| Reaction Details |
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 | Report a problem with these data |
| Target | Ubiquitin carboxyl-terminal hydrolase 30 |
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| Ligand | BDBM513577 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical Assay |
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| IC50 | <0.1±n/a nM |
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| Citation |  Kemp, MI; Stockley, ML; Madin, A 1-cyano-pyrrolidine derivatives as inhibitors of USP30 US Patent US11091488 Publication Date 8/17/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Ubiquitin carboxyl-terminal hydrolase 30 |
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| Name: | Ubiquitin carboxyl-terminal hydrolase 30 |
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| Synonyms: | Deubiquitinating enzyme 30 | UBP30_HUMAN | USP30 | Ub-specific protease 30 | Ubiquitin carboxyl-terminal hydrolase 30 (USP30) | Ubiquitin thioesterase 30 | Ubiquitin-specific-processing protease 30 |
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| Type: | Protein |
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| Mol. Mass.: | 58522.90 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q70CQ3 |
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| Residue: | 517 |
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| Sequence: | MLSSRAEAAMTAADRAIQRFLRTGAAVRYKVMKNWGVIGGIAAALAAGIYVIWGPITERK
KRRKGLVPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTL
LHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQ
PRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQ
SPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEK
VEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEFLMMDIYKYHLLG
HKPSQHNPKLNKNPGPTLELQDGPGAPTPVLNQPGAPKTQIFMNGACSPSLLPTLSAPMP
FPLPVVPDYSSSTYLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDT
VRKASLQEVLSSSAYLLFYERVLSRMQHQSQECKSEE
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| BDBM513577 |
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| n/a |
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| Name | BDBM513577 |
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| Synonyms: | (R)-3-(1,1-dioxido-5-(3-(pyridin-4- yl)phenyl)-1,2,5-thiadiazolidin-2- yl)pyrrolidine-1-carbonitrile | US11091488, Example 19 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H19N5O2S |
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| Mol. Mass. | 369.441 |
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| SMILES | O=S1(=O)N(CCN1c1cccc(c1)-c1ccncc1)[C@@H]1CCN(C1)C#N |
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| Structure | 
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