19(13)21(15)27/h1-12,20,27H,(H,24,26)
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US Patent


Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM156492
PNG
(US9023354, AD4-13067)
Show SMILES Oc1c(ccc2cccnc12)C(Nc1ccc(Cl)cn1)c1ccc(Cl)c(c1)C(F)(F)F
Show InChI InChI=1S/C22H14Cl2F3N3O/c23-14-5-8-18(29-11-14)30-19(13-4-7-17(24)16(10-13)22(25,26)27)15-6-3-12-2-1-9-28-20(12)21(15)31/h1-11,19,31H,(H,29,30)
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US Patent


Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM156495
PNG
(US9023354, AD4-13070)
Show SMILES Oc1c(ccc2cccnc12)C(Nc1ccc(F)cn1)c1c(F)c(F)cc(F)c1F
Show InChI InChI=1S/C21H12F5N3O/c22-11-4-6-15(28-9-11)29-20(16-17(25)13(23)8-14(24)18(16)26)12-5-3-10-2-1-7-27-19(10)21(12)30/h1-9,20,30H,(H,28,29)
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US Patent


Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM47310
PNG
(US9023354, AD4-13243)
Show SMILES Cc1cc(Cl)cnc1NC(c1ccc2cccnc2c1O)c1c(F)c(F)c(OCC(F)(F)F)c(F)c1F
Show InChI InChI=1S/C24H15ClF7N3O2/c1-10-7-12(25)8-34-23(10)35-20(13-5-4-11-3-2-6-33-19(11)21(13)36)14-15(26)17(28)22(18(29)16(14)27)37-9-24(30,31)32/h2-8,20,36H,9H2,1H3,(H,34,35)
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US Patent


Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM156540
PNG
(US9023354, AD4-13113)
Show SMILES Oc1c(ccc2cccnc12)C(Nc1ccc(F)cn1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H14Cl2FN3O/c22-16-7-4-13(10-17(16)23)19(27-18-8-5-14(24)11-26-18)15-6-3-12-2-1-9-25-20(12)21(15)28/h1-11,19,28H,(H,26,27)
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US Patent


Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM156479
PNG
(US9023354, AD4-13054)
Show SMILES Oc1c(ccc2cccnc12)C(Nc1ccc(Cl)cn1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H14Cl3N3O/c22-14-5-8-18(26-11-14)27-19(13-4-7-16(23)17(24)10-13)15-6-3-12-2-1-9-25-20(12)21(15)28/h1-11,19,28H,(H,26,27)
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Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM156420
PNG
(US9023354, AD4-12907)
Show SMILES Cc1ccnc(NC(c2ccccc2Cl)c2ccc3cccnc3c2O)c1
Show InChI InChI=1S/C22H18ClN3O/c1-14-10-12-24-19(13-14)26-21(16-6-2-3-7-18(16)23)17-9-8-15-5-4-11-25-20(15)22(17)27/h2-13,21,27H,1H3,(H,24,26)
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Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM156415
PNG
(US9023354, AD4-12902)
Show SMILES Cc1cccc(NC(c2ccc(OC(F)(F)F)cc2)c2ccc3cccnc3c2O)n1
Show InChI InChI=1S/C23H18F3N3O2/c1-14-4-2-6-19(28-14)29-20(16-7-10-17(11-8-16)31-23(24,25)26)18-12-9-15-5-3-13-27-21(15)22(18)30/h2-13,20,30H,1H3,(H,28,29)
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US Patent


Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM156626
PNG
(US9023354, AD4-13202)
Show SMILES Cc1nc(NC(c2ccc(Cl)c(Cl)c2)c2ccc3cccnc3c2O)c(Cl)cc1Cl
Show InChI InChI=1S/C22H15Cl4N3O/c1-11-16(24)10-18(26)22(28-11)29-19(13-5-7-15(23)17(25)9-13)14-6-4-12-3-2-8-27-20(12)21(14)30/h2-10,19,30H,1H3,(H,28,29)
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n/an/a 1.00E+4n/an/an/an/an/a25



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US Patent


Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM156620
PNG
(US9023354, AD4-13196)
Show SMILES COc1ccc(C(Nc2cc(C)c(Cl)cn2)c2ccc3cccnc3c2O)c(OC)c1OC
Show InChI InChI=1S/C25H24ClN3O4/c1-14-12-20(28-13-18(14)26)29-22(16-8-7-15-6-5-11-27-21(15)23(16)30)17-9-10-19(31-2)25(33-4)24(17)32-3/h5-13,22,30H,1-4H3,(H,28,29)
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US Patent


Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM156527
PNG
(US9023354, AD4-13099)
Show SMILES Oc1c(ccc2cccnc12)C(Nc1ccc(F)cn1)c1ccc(F)cc1Cl
Show InChI InChI=1S/C21H14ClF2N3O/c22-17-10-13(23)4-7-15(17)20(27-18-8-5-14(24)11-26-18)16-6-3-12-2-1-9-25-19(12)21(16)28/h1-11,20,28H,(H,26,27)
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US Patent


Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM156478
PNG
(US9023354, AD4-13053)
Show SMILES Oc1c(ccc2cccnc12)C(Nc1ccc(Cl)cn1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C22H15ClF3N3O/c23-16-8-10-18(28-12-16)29-19(14-3-6-15(7-4-14)22(24,25)26)17-9-5-13-2-1-11-27-20(13)21(17)30/h1-12,19,30H,(H,28,29)
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US Patent


Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM156632
PNG
(US9023354, AD4-13208)
Show SMILES COc1ccc(C(Nc2ncc(Cl)cc2C)c2ccc3cccnc3c2O)c(OC)c1OC
Show InChI InChI=1S/C25H24ClN3O4/c1-14-12-16(26)13-28-25(14)29-21(17-8-7-15-6-5-11-27-20(15)22(17)30)18-9-10-19(31-2)24(33-4)23(18)32-3/h5-13,21,30H,1-4H3,(H,28,29)
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Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM156543
PNG
(US9023354, AD4-13116)
Show SMILES Cc1cc(NC(c2ccccc2Cl)c2ccc3cccnc3c2O)ncc1F
Show InChI InChI=1S/C22H17ClFN3O/c1-13-11-19(26-12-18(13)24)27-21(15-6-2-3-7-17(15)23)16-9-8-14-5-4-10-25-20(14)22(16)28/h2-12,21,28H,1H3,(H,26,27)
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Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM156418
PNG
(US9023354, AD4-12905)
Show SMILES Cc1cccc(NC(c2cccc(Cl)c2Cl)c2ccc3cccnc3c2O)n1
Show InChI InChI=1S/C22H17Cl2N3O/c1-13-5-2-9-18(26-13)27-21(15-7-3-8-17(23)19(15)24)16-11-10-14-6-4-12-25-20(14)22(16)28/h2-12,21,28H,1H3,(H,26,27)
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Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM156517
PNG
(US9023354, AD4-13089)
Show SMILES Cc1cccc(NC(c2ccc3ccc(C)nc3c2O)c2c(Cl)cccc2Cl)n1
Show InChI InChI=1S/C23H19Cl2N3O/c1-13-5-3-8-19(26-13)28-22(20-17(24)6-4-7-18(20)25)16-12-11-15-10-9-14(2)27-21(15)23(16)29/h3-12,22,29H,1-2H3,(H,26,28)
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Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM47298
PNG
(BDBM64616 | US9023354, AD4-10960)
Show SMILES CCC(=O)NC(c1cccs1)c1cc([N+]([O-])=O)c2cccnc2c1O
Show InChI InChI=1S/C17H15N3O4S/c1-2-14(21)19-15(13-6-4-8-25-13)11-9-12(20(23)24)10-5-3-7-18-16(10)17(11)22/h3-9,15,22H,2H2,1H3,(H,19,21)
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Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM47300
PNG
(US9023354, AD4-10944)
Show SMILES Cc1ccc(C)c(c1)C(Nc1cccnc1)c1cc(Cl)c2cccnc2c1O
Show InChI InChI=1S/C23H20ClN3O/c1-14-7-8-15(2)18(11-14)21(27-16-5-3-9-25-13-16)19-12-20(24)17-6-4-10-26-22(17)23(19)28/h3-13,21,27-28H,1-2H3
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Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM156416
PNG
(US9023354, AD4-12903)
Show SMILES Cc1cccc(NC(c2cccc(c2)C(F)(F)F)c2ccc3cccnc3c2O)n1
Show InChI InChI=1S/C23H18F3N3O/c1-14-5-2-9-19(28-14)29-20(16-6-3-8-17(13-16)23(24,25)26)18-11-10-15-7-4-12-27-21(15)22(18)30/h2-13,20,30H,1H3,(H,28,29)
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Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM156621
PNG
(US9023354, AD4-13197)
Show SMILES COc1ccc(C(Nc2cc(Cl)c(Cl)cn2)c2ccc3cccnc3c2O)c(OC)c1OC
Show InChI InChI=1S/C24H21Cl2N3O4/c1-31-18-9-8-15(23(32-2)24(18)33-3)21(29-19-11-16(25)17(26)12-28-19)14-7-6-13-5-4-10-27-20(13)22(14)30/h4-12,21,30H,1-3H3,(H,28,29)
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Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM47303
PNG
(US9023354, AD4-10482)
Show SMILES Oc1c(ccc2cccnc12)C(Nc1ccccn1)c1ccccc1Cl
Show InChI InChI=1S/C21H16ClN3O/c22-17-8-2-1-7-15(17)20(25-18-9-3-4-12-23-18)16-11-10-14-6-5-13-24-19(14)21(16)26/h1-13,20,26H,(H,23,25)
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Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM47307
PNG
(BDBM50339143 | US9023354, AD4-10942)
Show SMILES Oc1c(ccc2cccnc12)C(Nc1cccnc1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C22H16F3N3O/c23-22(24,25)16-8-5-15(6-9-16)19(28-17-4-2-11-26-13-17)18-10-7-14-3-1-12-27-20(14)21(18)29/h1-13,19,28-29H
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Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM156635
PNG
(US9023354, AD4-13210)
Show SMILES COc1ccc(C(Nc2nc(C)c(Cl)cc2Cl)c2ccc3cccnc3c2O)c(OC)c1OC
Show InChI InChI=1S/C25H23Cl2N3O4/c1-13-17(26)12-18(27)25(29-13)30-21(15-8-7-14-6-5-11-28-20(14)22(15)31)16-9-10-19(32-2)24(34-4)23(16)33-3/h5-12,21,31H,1-4H3,(H,29,30)
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Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM156528
PNG
(US9023354, AD4-13101)
Show SMILES Cc1ccc2ccc(C(Nc3cccnc3)c3c(F)c(F)c(OCC(F)(F)F)c(F)c3F)c(O)c2n1
Show InChI InChI=1S/C24H16F7N3O2/c1-11-4-5-12-6-7-14(22(35)20(12)33-11)21(34-13-3-2-8-32-9-13)15-16(25)18(27)23(19(28)17(15)26)36-10-24(29,30)31/h2-9,21,34-35H,10H2,1H3
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Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM156639
PNG
(US9023354, AD4-13214)
Show SMILES COc1ccc(C(Nc2ncc(Cl)cc2OC)c2ccc3cccnc3c2O)c(OC)c1OC
Show InChI InChI=1S/C25H24ClN3O5/c1-31-18-10-9-17(23(33-3)24(18)34-4)21(29-25-19(32-2)12-15(26)13-28-25)16-8-7-14-6-5-11-27-20(14)22(16)30/h5-13,21,30H,1-4H3,(H,28,29)
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Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM156545
PNG
(US9023354, AD4-13118)
Show SMILES Cc1cc(NC(c2ccc3cccnc3c2O)c2cc(Cl)ccc2Cl)ncc1F
Show InChI InChI=1S/C22H16Cl2FN3O/c1-12-9-19(27-11-18(12)25)28-21(16-10-14(23)5-7-17(16)24)15-6-4-13-3-2-8-26-20(13)22(15)29/h2-11,21,29H,1H3,(H,27,28)
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US Patent


Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM156617
PNG
(US9023354, AD4-13193)
Show SMILES COc1ccc(cc1OC)C(Nc1ncc(Cl)cc1C)c1ccc2cccnc2c1O
Show InChI InChI=1S/C24H22ClN3O3/c1-14-11-17(25)13-27-24(14)28-21(16-7-9-19(30-2)20(12-16)31-3)18-8-6-15-5-4-10-26-22(15)23(18)29/h4-13,21,29H,1-3H3,(H,27,28)
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Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM156619
PNG
(US9023354, AD4-13195)
Show SMILES COc1ccc(cc1OC)C(Nc1cc(Cl)c(Cl)cn1)c1ccc2cccnc2c1O
Show InChI InChI=1S/C23H19Cl2N3O3/c1-30-18-8-6-14(10-19(18)31-2)21(28-20-11-16(24)17(25)12-27-20)15-7-5-13-4-3-9-26-22(13)23(15)29/h3-12,21,29H,1-2H3,(H,27,28)
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Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM156618
PNG
(US9023354, AD4-13194)
Show SMILES COc1ccc(cc1OC)C(Nc1cc(C)c(Cl)cn1)c1ccc2cccnc2c1O
Show InChI InChI=1S/C24H22ClN3O3/c1-14-11-21(27-13-18(14)25)28-22(16-7-9-19(30-2)20(12-16)31-3)17-8-6-15-5-4-10-26-23(15)24(17)29/h4-13,22,29H,1-3H3,(H,27,28)
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Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM156644
PNG
(US9023354, AD4-13219)
Show SMILES CCc1c(Cl)cnc(NC(c2ccc3cccnc3c2O)c2ccc(OC)c(OC)c2OC)c1F
Show InChI InChI=1S/C26H25ClFN3O4/c1-5-15-18(27)13-30-26(20(15)28)31-22(16-9-8-14-7-6-12-29-21(14)23(16)32)17-10-11-19(33-2)25(35-4)24(17)34-3/h6-13,22,32H,5H2,1-4H3,(H,30,31)
PDB
MMDB

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Similars
US Patent
n/an/a 3.00E+4n/an/an/an/an/a25



TBA

US Patent


Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM156483
PNG
(US9023354, AD4-13058)
Show SMILES Cc1cc(Cl)cnc1NC(c1ccc2cccnc2c1O)c1cc(ccc1Cl)C(F)(F)F
Show InChI InChI=1S/C23H16Cl2F3N3O/c1-12-9-15(24)11-30-22(12)31-20(17-10-14(23(26,27)28)5-7-18(17)25)16-6-4-13-3-2-8-29-19(13)21(16)32/h2-11,20,32H,1H3,(H,30,31)
PDB
MMDB

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UniChem

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US Patent
n/an/a 4.10E+4n/an/an/an/an/a25



TBA

US Patent


Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM156487
PNG
(US9023354, AD4-13062)
Show SMILES Oc1c(ccc2cccnc12)C(Nc1ccc(nc1)C(F)(F)F)c1cc(ccc1Cl)C(F)(F)F
Show InChI InChI=1S/C23H14ClF6N3O/c24-17-7-4-13(22(25,26)27)10-16(17)20(33-14-5-8-18(32-11-14)23(28,29)30)15-6-3-12-2-1-9-31-19(12)21(15)34/h1-11,20,33-34H
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

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DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.40E+4n/an/an/an/an/a25



TBA

US Patent


Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%