Affinity Data by USPatent=US9051240

USPatent US9051240

Found 7 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Amine oxidase [flavin-containing] B (Rattus norvegicus (rat))	BDBM19187 ((2S)-2-[({4-[(3-fluorophenyl)methoxy]phenyl}methyl...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB US Patent	n/a	n/a	100	n/a	n/a	n/a	n/a	7.4	n/a
Newron Pharmaceuticals S.P.A. US Patent					Assay Description The enzyme activity was assessed with a radioenzymatic assay using the substrate 14C-phenylethylamine (PEA) specific for MAO-B.The mitochondrial pell...				US Patent US9051240 (2015) BindingDB Entry DOI: 10.7270/Q2KK99J2
Newron Pharmaceuticals S.P.A. US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
Amine oxidase [flavin-containing] B (Rattus norvegicus (rat))	BDBM161094 (US9051240, (S)-(+)-2-[4-(2-Fluorobenzyloxy)-benzyl...) Show SMILES C[C@H](NCc1ccc(OCc2ccccc2F)cc1)C(N)=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	200	n/a	n/a	n/a	n/a	7.4	n/a
Newron Pharmaceuticals S.P.A. US Patent					Assay Description The enzyme activity was assessed with a radioenzymatic assay using the substrate 14C-phenylethylamine (PEA) specific for MAO-B.The mitochondrial pell...				US Patent US9051240 (2015) BindingDB Entry DOI: 10.7270/Q2KK99J2
Newron Pharmaceuticals S.P.A. US Patent					More data for this Ligand-Target Pair
Amine oxidase [flavin-containing] B (Rattus norvegicus (rat))	BDBM161089 (US9051240, 2-[2-(3-Butoxyphenyl)-ethylamino]-N-met...) Show SMILES CCCCOc1cccc(CCNCC(=O)NC)c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.10E+5	n/a	n/a	n/a	n/a	7.4	n/a
Newron Pharmaceuticals S.P.A. US Patent					Assay Description The enzyme activity was assessed with a radioenzymatic assay using the substrate 14C-phenylethylamine (PEA) specific for MAO-B.The mitochondrial pell...				US Patent US9051240 (2015) BindingDB Entry DOI: 10.7270/Q2KK99J2
Newron Pharmaceuticals S.P.A. US Patent					More data for this Ligand-Target Pair
Amine oxidase [flavin-containing] B (Rattus norvegicus (rat))	BDBM161090 (US9051240, 2-[2-(3-Butoxyphenyl)-ethylamino]-N,N-d...) Show SMILES CCCCOc1cccc(CCNCC(=O)N(C)C)c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.31E+5	n/a	n/a	n/a	n/a	7.4	n/a
Newron Pharmaceuticals S.P.A. US Patent					Assay Description The enzyme activity was assessed with a radioenzymatic assay using the substrate 14C-phenylethylamine (PEA) specific for MAO-B.The mitochondrial pell...				US Patent US9051240 (2015) BindingDB Entry DOI: 10.7270/Q2KK99J2
Newron Pharmaceuticals S.P.A. US Patent					More data for this Ligand-Target Pair
Amine oxidase [flavin-containing] B (Rattus norvegicus (rat))	BDBM161091 (US9051240, 2-[2-(3-Butoxy-2,6-difluorophenyl)-ethy...) Show SMILES CCCCOc1ccc(F)c(CCNCC(=O)N(C)C)c1F Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	7.4	n/a
Newron Pharmaceuticals S.P.A. US Patent					Assay Description The enzyme activity was assessed with a radioenzymatic assay using the substrate 14C-phenylethylamine (PEA) specific for MAO-B.The mitochondrial pell...				US Patent US9051240 (2015) BindingDB Entry DOI: 10.7270/Q2KK99J2
Newron Pharmaceuticals S.P.A. US Patent					More data for this Ligand-Target Pair
Amine oxidase [flavin-containing] B (Rattus norvegicus (rat))	BDBM161093 (US9051240, 2-[2-(3-Butoxyphenyl)-ethylamino]-N,N-d...) Show SMILES CCCCOc1cccc(CCNC(C)C(=O)N(C)C)c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	7.4	n/a
Newron Pharmaceuticals S.P.A. US Patent					Assay Description The enzyme activity was assessed with a radioenzymatic assay using the substrate 14C-phenylethylamine (PEA) specific for MAO-B.The mitochondrial pell...				US Patent US9051240 (2015) BindingDB Entry DOI: 10.7270/Q2KK99J2
Newron Pharmaceuticals S.P.A. US Patent					More data for this Ligand-Target Pair
Amine oxidase [flavin-containing] B (Rattus norvegicus (rat))	BDBM161092 (US9051240, 2-[2-(3-Butoxy-4-methoxyphenyl)-ethylam...) Show SMILES CCCCOc1cc(CCNCC(=O)N(C)C)ccc1OC Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	7.4	n/a
Newron Pharmaceuticals S.P.A. US Patent					Assay Description The enzyme activity was assessed with a radioenzymatic assay using the substrate 14C-phenylethylamine (PEA) specific for MAO-B.The mitochondrial pell...				US Patent US9051240 (2015) BindingDB Entry DOI: 10.7270/Q2KK99J2
Newron Pharmaceuticals S.P.A. US Patent					More data for this Ligand-Target Pair

* indicates data uncertainty>20%