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USPatent US9790196

Compile data set for download or QSAR
Found 12 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))		BDBM347514
PNG
(US9790196, Selective-2)
Show SMILES CN1CCN(CC1)C(=O)CNC1CC1c1ccc(cc1)C1CC1
Show InChI InChI=1S/C19H27N3O/c1-21-8-10-22(11-9-21)19(23)13-20-18-12-17(18)16-6-4-15(5-7-16)14-2-3-14/h4-7,14,17-18,20H,2-3,8-13H2,1H3
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n/an/a<100n/an/an/an/an/an/a



ORYZON GENOMICS S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....

US Patent US9790196 (2017)


BindingDB Entry DOI: 10.7270/Q2BP04XC
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))		BDBM347513
PNG
(US9790196, Selective-1)
Show SMILES CN1CCN(CC1)C(=O)CNC1CC1c1ccc(OCc2ccc(OCc3ccccc3)cc2)cc1
Show InChI InChI=1S/C30H35N3O3/c1-32-15-17-33(18-16-32)30(34)20-31-29-19-28(29)25-9-13-27(14-10-25)36-22-24-7-11-26(12-8-24)35-21-23-5-3-2-4-6-23/h2-14,28-29,31H,15-22H2,1H3
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n/an/a<100n/an/an/an/an/an/a



ORYZON GENOMICS S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....

US Patent US9790196 (2017)


BindingDB Entry DOI: 10.7270/Q2BP04XC
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))		BDBM347512
PNG
(US9790196, Dual-2)
Show SMILES NC(=O)CNC1CC1c1ccc(OCc2ccc(F)cc2)cc1
Show InChI InChI=1S/C18H19FN2O2/c19-14-5-1-12(2-6-14)11-23-15-7-3-13(4-8-15)16-9-17(16)21-10-18(20)22/h1-8,16-17,21H,9-11H2,(H2,20,22)
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n/an/a<200n/an/an/an/an/an/a



ORYZON GENOMICS S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....

US Patent US9790196 (2017)


BindingDB Entry DOI: 10.7270/Q2BP04XC
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))		BDBM347511
PNG
(US9790196, Dual-1)
Show SMILES NC(=O)CNC1CC1c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C18H20N2O2/c19-18(21)11-20-17-10-16(17)14-6-8-15(9-7-14)22-12-13-4-2-1-3-5-13/h1-9,16-17,20H,10-12H2,(H2,19,21)
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ORYZON GENOMICS S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....

US Patent US9790196 (2017)


BindingDB Entry DOI: 10.7270/Q2BP04XC
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))		BDBM347511
PNG
(US9790196, Dual-1)
Show SMILES NC(=O)CNC1CC1c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C18H20N2O2/c19-18(21)11-20-17-10-16(17)14-6-8-15(9-7-14)22-12-13-4-2-1-3-5-13/h1-9,16-17,20H,10-12H2,(H2,19,21)
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n/an/a<200n/an/an/an/an/an/a



ORYZON GENOMICS S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....

US Patent US9790196 (2017)


BindingDB Entry DOI: 10.7270/Q2BP04XC
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))		BDBM347512
PNG
(US9790196, Dual-2)
Show SMILES NC(=O)CNC1CC1c1ccc(OCc2ccc(F)cc2)cc1
Show InChI InChI=1S/C18H19FN2O2/c19-14-5-1-12(2-6-14)11-23-15-7-3-13(4-8-15)16-9-17(16)21-10-18(20)22/h1-8,16-17,21H,9-11H2,(H2,20,22)
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n/an/a<300n/an/an/an/an/an/a



ORYZON GENOMICS S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....

US Patent US9790196 (2017)


BindingDB Entry DOI: 10.7270/Q2BP04XC
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))		BDBM347513
PNG
(US9790196, Selective-1)
Show SMILES CN1CCN(CC1)C(=O)CNC1CC1c1ccc(OCc2ccc(OCc3ccccc3)cc2)cc1
Show InChI InChI=1S/C30H35N3O3/c1-32-15-17-33(18-16-32)30(34)20-31-29-19-28(29)25-9-13-27(14-10-25)36-22-24-7-11-26(12-8-24)35-21-23-5-3-2-4-6-23/h2-14,28-29,31H,15-22H2,1H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



ORYZON GENOMICS S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....

US Patent US9790196 (2017)


BindingDB Entry DOI: 10.7270/Q2BP04XC
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))		BDBM347511
PNG
(US9790196, Dual-1)
Show SMILES NC(=O)CNC1CC1c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C18H20N2O2/c19-18(21)11-20-17-10-16(17)14-6-8-15(9-7-14)22-12-13-4-2-1-3-5-13/h1-9,16-17,20H,10-12H2,(H2,19,21)
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n/an/a>1.00E+3n/an/an/an/an/an/a



ORYZON GENOMICS S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....

US Patent US9790196 (2017)


BindingDB Entry DOI: 10.7270/Q2BP04XC
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))		BDBM347514
PNG
(US9790196, Selective-2)
Show SMILES CN1CCN(CC1)C(=O)CNC1CC1c1ccc(cc1)C1CC1
Show InChI InChI=1S/C19H27N3O/c1-21-8-10-22(11-9-21)19(23)13-20-18-12-17(18)16-6-4-15(5-7-16)14-2-3-14/h4-7,14,17-18,20H,2-3,8-13H2,1H3
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



ORYZON GENOMICS S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....

US Patent US9790196 (2017)


BindingDB Entry DOI: 10.7270/Q2BP04XC
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))		BDBM347513
PNG
(US9790196, Selective-1)
Show SMILES CN1CCN(CC1)C(=O)CNC1CC1c1ccc(OCc2ccc(OCc3ccccc3)cc2)cc1
Show InChI InChI=1S/C30H35N3O3/c1-32-15-17-33(18-16-32)30(34)20-31-29-19-28(29)25-9-13-27(14-10-25)36-22-24-7-11-26(12-8-24)35-21-23-5-3-2-4-6-23/h2-14,28-29,31H,15-22H2,1H3
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



ORYZON GENOMICS S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....

US Patent US9790196 (2017)


BindingDB Entry DOI: 10.7270/Q2BP04XC
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))		BDBM347514
PNG
(US9790196, Selective-2)
Show SMILES CN1CCN(CC1)C(=O)CNC1CC1c1ccc(cc1)C1CC1
Show InChI InChI=1S/C19H27N3O/c1-21-8-10-22(11-9-21)19(23)13-20-18-12-17(18)16-6-4-15(5-7-16)14-2-3-14/h4-7,14,17-18,20H,2-3,8-13H2,1H3
PDB

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US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



ORYZON GENOMICS S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....

US Patent US9790196 (2017)


BindingDB Entry DOI: 10.7270/Q2BP04XC
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))		BDBM347512
PNG
(US9790196, Dual-2)
Show SMILES NC(=O)CNC1CC1c1ccc(OCc2ccc(F)cc2)cc1
Show InChI InChI=1S/C18H19FN2O2/c19-14-5-1-12(2-6-14)11-23-15-7-3-13(4-8-15)16-9-17(16)21-10-18(20)22/h1-8,16-17,21H,9-11H2,(H2,20,22)
PDB

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n/an/a>4.00E+4n/an/an/an/an/an/a



ORYZON GENOMICS S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....

US Patent US9790196 (2017)


BindingDB Entry DOI: 10.7270/Q2BP04XC
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%