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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Cell Reactant: | Histone deacetylase 8 (HDAC8) | ||
| Syringe Reactant: | BDBM50005711 | ||
| Meas. Tech.: | Enzyme Inhibition | ||
| Entry Date: | 09/14/15 | ||
| ΔG°: | -36±1 (kJ/mole) | ||
| pH: | 7.5±0 | ||
| Log10Kb: | 6.53± n/a | ||
| Temperature: | 25±0 (K) | ||
| ΔH° : | -36.9± (kJ/mole) | ||
| ΔHobs : | -37.4±2 (kJ/mole) | ||
| Ionic Strength: | n/a | ||
| n/a | |||
| Protons Released: | n/a | ||
| ΔCp : | n/a | ||
| Stoich. Param.: | n/a | ||
| ΔS° : | -0.003±0.00100 (kJ/mole-K) | ||
| Comments: | n/a | ||
| Citation |  Singh, RK; Suzuki, T; Mandal, T; Balsubramanian, N; Haldar, M; Mueller, DJ; Strode, JA; Cook, G; Mallik, S; Srivastava, DK Thermodynamics of binding of structurally similar ligands to histone deacetylase 8 sheds light on challenges in the rational design of potent and isozyme-selective inhibitors of the enzyme. Biochemistry53:7445-58 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article , ITC RUN data , Solution Info , Instrument Info | ||
| Histone deacetylase 8 (HDAC8) | |||
| Source: | n/a | ||
| Purity: | n/a | ||
| Prep. Method: | n/a | ||
| Name: | Histone deacetylase 8 | ||
| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 41749.60 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q9BY41 | ||
| Residue: | 377 | ||
| Sequence: |
| ||
| BDBM50005711 | |||
| Source: | n/a | ||
| Purity: | n/a | ||
| Prep. Method: | n/a | ||
| Name | BDBM50005711 | ||
| Synonyms: | CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichostatin A | Trichostatin A (TSA) | US10011611, Trichostatin A | US10722597, Compound Trichostatin | US11535598, Compound Trichostatin A | US20230322747, Compound trichostatin A | US9265734, TSA | ||
| Type | Small organic molecule | ||
| Emp. Form. | C17H22N2O3 | ||
| Mol. Mass. | 302.3682 | ||
| SMILES | C[C@H](\C=C(/C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C |r| | ||
| Structure | 
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