Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Cell Reactant: | Farnesyl Diphosphate Synthase (FPPS) | ||
| Syringe Reactant: | BDBM12578 | ||
| Meas. Tech.: | Isothermal Titration Calorimetry | ||
| Entry Date: | 12/13/06 | ||
| ΔG°: | -9.93± (kcal/mole) | ||
| pH: | 7.4±n/a | ||
| Log10Kb: | 7.31± n/a | ||
| Temperature: | 300±n/a (K) | ||
| ΔH° : | n/a | ||
| ΔHobs : | 1.65± (kcal/mole) | ||
| Ionic Strength: | n/a | ||
| no | |||
| Protons Released: | n/a | ||
| ΔCp : | n/a | ||
| Stoich. Param.: | n/a | ||
| ΔS° : | 0.0400± (kcal/mole-K) | ||
| Comments: | IC50=0.4 uM | ||
| Citation |  Yin, F; Cao, R; Goddard, A; Zhang, Y; Oldfield, E Enthalpy versus entropy-driven binding of bisphosphonates to farnesyl diphosphate synthase. J Am Chem Soc128:3524-5 (2006) [PubMed] Article | ||
| More Info.: | Get all data from this article , ITC RUN data , Solution Info , Data Fit Method , Instrument Info | ||
| Farnesyl Diphosphate Synthase (FPPS) | |||
| Source: | n/a | ||
| Purity: | n/a | ||
| Prep. Method: | n/a | ||
| Name: | Farnesyl Diphosphate Synthase (FPPS) | ||
| Synonyms: | n/a | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 41958.09 | ||
| Organism: | Trypanosoma brucei | ||
| Description: | Q86C09 | ||
| Residue: | 367 | ||
| Sequence: |
| ||
| BDBM12578 | |||
| Source: | n/a | ||
| Purity: | n/a | ||
| Prep. Method: | n/a | ||
| Name | BDBM12578 | ||
| Synonyms: | 2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosphonic acid | Bisphosphonate 3 | CGP-42446 | CHEMBL924 | JMC515594 Compound 55 | Reclast | US11279719, Example Zolendronic acid (ZOL) | ZOL | Zoledronate | Zometa | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl]phosphonic acid | zoledronic acid | ||
| Type | Small organic molecule | ||
| Emp. Form. | C5H10N2O7P2 | ||
| Mol. Mass. | 272.0896 | ||
| SMILES | OC(Cn1ccnc1)(P(O)(O)=O)P(O)(O)=O | ||
| Structure | 
| ||
|
Home |
| |
Search |
| |
Deposit |
| |
SiteMap |
| |
About us |
| |
Email us |
| |
Info |
|
©2000 BindingDB. All rights reserved. |
|||||||||||||