Reaction Details | |||
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Report a problem with these data | |||
Cell Reactant: | Grb2-SH2 | ||
Syringe Reactant: | pY317 S(-1)A | ||
Meas. Tech.: | ITC | ||
Entry Date: | 11/29/00 | ||
ΔG°: | -37.6±0.546 (kJ/mole) | ||
pH: | 7.5±n/a | ||
Log10Kb: | 6.70± n/a | ||
Temperature: | 293.15±n/a (K) | ||
ΔH° : | -30.2±1.55 (kJ/mole) | ||
ΔHobs : | -30.2± (kJ/mole) | ||
Ionic Strength: | n/a | ||
yes | |||
Protons Released: | 0 | ||
ΔCp : | n/a | ||
Stoich. Param.: | n/a | ||
ΔS° : | 0.025±0.00700 (kJ/mole-K) | ||
Comments: | n/a | ||
Citation | McNemar, C; Snow, ME; Windsor, WT; Prongay, A; Mui, P; Zhang, R; Durkin, J; Le, HV; Weber, PC Thermodynamic and structural analysis of phosphotyrosine polypeptide binding to Grb2-SH2. Biochemistry36:10006-14 (1997) [PubMed] Article | ||
More Info.: | Get all data from this article , ITC RUN data , Solution Info , Instrument Info | ||
Grb2-SH2 | |||
Source: | DNA construct for the Grb2-SH2 domain was expressed in E.coli | ||
Purity: | >98% | ||
Prep. Method: | Mono-Q and Mono-S columns | ||
Name: | Growth factor receptor-bound protein 2 | ||
Synonyms: | ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2 | ||
Type: | Protein | ||
Mol. Mass.: | 25205.04 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P62993 | ||
Residue: | 217 | ||
Sequence: |
| ||
pY317 S(-1)A | |||
Source: | AnaSpec Inc. (San Jose, CA) | ||
Purity: | n/a | ||
Prep. Method: | Fmoc solid-phase peptide synthesis | ||
Name: | pY317 S(-1)A | ||
Synonyms: | pY317S(-1)A | ||
Type: | Peptide | ||
Mol. Mass.: | 692.76 | ||
Organism: | n/a | ||
Description: | alanine substitution of pY317 (phosphotyrosine polypeptide) | ||
Residue: | 6 | ||
Sequence: |
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