| Reaction Details |
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 | Report a problem with these data |
| Target | Pantetheinase [22-493] |
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| Ligand | BDBM510546 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzymatic Assay |
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| IC50 | 0.300±n/a nM |
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| Citation |  Fleck, MT; Godbout, C; Koolman, HF Heteroaromatic compounds as Vanin inhibitors US Patent US11078182 Publication Date 8/3/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Pantetheinase [22-493] |
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| Name: | Pantetheinase [22-493] |
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| Synonyms: | Pantetheinase (VNN1)(22-493) | VNN1 | VNN1_HUMAN |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 52490.93 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 22-493 |
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| Residue: | 472 |
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| Sequence: | QDTFTAAVYEHAAILPNATLTPVSREEALALMNRNLDILEGAITSAADQGAHIIVTPEDA
IYGWNFNRDSLYPYLEDIPDPEVNWIPCNNRNRFGQTPVQERLSCLAKNNSIYVVANIGD
KKPCDTSDPQCPPDGRYQYNTDVVFDSQGKLVARYHKQNLFMGENQFNVPKEPEIVTFNT
TFGSFGIFTCFDILFHDPAVTLVKDFHVDTIVFPTAWMNVLPHLSAVEFHSAWAMGMRVN
FLASNIHYPSKKMTGSGIYAPNSSRAFHYDMKTEEGKLLLSQLDSHPSHSAVVNWTSYAS
SIEALSSGNKEFKGTVFFDEFTFVKLTGVAGNYTVCQKDLCCHLSYKMSENIPNEVYALG
AFDGLHTVEGRYYLQICTLLKCKTTNLNTCGDSAETASTRFEMFSLSGTFGTQYVFPEVL
LSENQLAPGEFQVSTDGRLFSLKPTSGPVLTVTLFGRLYEKDWASNASSGLT
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| BDBM510546 |
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| n/a |
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| Name | BDBM510546 |
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| Synonyms: | N-tert-Butyl-5-[3-methyl-3-(pyridin-2-yl)azetidine-1-carbonyl]pyridin-2-amine | US11078182, Ex. 8 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H24N4O |
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| Mol. Mass. | 324.4201 |
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| SMILES | CC(C)(C)Nc1ccc(cn1)C(=O)N1CC(C)(C1)c1ccccn1 |
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| Structure | 
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