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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Cell Reactant: | Ephrin type-A receptor 3 ligand binding domain (EphA3-LBD) | ||
| Syringe Reactant: | BDBM223311 | ||
| Meas. Tech.: | Enzyme Inhibition | ||
| Entry Date: | 04/27/17 | ||
| ΔG°: | -7.31± (kcal/mole) | ||
| pH: | 6.5±0 | ||
| Log10Kb: | 5.32± n/a | ||
| Temperature: | 300.15±0 (K) | ||
| ΔH° : | -1.54±0.310 (kcal/mole) | ||
| ΔHobs: | n/a | ||
| Ionic Strength: | n/a | ||
| n/a | |||
| Protons Released: | n/a | ||
| ΔCp : | n/a | ||
| Stoich. Param.: | n/a | ||
| ΔS° : | 0.0200±0 (kcal/mole-K) | ||
| Comments: | n/a | ||
| Citation |  Wu, B; De, SK; Kulinich, A; Salem, AF; Koeppen, J; Wang, R; Barile, E; Wang, S; Zhang, D; Ethell, I; Pellecchia, M Potent and Selective EphA4 Agonists for the Treatment of ALS. Cell Chem Biol24:293-305 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article , ITC RUN data | ||
| Ephrin type-A receptor 3 ligand binding domain (EphA3-LBD) | |||
| Source: | n/a | ||
| Purity: | n/a | ||
| Prep. Method: | n/a | ||
| Name: | Ephrin type-A receptor 3 [29-207] | ||
| Synonyms: | EPHA3 | EPHA3_HUMAN | ETK | ETK1 | Ephrin type-A receptor 3 ligand binding domain (EphA3-LBD) | HEK | TYRO4 | ||
| Type: | Protein | ||
| Mol. Mass.: | 20707.76 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Human EphA3-LBD (29-207 aa) | ||
| Residue: | 179 | ||
| Sequence: |
| ||
| BDBM223311 | |||
| Source: | n/a | ||
| Purity: | n/a | ||
| Prep. Method: | n/a | ||
| Name | BDBM223311 | ||
| Synonyms: | 123C4 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C43H47ClN8O6 | ||
| Mol. Mass. | 807.336 | ||
| SMILES | COc1ccc2[nH]cc(CCNC(=O)[C@H](Cc3ccncc3)NC(=O)[C@H](Cc3ccc(Cl)cc3)NC(=O)[C@H](Cc3c[nH]c4ccc(O)cc34)NC(=O)CCCN)c2c1 |r| | ||
| Structure | 
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