Reaction Details | |||
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Cell Reactant: | Methylthioadenosine Phosphorylase (MTAP) | ||
Syringe Reactant: | BDBM218802 | ||
Meas. Tech.: | Enzyme Inhibition | ||
Entry Date: | 03/22/17 | ||
Δ G ° : | n/a | ||
pH: | 7.4±0 | ||
Log10Kb: | n/a | ||
Temperature: | 319.15±0 (K) | ||
ΔH° : | -96.3±3 (kJ/mole) | ||
ΔHobs: | n/a | ||
Ionic Strength: | n/a | ||
n/a | |||
Protons Released: | n/a | ||
ΔCp : | n/a | ||
Stoich. Param.: | n/a | ||
ΔS° : | n/a | ||
Comments: | n/a | ||
Citation | Firestone, RS; Cameron, SA; Karp, JM; Arcus, VL; Schramm, VL Heat Capacity Changes for Transition-State Analogue Binding and Catalysis with Human 5'-Methylthioadenosine Phosphorylase. ACS Chem Biol12:464-473 (2017) [PubMed] Article | ||
More Info.: | Get all data from this article , ITC RUN data , Instrument Info | ||
Methylthioadenosine Phosphorylase (MTAP) | |||
Source: | n/a | ||
Purity: | n/a | ||
Prep. Method: | n/a | ||
Name: | S-methyl-5'-thioadenosine phosphorylase | ||
Synonyms: | 5'-Methylthioadenosine phosphorylase (MTAP) | MSAP | MTA phosphorylase | MTAP | MTAP_HUMAN | MTAPase | Methylthioadenosine Phosphorylase (MTAP) | S-methyl-5 -thioadenosine phosphorylase | ||
Type: | Enzyme | ||
Mol. Mass.: | 31239.23 | ||
Organism: | Homo sapiens (Human) | ||
Description: | n/a | ||
Residue: | 283 | ||
Sequence: |
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BDBM218802 | |||
Source: | n/a | ||
Purity: | n/a | ||
Prep. Method: | n/a | ||
Name | BDBM218802 | ||
Synonyms: | DADMe-ImmH | ||
Type | Small organic molecule | ||
Emp. Form. | C12H17N4O3 | ||
Mol. Mass. | 265.2878 | ||
SMILES | OCC1C[NH+](Cc2c[nH]c3c2nc[nH]c3=O)C[C@H]1O |r| | ||
Structure |
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