Reaction Details |
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Target | Serine/threonine-protein kinase pim-1 |
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Ligand | BDBM376833 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Pim Enzyme Assays |
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IC50 | <10±n/a nM |
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Citation | Vechorkin, O; Li, Y; Sokolsky, A; Wang, A; Zhu, W; Zhuo, J Heterocyclic compounds useful as Pim kinase inhibitors US Patent US11053215 Publication Date 7/6/2021 |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase pim-1 |
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Name: | Serine/threonine-protein kinase pim-1 |
Synonyms: | PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1) |
Type: | Protein |
Mol. Mass.: | 35681.82 |
Organism: | Homo sapiens (Human) |
Description: | P11309 |
Residue: | 313 |
Sequence: | MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD
NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL
ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG
ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI
PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA
EIHLHSLSPGPSK
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BDBM376833 |
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n/a |
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Name | BDBM376833 |
Synonyms: | N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridin-3-yl}-5-fluoro-3-[(2R,4S)-4-hydroxy-2-methylpyrrolidin-1-yl]quinoline-8-carboxamide | US10450296, Example 164 | US11053215, Example 164 | US9920032, Example 164 |
Type | Small organic molecule |
Emp. Form. | C27H32FN5O2 |
Mol. Mass. | 477.5737 |
SMILES | C[C@@H]1C[C@H](O)CN1c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1 |r| |
Structure |
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