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| Solution Information | help | |
| Enzyme: | Neuropeptide Y receptor type 2 | |
| inhibitor: | BDBM44012 | |
| substrate: | n/a | |
| Solution Type: | Aqueous | |
| pH at Preparation: | n/a | |
| Temp. Prep.: | n/a | |
| Comments: | Assay Overview: The purpose of this assay is to determine whether compounds identified as active in a set of previous experiments entitled, "Primary cell-based high-throughput screening assay for potentiators or agonists of NPY-Y1" (AID 1304), "Fluorescence-based counterscreen assay for potentiators of NPY-Y1: cell-based high-throughput screening assay to identify agonists of NPY-Y1" (AID 1697), and inactive in a set of previous experiments entitled, "Primary cell-based high-throughput screening assay for potentiators or agonists of NPY-Y2," (AID 1359) and "Fluorescence-based counterscreen assay for potentiators or agonists of NPY-Y1: cell-based high-throughput screening assay to identify inhibitors of cyclic nucleotide gated ion channel (CNGC) activity" (AID 1704) were nonselective due to activation of NPY-Y2. In this assay, a cell line transfected with Y2 and a cyclic-nucleotide gated channel (CNGC) is used to measure direct agonism of the Y2 receptor by test compound in the abs | |
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