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USPatent US9790229

Compile Data Set for Download or QSAR

Found 360 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348611
PNG
(US10577374, Compound 334 | US9790229, Compound 334)
Show SMILES Nc1ncnc(N2CC[C@@H]([C@H](C2)N2CCCC(Nc3cc(Cl)cc(Cl)c3)C2=O)C(F)(F)F)c1F |r|
Show InChI InChI=1S/C21H22Cl2F4N6O/c22-11-6-12(23)8-13(7-11)31-15-2-1-4-33(20(15)34)16-9-32(5-3-14(16)21(25,26)27)19-17(24)18(28)29-10-30-19/h6-8,10,14-16,31H,1-5,9H2,(H2,28,29,30)/t14-,15?,16-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348612
PNG
(US10577374, Compound 335 | US9790229, Compound 335)
Show SMILES Nc1ncnc(N2CC[C@H]([C@@H](C2)N2CCC[C@@H](Nc3cc(Cl)cc(Cl)c3)C2=O)C(F)(F)F)c1F |r|
Show InChI InChI=1S/C21H22Cl2F4N6O/c22-11-6-12(23)8-13(7-11)31-15-2-1-4-33(20(15)34)16-9-32(5-3-14(16)21(25,26)27)19-17(24)18(28)29-10-30-19/h6-8,10,14-16,31H,1-5,9H2,(H2,28,29,30)/t14-,15-,16-/m1/s1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348624
PNG
(US10577374, Compound 347 | US9790229, Compound 347)
Show SMILES Nc1ncnc(N2CCC[C@H](C2)N2CC=CC[C@@H](Nc3cc(F)cc(Cl)c3)C2=O)c1F |r,c:15|
Show InChI InChI=1S/C21H23ClF2N6O/c22-13-8-14(23)10-15(9-13)28-17-5-1-2-7-30(21(17)31)16-4-3-6-29(11-16)20-18(24)19(25)26-12-27-20/h1-2,8-10,12,16-17,28H,3-7,11H2,(H2,25,26,27)/t16-,17-/m1/s1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348632
PNG
(US10577374, Compound 355 | US9790229, Compound 355)
Show SMILES FC(F)(F)[C@H]1CCN(C[C@@H]1N1CC[C@@H](Nc2cc(Cl)cc(Cl)c2)C1=O)c1ncnc2[nH]ncc12 |r|
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348637
PNG
(US10577374, Compound 360 | US9790229, Compound 360)
Show SMILES Fc1cc(Cl)cc(NC2CCCN([C@@H]3CCCN(C3)c3ncnc4[nH]ncc34)C2=O)c1 |r|
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348389
PNG
(US10577374, Compound 112 | US9790229, Compound 112)
Show SMILES Fc1cc(F)c(NC(=O)Nc2csc(n2)C2CCCN(C2)c2ncnc3[nH]ncc23)c(c1)N1CCCC1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348390
PNG
(US10577374, Compound 113 | US9790229, Compound 113)
Show SMILES Nc1ncnc(N2CCCC(C2)c2nc(NC(=O)Nc3c(F)cc(F)cc3N3CCCC3)cs2)c1C#N
Show InChI InChI=1S/C24H25F2N9OS/c25-15-8-17(26)20(18(9-15)34-5-1-2-6-34)33-24(36)32-19-12-37-23(31-19)14-4-3-7-35(11-14)22-16(10-27)21(28)29-13-30-22/h8-9,12-14H,1-7,11H2,(H2,28,29,30)(H2,32,33,36)
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348412
PNG
(US10577374, Compound 135 | US9790229, Compound 135)
Show SMILES OCCN1CCN(CC1c1cccc(NC(=O)Nc2c(F)cccc2N2CCCC2)c1)c1ncnc2[nH]ccc12
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348424
PNG
(US10577374, Compound 147 | US9790229, Compound 147)
Show SMILES Fc1ccc(NC(=O)Nc2cccc(c2)C2CCCN(C2)c2ncnc3[nH]ccc23)c(c1)N1CCCC1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348427
PNG
(US10577374, Compound 150 | US9790229, Compound 150)
Show SMILES O[C@H]1CN(C[C@@H]1O)c1ccccc1NC(=O)Nc1cccc(c1)C1CCCN(C1)c1ncnc2[nH]ccc12 |r|
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348428
PNG
(US10577374, Compound 151 | US9790229, Compound 151)
Show SMILES CC(C)c1ccccc1NC(=O)Nc1cccc(c1)C1CCCN(C1)c1ncnc2[nH]ccc12
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348429
PNG
(US10577374, Compound 152 | US9790229, Compound 152)
Show SMILES OC[C@@H]1CCCN1c1ccccc1NC(=O)Nc1cccc(c1)C1CCCN(C1)c1ncnc2[nH]ccc12 |r|
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348596
PNG
(US10577374, Compound 319 | US9790229, Compound 319)
Show SMILES Nc1ncnc(N2CCC[C@H](C2)N2CCCC(Nc3ccccc3S(=O)(=O)c3ccccc3)C2=O)c1F |r|
Show InChI InChI=1S/C26H29FN6O3S/c27-23-24(28)29-17-30-25(23)32-14-6-8-18(16-32)33-15-7-12-21(26(33)34)31-20-11-4-5-13-22(20)37(35,36)19-9-2-1-3-10-19/h1-5,9-11,13,17-18,21,31H,6-8,12,14-16H2,(H2,28,29,30)/t18-,21?/m1/s1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348599
PNG
(US10577374, Compound 322 | US9790229, Compound 322)
Show SMILES FC(F)(F)[C@H]1CCN(C[C@@H]1N1CC[C@@H](Nc2cc(Cl)cc(Cl)c2)C1=O)c1ncnc2[nH]ccc12 |r|
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348618
PNG
(US10577374, Compound 341 | US9790229, Compound 341)
Show SMILES Nc1ncnc(N2CC[C@@H](F)[C@H](C2)N2CCC[C@@H](Nc3cc(F)cc(Cl)c3)C2=O)c1F |r|
Show InChI InChI=1S/C20H22ClF3N6O/c21-11-6-12(22)8-13(7-11)28-15-2-1-4-30(20(15)31)16-9-29(5-3-14(16)23)19-17(24)18(25)26-10-27-19/h6-8,10,14-16,28H,1-5,9H2,(H2,25,26,27)/t14-,15-,16+/m1/s1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348327
PNG
(US10577374, Compound 50 | US9790229, Compound 50)
Show SMILES Clc1cccc(N2CCCC2)c1NC(=O)Nc1cccc(c1)C1CCCN(C1)c1ncnc2[nH]ccc12
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348387
PNG
(US10577374, Compound 110 | US9790229, Compound 110)
Show SMILES O=C(Nc1csc(n1)C1CCCN(C1)c1ncnc2[nH]ncc12)Nc1ccccc1N1CCCC1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348388
PNG
(US10577374, Compound 111 | US9790229, Compound 111)
Show SMILES Fc1cc(F)c(NC(=O)Nc2csc(n2)C2CCCN(C2)c2ncnc3[nH]ccc23)c(c1)N1CCCC1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348562
PNG
(US10577374, Compound 285 | US9790229, Compound 285)
Show SMILES Fc1cc(Cl)cc(NC2CCCN([C@@H]3CCCN(C3)c3c(cnc4[nH]ccc34)C#N)C2=O)c1 |r|
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348591
PNG
(US10577374, Compound 314 | US9790229, Compound 314)
Show SMILES Nc1ncnc(N2CCC[C@H](C2)N2CCC[C@@H](Nc3cc(F)cc(Cl)c3)C2=O)c1F |r|
Show InChI InChI=1S/C20H23ClF2N6O/c21-12-7-13(22)9-14(8-12)27-16-4-2-6-29(20(16)30)15-3-1-5-28(10-15)19-17(23)18(24)25-11-26-19/h7-9,11,15-16,27H,1-6,10H2,(H2,24,25,26)/t15-,16-/m1/s1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348593
PNG
(US10577374, Compound 316 | US9790229, Compound 316)
Show SMILES Fc1cc(Cl)cc(N[C@@H]2CCCN([C@@H]3CCCN(C3)c3ncnc4[nH]ccc34)C2=O)c1 |r|
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348606
PNG
(US10577374, Compound 329 | US9790229, Compound 329)
Show SMILES Nc1ncnc(N2CC[C@@H]([C@H](C2)N2CCCC(Nc3cc(F)cc(Cl)c3)C2=O)C(F)(F)F)c1F |r|
Show InChI InChI=1S/C21H22ClF5N6O/c22-11-6-12(23)8-13(7-11)31-15-2-1-4-33(20(15)34)16-9-32(5-3-14(16)21(25,26)27)19-17(24)18(28)29-10-30-19/h6-8,10,14-16,31H,1-5,9H2,(H2,28,29,30)/t14-,15?,16-/m0/s1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348616
PNG
(US10577374, Compound 339 | US9790229, Compound 339)
Show SMILES FC(F)(F)[C@H]1CCN(C[C@@H]1N1CCCC(Nc2cc(Cl)cc(Cl)c2)C1=O)c1ncnc2[nH]ccc12 |r|
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348555
PNG
(US10577374, Compound 278 | US9790229, Compound 278)
Show SMILES Nc1ncnc(N2CCC[C@H](C2)N2CCCC(Nc3cc(Cl)cc(Cl)c3)C2=O)c1F |r|
Show InChI InChI=1S/C20H23Cl2FN6O/c21-12-7-13(22)9-14(8-12)27-16-4-2-6-29(20(16)30)15-3-1-5-28(10-15)19-17(23)18(24)25-11-26-19/h7-9,11,15-16,27H,1-6,10H2,(H2,24,25,26)/t15-,16?/m1/s1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348560
PNG
(US10577374, Compound 283 | US9790229, Compound 283)
Show SMILES Nc1ncnc(N2C[C@@H](O)C[C@H](C2)N2CCCC(Nc3cc(Cl)cc(Cl)c3)C2=O)c1F |r|
Show InChI InChI=1S/C20H23Cl2FN6O2/c21-11-4-12(22)6-13(5-11)27-16-2-1-3-29(20(16)31)14-7-15(30)9-28(8-14)19-17(23)18(24)25-10-26-19/h4-6,10,14-16,27,30H,1-3,7-9H2,(H2,24,25,26)/t14-,15+,16?/m1/s1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348582
PNG
(US10577374, Compound 305 | US9790229, Compound 305)
Show SMILES FC(F)(F)c1cc(Cl)cc(NC2CCCN([C@@H]3CCCN(C3)c3ncnc4[nH]ncc34)C2=O)c1 |r|
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348584
PNG
(US10577374, Compound 307 | US9790229, Compound 307)
Show SMILES FC(F)(F)c1cc(NC2CCCN([C@@H]3CCCN(C3)c3ncnc4[nH]ncc34)C2=O)cc(c1)C(F)(F)F |r|
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348585
PNG
(US10577374, Compound 308 | US9790229, Compound 308)
Show SMILES Nc1ncnc(N2CCC[C@H](C2)N2CCCC(Nc3cc(Cl)cc(c3)C(F)(F)F)C2=O)c1F |r|
Show InChI InChI=1S/C21H23ClF4N6O/c22-13-7-12(21(24,25)26)8-14(9-13)30-16-4-2-6-32(20(16)33)15-3-1-5-31(10-15)19-17(23)18(27)28-11-29-19/h7-9,11,15-16,30H,1-6,10H2,(H2,27,28,29)/t15-,16?/m1/s1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348589
PNG
(US10577374, Compound 312 | US9790229, Compound 312)
Show SMILES Nc1ncnc(N2CCC[C@H](C2)N2CCC[C@H](Nc3cc(Cl)cc(c3)C(F)(F)F)C2=O)c1F |r|
Show InChI InChI=1S/C21H23ClF4N6O/c22-13-7-12(21(24,25)26)8-14(9-13)30-16-4-2-6-32(20(16)33)15-3-1-5-31(10-15)19-17(23)18(27)28-11-29-19/h7-9,11,15-16,30H,1-6,10H2,(H2,27,28,29)/t15-,16+/m1/s1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348594
PNG
(US10577374, Compound 317 | US9790229, Compound 317)
Show SMILES Fc1cc(Cl)cc(N[C@H]2CCCN([C@@H]3CCCN(C3)c3ncnc4[nH]ccc34)C2=O)c1 |r|
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348627
PNG
(US10577374, Compound 350 | US9790229, Compound 350)
Show SMILES Nc1ncnc(N2CC[C@H]([C@@H](C2)N2CC=CC[C@@H](Nc3cc(F)cc(Cl)c3)C2=O)C(F)(F)F)c1F |r,c:15|
Show InChI InChI=1S/C22H22ClF5N6O/c23-12-7-13(24)9-14(8-12)32-16-3-1-2-5-34(21(16)35)17-10-33(6-4-15(17)22(26,27)28)20-18(25)19(29)30-11-31-20/h1-2,7-9,11,15-17,32H,3-6,10H2,(H2,29,30,31)/t15-,16-,17-/m1/s1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348629
PNG
(US10577374, Compound 352 | US9790229, Compound 352)
Show SMILES Fc1cc(Cl)cc(NC2CCCN([C@H]3CN(CC[C@@H]3C(F)(F)F)c3ncnc4[nH]ccc34)C2=O)c1 |r|
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348323
PNG
(US10577374, Compound 46 | US9790229, Compound 46)
Show SMILES O=C(Nc1cccc(c1)[C@H]1CCCN(C1)c1ncnc2[nH]ccc12)Nc1ccccc1N1CCCC1 |r|
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348384
PNG
(US10577374, Compound 107 | US9790229, Compound 107)
Show SMILES O=C(Nc1csc(n1)C1CCCN(C1)c1ncnc2[nH]ccc12)Nc1ccccc1N1CCCC1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348430
PNG
(US10577374, Compound 153 | US9790229, Compound 153)
Show SMILES Clc1cccc(Cl)c1NC(=O)Nc1cccc(c1)[C@H]1CCCN(C1)c1ncnc2[nH]ccc12 |r|
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348433
PNG
(US10577374, Compound 156 | US9790229, Compound 156)
Show SMILES CC(C)(C)c1ccccc1NC(=O)Nc1cccc(c1)[C@H]1CCCN(C1)c1ncnc2[nH]ccc12 |r|
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348554
PNG
(US10577374, Compound 277 | US9790229, Compound 277)
Show SMILES Nc1ncnc(N2CCC[C@H](C2)N2CCCC(Nc3cc(F)cc(Cl)c3)C2=O)c1F |r|
Show InChI InChI=1S/C20H23ClF2N6O/c21-12-7-13(22)9-14(8-12)27-16-4-2-6-29(20(16)30)15-3-1-5-28(10-15)19-17(23)18(24)25-11-26-19/h7-9,11,15-16,27H,1-6,10H2,(H2,24,25,26)/t15-,16?/m1/s1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348578
PNG
(US10577374, Compound 301 | US9790229, Compound 301)
Show SMILES Fc1c(Cl)cc(NC2CCCN([C@@H]3CCCN(C3)c3ncnc4[nH]ccc34)C2=O)cc1Cl |r|
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348588
PNG
(US10577374, Compound 311 | US9790229, Compound 311)
Show SMILES Nc1ncnc(N2CCC[C@H](C2)N2CCC[C@@H](Nc3cc(Cl)cc(c3)C(F)(F)F)C2=O)c1F |r|
Show InChI InChI=1S/C21H23ClF4N6O/c22-13-7-12(21(24,25)26)8-14(9-13)30-16-4-2-6-32(20(16)33)15-3-1-5-31(10-15)19-17(23)18(27)28-11-29-19/h7-9,11,15-16,30H,1-6,10H2,(H2,27,28,29)/t15-,16-/m1/s1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348600
PNG
(US10577374, Compound 323 | US9790229, Compound 323)
Show SMILES Clc1cc(Cl)cc(N[C@@H]2CCN([C@@H]3CCCN(C3)c3ncnc4[nH]ccc34)C2=O)c1 |r|
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348601
PNG
(US10577374, Compound 324 | US9790229, Compound 324)
Show SMILES Nc1ncnc(N2CC[C@H](O)[C@H](C2)N2CCCC(Nc3cc(F)cc(Cl)c3)C2=O)c1F |r|
Show InChI InChI=1S/C20H23ClF2N6O2/c21-11-6-12(22)8-13(7-11)27-14-2-1-4-29(20(14)31)15-9-28(5-3-16(15)30)19-17(23)18(24)25-10-26-19/h6-8,10,14-16,27,30H,1-5,9H2,(H2,24,25,26)/t14?,15-,16-/m0/s1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348604
PNG
(US10577374, Compound 327 | US9790229, Compound 327)
Show SMILES Nc1ncnc(N2CC[C@@H](O)[C@@H](C2)N2CCC[C@@H](Nc3cc(Cl)cc(Cl)c3)C2=O)c1F |r|
Show InChI InChI=1S/C20H23Cl2FN6O2/c21-11-6-12(22)8-13(7-11)27-14-2-1-4-29(20(14)31)15-9-28(5-3-16(15)30)19-17(23)18(24)25-10-26-19/h6-8,10,14-16,27,30H,1-5,9H2,(H2,24,25,26)/t14-,15-,16-/m1/s1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348621
PNG
(US10577374, Compound 344 | US9790229, Compound 344)
Show SMILES Nc1ncnc(N2CCOCC(C2)N2CCCC(Nc3cc(Cl)cc(Cl)c3)C2=O)c1F
Show InChI InChI=1S/C20H23Cl2FN6O2/c21-12-6-13(22)8-14(7-12)27-16-2-1-3-29(20(16)30)15-9-28(4-5-31-10-15)19-17(23)18(24)25-11-26-19/h6-8,11,15-16,27H,1-5,9-10H2,(H2,24,25,26)
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348625
PNG
(US10577374, Compound 348 | US9790229, Compound 348)
Show SMILES Nc1ncnc(N2CCC[C@H](C2)N2CC(O)C(O)C[C@@H](Nc3cc(F)cc(Cl)c3)C2=O)c1F |r|
Show InChI InChI=1S/C21H25ClF2N6O3/c22-11-4-12(23)6-13(5-11)28-15-7-16(31)17(32)9-30(21(15)33)14-2-1-3-29(8-14)20-18(24)19(25)26-10-27-20/h4-6,10,14-17,28,31-32H,1-3,7-9H2,(H2,25,26,27)/t14-,15-,16?,17?/m1/s1
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n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348634
PNG
(US10577374, Compound 357 | US9790229, Compound 357)
Show SMILES Clc1cc(Cl)cc(N[C@H]2CCN([C@@H]3CCCN(C3)c3ncnc4[nH]ccc34)C2=O)c1 |r|
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348636
PNG
(US10577374, Compound 359 | US9790229, Compound 359)
Show SMILES Nc1ncnc(N2CC(CC(F)(F)C2)N2CCCC(Nc3cc(F)cc(Cl)c3)C2=O)c1F
Show InChI InChI=1S/C20H21ClF4N6O/c21-11-4-12(22)6-13(5-11)29-15-2-1-3-31(19(15)32)14-7-20(24,25)9-30(8-14)18-16(23)17(26)27-10-28-18/h4-6,10,14-15,29H,1-3,7-9H2,(H2,26,27,28)
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348329
PNG
(US10577374, Compound 52 | US9790229, Compound 52)
Show SMILES C[C@@H]1CCCN1c1cccc(F)c1NC(=O)Nc1cccc(c1)C1CCCN(C1)c1ncnc2[nH]ccc12 |r|
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348386
PNG
(US10577374, Compound 109 | US9790229, Compound 109)
Show SMILES Nc1ncnc(N2CCCC(C2)c2nc(NC(=O)Nc3ccccc3N3CCCC3)cs2)c1C#N
Show InChI InChI=1S/C24H27N9OS/c25-12-17-21(26)27-15-28-22(17)33-11-5-6-16(13-33)23-30-20(14-35-23)31-24(34)29-18-7-1-2-8-19(18)32-9-3-4-10-32/h1-2,7-8,14-16H,3-6,9-11,13H2,(H2,26,27,28)(H2,29,31,34)
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348425
PNG
(US10577374, Compound 148 | US9790229, Compound 148)
Show SMILES O[C@H]1CN(C[C@H]1O)c1ccccc1NC(=O)Nc1cccc(c1)C1CCCN(C1)c1ncnc2[nH]ccc12 |r|
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348583
PNG
(US10577374, Compound 306 | US9790229, Compound 306)
Show SMILES Fc1c(Cl)cc(NC2CCCN([C@@H]3CCCN(C3)c3ncnc4[nH]ncc34)C2=O)cc1Cl |r|
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US9790229 (2017)


BindingDB Entry DOI: 10.7270/Q22809RK
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%