Reaction Details | |||
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Report a problem with these data | |||
Cell Reactant: | v-Src SH2 Domain | ||
Syringe Reactant: | BDBM22597 | ||
Meas. Tech.: | Isothermal Titration Calorimetry | ||
Entry Date: | 06/14/08 | ||
ΔG°: | -21.4± (kJ/mole) | ||
pH: | 6±n/a | ||
Log10Kb: | 3.76± 2.95 | ||
Temperature: | 298.15±n/a (K) | ||
ΔH° : | n/a | ||
ΔHobs : | -3.30±0.490 (kJ/mole) | ||
Ionic Strength: | n/a | ||
no | |||
Protons Released: | n/a | ||
ΔCp : | n/a | ||
Stoich. Param.: | n/a | ||
ΔS° : | 0.0607± (kJ/mole-K) | ||
Comments: | ITC data were obtained through competition experiments using high affinity peptide (PQpYEEIPI) as the competitor. | ||
Citation | Taylor, JD; Gilbert, PJ; Williams, MA; Pitt, WR; Ladbury, JE Identification of novel fragment compounds targeted against the pY pocket of v-Src SH2 by computational and NMR screening and thermodynamic evaluation. Proteins67:981-90 (2007) [PubMed] Article | ||
More Info.: | Get all data from this article , ITC RUN data , Solution Info , Data Fit Method , Instrument Info | ||
v-Src SH2 Domain | |||
Source: | n/a | ||
Purity: | n/a | ||
Prep. Method: | n/a | ||
Name: | Tyrosine-protein kinase transforming protein Src | ||
Synonyms: | SRC_RSVSA | V-SRC | p60-Src | v-Src SH2 Domain | ||
Type: | SH2 Domain | ||
Mol. Mass.: | 58884.32 | ||
Organism: | Avian leukosis virus (RSA) | ||
Description: | P00524 | ||
Residue: | 526 | ||
Sequence: |
| ||
BDBM22597 | |||
Source: | n/a | ||
Purity: | n/a | ||
Prep. Method: | n/a | ||
Name | BDBM22597 | ||
Synonyms: | (2S)-2-amino-3-[4-(phosphonooxy)phenyl]propanoic acid | Phosphonotyrosine | Phosphotyrosine (pY) | ||
Type | Phosphoamino Acid | ||
Emp. Form. | C9H12NO6P | ||
Mol. Mass. | 261.1684 | ||
SMILES | N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(O)=O | ||
Structure |
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