| Reaction Details |
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 | Report a problem with these data |
| Target | Ubiquitin carboxyl-terminal hydrolase 30 |
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| Ligand | BDBM513598 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical Assay |
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| IC50 | 0.55±n/a nM |
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| Citation |  Kemp, MI; Stockley, ML; Madin, A 1-cyano-pyrrolidine derivatives as inhibitors of USP30 US Patent US11091488 Publication Date 8/17/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Ubiquitin carboxyl-terminal hydrolase 30 |
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| Name: | Ubiquitin carboxyl-terminal hydrolase 30 |
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| Synonyms: | Deubiquitinating enzyme 30 | UBP30_HUMAN | USP30 | Ub-specific protease 30 | Ubiquitin carboxyl-terminal hydrolase 30 (USP30) | Ubiquitin thioesterase 30 | Ubiquitin-specific-processing protease 30 |
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| Type: | Protein |
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| Mol. Mass.: | 58522.90 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q70CQ3 |
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| Residue: | 517 |
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| Sequence: | MLSSRAEAAMTAADRAIQRFLRTGAAVRYKVMKNWGVIGGIAAALAAGIYVIWGPITERK
KRRKGLVPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTL
LHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQ
PRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQ
SPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEK
VEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEFLMMDIYKYHLLG
HKPSQHNPKLNKNPGPTLELQDGPGAPTPVLNQPGAPKTQIFMNGACSPSLLPTLSAPMP
FPLPVVPDYSSSTYLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDT
VRKASLQEVLSSSAYLLFYERVLSRMQHQSQECKSEE
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| BDBM513598 |
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| n/a |
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| Name | BDBM513598 |
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| Synonyms: | (3S,4R)-3-methyl-4-(5-(3-(4-methylpiperazin-1-yl)phenyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl)pyrrolidine-1-carbonitrile | US11091488, Example 40 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H28N6O2S |
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| Mol. Mass. | 404.53 |
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| SMILES | C[C@H]1CN(C[C@@H]1N1CCN(c2cccc(c2)N2CCN(C)CC2)S1(=O)=O)C#N |r| |
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| Structure | 
|
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