Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Cell Reactant: | BDBM18036 | ||
Syringe Reactant: | Renin | ||
Meas. Tech.: | Isothermal Titration Calorimetry | ||
Entry Date: | 09/19/07 | ||
ΔG°: | -7.5± (kcal/mole) | ||
pH: | 7±n/a | ||
Log10Kb: | 5.45± n/a | ||
Temperature: | 301.15±n/a (K) | ||
ΔH° : | n/a | ||
ΔHobs : | -9.5± (kcal/mole) | ||
Ionic Strength: | n/a | ||
no | |||
Protons Released: | n/a | ||
ΔCp : | n/a | ||
Stoich. Param.: | n/a | ||
ΔS° : | -0.0100± (kcal/mole-K) | ||
Comments: | n/a | ||
Citation | Sarver, RW; Peevers, J; Cody, WL; Ciske, FL; Dyer, J; Emerson, SD; Hagadorn, JC; Holsworth, DD; Jalaie, M; Kaufman, M; Mastronardi, M; McConnell, P; Powell, NA; Quin, J; Van Huis, CA; Zhang, E; Mochalkin, I Binding thermodynamics of substituted diaminopyrimidine renin inhibitors. Anal Biochem360:30-40 (2007) [PubMed] Article | ||
More Info.: | Get all data from this article , ITC RUN data , Solution Info , Data Fit Method , Instrument Info | ||
BDBM18036 | |||
Source: | n/a | ||
Purity: | n/a | ||
Prep. Method: | n/a | ||
Name | BDBM18036 | ||
Synonyms: | 5-(4-{[(3,5-difluorophenyl)methyl]amino}phenyl)-6-ethylpyrimidine-2,4-diamine | diaminopyrimidine renin inhibitor compound, 1 | ||
Type | Small organic molecule | ||
Emp. Form. | C19H19F2N5 | ||
Mol. Mass. | 355.3845 | ||
SMILES | CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)cc(F)c2)cc1 | ||
Structure | |||
Renin | |||
Source: | Recombinant human renin expressed in CHO cells | ||
Purity: | Purified crystalizable protein. | ||
Prep. Method: | Mature renin was eluted and loaded onto Blue Sepharose 6 Fast Flow. The unbound fraction containing renin was buffer exchanged and loaded onto POROS S/20. Renin was eluted and dialyzed. Purified renin was concentrated to 12 mg/mL and stored at -70C. | ||
Name: | Renin | ||
Synonyms: | Angiotensinogenase | REN | RENI_HUMAN | ||
Type: | Enzyme | ||
Mol. Mass.: | 45058.99 | ||
Organism: | Homo sapiens (Human) | ||
Description: | n/a | ||
Residue: | 406 | ||
Sequence: |
|
Home |
| |
Search |
| |
Deposit |
| |
SiteMap |
| |
About us |
| |
Email us |
| |
Info |
|
©2000 BindingDB. All rights reserved. |