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USPatent US9957265

Compile Data Set for Download or QSAR

Found 226 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391489
PNG
((3S,4S)-3-{3-[(2-methyl-1,3-benzothiazol-6-yl)amin...)
Show SMILES Cc1nc2ccc(Nc3nn(C4COCC[C@@H]4C#N)c4cc[nH]c(=O)c34)cc2s1 |r|
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n/an/a 30n/an/an/an/an/an/a



GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391421
PNG
(US9957265, 1-34)
Show SMILES CC1N(C)S(=O)(=O)c2ccc(Nc3nn([C@H]4COCC[C@@H]4C#N)c4cc[nH]c(=O)c34)cc12 |r|
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GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391466
PNG
(US9957265, 1-79)
Show SMILES CCN(C(C)(C)C)S(=O)(=O)c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1 |r|
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GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391420
PNG
(US9957265, 1-33)
Show SMILES COC(C)(c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1)C(F)(F)F |r|
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GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391429
PNG
(US9957265, 1-42 | US9957265, 1-43)
Show SMILES FC(F)(F)C(N1CCCC1)c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1 |r|
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GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391391
PNG
(US9957265, 1-4)
Show SMILES CN1Cc2cc(Nc3nn([C@H]4COCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc2S1(=O)=O |r|
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GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391451
PNG
(US9957265, 1-64)
Show SMILES CC(C)(C)OC(=O)CN1Cc2cc(Nc3nn([C@H]4COCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc2S1(=O)=O |r|
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GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391464
PNG
(US9957265, 1-77 | US9957265, 1-78)
Show SMILES CC1CCN1S(=O)(=O)c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1 |r|
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GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391394
PNG
(US9957265, 1-62 | US9957265, 1-7)
Show SMILES FC(F)(F)CN1Cc2cc(Nc3nn([C@H]4COCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc2S1(=O)=O |r|
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GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391405
PNG
(US9957265, 1-18 | US9957265, 1-19 | US9957265, 1-5...)
Show SMILES CN(C)C(c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1)C(F)(F)F |r|
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GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391394
PNG
(US9957265, 1-62 | US9957265, 1-7)
Show SMILES FC(F)(F)CN1Cc2cc(Nc3nn([C@H]4COCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc2S1(=O)=O |r|
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GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM391487
PNG
(US9957265, 1-100 | US9957265, 1-101)
Show SMILES CC(C)NC1(C)C(=O)Nc2cc(Nc3nn(C4COCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc12 |r|
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GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391491
PNG
(US9957265, 2-3 | US9957265, 2-4)
Show SMILES CC(O)(c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1)C(F)(F)F |r|
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GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391405
PNG
(US9957265, 1-18 | US9957265, 1-19 | US9957265, 1-5...)
Show SMILES CN(C)C(c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1)C(F)(F)F |r|
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GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391429
PNG
(US9957265, 1-42 | US9957265, 1-43)
Show SMILES FC(F)(F)C(N1CCCC1)c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1 |r|
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GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391495
PNG
(US9957265, 2-7 | US9957265, 2-8)
Show SMILES FC(F)(F)C1(CCCCN1)c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1 |r|
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GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391495
PNG
(US9957265, 2-7 | US9957265, 2-8)
Show SMILES FC(F)(F)C1(CCCCN1)c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1 |r|
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GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM391487
PNG
(US9957265, 1-100 | US9957265, 1-101)
Show SMILES CC(C)NC1(C)C(=O)Nc2cc(Nc3nn(C4COCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc12 |r|
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GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391389
PNG
(US9957265, 1-2)
Show SMILES CS(=O)(=O)c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1 |r|
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GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM391495
PNG
(US9957265, 2-7 | US9957265, 2-8)
Show SMILES FC(F)(F)C1(CCCCN1)c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1 |r|
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GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391490
PNG
(US9957265, 2-2)
Show SMILES CC1(C)C(=O)Nc2cc(Nc3nn(C4COCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc12 |r|
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GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391392
PNG
(US9957265, 1-5)
Show SMILES CC(C)(C)N1Cc2cc(Nc3nn([C@H]4COCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc2S1(=O)=O |r|
PDB

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GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391485
PNG
(US9957265, 1-98 | US9957265, 1-99)
Show SMILES FC(F)(F)C1(CCNC1)c1ccc(Nc2nn(C3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1 |r|
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GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM391495
PNG
(US9957265, 2-7 | US9957265, 2-8)
Show SMILES FC(F)(F)C1(CCCCN1)c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1 |r|
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GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391443
PNG
(US9957265, 1-56 | US9957265, 1-57)
Show SMILES FC(F)(F)C(N1CCC1)c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1 |r|
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GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391491
PNG
(US9957265, 2-3 | US9957265, 2-4)
Show SMILES CC(O)(c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1)C(F)(F)F |r|
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GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391481
PNG
(US9957265, 1-94 | US9957265, 1-95)
Show SMILES OC(c1ccncc1)(c1ccc(Nc2nn(C3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1)C(F)(F)F |r|
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n/an/a 60n/an/an/an/an/an/a



GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391395
PNG
(US9957265, 1-8 | US9957265, 1-9)
Show SMILES NC(c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1)C(F)(F)F |r|
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n/an/a 60n/an/an/an/an/an/a



GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391487
PNG
(US9957265, 1-100 | US9957265, 1-101)
Show SMILES CC(C)NC1(C)C(=O)Nc2cc(Nc3nn(C4COCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc12 |r|
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n/an/a 60n/an/an/an/an/an/a



GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391441
PNG
(US9957265, 1-54 | US9957265, 1-55)
Show SMILES CCNC(c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1)C(F)(F)F |r|
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n/an/a 70n/an/an/an/an/an/a



GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391485
PNG
(US9957265, 1-98 | US9957265, 1-99)
Show SMILES FC(F)(F)C1(CCNC1)c1ccc(Nc2nn(C3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1 |r|
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GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391405
PNG
(US9957265, 1-18 | US9957265, 1-19 | US9957265, 1-5...)
Show SMILES CN(C)C(c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1)C(F)(F)F |r|
PDB

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n/an/a 70n/an/an/an/an/an/a



GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391483
PNG
(US9957265, 1-96 | US9957265, 1-97)
Show SMILES OC(c1ccc(Nc2nn(C3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1)(c1ccccn1)C(F)(F)F |r|
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n/an/a 70n/an/an/an/an/an/a



GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391407
PNG
(US9957265, 1-20 | US9957265, 1-21)
Show SMILES CC1(C)CCCC(O)(C1)c1ccc(Nc2nn(C3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1 |r|
PDB

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GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391393
PNG
(US9957265, 1-6)
Show SMILES CN(C)S(=O)(=O)c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1 |r|
PDB

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n/an/a 70n/an/an/an/an/an/a



GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391487
PNG
(US9957265, 1-100 | US9957265, 1-101)
Show SMILES CC(C)NC1(C)C(=O)Nc2cc(Nc3nn(C4COCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc12 |r|
PDB

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GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391467
PNG
(US9957265, 1-80 | US9957265, 1-81)
Show SMILES FC(F)(F)C(NC1CC1)c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1 |r|
PDB

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n/an/a 70n/an/an/an/an/an/a



GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391405
PNG
(US9957265, 1-18 | US9957265, 1-19 | US9957265, 1-5...)
Show SMILES CN(C)C(c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1)C(F)(F)F |r|
PDB

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n/an/a 70n/an/an/an/an/an/a



GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391453
PNG
(US9957265, 1-66)
Show SMILES CC(C)C(C)(C)S(=O)(=O)c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1 |r|
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n/an/a 70n/an/an/an/an/an/a



GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391456
PNG
(US9957265, 1-69)
Show SMILES O=c1[nH]ccc2n(nc(Nc3ccc(cc3)S(=O)(=O)N3CCC3)c12)[C@H]1COCC[C@@H]1C#N |r|
PDB

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n/an/a 80n/an/an/an/an/an/a



GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM391466
PNG
(US9957265, 1-79)
Show SMILES CCN(C(C)(C)C)S(=O)(=O)c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1 |r|
PDB

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n/an/a 80n/an/an/an/an/an/a



GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391481
PNG
(US9957265, 1-94 | US9957265, 1-95)
Show SMILES OC(c1ccncc1)(c1ccc(Nc2nn(C3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1)C(F)(F)F |r|
PDB

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n/an/a 80n/an/an/an/an/an/a



GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391400
PNG
(US9957265, 1-13)
Show SMILES CC(C)(C)S(=O)(=O)c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1 |r|
PDB

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GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391407
PNG
(US9957265, 1-20 | US9957265, 1-21)
Show SMILES CC1(C)CCCC(O)(C1)c1ccc(Nc2nn(C3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1 |r|
PDB

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GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391439
PNG
(US9957265, 1-52 | US9957265, 1-53)
Show SMILES CC(C)NC(c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1)C(F)(F)F |r|
PDB

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n/an/a 80n/an/an/an/an/an/a



GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391439
PNG
(US9957265, 1-52 | US9957265, 1-53)
Show SMILES CC(C)NC(c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1)C(F)(F)F |r|
PDB

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GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM391405
PNG
(US9957265, 1-18 | US9957265, 1-19 | US9957265, 1-5...)
Show SMILES CN(C)C(c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1)C(F)(F)F |r|
PDB

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GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM391429
PNG
(US9957265, 1-42 | US9957265, 1-43)
Show SMILES FC(F)(F)C(N1CCCC1)c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1 |r|
PDB

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GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391437
PNG
(US9957265, 1-50 | US9957265, 1-51)
Show SMILES CC(C)(C)NC(c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1)C(F)(F)F |r|
PDB

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n/an/a 80n/an/an/an/an/an/a



GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391441
PNG
(US9957265, 1-54 | US9957265, 1-55)
Show SMILES CCNC(c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1)C(F)(F)F |r|
PDB

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n/an/a 80n/an/an/an/an/an/a



GSK



Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


Bioorg Med Chem Lett 19: 469-73 (2009)


BindingDB Entry DOI: 10.7270/Q2FQ9ZX0
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 226 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%