Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Cell Reactant: | Histone deacetylase 8 (HDAC8) | ||
| Syringe Reactant: | BDBM152693 | ||
| Meas. Tech.: | Enzyme Inhibition | ||
| Entry Date: | 09/14/15 | ||
| ΔG°: | -7.89±0.480 (kcal/mole) | ||
| pH: | 7.5±0 | ||
| Log10Kb: | 5.98± n/a | ||
| Temperature: | 25±0 (K) | ||
| ΔH° : | -6.65± (kcal/mole) | ||
| ΔHobs : | -2.73±0.240 (kcal/mole) | ||
| Ionic Strength: | n/a | ||
| n/a | |||
| Protons Released: | n/a | ||
| ΔCp : | n/a | ||
| Stoich. Param.: | n/a | ||
| ΔS° : | 0±0 (kcal/mole-K) | ||
| Comments: | n/a | ||
| Citation |  Singh, RK; Suzuki, T; Mandal, T; Balsubramanian, N; Haldar, M; Mueller, DJ; Strode, JA; Cook, G; Mallik, S; Srivastava, DK Thermodynamics of binding of structurally similar ligands to histone deacetylase 8 sheds light on challenges in the rational design of potent and isozyme-selective inhibitors of the enzyme. Biochemistry53:7445-58 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article , ITC RUN data , Solution Info , Instrument Info | ||
| Histone deacetylase 8 (HDAC8) | |||
| Source: | n/a | ||
| Purity: | n/a | ||
| Prep. Method: | n/a | ||
| Name: | Histone deacetylase 8 | ||
| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 41749.60 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q9BY41 | ||
| Residue: | 377 | ||
| Sequence: |
| ||
| BDBM152693 | |||
| Source: | n/a | ||
| Purity: | n/a | ||
| Prep. Method: | n/a | ||
| Name | BDBM152693 | ||
| Synonyms: | MH-12/4 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H24N2O3 | ||
| Mol. Mass. | 376.4483 | ||
| SMILES | CC(NC(=O)CCCC1C=Cc2ccc3C=CCc4ccc1c2c34)C(=O)NO |c:9,15| | ||
| Structure | 
| ||
|
Home |
| |
Search |
| |
Deposit |
| |
SiteMap |
| |
About us |
| |
Email us |
| |
Info |
|
©2000 BindingDB. All rights reserved. |
|||||||||||||