| Reaction Details |
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 | Report a problem with these data |
| Target | Casein kinase I isoform epsilon |
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| Ligand | BDBM302780 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinase Assay |
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| IC50 | <10±n/a nM |
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| Citation |  Velaparthi, U; Darne, CP; Liu, P; Wittman, MD; Pearce, BC; Araujo, EM; Dasgupta, B; Nair, JS; Janakiraman, SK; Rachamreddy, CR; Mettu, MR; Karuppiah, AM; Reddy, BS; Nagalakshmi, P; Bora, RO; Maheshwarappa, SH; Kumaravel, S; Mullick, D; Sistla, R Substituted 4,5,6,7-tetrahydropyrazolo[1,5-A]pyrazine derivatives as casein kinase 1 D/E inhibitors US Patent US9598423 Publication Date 3/21/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Casein kinase I isoform epsilon |
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| Name: | Casein kinase I isoform epsilon |
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| Synonyms: | Axin-1/Casein kinase I epsilon | CKI-epsilon | CKIe | CSNK1E | Casein kinase 1 epsilon (CK1Æ) | Casein kinase I epsilon | Casein kinase I isoform epsilon (CK1 epsilon) | Casein kinase I isoform epsilon (CK1E) | Casein kinase I isoform epsilon (CK1epsilon) | KC1E_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 47340.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49674 |
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| Residue: | 416 |
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| Sequence: | MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQ
GGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIH
SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYA
SINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVL
CKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARN
PEDVDRERREHEREERMGQLRGSATRALPPGPPTGATANRLRSAAEPVASTPASRIQPAG
NTSPRAISRVDRERKVSMRLHRGAPANVSSSDLTGRQEVSRIPASQTSVPFDHLGK
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| BDBM302780 |
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| n/a |
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| Name | BDBM302780 |
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| Synonyms: | (S)-2-(3- Chlorophenyl)-N5- (4-cyano-3-fluorophenyl)- 7-(fluoromethyl)-6,7- dihydropyrazolo [1,5-a]pyrazine- 3,5(4H)-dicarboxamide | US9598423, Example A8 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H17ClF2N6O2 |
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| Mol. Mass. | 470.859 |
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| SMILES | NC(=O)c1c2CN(C[C@@H](CF)n2nc1-c1cccc(Cl)c1)C(=O)Nc1ccc([N+]#[C-])c(F)c1 |r,$;;;;;;;;;;;;;;;;;;;;;;;HN;;;;;;;;;$| |
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| Structure | 
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