Solution Information | help | |
Enzyme: | Ion channel NompC | |
inhibitor: | BDBM46900 | |
substrate: | n/a | |
Solution Type: | Aqueous | |
pH at Preparation: | n/a | |
Temp. Prep.: | n/a | |
Comments: | Assay Overview: The purpose of this assay is to determine dose response curves for compounds identified as active in a previous set of experiments entitled, "Primary cell-based high-throughput screening assay to identify agonists of the transient receptor potential channel ML3" (PubChem AID 1448), inactive in a set of experiments entitled, "Primary cell-based high-throughput screening assay to identify agonists of the transient receptor potential channel N1 (TRPN1)" (PubChem AID 1424), and that confirmed activity in a set of experiments entitled, "Confirmation cell-based high-throughput screening assay to identify agonists of the transient receptor potential channel ML3" (PubChem AID 1526). This assay also serves as a counterscreen to determine whether compounds act as nonselective agonists due to activation of TRPN1. This assay employs a HEK293 cell line that stably expresses the zebrafish TRPN1-YFP cation channel. The cells are treated with test compounds followed by measurement of | |
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