| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Androgen receptor |
|---|
| Ligand | BDBM508515 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Androgen Receptor Binding Assay |
|---|
| Ki | 62.0±n/a nM |
|---|
| Citation |  Wohlfahrt, G; Törmäkangas, O; Salo, H; Höglund, I; Karjalainen, A; Koivikko, P; Holm, P; Rasku, S; Vesalainen, A Androgen receptor modulating compounds US Patent US11046713 Publication Date 6/29/2021 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Androgen receptor |
|---|
| Name: | Androgen receptor |
|---|
| Synonyms: | ANDR_HUMAN | AR | Androgen Receptor | Androgen receptor (AR) | Androgen receptor/Baculoviral IAP repeat-containing protein 2 | DHTR | Dihydrotestosterone receptor | NR3C4 | Nuclear receptor subfamily 3 group C member 4 |
|---|
| Type: | Receptor |
|---|
| Mol. Mass.: | 99185.27 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | CHO cells were stably transfected with human AR gene.
|
|---|
| Residue: | 920 |
|---|
| Sequence: | MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREVIQNPGPRHPEAASAAPPGASLLLLQQQ
QQQQQQQQQQQQQQQQQQQQETSPRQQQQQQGEDGSPQAHRRGPTGYLVLDEEQQPSQPQ
SALECHPERGCVPEPGAAVAASKGLPQQLPAPPDEDDSAAPSTLSLLGPTFPGLSSCSAD
LKDILSEASTMQLLQQQQQEAVSEGSSSGRAREASGAPTSSKDNYLGGTSTISDNAKELC
KAVSVSMGLGVEALEHLSPGEQLRGDCMYAPLLGVPPAVRPTPCAPLAECKGSLLDDSAG
KSTEDTAEYSPFKGGYTKGLEGESLGCSGSAAAGSSGTLELPSTLSLYKSGALDEAAAYQ
SRDYYNFPLALAGPPPPPPPPHPHARIKLENPLDYGSAWAAAAAQCRYGDLASLHGAGAA
GPGSGSPSAAASSSWHTLFTAEEGQLYGPCGGGGGGGGGGGGGGGGGGGGGGGEAGAVAP
YGYTRPPQGLAGQESDFTAPDVWYPGGMVSRVPYPSPTCVKSEMGPWMDSYSGPYGDMRL
ETARDHVLPIDYYFPPQKTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRN
DCTIDKFRRKNCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGEASSTTSPTEETTQKL
TVSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWA
KALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSR
MYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELD
RIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEII
SVQVPKILSGKVKPIYFHTQ
|
|
|
|---|
| BDBM508515 |
|---|
| n/a |
|---|
| Name | BDBM508515 |
|---|
| Synonyms: | N-(2-(5-(3,4-dichlorophenyl)furan-2-yl)ethyl)-3-(morpholine-4-carbonyl)-1H-pyrazole-5-carboxamide | US11046713, Example 8 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H18Cl2N4O4 |
|---|
| Mol. Mass. | 449.287 |
|---|
| SMILES | Clc1cccc(-c2ccc(CNC(=O)c3cc(n[nH]3)C(=O)N3CCOCC3)o2)c1Cl |
|---|
| Structure | 
|
|---|
Search and Browse
